CNN1

Summary

CNN1 (calponin 1, HGNC:2155) is a protein-coding gene on chromosome 19p13.2, encoding Calponin-1 (P51911). Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction.

Predicted to enable actin filament binding activity. Involved in negative regulation of vascular associated smooth muscle cell proliferation. Located in cytoskeleton.

Source: NCBI Gene 1264 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 63 total
• MANE Select transcript: NM_001299

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:2155
Approved symbol	CNN1
Name	calponin 1
Location	19p13.2
Locus type	gene with protein product
Status	Approved
Aliases	SMCC, Sm-Calp
Ensembl gene	ENSG00000130176
Ensembl biotype	protein_coding
OMIM	600806
Entrez	1264

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 15 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000252456, ENST00000535659, ENST00000585869, ENST00000586059, ENST00000586577, ENST00000587087, ENST00000588468, ENST00000588935, ENST00000592338, ENST00000592923, ENST00000873889, ENST00000873890, ENST00000873891, ENST00000873892, ENST00000873893, ENST00000962387

RefSeq mRNA: 3 — MANE Select: NM_001299 NM_001299, NM_001308341, NM_001308342

CCDS: CCDS12263, CCDS77238

Canonical transcript exons

ENST00000252456 — 7 exons

Exon	Start	End
ENSE00000679861	11549323	11549469
ENSE00000679862	11547797	11547907
ENSE00000679863	11546832	11546969
ENSE00000679864	11546675	11546741
ENSE00000864719	11549550	11550323
ENSE00002789578	11538851	11538990
ENSE00003590752	11541076	11541197

Expression profiles

Bgee: expression breadth ubiquitous, 229 present calls, max score 99.92.

FANTOM5 (CAGE): breadth broad, TPM avg 36.6013 / max 4973.7087, expressed in 902 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
173931	33.7707	858
208692	2.0930	498
173934	0.3176	123
173933	0.2195	115
173935	0.0955	46
173932	0.0759	26
173936	0.0291	14

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
saphenous vein	UBERON:0007318	99.92	gold quality
lower esophagus muscularis layer	UBERON:0035833	99.82	gold quality
popliteal artery	UBERON:0002250	99.81	gold quality
tibial artery	UBERON:0007610	99.81	gold quality
lower esophagus	UBERON:0013473	99.81	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	99.74	gold quality
right coronary artery	UBERON:0001625	99.73	gold quality
cauda epididymis	UBERON:0004360	99.73	gold quality
body of uterus	UBERON:0009853	99.73	gold quality
aorta	UBERON:0000947	99.72	gold quality
seminal vesicle	UBERON:0000998	99.72	gold quality
mucosa of stomach	UBERON:0001199	99.68	gold quality
urethra	UBERON:0000057	99.67	gold quality
myometrium	UBERON:0001296	99.67	gold quality
left uterine tube	UBERON:0001303	99.66	gold quality
ascending aorta	UBERON:0001496	99.61	gold quality
thoracic aorta	UBERON:0001515	99.61	gold quality
muscle layer of sigmoid colon	UBERON:0035805	99.60	gold quality
blood vessel layer	UBERON:0004797	99.59	gold quality
descending thoracic aorta	UBERON:0002345	99.52	gold quality
left coronary artery	UBERON:0001626	99.51	gold quality
vena cava	UBERON:0004087	99.51	gold quality
coronary artery	UBERON:0001621	99.50	gold quality
gall bladder	UBERON:0002110	99.21	gold quality
lower esophagus mucosa	UBERON:0035834	99.00	gold quality
endocervix	UBERON:0000458	98.87	gold quality
adult organism	UBERON:0007023	98.82	gold quality
fundus of stomach	UBERON:0001160	98.78	gold quality
superficial temporal artery	UBERON:0001614	98.73	gold quality
nipple	UBERON:0002030	98.70	gold quality

Single-cell (SCXA)

Detected in 8 experiment(s), a significant marker in 7.

Experiment	Marker?	Max mean expression
E-MTAB-10287	yes	2686.67
E-MTAB-10885	yes	1579.59
E-MTAB-8205	yes	136.97
E-HCAD-1	yes	37.29
E-MTAB-8410	yes	29.34
E-HCAD-11	yes	11.42
E-GEOD-124858	no	41.78
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): EGR2, HMGXB4, MYOCD, SRF, TCF21, TCF3

miRNA regulators (miRDB)

59 targeting CNN1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-218-5P	99.93	72.22	2103
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-106A-5P	99.90	73.94	2683
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-17-5P	99.89	73.83	2665
HSA-MIR-424-5P	99.89	71.90	2641
HSA-MIR-6838-5P	99.89	71.94	2690
HSA-MIR-106B-5P	99.88	74.72	2795
HSA-MIR-20A-5P	99.88	74.76	2769
HSA-MIR-20B-5P	99.88	74.01	2621
HSA-MIR-519D-3P	99.88	73.97	2607
HSA-MIR-93-5P	99.88	73.98	2606
HSA-MIR-526B-3P	99.88	74.06	2587
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-3121-3P	99.82	71.96	3630
HSA-MIR-1825	99.72	68.11	1089
HSA-MIR-6751-5P	99.56	64.99	1145
HSA-MIR-199A-5P	99.51	69.71	1107
HSA-MIR-199B-5P	99.51	69.74	1098
HSA-MIR-1275	99.47	67.90	2749
HSA-MIR-4498	99.47	67.42	2360

Literature-anchored findings (GeneRIF, showing 20)

• expression in tumor vessels is a new and useful means to predict prognosis of hepatocellular carcinoma after hepatic resection (PMID:11920541)
• results suggest that regulation of h1-calponin is involved in the regulation of differentiation of AR42J cells into insulin-producing cells (PMID:12606518)
• the calponin homology domain of Vav1 associates with calmodulin and is prerequisite to T cell antigen receptor-induced calcium release in Jurkat T lymphocytes (PMID:17550897)
• analysis of distinct sites of interaction that form the calponin: gelsolin complex and two calcium switches that control its activity (PMID:17556051)
• expression of vascular CNN1 in the peripheral region of colon cancer tissues was significantly reduced in association with tumor progression, lymphatic invasion, vascular invasion and recurrence. (PMID:17707120)
• Calponin and alpha-inhibin are the most useful positive markers for serous microcystic adenoma, and are negative in most entities in the differential diagnosis. (PMID:19391217)
• The point mutation S175T exhibited more resistance to actin rearrangement by cytochalasin D and PDBu than intact CNh1, suppressing cell motility induced by PDBu. (PMID:20530411)
• Inhibition of calponin-1 expression can inhibit uterine smooth muscle cell migration and cause the morphological change and rearrangement of F-actin without affecting its proliferation and apoptosis in vitro. (PMID:20584679)
• Calponin-1 expression in the uterine smooth muscle tissue of the body and the lower uterine segment of smooth muscle tissues was significantly different. (PMID:21051832)
• D2-40 immunohistochemistry reliably identifies the myoepithelial cells of breast in a variety of lesions in a pattern similar to that of calponin and p63. (PMID:21326813)
• A single intronic CArG element is necessary but insufficient for proper CNN1 expression in vivo. CNN1 overexpression antagonizes arterial injury-induced neointimal formation. (PMID:21817093)
• Expression of transforming growth factor-beta (4.3 +/- 1.4 vs 2.6 +/- 2.3, p = 0.01) and calponin (3.7 +/- 0.7 vs 0.6 +/- 1.1, p = 0.05) was lower from infants with vs without a PDA. (PMID:23731614)
• CNN1 immunohistochemical staining allows ready recognition of intracytoplasmic inclusions, aiding diagnosis of infantile digital fibromatosis. (PMID:24117680)
• Calponin knockdown inhibits autophosphorylation. (PMID:24350264)
• epsilonPKC/ERK/mTOR pathway activation induced by the rescued expression of CNN1 contributed to the improvement of cardiac dysfunction and pathological changes observed in transgenic mice. (PMID:24631115)
• Loss of myoepithelial calponin was specifically associated with gain of the basal marker p63 in adjacent tumor cells. (PMID:26343330)
• Loss of CNN1 expression is associated with Ovarian Cancer. (PMID:26504022)
• Studied maternal serum calponin 1 levels in the prediction of delivery within 7 days among pregnancies complicated with threatened preterm labor. Of 73 women included in the study, found the maternal serum calponin 1 level was significantly high in women who delivered within 7 days vs. those who delivered after 7 days. (PMID:28068849)
• Calponin and MUC6 complement inhibin as diagnostic immunomarkers of serous cystadenoma in endoscopic ultrasound-guided aspiration/biopsy specimens. (PMID:33657658)
• Long non-coding RNA MEG3 acts as a suppressor in breast cancer by regulating miR-330/CNN1. (PMID:38240701)

Cross-species orthologs

10 orthologs

Organism	Symbol	Gene ID
danio_rerio	cnn1a	ENSDARG00000017193
danio_rerio	cnn1b	ENSDARG00000102398
mus_musculus	Cnn1	ENSMUSG00000001349
rattus_norvegicus	Cnn1	ENSRNOG00000027736
drosophila_melanogaster	Mp20	FBGN0002789
drosophila_melanogaster	Chd64	FBGN0035499
caenorhabditis_elegans	cpn-1	WBGENE00000777
caenorhabditis_elegans		WBGENE00000778
caenorhabditis_elegans	cpn-3	WBGENE00000779
caenorhabditis_elegans	cpn-4	WBGENE00000780

Paralogs (5): CNN2 (ENSG00000064666), CNN3 (ENSG00000117519), TAGLN3 (ENSG00000144834), TAGLN (ENSG00000149591), TAGLN2 (ENSG00000158710)

Protein

Protein identifiers

Calponin-1 — P51911 (reviewed: P51911)

Alternative names: Basic calponin, Calponin H1, smooth muscle

All UniProt accessions (9): P51911, B7Z7E1, K7ENC5, K7EQ72, K7ER02, K7ERK4, K7ERM8, K7ESJ2, V9HWA5

UniProt curated annotations — full annotation on UniProt →

Function. Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

Subunit / interactions. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1.

Tissue specificity. Smooth muscle, and tissues containing significant amounts of smooth muscle.

Similarity. Belongs to the calponin family.

Isoforms (2)

UniProt ID	Names	Canonical?
P51911-1	1	yes
P51911-2	2

RefSeq proteins (3): NP_001290, NP_001295270, NP_001295271 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000557	Calponin_repeat	Repeat
IPR001715	CH_dom	Domain
IPR001997	Calponin/LIMCH1	Family
IPR003096	SM22_calponin	Family
IPR036872	CH_dom_sf	Homologous_superfamily
IPR050606	Calponin-like	Family

Pfam: PF00307, PF00402

UniProt features (23 total): helix 7, modified residue 5, sequence conflict 4, repeat 3, chain 1, domain 1, splice variant 1, strand 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
1WYP	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P51911-F1	72.06	0.33

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (5): 170, 175, 180, 184, 259

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9927432	Developmental Lineage of Mammary Gland Myoepithelial Cells

MSigDB gene sets: 188 (showing top): WALLACE_PROSTATE_CANCER_RACE_UP, WWTAAGGC_UNKNOWN, GOBP_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN, GOBP_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION, MCBRYAN_PUBERTAL_TGFB1_TARGETS_UP, MCBRYAN_TERMINAL_END_BUD_UP, KYNG_DNA_DAMAGE_DN, TGACCTY_ERR1_Q2, TOMLINS_PROSTATE_CANCER_DN, GOBP_MUSCLE_CELL_PROLIFERATION, LA_MEN1_TARGETS, SRF_Q5_01, CHEN_LVAD_SUPPORT_OF_FAILING_HEART_UP

GO Biological Process (4): regulation of smooth muscle contraction (GO:0006940), actin filament organization (GO:0007015), actomyosin structure organization (GO:0031032), negative regulation of vascular associated smooth muscle cell proliferation (GO:1904706)

GO Molecular Function (4): calmodulin binding (GO:0005516), actin filament binding (GO:0051015), actin binding (GO:0003779), protein binding (GO:0005515)

GO Cellular Component (3): cytoskeleton (GO:0005856), focal adhesion (GO:0005925), actin cytoskeleton (GO:0015629)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Developmental Lineages of the Mammary Gland	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
actin cytoskeleton organization	2
regulation of muscle contraction	1
smooth muscle contraction	1
supramolecular fiber organization	1
negative regulation of smooth muscle cell proliferation	1
regulation of vascular associated smooth muscle cell proliferation	1
vascular associated smooth muscle cell proliferation	1
protein binding	1
actin binding	1
protein-containing complex binding	1
cytoskeletal protein binding	1
binding	1
intracellular membraneless organelle	1
cell-substrate junction	1
cytoskeleton	1

Protein interactions and networks

STRING

3542 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CNN1	CALM1	P02593	942
CNN1	CALML3	P27482	941
CNN1	CALML5	Q9NZT1	941
CNN1	CALML6	Q8TD86	936
CNN1	CALML4	Q96GE6	935
CNN1	MYH11	P35749	860
CNN1	ACTA2	P03996	842
CNN1	CALD1	Q05682	826
CNN1	MYOCD	Q8IZQ8	794
CNN1	SPEF1	Q9Y4P9	764
CNN1	SMTN	P53814	759
CNN1	NAV3	Q8IVL0	698
CNN1	NAV2	Q8IVL1	692
CNN1	SRF	P11831	675
CNN1	RGCC	Q9H4X1	656

IntAct

32 interactions, top by confidence:

A	B	Type	Score
CIAPIN1	GLRX3	psi-mi:“MI:0914”(association)	0.960
MYEOV	CNN1	psi-mi:“MI:0914”(association)	0.560
MYEOV	CNN1	psi-mi:“MI:0915”(physical association)	0.560
PLRG1	CNN1	psi-mi:“MI:0915”(physical association)	0.490
CNN1	TFPT	psi-mi:“MI:0915”(physical association)	0.490
CNN1	CCHCR1	psi-mi:“MI:0915”(physical association)	0.490
CNN1	COG6	psi-mi:“MI:0915”(physical association)	0.490
CNN1	SYCE1	psi-mi:“MI:0915”(physical association)	0.490
CNN1	NCAPD2	psi-mi:“MI:0915”(physical association)	0.490
CNN1	PLRG1	psi-mi:“MI:0915”(physical association)	0.490
RNF150	CNN1	psi-mi:“MI:0915”(physical association)	0.400
DOK6	CNN1	psi-mi:“MI:0915”(physical association)	0.400
SSUH2	CNN1	psi-mi:“MI:0915”(physical association)	0.400
	CNN1	psi-mi:“MI:0915”(physical association)	0.400
CNN1	MYBPC3	psi-mi:“MI:0915”(physical association)	0.370
TK	AP3B1	psi-mi:“MI:0914”(association)	0.350
BVLF1	VWA8	psi-mi:“MI:0914”(association)	0.350
ESR2		psi-mi:“MI:0914”(association)	0.350
FAM3D	CNN1	psi-mi:“MI:0914”(association)	0.350
AK4	CNN1	psi-mi:“MI:0914”(association)	0.350

BioGRID (36): MTHFD1 (Co-fractionation), MTHFD1L (Co-fractionation), CNN1 (Affinity Capture-MS), CNN1 (Affinity Capture-MS), TFPT (Two-hybrid), SYCE1 (Two-hybrid), CCHCR1 (Two-hybrid), COG6 (Two-hybrid), CNN1 (Two-hybrid), NCAPD2 (Two-hybrid), TPM1 (Reconstituted Complex), ACTA1 (Reconstituted Complex), CALM1 (Reconstituted Complex), MYO1A (Reconstituted Complex), CNN1 (Affinity Capture-MS)

ESM2 similar proteins: A0A0G2UGT2, A0A0P0E482, A0A2Z6UD27, A0A646QV53, A7EWX9, A7XUK7, B3EWR1, B8WI85, C0HK25, C0HL90, H2FH31, O18423, O18424, O61064, O74703, O77009, P08696, P09334, P09335, P09336, P09338, P19616, P26932, P40483, P49714, P51911, P55296, P80708, P84331, Q00801, Q00802, Q05097, Q08091, Q08092, Q08290, Q15417, Q27084, Q2HJ38, Q32L92, Q3LX99

Diamond homologs: B9EUM5, O14185, O14188, P14318, P19966, P26932, P31232, P37397, P37802, P37803, P37804, P37805, P46940, P51911, Q01995, Q08091, Q08092, Q08093, Q08094, Q08290, Q08873, Q12280, Q15052, Q15417, Q24799, Q2HJ38, Q32L92, Q3SYU6, Q3ZBY2, Q4R5J4, Q54TK8, Q55E26, Q55GV9, Q5AH02, Q5E9F5, Q5R6R2, Q5RFN6, Q5XFX0, Q5XXR3, Q5ZLR6

SIGNOR signaling

3 interactions.

A	Effect	B	Mechanism
SRF	“up-regulates quantity by expression”	CNN1	“transcriptional regulation”
FYN	“down-regulates activity”	CNN1	phosphorylation

Disease & clinical

Clinical variants and AI predictions

ClinVar

63 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	54
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

962 predictions. Top by Δscore:

Variant	Effect	Δscore
19:11541068:C:A	acceptor_gain	1.0000
19:11541074:A:AG	acceptor_gain	1.0000
19:11541074:AGCT:A	acceptor_gain	1.0000
19:11541075:G:GA	acceptor_gain	1.0000
19:11541075:GC:G	acceptor_gain	1.0000
19:11541075:GCT:G	acceptor_gain	1.0000
19:11541075:GCTG:G	acceptor_gain	1.0000
19:11541194:GCGA:G	donor_gain	1.0000
19:11541196:GA:G	donor_gain	1.0000
19:11541198:G:GG	donor_gain	1.0000
19:11546739:CAGGT:C	donor_loss	1.0000
19:11546740:AGGTG:A	donor_loss	1.0000
19:11546742:G:A	donor_loss	1.0000
19:11546743:T:G	donor_loss	1.0000
19:11546827:TCTAG:T	acceptor_loss	1.0000
19:11546828:CTAGC:C	acceptor_loss	1.0000
19:11546829:TA:T	acceptor_loss	1.0000
19:11546830:A:AG	acceptor_gain	1.0000
19:11546830:AGCT:A	acceptor_gain	1.0000
19:11546830:AGCTG:A	acceptor_gain	1.0000
19:11546831:G:GT	acceptor_gain	1.0000
19:11546831:GC:G	acceptor_gain	1.0000
19:11546831:GCT:G	acceptor_gain	1.0000
19:11546831:GCTG:G	acceptor_gain	1.0000
19:11546831:GCTGG:G	acceptor_gain	1.0000
19:11546965:GCATG:G	donor_gain	1.0000
19:11547795:A:AG	acceptor_gain	1.0000
19:11547796:G:GT	acceptor_gain	1.0000
19:11547871:G:T	donor_gain	1.0000
19:11547875:C:G	donor_gain	1.0000

AlphaMissense

1967 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:11549326:G:C	G169R	1.000
19:11549369:G:A	G183D	1.000
19:11549377:C:A	R186S	1.000
19:11538965:G:A	G13E	0.999
19:11541113:T:C	L34P	0.999
19:11541182:G:A	G57D	0.999
19:11541182:G:T	G57V	0.999
19:11546733:T:A	W82R	0.999
19:11546733:T:C	W82R	0.999
19:11546735:G:C	W82C	0.999
19:11546735:G:T	W82C	0.999
19:11546833:T:C	L85P	0.999
19:11546911:T:A	L111Q	0.999
19:11546911:T:C	L111P	0.999
19:11549327:G:A	G169D	0.999
19:11549349:G:C	Q176H	0.999
19:11549349:G:T	Q176H	0.999
19:11549368:G:C	G183R	0.999
19:11549442:G:C	Q207H	0.999
19:11549442:G:T	Q207H	0.999
19:11549446:G:C	G209R	0.999
19:11549447:G:A	G209D	0.999
19:11549569:G:A	G223E	0.999
19:11549686:G:A	G262E	0.999
19:11549694:C:A	R265S	0.999
19:11541121:T:A	W37R	0.998
19:11541121:T:C	W37R	0.998
19:11541173:T:C	L54P	0.998
19:11541181:G:C	G57R	0.998
19:11546895:T:C	F106L	0.998

dbSNP variants (sampled 300 via entrez): RS1000149822 (19:11538234 G>C), RS1000222449 (19:11545972 A>G,T), RS1000334866 (19:11548498 C>T), RS1000417104 (19:11538454 G>T), RS1000422435 (19:11546320 G>A,C), RS1000561823 (19:11544535 A>G), RS1000742494 (19:11538868 C>A,G,T), RS1000760828 (19:11544668 T>C,G), RS1001065808 (19:11547342 A>G), RS1001116147 (19:11548142 C>T), RS1001253894 (19:11547898 T>C), RS1001427621 (19:11547604 T>C), RS1001461369 (19:11550765 C>T), RS1001634838 (19:11547257 C>T), RS1001746078 (19:11543131 C>T)

Disease associations

OMIM: gene MIM:600806 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST003563_11	Presence of antiphospholipid antibodies	3.000000e-06
GCST003563_12	Presence of antiphospholipid antibodies	4.000000e-06
GCST003563_6	Presence of antiphospholipid antibodies	5.000000e-08

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

79 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, increases expression	3
Benzo(a)pyrene	increases methylation, affects methylation, increases expression	2
Cadmium	increases expression, decreases expression, increases abundance	2
Doxorubicin	affects expression, increases expression	2
Silicon Dioxide	affects expression, increases expression	2
Valproic Acid	affects expression, increases methylation	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	increases expression	2
Cyclosporine	decreases expression	2
Cadmium Chloride	decreases expression, increases abundance	2
methylmercuric chloride	increases expression	1
triphenyl phosphate	decreases expression	1
propionaldehyde	increases expression	1
trichostatin A	affects expression	1
trimellitic anhydride	decreases expression	1
sodium arsenite	decreases expression, increases abundance	1
butyraldehyde	increases expression	1
zinc chromate	decreases expression, increases abundance	1
nickel sulfate	decreases expression	1
triadimefon	decreases expression	1
pentanal	increases expression	1
brequinar	decreases expression	1
bisindolylmaleimide I	decreases expression	1
chromium hexavalent ion	decreases expression, increases abundance	1
perfluorooctane sulfonic acid	decreases expression	1
CGP 52608	increases reaction, affects binding	1
SB 203580	decreases reaction, increases expression	1
entinostat	increases expression	1
monomethylarsonous acid	increases expression	1
Roflumilast	increases expression, decreases reaction	1
2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B1NP	Abcam HeLa CNN1 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.