CNOT10

Summary

CNOT10 (CCR4-NOT transcription complex subunit 10, HGNC:23817) is a protein-coding gene on chromosome 3p22.3, encoding CCR4-NOT transcription complex subunit 10 (Q9H9A5). Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regul….

Predicted to be involved in mRNA catabolic process and negative regulation of translation. Located in membrane. Part of CCR4-NOT complex.

Source: NCBI Gene 25904 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 111 total
• Druggable target: yes
• MANE Select transcript: NM_015442

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23817
Approved symbol	CNOT10
Name	CCR4-NOT transcription complex subunit 10
Location	3p22.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ12890, FLJ13165
Ensembl gene	ENSG00000182973
Ensembl biotype	protein_coding
OMIM	620508
Entrez	25904

Gene structure

Transcript identifiers

Ensembl transcripts: 48 — 34 protein_coding, 6 protein_coding_CDS_not_defined, 5 retained_intron, 3 nonsense_mediated_decay

ENST00000328834, ENST00000331889, ENST00000416457, ENST00000430408, ENST00000435630, ENST00000454516, ENST00000455381, ENST00000463697, ENST00000466103, ENST00000468599, ENST00000471003, ENST00000473064, ENST00000476967, ENST00000479397, ENST00000481526, ENST00000485136, ENST00000494439, ENST00000556853, ENST00000866038, ENST00000866039, ENST00000866040, ENST00000866041, ENST00000866042, ENST00000866043, ENST00000866044, ENST00000866045, ENST00000866046, ENST00000866047, ENST00000866048, ENST00000866049, ENST00000866050, ENST00000866051, ENST00000933338, ENST00000933339, ENST00000933340, ENST00000933341, ENST00000933342, ENST00000933343, ENST00000933344, ENST00000933345, ENST00000933346, ENST00000969495, ENST00000969496, ENST00000969497, ENST00000969498, ENST00000969499, ENST00000969500, ENST00000969501

RefSeq mRNA: 7 — MANE Select: NM_015442 NM_001256741, NM_001256742, NM_001393366, NM_001393367, NM_001393368, NM_001393369, NM_015442

CCDS: CCDS2655, CCDS58821, CCDS58822

Canonical transcript exons

ENST00000328834 — 19 exons

Exon	Start	End
ENSE00001875884	32773457	32773875
ENSE00003491184	32734800	32734976
ENSE00003496988	32703868	32703962
ENSE00003501416	32708670	32708820
ENSE00003522906	32733423	32733544
ENSE00003526318	32764682	32764809
ENSE00003533410	32716225	32716311
ENSE00003546465	32725450	32725599
ENSE00003565318	32727668	32727870
ENSE00003574369	32720114	32720231
ENSE00003577546	32764455	32764490
ENSE00003589243	32759458	32759571
ENSE00003598375	32713227	32713369
ENSE00003598426	32717154	32717237
ENSE00003621523	32769887	32769962
ENSE00003640744	32704811	32704972
ENSE00003653218	32762733	32762863
ENSE00003653342	32737410	32737490
ENSE00003930949	32685188	32685482

Expression profiles

Bgee: expression breadth ubiquitous, 204 present calls, max score 94.21.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 25.5694 / max 270.4276, expressed in 1810 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
35892	12.8411	1768
35891	11.3663	1768
35889	0.8420	592
35890	0.4070	188
35895	0.0922	26
35893	0.0192	4
35894	0.0017	1

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	94.21	gold quality
left testis	UBERON:0004533	94.06	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	93.29	gold quality
testis	UBERON:0000473	92.65	gold quality
right uterine tube	UBERON:0001302	91.59	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	91.51	gold quality
ventricular zone	UBERON:0003053	91.43	gold quality
adenohypophysis	UBERON:0002196	91.28	gold quality
colonic epithelium	UBERON:0000397	91.10	gold quality
ganglionic eminence	UBERON:0004023	90.85	gold quality
mucosa of transverse colon	UBERON:0004991	90.67	gold quality
skin of abdomen	UBERON:0001416	89.94	gold quality
skin of leg	UBERON:0001511	89.88	gold quality
bone marrow cell	CL:0002092	89.87	gold quality
adrenal tissue	UBERON:0018303	89.86	gold quality
right ovary	UBERON:0002118	89.70	gold quality
rectum	UBERON:0001052	89.68	gold quality
calcaneal tendon	UBERON:0003701	89.64	gold quality
cortical plate	UBERON:0005343	89.64	gold quality
granulocyte	CL:0000094	89.53	gold quality
right lobe of thyroid gland	UBERON:0001119	89.34	gold quality
body of pancreas	UBERON:0001150	89.32	gold quality
left ovary	UBERON:0002119	89.22	gold quality
pituitary gland	UBERON:0000007	89.14	gold quality
leukocyte	CL:0000738	89.11	gold quality
monocyte	CL:0000576	89.10	gold quality
tibial nerve	UBERON:0001323	89.00	gold quality
spleen	UBERON:0002106	88.96	gold quality
metanephros cortex	UBERON:0010533	88.90	gold quality
body of uterus	UBERON:0009853	88.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.86

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

24 targeting CNOT10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-8075	99.97	67.20	962
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-4307	99.82	70.45	3374
HSA-MIR-3064-5P	99.26	66.13	1497
HSA-MIR-3085-3P	99.26	66.16	1490
HSA-MIR-6504-5P	99.26	65.95	1487
HSA-MIR-149-5P	99.25	67.16	1315
HSA-MIR-664A-3P	99.22	71.08	2696
HSA-MIR-6071	99.16	67.77	1780
HSA-MIR-3926	98.95	69.26	1438
HSA-MIR-4774-3P	98.90	67.82	737
HSA-MIR-500A-5P	98.76	69.13	1241
HSA-MIR-548S	98.50	67.17	1213
HSA-MIR-633	98.35	69.45	1167
HSA-MIR-3132	97.96	67.91	711
HSA-MIR-197-5P	97.23	68.10	596
HSA-MIR-4794	96.47	65.53	1063
HSA-MIR-4435	95.90	65.47	1201
HSA-MIR-664A-5P	95.84	64.93	949

Literature-anchored findings (GeneRIF, showing 2)

• CNOT11 interacts with the first amino acids of CNOT1 and with CNOT10 and is required for the association of CNOT10 with the CCR4-NOT complex. (PMID:23232451)
• Human CNOT10 and CNOT11 form a complex that interacts with the CNOT1 N-terminal domain. (PMID:23303381)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	cnot10	ENSDARG00000058528
mus_musculus	Cnot10	ENSMUSG00000056167
rattus_norvegicus	Cnot10	ENSRNOG00000052305
drosophila_melanogaster	Not10	FBGN0260444

Protein

Protein identifiers

CCR4-NOT transcription complex subunit 10 — Q9H9A5 (reviewed: Q9H9A5)

All UniProt accessions (5): Q9H9A5, E9PCN5, H7BZZ7, H7C0K1, H7C1X9

UniProt curated annotations — full annotation on UniProt →

Function. Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex.

Subunit / interactions. Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold.

Subcellular location. Cytoplasm. Nucleus.

Similarity. Belongs to the CNOT10 family.

Isoforms (6)

UniProt ID	Names	Canonical?
Q9H9A5-1	1	yes
Q9H9A5-2	2
Q9H9A5-3	3
Q9H9A5-4	4
Q9H9A5-5	5
Q9H9A5-6	6

RefSeq proteins (7): NP_001243670, NP_001243671, NP_001380295, NP_001380296, NP_001380297, NP_001380298, NP_056257* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011990	TPR-like_helical_dom_sf	Homologous_superfamily
IPR019734	TPR_rpt	Repeat
IPR039740	CNOT10	Family

UniProt features (70 total): helix 31, turn 8, sequence conflict 7, compositionally biased region 5, splice variant 5, region of interest 4, strand 4, sequence variant 2, initiator methionine 1, chain 1, modified residue 1, coiled-coil region 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
8FY3	ELECTRON MICROSCOPY	2.88
8BFI	X-RAY DIFFRACTION	3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H9A5-F1	79.87	0.60

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 2

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-429947	Deadenylation of mRNA
R-HSA-6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
R-HSA-9820841	M-decay: degradation of maternal mRNAs by maternally stored factors

MSigDB gene sets: 91 (showing top): GOBP_REGULATION_OF_MRNA_CATABOLIC_PROCESS, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOBP_NEGATIVE_REGULATION_OF_TRANSLATION, GOBP_TRANSLATION, GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION, GOBP_REGULATION_OF_CATABOLIC_PROCESS, GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS, REACTOME_DEADENYLATION_OF_MRNA, chr3p22, GOBP_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS, GOBP_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN, GOBP_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING, REACTOME_METABOLISM_OF_RNA, GOBP_REGULATION_OF_TRANSLATION

GO Biological Process (5): nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289), mRNA catabolic process (GO:0006402), negative regulation of translation (GO:0017148), regulatory ncRNA-mediated gene silencing (GO:0031047), regulation of translation (GO:0006417)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (5): nucleus (GO:0005634), cytosol (GO:0005829), membrane (GO:0016020), CCR4-NOT complex (GO:0030014), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Deadenylation-dependent mRNA decay	1
TP53 Regulates Transcription of Cell Cycle Genes	1
Maternal to zygotic transition (MZT)	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
negative regulation of gene expression	3
cellular anatomical structure	3
translation	2
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	1
nuclear-transcribed mRNA catabolic process	1
RNA catabolic process	1
mRNA metabolic process	1
regulation of translation	1
negative regulation of protein metabolic process	1
post-transcriptional regulation of gene expression	1
regulation of protein metabolic process	1
binding	1
intracellular membrane-bounded organelle	1
cytoplasm	1
intracellular protein-containing complex	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1150 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CNOT10	CNOT2	Q9NZN8	995
CNOT10	CNOT1	A5YKK6	995
CNOT10	CNOT3	O75175	995
CNOT10	CNOT11	Q9UKZ1	994
CNOT10	CNOT9	Q92600	994
CNOT10	CNOT6	Q9ULM6	961
CNOT10	CNOT7	Q9UIV1	959
CNOT10	CNOT6L	Q96LI5	951
CNOT10	CNOT8	Q9UFF9	915
CNOT10	CNOT4	O95628	906
CNOT10	VCF1	Q969W3	775
CNOT10	CNOT12	Q9C0C2	714
CNOT10	CCDC127	Q96BQ5	703
CNOT10	TADA2B	Q86TJ2	649
CNOT10	ZKSCAN5	Q9Y2L8	623

IntAct

122 interactions, top by confidence:

A	B	Type	Score
MED4	MED19	psi-mi:“MI:2364”(proximity)	0.900
CNOT11	CNOT1	psi-mi:“MI:0914”(association)	0.770
CNOT2	CNOT1	psi-mi:“MI:0914”(association)	0.740
CNOT3	CNOT1	psi-mi:“MI:0914”(association)	0.740
CNOT10	CNOT11	psi-mi:“MI:0915”(physical association)	0.740
CNOT11	CNOT10	psi-mi:“MI:0915”(physical association)	0.740
TOB1	CNOT1	psi-mi:“MI:0914”(association)	0.710
TNRC6C	CNOT1	psi-mi:“MI:0914”(association)	0.690
HTT	CNOT10	psi-mi:“MI:0915”(physical association)	0.670
CNOT10	CNOT6L	psi-mi:“MI:0915”(physical association)	0.660
CNOT6	CNOT10	psi-mi:“MI:0915”(physical association)	0.660
CAPZB	CNOT1	psi-mi:“MI:0914”(association)	0.640
CAPZA2	CNOT1	psi-mi:“MI:0914”(association)	0.640
TNRC6C	CNOT1	psi-mi:“MI:0914”(association)	0.620
CNOT10	RAVER1	psi-mi:“MI:0915”(physical association)	0.560
TNRC6C	CNOT10	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (203): CNOT10 (Reconstituted Complex), CNOT10 (Affinity Capture-Western), CNOT10 (Affinity Capture-MS), CNOT10 (Affinity Capture-MS), CNOT10 (Affinity Capture-MS), CNOT10 (Affinity Capture-MS), CNOT10 (Affinity Capture-MS), CNOT10 (Affinity Capture-MS), CNOT10 (Proximity Label-MS), CNOT10 (Proximity Label-MS), CNOT10 (Proximity Label-MS), CNOT10 (Proximity Label-MS), CNOT10 (Proximity Label-MS), CNOT10 (Proximity Label-MS), CNOT10 (Proximity Label-MS)

ESM2 similar proteins: A0JN62, A2RT67, A2RUS2, A2VDU2, A4IFB6, A4IIM3, A7MBL8, B1H2P5, B4F779, O94967, P48553, Q08CL8, Q0VEJ0, Q14161, Q15650, Q3TLI0, Q4R350, Q5RAQ5, Q5RCP7, Q5RDV5, Q5TKA1, Q5XIA4, Q5ZIW2, Q5ZJK1, Q68CZ1, Q6AYF1, Q6QD73, Q7TSG1, Q7ZYH1, Q8BH15, Q8BIK4, Q8BKH7, Q8C735, Q8CG73, Q8CGF6, Q8IWR0, Q8IZQ1, Q8N6S4, Q8N960, Q8NEU8

Diamond homologs: A4IFB6, Q08CL8, Q4R350, Q5XIA4, Q5ZIW2, Q6DE97, Q6NU53, Q8BH15, Q9H9A5, Q9V3G6

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
CNOT10	“form complex”	“CCR4-NOT complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 93 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	9	88.2×	8e-14
Deadenylation of mRNA	7	58.0×	2e-09
M-decay: degradation of maternal mRNAs by maternally stored factors	8	49.2×	5e-10
Loss of Nlp from mitotic centrosomes	6	18.0×	6e-05
Loss of proteins required for interphase microtubule organization from the centrosome	6	18.0×	6e-05
AURKA Activation by TPX2	6	17.2×	7e-05
Recruitment of mitotic centrosome proteins and complexes	6	15.4×	1e-04
Regulation of PLK1 Activity at G2/M Transition	6	14.4×	1e-04

GO biological processes:

GO term	Partners	Fold	FDR
nuclear-transcribed mRNA poly(A) tail shortening	7	70.2×	2e-09
regulation of translation	7	19.1×	1e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

111 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	78
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3081 predictions. Top by Δscore:

Variant	Effect	Δscore
3:32685480:CAGG:C	donor_loss	1.0000
3:32685481:AGG:A	donor_loss	1.0000
3:32685482:GG:G	donor_loss	1.0000
3:32685483:GTAG:G	donor_loss	1.0000
3:32685484:T:A	donor_loss	1.0000
3:32703963:G:GG	donor_gain	1.0000
3:32704809:A:AG	acceptor_gain	1.0000
3:32704809:AGTCT:A	acceptor_gain	1.0000
3:32704810:G:GG	acceptor_gain	1.0000
3:32704810:GTCT:G	acceptor_gain	1.0000
3:32704810:GTCTG:G	acceptor_gain	1.0000
3:32708667:TA:T	acceptor_loss	1.0000
3:32708668:A:AC	acceptor_loss	1.0000
3:32708668:A:AG	acceptor_gain	1.0000
3:32708669:G:GG	acceptor_gain	1.0000
3:32708784:G:GG	donor_gain	1.0000
3:32708818:TTGGT:T	donor_loss	1.0000
3:32708820:GGTA:G	donor_loss	1.0000
3:32708821:G:GG	donor_gain	1.0000
3:32708821:GTA:G	donor_loss	1.0000
3:32708822:TAT:T	donor_loss	1.0000
3:32716223:AGACT:A	acceptor_gain	1.0000
3:32716224:GA:G	acceptor_gain	1.0000
3:32716224:GACT:G	acceptor_gain	1.0000
3:32716224:GACTG:G	acceptor_gain	1.0000
3:32717148:T:TA	acceptor_gain	1.0000
3:32717149:GACA:G	acceptor_loss	1.0000
3:32717151:CA:C	acceptor_loss	1.0000
3:32717152:A:AG	acceptor_gain	1.0000
3:32717153:G:C	acceptor_loss	1.0000

AlphaMissense

4926 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:32717199:A:G	K236E	1.000
3:32717200:A:T	K236I	1.000
3:32717201:A:C	K236N	1.000
3:32717201:A:T	K236N	1.000
3:32717203:G:C	R237T	1.000
3:32717203:G:T	R237M	1.000
3:32717204:G:C	R237S	1.000
3:32717204:G:T	R237S	1.000
3:32717211:A:C	K240Q	1.000
3:32717211:A:G	K240E	1.000
3:32717212:A:T	K240M	1.000
3:32717213:G:C	K240N	1.000
3:32717213:G:T	K240N	1.000
3:32720135:A:G	K256E	1.000
3:32720137:A:C	K256N	1.000
3:32720137:A:T	K256N	1.000
3:32720138:A:C	S257R	1.000
3:32720140:C:A	S257R	1.000
3:32720140:C:G	S257R	1.000
3:32720147:G:A	E260K	1.000
3:32720172:A:T	K268I	1.000
3:32720173:A:C	K268N	1.000
3:32720173:A:T	K268N	1.000
3:32720174:G:C	A269P	1.000
3:32720175:C:A	A269D	1.000
3:32720180:A:G	K271E	1.000
3:32720184:T:C	L272P	1.000
3:32725481:C:A	N298K	1.000
3:32725481:C:G	N298K	1.000
3:32725483:T:C	L299P	1.000

dbSNP variants (sampled 300 via entrez): RS1000033811 (3:32771664 A>C), RS1000045875 (3:32730036 G>T), RS1000079858 (3:32692074 T>C), RS1000112149 (3:32764042 A>G), RS1000154190 (3:32724615 T>C), RS1000154839 (3:32684385 T>C), RS1000164036 (3:32684435 T>C), RS1000190693 (3:32773943 T>C), RS1000214484 (3:32684725 ATAAT>A), RS1000228484 (3:32695475 G>A,T), RS1000240792 (3:32731124 G>A), RS1000242584 (3:32689858 G>A), RS1000294550 (3:32730912 G>A), RS1000308834 (3:32700896 G>A), RS1000314781 (3:32771469 C>T)

Disease associations

OMIM: gene MIM:620508 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST009310_25	Sensorimotor dexterity	9.000000e-06
GCST010396_189	Gut microbiota (bacterial taxa, hurdle binary method)	3.000000e-06
GCST012174_1	Diabetic retinopathy in type 2 diabetes	7.000000e-10

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0008354	cognitive function measurement
EFO:0007874	gut microbiome measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4105878 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

16 total (human), top 16 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects methylation, decreases expression	2
Arsenic	affects methylation, decreases expression, increases abundance	2
Cyclosporine	increases expression	2
aristolochic acid I	decreases expression	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
sodium arsenite	decreases expression, increases abundance	1
2,3,5-(triglutathion-S-yl)hydroquinone	increases ADP-ribosylation	1
abrine	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Doxorubicin	decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Ivermectin	decreases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Cadmium Chloride	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4012563	Binding	Binding affinity to CCR4-NOT transcription complex subunit 10 in human INA-6 cells after 3 hrs by nanoLC-MS/MS method	Ugi Reaction-Derived α-Acyl Aminocarboxamides Bind to Phosphatidylinositol 3-Kinase-Related Kinases, Inhibit HSF1-Dependent Heat Shock Response, and Induce Apoptosis in Multiple Myeloma Cells. — J Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.