CNNM1

Summary

CNNM1 (cyclin and CBS domain divalent metal cation transport mediator 1, HGNC:102) is a protein-coding gene on chromosome 10q24.2, encoding Metal transporter CNNM1 (Q9NRU3). Probable metal transporter.

This gene encodes a member of the ancient conserved domain protein family. The encoded protein may bind copper. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 26507 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 138 total
• MANE Select transcript: NM_020348

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:102
Approved symbol	CNNM1
Name	cyclin and CBS domain divalent metal cation transport mediator 1
Location	10q24.2
Locus type	gene with protein product
Status	Approved
Aliases	SLC70A1
Ensembl gene	ENSG00000119946
Ensembl biotype	protein_coding
OMIM	607802
Entrez	26507

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 3 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000356713, ENST00000488090, ENST00000696687, ENST00000914274

RefSeq mRNA: 4 — MANE Select: NM_020348 NM_001345887, NM_001345888, NM_001345889, NM_020348

CCDS: CCDS7478, CCDS91317

Canonical transcript exons

ENST00000356713 — 11 exons

Exon	Start	End
ENSE00000811261	99364417	99364516
ENSE00000811263	99377055	99377218
ENSE00000811265	99387820	99388003
ENSE00000811267	99388152	99388301
ENSE00000811268	99390306	99390407
ENSE00001237436	99364955	99365002
ENSE00001237443	99362227	99362396
ENSE00001237461	99329356	99330960
ENSE00001353296	99360835	99360975
ENSE00001914060	99391437	99394330
ENSE00002490052	99357512	99357655

Expression profiles

Bgee: expression breadth ubiquitous, 176 present calls, max score 84.16.

FANTOM5 (CAGE): breadth broad, TPM avg 1.8058 / max 52.4389, expressed in 439 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
106485	1.6181	423
106484	0.1754	98
106486	0.0123	3

Top tissues by expression

272 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
postcentral gyrus	UBERON:0002581	84.16	gold quality
prefrontal cortex	UBERON:0000451	83.49	gold quality
parietal lobe	UBERON:0001872	83.34	gold quality
lateral nuclear group of thalamus	UBERON:0002736	83.14	gold quality
right hemisphere of cerebellum	UBERON:0014890	82.28	gold quality
right frontal lobe	UBERON:0002810	82.24	gold quality
Brodmann (1909) area 46	UBERON:0006483	82.23	gold quality
frontal cortex	UBERON:0001870	82.21	gold quality
cerebellar hemisphere	UBERON:0002245	82.13	gold quality
cerebellar cortex	UBERON:0002129	82.06	gold quality
Brodmann (1909) area 9	UBERON:0013540	81.96	gold quality
sperm	CL:0000019	81.79	silver quality
nucleus accumbens	UBERON:0001882	81.47	gold quality
superior frontal gyrus	UBERON:0002661	81.47	gold quality
caudate nucleus	UBERON:0001873	81.44	gold quality
male germ cell	CL:0000015	81.32	silver quality
lateral globus pallidus	UBERON:0002476	81.29	gold quality
cerebellum	UBERON:0002037	81.24	gold quality
neocortex	UBERON:0001950	80.87	gold quality
putamen	UBERON:0001874	80.80	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	80.79	gold quality
cerebral cortex	UBERON:0000956	79.02	gold quality
anterior cingulate cortex	UBERON:0009835	78.96	gold quality
cingulate cortex	UBERON:0003027	78.95	gold quality
telencephalon	UBERON:0001893	78.88	gold quality
orbitofrontal cortex	UBERON:0004167	78.02	gold quality
forebrain	UBERON:0001890	77.75	gold quality
brain	UBERON:0000955	77.47	gold quality
occipital lobe	UBERON:0002021	77.44	gold quality
right testis	UBERON:0004534	77.38	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-5061	yes	229.21
E-ANND-3	yes	5.17
E-MTAB-8060	no	213.62

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

153 targeting CNNM1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-4425	100.00	67.59	1049
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-557	99.96	70.01	1640
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-6772-5P	99.94	67.01	577
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-552-5P	99.93	68.56	1583
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-450B-5P	99.92	71.48	3175
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-129-5P	99.88	70.26	3273
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-12119	99.87	68.35	1653
HSA-MIR-6124	99.87	69.78	3551
HSA-MIR-10395-5P	99.86	67.35	676
HSA-MIR-3151-5P	99.86	63.83	1069
HSA-MIR-4728-5P	99.85	69.39	4718

Literature-anchored findings (GeneRIF, showing 1)

• SNHG7 Facilitates Hepatocellular Carcinoma Occurrence by Sequestering miR-9-5p to Upregulate CNNM1 Expression. (PMID:32397799)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	cnnm1	ENSDARG00000078087
mus_musculus	Cnnm1	ENSMUSG00000025189
rattus_norvegicus	Cnnm1	ENSRNOG00000016302
drosophila_melanogaster	uex	FBGN0262124
caenorhabditis_elegans		WBGENE00011260
caenorhabditis_elegans		WBGENE00016343
caenorhabditis_elegans		WBGENE00016879

Paralogs (3): CNNM2 (ENSG00000148842), CNNM4 (ENSG00000158158), CNNM3 (ENSG00000168763)

Protein

Protein identifiers

Metal transporter CNNM1 — Q9NRU3 (reviewed: Q9NRU3)

Alternative names: Ancient conserved domain-containing protein 1, Cyclin-M1

All UniProt accessions (2): Q9NRU3, A0A8Q3SIV9

UniProt curated annotations — full annotation on UniProt →

Function. Probable metal transporter.

Subcellular location. Cell membrane.

Tissue specificity. Restricted to brain and testis.

Miscellaneous. Shares weak sequence similarity with the cyclin family, hence its name. However, it has no cyclin-like function in vivo.

Similarity. Belongs to the ACDP family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9NRU3-1	1	yes
Q9NRU3-2	2

RefSeq proteins (4): NP_001332816, NP_001332817, NP_001332818, NP_065081* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000644	CBS_dom	Domain
IPR002550	CNNM	Domain
IPR044751	Ion_transp-like_CBS	Domain
IPR045095	ACDP	Family
IPR046342	CBS_dom_sf	Homologous_superfamily
IPR057492	Ig_CNNM1/2/4_N	Domain

Pfam: PF00571, PF01595, PF25511, PF25562

UniProt features (21 total): transmembrane region 4, region of interest 4, compositionally biased region 3, modified residue 3, domain 3, chain 1, splice variant 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NRU3-F1	67.07	0.24

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 821, 824, 850

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 100 (showing top): AHRARNT_01, BENPORATH_ES_WITH_H3K27ME3, AP2_Q3, USF_C, STARK_HYPPOCAMPUS_22Q11_DELETION_UP, MYCMAX_01, YY1_02, CAATGCA_MIR33, GATA2_01, RYTTCCTG_ETS2_B, GOBP_MONOATOMIC_ION_HOMEOSTASIS, GOCC_NEURON_PROJECTION, RGAGGAARY_PU1_Q6, NERF_Q2, GOBP_TRANSMEMBRANE_TRANSPORT

GO Biological Process (3): monoatomic ion transport (GO:0006811), magnesium ion homeostasis (GO:0010960), transmembrane transport (GO:0055085)

GO Molecular Function (2): transmembrane transporter activity (GO:0022857), protein binding (GO:0005515)

GO Cellular Component (4): plasma membrane (GO:0005886), dendrite (GO:0030425), neuronal cell body (GO:0043025), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transport	2
monoatomic cation homeostasis	1
inorganic ion homeostasis	1
cellular process	1
transporter activity	1
transmembrane transport	1
binding	1
membrane	1
cell periphery	1
neuron projection	1
dendritic tree	1
somatodendritic compartment	1
cell body	1
cellular anatomical structure	1

Protein interactions and networks

STRING

808 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CNNM1	H7C2H4	H7C2H4	911
CNNM1	P0DN79	P0DN79	905
CNNM1	COX11	Q9Y6N1	704
CNNM1	TRPM6	Q9BX84	696
CNNM1	SLC41A1	Q8IVJ1	676
CNNM1	HPSE2	Q8WWQ2	649
CNNM1	SLC41A2	Q96JW4	598
CNNM1	TRPM7	Q96QT4	595
CNNM1	NIPAL3	Q6P499	519
CNNM1	SLC41A3	Q96GZ6	515
CNNM1	MRS2	Q9HD23	505
CNNM1	NIPAL2	Q9H841	495
CNNM1	NIPAL1	Q6NVV3	494
CNNM1	NIPAL4	Q0D2K0	463
CNNM1	NIPA2	Q8N8Q9	451

IntAct

89 interactions, top by confidence:

A	B	Type	Score
PTP4A1	CNNM1	psi-mi:“MI:0915”(physical association)	0.850
MAPK14	OBSL1	psi-mi:“MI:0914”(association)	0.790
CNNM1	PTP4A2	psi-mi:“MI:0915”(physical association)	0.760
PTP4A2	CNNM1	psi-mi:“MI:0915”(physical association)	0.760
PTP4A2	PTP4A3	psi-mi:“MI:0914”(association)	0.640
HSF2BP	CNNM1	psi-mi:“MI:0915”(physical association)	0.560
GPR21	TMEM120B	psi-mi:“MI:0914”(association)	0.530
ARL15	SLC25A20	psi-mi:“MI:0914”(association)	0.530
CHRND	TPST2	psi-mi:“MI:0914”(association)	0.530
FUT3	C1QL1	psi-mi:“MI:0914”(association)	0.530
SLC22A15	ZFPL1	psi-mi:“MI:0914”(association)	0.530
PTP4A1	ATE1	psi-mi:“MI:0914”(association)	0.530
SCGB1D4	EGFR	psi-mi:“MI:0914”(association)	0.530
PTP4A1	PSMD3	psi-mi:“MI:0914”(association)	0.420
PTP4A2	USP11	psi-mi:“MI:2364”(proximity)	0.420
PTP4A1	PSMD3	psi-mi:“MI:2364”(proximity)	0.420
PTP4A1	FDFT1	psi-mi:“MI:0914”(association)	0.350
PCDHA4	TMEM223	psi-mi:“MI:0914”(association)	0.350
TTYH1	TMEM223	psi-mi:“MI:0914”(association)	0.350
HLA-DRA	TMEM223	psi-mi:“MI:0914”(association)	0.350
CHRNA3	TMEM223	psi-mi:“MI:0914”(association)	0.350
ZDHHC12	NBAS	psi-mi:“MI:0914”(association)	0.350
BTNL8	TMEM131L	psi-mi:“MI:0914”(association)	0.350
TCTN2	TMEM131L	psi-mi:“MI:0914”(association)	0.350
CHRNB2	TMEM131L	psi-mi:“MI:0914”(association)	0.350
PCDHA12	KLRG2	psi-mi:“MI:0914”(association)	0.350
SIDT2	KLRG2	psi-mi:“MI:0914”(association)	0.350

BioGRID (112): CNNM1 (Affinity Capture-MS), CNNM1 (Affinity Capture-MS), CNNM1 (Affinity Capture-MS), CNNM1 (Affinity Capture-MS), CNNM1 (Affinity Capture-MS), CNNM1 (Affinity Capture-MS), CNNM1 (Affinity Capture-MS), CNNM1 (Affinity Capture-MS), CNNM1 (Affinity Capture-MS), CNNM1 (Affinity Capture-MS), CNNM1 (Affinity Capture-MS), CNNM1 (Affinity Capture-MS), CNNM1 (Affinity Capture-MS), CNNM1 (Affinity Capture-MS), CNNM1 (Affinity Capture-MS)

ESM2 similar proteins: A0A0B4J1F4, A0A0G2JXN2, A2AWP8, A2RRH5, C9J798, O43374, O70277, O95294, P04629, P59926, Q0GA42, Q13368, Q14318, Q16512, Q29RM4, Q2HY40, Q2T9P3, Q2TBA3, Q5BIM1, Q5M7W1, Q5R5M3, Q5R811, Q5T7P8, Q5XIS9, Q62746, Q6PFQ7, Q6PFY8, Q7TNM2, Q7TP90, Q7Z4K8, Q8BG60, Q8BHT7, Q8BQC3, Q8C6N3, Q8CIW5, Q8IZ69, Q8NCT1, Q920N2, Q92546, Q925B4

Diamond homologs: A0A0B7P9G0, A0A131MCZ8, A0JPA0, A3QM97, A8EZU0, A8F2M1, A8GPR9, A8GTI4, A8GUH1, O05961, P0C588, Q0GA42, Q12296, Q1RGX2, Q32NY4, Q3TWN3, Q4UK99, Q4V3C7, Q54318, Q57368, Q5U2P1, Q67XQ0, Q68W10, Q69ZF7, Q6P4Q7, Q8NE01, Q8RY60, Q8VZI2, Q92GI2, Q9GYL2, Q9H8M5, Q9LTD8, Q9NRU3, Q9USJ3, Q9ZQR4, Q9ZVS8, Q9CM13, Q9LK65, P75586, Q49399

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 124 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
R-HSA-425366	5	12.8×	2e-03
Neurotransmitter receptors and postsynaptic signal transmission	7	9.9×	5e-04
Transmission across Chemical Synapses	7	7.5×	2e-03
SLC-mediated transmembrane transport	8	6.7×	1e-03
Neuronal System	8	5.0×	5e-03
Transport of small molecules	10	3.5×	1e-02

GO biological processes:

GO term	Partners	Fold	FDR
acetylcholine receptor signaling pathway	5	29.2×	2e-04
membrane depolarization	5	23.9×	3e-04
monoatomic ion transmembrane transport	8	15.6×	3e-05
monoatomic ion transport	6	8.8×	6e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

138 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	111
Likely benign	2
Benign	13

Top pathogenic / likely-pathogenic (0)

SpliceAI

2024 predictions. Top by Δscore:

Variant	Effect	Δscore
10:99330948:GAGTT:G	donor_gain	1.0000
10:99330956:GAAGG:G	donor_gain	1.0000
10:99330958:AGGG:A	donor_loss	1.0000
10:99330959:GG:G	donor_gain	1.0000
10:99330959:GGGT:G	donor_loss	1.0000
10:99330960:GG:G	donor_gain	1.0000
10:99357507:TCTA:T	acceptor_loss	1.0000
10:99357508:CTA:C	acceptor_loss	1.0000
10:99357509:TAG:T	acceptor_loss	1.0000
10:99357510:A:AG	acceptor_gain	1.0000
10:99357510:A:T	acceptor_loss	1.0000
10:99357510:AG:A	acceptor_gain	1.0000
10:99357511:G:GA	acceptor_gain	1.0000
10:99357511:GG:G	acceptor_gain	1.0000
10:99357511:GGA:G	acceptor_gain	1.0000
10:99357511:GGAA:G	acceptor_gain	1.0000
10:99357511:GGAAA:G	acceptor_gain	1.0000
10:99357656:G:GG	donor_gain	1.0000
10:99360822:T:TA	acceptor_gain	1.0000
10:99360824:T:TA	acceptor_gain	1.0000
10:99360831:ACAGC:A	acceptor_loss	1.0000
10:99360832:CAGC:C	acceptor_loss	1.0000
10:99360833:A:AG	acceptor_gain	1.0000
10:99360833:AGCT:A	acceptor_gain	1.0000
10:99360834:G:GT	acceptor_gain	1.0000
10:99360834:GC:G	acceptor_gain	1.0000
10:99360834:GCT:G	acceptor_gain	1.0000
10:99360834:GCTG:G	acceptor_gain	1.0000
10:99360834:GCTGA:G	acceptor_gain	1.0000
10:99362211:A:AG	acceptor_gain	1.0000

AlphaMissense

6095 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:99330730:T:A	L448H	1.000
10:99330730:T:C	L448P	1.000
10:99330781:C:A	P465Q	1.000
10:99330838:T:C	L484S	1.000
10:99330952:T:C	F522S	1.000
10:99330956:G:C	K523N	1.000
10:99330956:G:T	K523N	1.000
10:99357520:C:G	H528D	1.000
10:99357524:T:C	L529P	1.000
10:99357526:G:C	A530P	1.000
10:99357533:T:A	V532D	1.000
10:99357583:G:C	G549R	1.000
10:99357584:G:T	G549V	1.000
10:99357590:T:A	V551D	1.000
10:99357599:A:T	E554V	1.000
10:99357602:A:C	D555A	1.000
10:99357612:G:C	E558D	1.000
10:99357612:G:T	E558D	1.000
10:99357632:T:C	I565T	1.000
10:99357632:T:G	I565S	1.000
10:99362386:T:C	L673P	1.000
10:99364417:G:C	G677R	1.000
10:99364456:T:C	F690L	1.000
10:99364458:T:A	F690L	1.000
10:99364458:T:G	F690L	1.000
10:99364471:T:C	F695L	1.000
10:99364473:T:A	F695L	1.000
10:99364473:T:G	F695L	1.000
10:99364484:G:A	G699D	1.000
10:99377187:T:A	V770D	1.000

dbSNP variants (sampled 300 via entrez): RS1000066093 (10:99359937 CAAAA>C,CAAA,CAAAAA), RS1000078270 (10:99369037 A>G), RS1000140994 (10:99378371 T>A), RS1000146473 (10:99360131 A>C), RS1000170379 (10:99373718 G>A), RS1000182556 (10:99328294 T>C,G), RS1000193442 (10:99378614 G>A), RS1000314133 (10:99335727 G>A,C), RS1000319875 (10:99380316 A>G), RS1000377364 (10:99384994 G>A,T), RS1000394716 (10:99340606 G>A), RS1000512897 (10:99335171 T>C), RS1000517219 (10:99379838 A>C,T), RS1000521198 (10:99380247 A>G), RS1000603093 (10:99378897 G>A)

Disease associations

OMIM: gene MIM:607802 | disease phenotypes:

GenCC curated gene-disease

Mondo (1): breast ductal adenocarcinoma (MONDO:0005590)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST001438_10	Crohn’s disease	5.000000e-07
GCST004482_104	Peripheral arterial disease (traffic-related air pollution interaction)	9.000000e-08
GCST005999_19	Aspartate aminotransferase levels	1.000000e-25
GCST007856_1	Colorectal cancer or advanced adenoma	4.000000e-06
GCST007856_18	Colorectal cancer or advanced adenoma	7.000000e-15
GCST011351_17	Aspartate aminotransferase levels	5.000000e-24

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0007908	traffic air pollution measurement
EFO:0004736	aspartate aminotransferase measurement

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D018270	Carcinoma, Ductal, Breast	C04.557.470.200.025.232.500; C04.557.470.615.132.500; C04.588.180.390; C17.800.090.500.390

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
potassium chromate(VI)	decreases expression, increases expression, affects cotreatment	2
aristolochic acid I	decreases expression	1
FR900359	increases phosphorylation	1
dicrotophos	increases expression	1
tris(2-butoxyethyl) phosphate	affects expression	1
sodium arsenite	affects expression	1
butyraldehyde	decreases expression	1
nickel sulfate	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, affects response to substance, increases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
chromium hexavalent ion	affects expression	1
CGP 52608	affects binding, increases reaction	1
abrine	decreases expression	1
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	decreases expression, affects cotreatment	1
bisphenol S	affects cotreatment, increases methylation	1
Resveratrol	affects cotreatment, decreases expression	1
Sunitinib	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Leflunomide	increases expression	1
Benzo(a)pyrene	affects methylation	1
Copper	affects cotreatment, decreases expression	1
Estradiol	increases expression	1
Lipopolysaccharides	affects response to substance, increases expression, affects cotreatment	1
Phthalic Acids	decreases methylation	1
Testosterone	decreases expression	1
Tetrachlorodibenzodioxin	decreases expression, affects cotreatment	1
Tobacco Smoke Pollution	increases expression	1
Triclosan	decreases expression	1
Urethane	decreases expression	1
Valproic Acid	increases methylation	1

Clinical trials (associated diseases)

11 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT03414970	PHASE3	ACTIVE_NOT_RECRUITING	Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer
NCT00461344	PHASE2	TERMINATED	Docetaxel + Doxorubicin as Neoadjuvant Chemotherapy in Patients With Breast Cancer
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