CNKSR3

Summary

CNKSR3 (CNKSR family member 3, HGNC:23034) is a protein-coding gene on chromosome 6q25.2, encoding Connector enhancer of kinase suppressor of ras 3 (Q6P9H4). Involved in transepithelial sodium transport.

Predicted to be involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of peptidyl-serine phosphorylation; and positive regulation of sodium ion transport. Predicted to act upstream of or within positive regulation of sodium ion transmembrane transporter activity. Predicted to be located in apical plasma membrane and cytoplasm.

Source: NCBI Gene 154043 — RefSeq curated summary.

At a glance

• GWAS associations: 36
• Clinical variants (ClinVar): 294 total
• MANE Select transcript: NM_173515

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23034
Approved symbol	CNKSR3
Name	CNKSR family member 3
Location	6q25.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ31349
Ensembl gene	ENSG00000153721
Ensembl biotype	protein_coding
OMIM	617476
Entrez	154043

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 7 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000424998, ENST00000433165, ENST00000454664, ENST00000479339, ENST00000607772, ENST00000904025, ENST00000904026, ENST00000904027, ENST00000950871

RefSeq mRNA: 5 — MANE Select: NM_173515 NM_001368116, NM_001368117, NM_001368118, NM_001368119, NM_173515

CCDS: CCDS5246, CCDS94023

Canonical transcript exons

ENST00000607772 — 13 exons

Exon	Start	End
ENSE00001012069	154414299	154414423
ENSE00001012072	154422506	154422652
ENSE00001012081	154422915	154422983
ENSE00001792637	154428128	154428187
ENSE00001854789	154510063	154510685
ENSE00002452609	154410343	154410432
ENSE00002507000	154430472	154430591
ENSE00002519544	154441292	154441379
ENSE00002731083	154410934	154411142
ENSE00003458810	154433466	154433507
ENSE00003506942	154450095	154450258
ENSE00003643126	154442088	154442290
ENSE00003700915	154387515	154406652

Expression profiles

Bgee: expression breadth ubiquitous, 242 present calls, max score 95.37.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.5354 / max 725.4473, expressed in 1441 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
76321	4.4564	1076
76319	2.6163	1175
76322	1.1433	600
76320	0.1282	35
76318	0.1218	51
76316	0.0415	9
204262	0.0229	13
76317	0.0050	3

Top tissues by expression

254 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
esophagus squamous epithelium	UBERON:0006920	95.37	gold quality
pigmented layer of retina	UBERON:0001782	94.23	gold quality
ileal mucosa	UBERON:0000331	93.87	gold quality
cartilage tissue	UBERON:0002418	92.27	gold quality
palpebral conjunctiva	UBERON:0001812	91.27	gold quality
amniotic fluid	UBERON:0000173	90.82	gold quality
vena cava	UBERON:0004087	90.54	gold quality
tibia	UBERON:0000979	90.36	gold quality
oral cavity	UBERON:0000167	89.88	gold quality
ventricular zone	UBERON:0003053	89.85	gold quality
parotid gland	UBERON:0001831	89.50	gold quality
liver	UBERON:0002107	89.14	gold quality
lower esophagus mucosa	UBERON:0035834	88.53	gold quality
left ventricle myocardium	UBERON:0006566	88.51	gold quality
jejunal mucosa	UBERON:0000399	88.38	gold quality
right lobe of liver	UBERON:0001114	87.77	gold quality
gingival epithelium	UBERON:0001949	87.16	gold quality
gingiva	UBERON:0001828	87.11	gold quality
body of pancreas	UBERON:0001150	86.22	gold quality
smooth muscle tissue	UBERON:0001135	86.07	gold quality
esophagus mucosa	UBERON:0002469	86.06	gold quality
calcaneal tendon	UBERON:0003701	86.05	gold quality
kidney epithelium	UBERON:0004819	85.88	gold quality
body of uterus	UBERON:0009853	85.55	gold quality
ascending aorta	UBERON:0001496	85.54	gold quality
pancreas	UBERON:0001264	85.46	gold quality
thoracic aorta	UBERON:0001515	85.46	gold quality
adult mammalian kidney	UBERON:0000082	85.32	gold quality
corpus epididymis	UBERON:0004359	85.27	gold quality
descending thoracic aorta	UBERON:0002345	85.14	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-8142	yes	50.59
E-GEOD-150728	no	1977.46
E-MTAB-8271	no	210.00
E-GEOD-124858	no	188.34
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): FOXC1

miRNA regulators (miRDB)

83 targeting CNKSR3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-12121	99.99	66.64	255
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-381-3P	99.93	71.87	2854
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-300	99.92	71.76	2856
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-124-3P	99.89	73.74	3043
HSA-MIR-506-3P	99.89	73.55	3057
HSA-MIR-30A-3P	99.87	69.74	2928

Literature-anchored findings (GeneRIF, showing 7)

• CNKSR3, a homologue of scaffold proteins involved in MAPK pathway regulation, is a direct target of MR and is required for the maintenance of transepithelial sodium transport in the kidney. (PMID:19567370)
• CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration. (PMID:22085542)
• two gene markers (CNKSR3 and SPTBN2) differentiate between aspirin-exacerbated respiratory disease and aspirin-tolerant asthma with a perfect discriminative power (PMID:22457146)
• CNK3 is a molecular scaffold, which coordinates the assembly of a multiprotein ENaC-regulatory complex and hence plays a central role in Na(+) homeostasis. (PMID:22851176)
• Cox regression and Kaplan-Meier survival analysis identified that amplification of the CNKSR3 gene (log-rank, P = 0.022) with an associated increase in its protein expression (log-rank, P = 0.011) correlated with longer patient survival. (PMID:23357503)
• SCAF8-CNKSR3 variant rs955333 was not associated with diabetic kidney disease but showed association with diabetic retinopathy in Chinese type 2 diabetes patients (PMID:28401168)
• Significance of miR-15a-5p and CNKSR3 as Novel Prognostic Biomarkers in Non-Small Cell Lung Cancer (PMID:30019650)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Cnksr3	ENSMUSG00000015202
rattus_norvegicus	Cnksr3	ENSRNOG00000018052
drosophila_melanogaster	cnk	FBGN0286070
caenorhabditis_elegans		WBGENE00000564

Paralogs (4): IPCEF1 (ENSG00000074706), CNKSR1 (ENSG00000142675), CNKSR2 (ENSG00000149970), SAMD3 (ENSG00000164483)

Protein

Protein identifiers

Connector enhancer of kinase suppressor of ras 3 — Q6P9H4 (reviewed: Q6P9H4)

Alternative names: CNK homolog protein 3, CNKSR family member 3, Maguin-like protein

All UniProt accessions (3): Q6P9H4, A0A5H1ZRR2, Q5T4Y8

UniProt curated annotations — full annotation on UniProt →

Function. Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC).

Subunit / interactions. Interacts with epithelial sodium channel ENaC. Interacts directly with SCNN1A (ENaC subunit alpha) and SCNN1B (ENaC subunit beta) C-terminal tails. Interacts with ENaC regulatory proteins NEDD4L, RAF1 and SGK1.

Subcellular location. Cytoplasm. Apical cell membrane.

Domain organisation. The PDZ domain is required for interaction with ENaC and SGK1, but not for interaction with NEDDL4 and RAF1.

Induction. Up-regulated by aldosterone (at protein level).

Similarity. Belongs to the CNKSR family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q6P9H4-1	CNK3	yes
G9CGD6-1	CNK3-IPCEF1-1, CNK3/IPCEF1 Long-1
G9CGD6-2	CNK3-IPCEF1-2, CNK3/IPCEF1 Long-2
G9CGD6-3	CNK3-IPCEF1-3, CNK3/IPCEF1 Short

RefSeq proteins (5): NP_001355045, NP_001355046, NP_001355047, NP_001355048, NP_775786* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001478	PDZ	Domain
IPR001660	SAM	Domain
IPR010599	CNK2/3_dom	Domain
IPR013761	SAM/pointed_sf	Homologous_superfamily
IPR017874	CRIC_domain	Domain
IPR036034	PDZ_sf	Homologous_superfamily
IPR049628	CNK1-3_SAM	Domain
IPR051566	CNKSR	Family

Pfam: PF00536, PF00595, PF06663, PF10534

UniProt features (12 total): domain 4, region of interest 3, sequence conflict 2, modified residue 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6P9H4-F1	64.67	0.29

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 381, 383

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 429 (showing top): GOBP_ENDOTHELIAL_CELL_DEVELOPMENT, RNGTGGGC_UNKNOWN, GOBP_NEGATIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE, RRAGTTGT_UNKNOWN, GOBP_EPITHELIUM_DEVELOPMENT, YAATNRNNNYNATT_UNKNOWN, WANG_CLIM2_TARGETS_UP, PAX4_01, GOBP_REGULATION_OF_PHOSPHORYLATION, GOBP_EPITHELIAL_CELL_DEVELOPMENT, PEREZ_TP63_TARGETS, GCANCTGNY_MYOD_Q6, MODULE_45, GOBP_PEPTIDYL_SERINE_MODIFICATION, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN

GO Biological Process (4): positive regulation of sodium ion transport (GO:0010765), negative regulation of peptidyl-serine phosphorylation (GO:0033137), negative regulation of ERK1 and ERK2 cascade (GO:0070373), regulation of signal transduction (GO:0009966)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (4): cytoplasm (GO:0005737), apical plasma membrane (GO:0016324), plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
regulation of sodium ion transport	1
sodium ion transport	1
positive regulation of monoatomic ion transport	1
negative regulation of protein phosphorylation	1
peptidyl-serine phosphorylation	1
regulation of peptidyl-serine phosphorylation	1
negative regulation of MAPK cascade	1
ERK1 and ERK2 cascade	1
regulation of ERK1 and ERK2 cascade	1
signal transduction	1
regulation of cell communication	1
regulation of signaling	1
regulation of response to stimulus	1
binding	1
intracellular anatomical structure	1
apical part of cell	1
plasma membrane region	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

472 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CNKSR3	SCAF8	Q9UPN6	664
CNKSR3	CYTH2	Q99418	635
CNKSR3	A0A2Q2T6B6	A0A2Q2T6B6	603
CNKSR3	CCDC175	P0C221	563
CNKSR3	CLDN20	P56880	559
CNKSR3	TIAM2	Q8IVF5	536
CNKSR3	ARF6	P26438	479
CNKSR3	TFB1M	Q8WVM0	475
CNKSR3	ZNF619	Q8N2I2	474
CNKSR3	OPRM1	P35372	471
CNKSR3	UBOX5	O94941	458
CNKSR3	SAXO2	Q658L1	457
CNKSR3	GPRIN3	Q6ZVF9	440
CNKSR3	VWC2	Q2TAL6	407
CNKSR3	CLVS2	Q5SYC1	397

IntAct

76 interactions, top by confidence:

A	B	Type	Score
CNOT2	CNOT1	psi-mi:“MI:0914”(association)	0.740
CNKSR3	NMI	psi-mi:“MI:0915”(physical association)	0.670
NMI	CNKSR3	psi-mi:“MI:0915”(physical association)	0.670
YWHAG	BLTP3B	psi-mi:“MI:2364”(proximity)	0.640
YWHAH	BLTP3B	psi-mi:“MI:2364”(proximity)	0.570
N4BP3	CNKSR3	psi-mi:“MI:0915”(physical association)	0.560
JRK	CNKSR3	psi-mi:“MI:0915”(physical association)	0.560
DDX6	CNKSR3	psi-mi:“MI:0915”(physical association)	0.560
CDKN2B	CNKSR3	psi-mi:“MI:0915”(physical association)	0.560
EIF4A3	CNKSR3	psi-mi:“MI:0915”(physical association)	0.560
FAM76B	CNKSR3	psi-mi:“MI:0915”(physical association)	0.560
CNKSR3	GPKOW	psi-mi:“MI:0915”(physical association)	0.560
HAVCR2	TCAF2	psi-mi:“MI:0914”(association)	0.530
CNKSR3	COLGALT2	psi-mi:“MI:0914”(association)	0.530
MINK1	CNOT1	psi-mi:“MI:0914”(association)	0.530
PLOD3	COL4A1	psi-mi:“MI:0914”(association)	0.530
TAMALIN	CNKSR3	psi-mi:“MI:0407”(direct interaction)	0.440
FRMPD4	CNKSR3	psi-mi:“MI:0407”(direct interaction)	0.440
MAP2K2	CNKSR3	psi-mi:“MI:0407”(direct interaction)	0.440
ABCC4	CNKSR3	psi-mi:“MI:0407”(direct interaction)	0.440
ARHGEF16	CNKSR3	psi-mi:“MI:0407”(direct interaction)	0.440
ASIC3	CNKSR3	psi-mi:“MI:0407”(direct interaction)	0.440
ATP2B4	CNKSR3	psi-mi:“MI:0407”(direct interaction)	0.440
CYSLTR2	CNKSR3	psi-mi:“MI:0407”(direct interaction)	0.440
DGKK	CNKSR3	psi-mi:“MI:0407”(direct interaction)	0.440

BioGRID (75): CNKSR3 (Two-hybrid), CNKSR3 (Affinity Capture-MS), ARHGAP39 (Affinity Capture-MS), VCPIP1 (Affinity Capture-MS), CNKSR3 (Affinity Capture-MS), DIP2B (Affinity Capture-MS), CNKSR3 (Affinity Capture-MS), COLGALT2 (Affinity Capture-MS), NISCH (Affinity Capture-MS), CNKSR3 (Proximity Label-MS), CNKSR3 (Proximity Label-MS), CNKSR3 (Two-hybrid), CNKSR3 (Two-hybrid), CNKSR3 (Two-hybrid), CNKSR3 (Two-hybrid)

ESM2 similar proteins: A0A0G2K2P5, A0JNJ1, B1WAP7, G9CGD6, O14640, O75122, O88382, O95049, O97758, P34908, P39447, P51141, P54792, P70175, Q05AS8, Q07157, Q16825, Q5F488, Q5IS48, Q5SGD7, Q5TCQ9, Q5XI81, Q61062, Q62136, Q62728, Q62936, Q6DKE2, Q6P9H4, Q6ZM86, Q812E4, Q86UL8, Q8BMA3, Q8IVH8, Q8JHI3, Q8TDW5, Q920B0, Q924I2, Q925T6, Q92997, Q95168

Diamond homologs: A0JN54, A8JQ65, B3LXF2, B3NYS4, B4I4Y1, B4JHJ7, B4K6T8, B4PRE2, B4R0A5, D3YWQ0, D3YXJ0, D3YZU1, D3ZEY4, E9PUQ8, F1MAB7, F4JKI3, F4JQ95, G9CGD6, O08560, O75912, O88673, P09216, P10830, P16054, P20192, P23298, P23743, P34885, P49619, P49620, P49621, P51556, P52429, P52824, P90980, Q01583, Q02156, Q03603, Q05655, Q09103

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 59 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Activation of BAD and translocation to mitochondria	6	103.8×	2e-09
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	6	91.6×	2e-09
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	6	91.6×	2e-09
Activation of BH3-only proteins	6	67.7×	1e-08
RHO GTPases activate PKNs	6	43.3×	2e-07
Intrinsic Pathway for Apoptosis	6	39.9×	3e-07
Apoptosis	7	26.7×	3e-07
Translocation of SLC2A4 (GLUT4) to the plasma membrane	7	24.6×	4e-07

GO biological processes:

GO term	Partners	Fold	FDR
protein targeting	5	32.7×	1e-04
intracellular protein localization	8	14.9×	3e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

294 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	224
Likely benign	13
Benign	5

Top pathogenic / likely-pathogenic (0)

SpliceAI

9603 predictions. Top by Δscore:

Variant	Effect	Δscore
3:65361333:CCAAT:C	acceptor_gain	1.0000
3:65361334:CAAT:C	acceptor_gain	1.0000
3:65361334:CAATC:C	acceptor_gain	1.0000
3:65361335:AAT:A	acceptor_gain	1.0000
3:65361336:AT:A	acceptor_gain	1.0000
3:65361336:ATC:A	acceptor_loss	1.0000
3:65361337:TC:T	acceptor_loss	1.0000
3:65361338:C:CC	acceptor_gain	1.0000
3:65361338:C:CG	acceptor_loss	1.0000
3:65363460:CTTA:C	donor_loss	1.0000
3:65363463:A:AC	donor_gain	1.0000
3:65363463:AC:A	donor_gain	1.0000
3:65363464:C:CC	donor_gain	1.0000
3:65363464:C:CG	donor_loss	1.0000
3:65363464:CC:C	donor_gain	1.0000
3:65363464:CCCT:C	donor_gain	1.0000
3:65363604:TGCTC:T	acceptor_gain	1.0000
3:65363605:GCTC:G	acceptor_gain	1.0000
3:65363605:GCTCC:G	acceptor_gain	1.0000
3:65363606:CTC:C	acceptor_gain	1.0000
3:65363606:CTCC:C	acceptor_gain	1.0000
3:65363606:CTCCT:C	acceptor_gain	1.0000
3:65363607:TC:T	acceptor_gain	1.0000
3:65363607:TCCT:T	acceptor_gain	1.0000
3:65363608:CC:C	acceptor_gain	1.0000
3:65363609:C:CC	acceptor_gain	1.0000
3:65363611:A:AC	acceptor_gain	1.0000
3:65363611:A:C	acceptor_gain	1.0000
3:65363612:T:TC	acceptor_gain	1.0000
3:65363613:T:C	acceptor_gain	1.0000

AlphaMissense

3591 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:154422630:A:G	L274P	1.000
6:154422646:A:G	W269R	1.000
6:154422646:A:T	W269R	1.000
6:154422648:C:T	G268E	1.000
6:154422940:A:T	V258D	1.000
6:154428177:A:T	I227N	1.000
6:154441311:A:G	L163P	1.000
6:154450108:A:G	L68P	1.000
6:154450168:A:G	L48P	1.000
6:154450192:A:G	L40P	1.000
6:154510070:C:A	W15C	1.000
6:154510070:C:G	W15C	1.000
6:154510072:A:G	W15R	1.000
6:154510072:A:T	W15R	1.000
6:154510094:C:A	W7C	1.000
6:154510094:C:G	W7C	1.000
6:154510096:A:G	W7R	1.000
6:154510096:A:T	W7R	1.000
6:154422644:C:A	W269C	0.999
6:154422644:C:G	W269C	0.999
6:154422645:C:G	W269S	0.999
6:154422649:C:G	G268R	0.999
6:154422649:C:T	G268R	0.999
6:154422931:A:T	V261D	0.999
6:154422934:T:G	Q260P	0.999
6:154422946:T:A	D256V	0.999
6:154428154:G:C	H235D	0.999
6:154428173:T:A	K228N	0.999
6:154428173:T:G	K228N	0.999
6:154428175:T:C	K228E	0.999

dbSNP variants (sampled 300 via entrez): RS1000019787 (6:154389684 A>C), RS1000027147 (6:154494364 C>A,T), RS1000056758 (6:154494528 T>A), RS1000084418 (6:154432881 G>A), RS1000106523 (6:154390059 T>C), RS1000121939 (6:154487857 T>C), RS1000127023 (6:154405267 C>A,T), RS1000181081 (6:154456424 G>A), RS1000190746 (6:154429667 T>C,G), RS1000191055 (6:154500724 G>A), RS1000240159 (6:154417959 A>G), RS1000279828 (6:154471364 C>A), RS1000318684 (6:154500528 T>A), RS1000345629 (6:154423647 A>G), RS1000408881 (6:154452783 C>G,T)

Disease associations

OMIM: gene MIM:617476 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

36 associations (top):

Study	Trait	p-value
GCST001430_5	Parkinson’s disease	9.000000e-07
GCST001607_9	Renal function-related traits (eGRFcrea)	5.000000e-06
GCST001925_7	PR interval	8.000000e-06
GCST002251_3	Homeostasis model assessment of beta-cell function (dietary factor interaction)	6.000000e-06
GCST002729_1	Crohn’s disease-related phenotypes	2.000000e-08
GCST002729_5	Crohn’s disease-related phenotypes	5.000000e-07
GCST002920_6	Neuroticism	2.000000e-08
GCST002930_5	Cobalt levels	2.000000e-06
GCST003098_16	Diabetic kidney disease	6.000000e-09
GCST003127_9	Lipoprotein (a) levels	4.000000e-10
GCST003264_1611	Post bronchodilator FEV1/FVC ratio	1.000000e-06
GCST003831_13	Asthma	2.000000e-06
GCST003832_21	Asthma (childhood onset)	2.000000e-06
GCST004125_18	Type 2 diabetes (age of onset)	9.000000e-06
GCST004288_3	Adolescent idiopathic scoliosis	2.000000e-12
GCST004881_2	Knee osteoarthritis	3.000000e-07
GCST005174_7	Coronary artery calcified atherosclerotic plaque score in type 2 diabetes	9.000000e-06
GCST006940_141	Neurociticism	1.000000e-08
GCST008059_236	Estimated glomerular filtration rate	4.000000e-10
GCST008758_40	Pre-treatment viral load in HIV-1 infection	4.000000e-16
GCST010002_428	Refractive error	5.000000e-11
GCST010052_1	Ocular sarcoidosis in sarcoidosis	8.000000e-08
GCST010054_61	Ocular sarcoidosis	1.000000e-08
GCST010105_117	Nicotine dependence symptom count	2.000000e-06
GCST010105_157	Nicotine dependence symptom count	2.000000e-06
GCST010698_44	Subcortical volume (min-P)	1.000000e-11
GCST010699_15	Brain morphology (min-P)	3.000000e-10
GCST010701_35	Cortical surface area (MOSTest)	6.000000e-25
GCST010702_138	Subcortical volume (MOSTest)	4.000000e-14
GCST010703_242	Brain morphology (MOSTest)	7.000000e-12

EFO canonical traits (17, from GWAS)

EFO ID	Trait name
EFO:0004462	PR interval
EFO:0004469	HOMA-B
EFO:0008111	diet measurement
EFO:0006818	stricture
EFO:0006820	complicated disease course
EFO:0007660	neuroticism measurement
EFO:0006925	lipoprotein A measurement
EFO:0004713	FEV/FVC ratio
EFO:0004723	coronary artery calcification
EFO:0010125	viral load
EFO:0010723	ocular sarcoidosis
EFO:0009262	nicotine dependence symptom count
EFO:0004346	neuroimaging measurement
EFO:0009819	comparative body size at age 10, self-reported
EFO:1001930	idiopathic osteonecrosis of the femoral head
EFO:0600027	hemoglobin change measurement
EFO:0004532	serum gamma-glutamyl transferase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs6917661	CNKSR3		0.00	0

CTD chemical–gene interactions

45 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Estradiol	increases expression, increases reaction, affects expression, affects cotreatment, decreases expression	4
trichostatin A	increases expression, affects cotreatment	3
Benzo(a)pyrene	decreases expression, increases methylation	3
Tretinoin	decreases expression, increases expression	2
Valproic Acid	affects expression, increases expression	2
Aflatoxin B1	decreases expression, increases methylation	2
aristolochic acid I	increases expression	1
arsenite	affects binding, decreases reaction	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
sodium arsenite	affects cotreatment, decreases expression, increases abundance	1
cobaltous chloride	increases expression	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
S-(1,2-dichlorovinyl)cysteine	increases expression, decreases reaction	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
pentanal	decreases expression	1
perfluorooctane sulfonic acid	decreases expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	increases expression, affects cotreatment	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
jinfukang	affects cotreatment, decreases expression	1
(+)-JQ1 compound	increases expression	1
PCI 5002	affects cotreatment, increases expression	1
Temozolomide	increases expression	1
Leflunomide	increases expression	1
Arsenic	decreases expression, increases abundance, affects cotreatment	1
Caffeine	decreases phosphorylation	1
Carbamazepine	affects expression	1
Cisplatin	affects cotreatment, decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2UM	Abcam HEK293T CNKSR3 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.