CNOT6

Summary

CNOT6 (CCR4-NOT transcription complex subunit 6, HGNC:14099) is a protein-coding gene on chromosome 5q35.3, encoding CCR4-NOT transcription complex subunit 6 (Q9ULM6). Poly(A) nuclease with 3’-5’ RNase activity.

This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3’-5’ RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation.

Source: NCBI Gene 57472 — RefSeq curated summary.

At a glance

• GWAS associations: 12
• Clinical variants (ClinVar): 100 total — 1 pathogenic
• Druggable target: yes
• MANE Select transcript: NM_001370472

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14099
Approved symbol	CNOT6
Name	CCR4-NOT transcription complex subunit 6
Location	5q35.3
Locus type	gene with protein product
Status	Approved
Aliases	CCR4, KIAA1194, Ccr4a
Ensembl gene	ENSG00000113300
Ensembl biotype	protein_coding
OMIM	608951
Entrez	57472

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 7 protein_coding, 3 protein_coding_CDS_not_defined

ENST00000261951, ENST00000393356, ENST00000502447, ENST00000504343, ENST00000507016, ENST00000510148, ENST00000618123, ENST00000968017, ENST00000968018, ENST00000968019

RefSeq mRNA: 3 — MANE Select: NM_001370472 NM_001370472, NM_001370473, NM_001370474

CCDS: CCDS4455

Canonical transcript exons

ENST00000261951 — 12 exons

Exon	Start	End
ENSE00000770532	180567849	180568003
ENSE00000973892	180564489	180564593
ENSE00000973893	180564675	180564743
ENSE00000973894	180565820	180565977
ENSE00000973895	180567088	180567242
ENSE00000973897	180571230	180571432
ENSE00001056018	180553386	180553471
ENSE00001150547	180569110	180569340
ENSE00001410297	180494379	180494763
ENSE00001420000	180573988	180578358
ENSE00003496346	180549931	180550117
ENSE00003583232	180529275	180529388

Expression profiles

Bgee: expression breadth ubiquitous, 284 present calls, max score 98.79.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 21.0031 / max 237.9970, expressed in 1808 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
60642	19.4154	1807
60643	1.5877	889

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	98.79	gold quality
oocyte	CL:0000023	98.41	gold quality
buccal mucosa cell	CL:0002336	92.75	gold quality
cerebellar vermis	UBERON:0004720	92.30	gold quality
ganglionic eminence	UBERON:0004023	92.05	gold quality
cortical plate	UBERON:0005343	91.94	gold quality
embryo	UBERON:0000922	90.94	gold quality
ventricular zone	UBERON:0003053	90.94	gold quality
esophagus squamous epithelium	UBERON:0006920	90.19	gold quality
pigmented layer of retina	UBERON:0001782	89.45	gold quality
epithelium of nasopharynx	UBERON:0001951	88.10	gold quality
nasopharynx	UBERON:0001728	88.08	gold quality
trabecular bone tissue	UBERON:0002483	87.93	gold quality
amniotic fluid	UBERON:0000173	87.75	gold quality
eye	UBERON:0000970	87.74	gold quality
bronchial epithelial cell	CL:0002328	87.58	gold quality
epithelium of esophagus	UBERON:0001976	87.57	gold quality
gingival epithelium	UBERON:0001949	87.56	gold quality
gingiva	UBERON:0001828	87.42	gold quality
endometrium	UBERON:0001295	87.30	gold quality
palpebral conjunctiva	UBERON:0001812	87.19	gold quality
mucosa of paranasal sinus	UBERON:0005030	87.19	gold quality
Brodmann (1909) area 23	UBERON:0013554	87.11	gold quality
jejunal mucosa	UBERON:0000399	86.71	gold quality
bone marrow	UBERON:0002371	86.40	gold quality
sural nerve	UBERON:0015488	86.22	gold quality
leukocyte	CL:0000738	85.95	gold quality
monocyte	CL:0000576	85.94	gold quality
mononuclear cell	CL:0000842	85.90	gold quality
sperm	CL:0000019	85.85	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.30

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• CCR4 and BTG2 interact and have a role in cell-cycle regulation (PMID:12771185)
• CCR4 plays a role in the regulation of certain endogenous RARalpha target genes and RCD1 and CCR4 might mediate their function through their interaction with NIF-1 (PMID:18180299)
• hCCR4/cNOT6 targets DNA-damage response proteins (PMID:18818012)
• Data show that Ccr4-Not function in RNA splicing and nuclear export, and that CNOT6 binds CNOT8 in yeast two-hybrid assays. (PMID:19558367)
• Results identified CNOT6/CNOT6L as a key regulator of insulin-like growth factor-binding protein 5, which mediates cell cycle arrest and senescence via a p53-dependent pathway. (PMID:21233283)
• These results indicate that Caf1 and Ccr4 cooperate in mRNA deadenylation and suggest that the enzyme activities of Caf1 and Ccr4 are regulated via allosteric interactions within the nuclease module. (PMID:25944446)
• miR-29c-3p promotes the senescence of Mesenchymal stem cells by targeting CNOT6 through p53-p21 and p16-pRB pathways. (PMID:26792405)
• The CNOT6 rs2453176 Single Nucleotide Polymorphism may be a new functional susceptible locus for lung cancer risk. (PMID:27805284)
• Studied hepatic role in metabolic homeostasis of fibroblast growth factor 21(FGF21) and the “CCR4-NOT complex” (a multisubunit protein complex composed of “CCR4-NOT transcription complex subunit 6 like” (CNOT6L) and “CCR4-NOT transcription complex subunit 6” (CNOT6). Results show CNOT6L plays a major role in regulation FGF21 levels. (PMID:30926667)
• Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex. (PMID:34038562)

Cross-species orthologs

8 orthologs

Organism	Symbol	Gene ID
danio_rerio	cnot6a	ENSDARG00000008255
danio_rerio	cnot6b	ENSDARG00000101072
mus_musculus	Cnot6	ENSMUSG00000020362
rattus_norvegicus	Cnot6	ENSRNOG00000054891
drosophila_melanogaster	twin	FBGN0011725
drosophila_melanogaster	angel	FBGN0016762
caenorhabditis_elegans		WBGENE00000376
caenorhabditis_elegans		WBGENE00020955

Paralogs (5): ANGEL1 (ENSG00000013523), CNOT6L (ENSG00000138767), NOCT (ENSG00000151014), ANGEL2 (ENSG00000174606), PDE12 (ENSG00000174840)

Protein

Protein identifiers

CCR4-NOT transcription complex subunit 6 — Q9ULM6 (reviewed: Q9ULM6)

Alternative names: CCR4 carbon catabolite repression 4-like, Carbon catabolite repressor protein 4 homolog, Cytoplasmic deadenylase

All UniProt accessions (2): Q9ULM6, D6R9H6

UniProt curated annotations — full annotation on UniProt →

Function. Poly(A) nuclease with 3’-5’ RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence.

Subunit / interactions. Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8. Interacts with CNOT7 and CNOT8. Interacts with UNR. Interacts with ZFP36L1 (via N-terminus). Interacts with ZNF335.

Subcellular location. Cytoplasm. Nucleus.

Cofactor. Binds 2 magnesium ions, but the ions interact each with only 1 or 2 residues.

Similarity. Belongs to the CCR4/nocturin family.

RefSeq proteins (3): NP_001357401, NP_001357402, NP_001357403 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001611	Leu-rich_rpt	Repeat
IPR003591	Leu-rich_rpt_typical-subtyp	Repeat
IPR005135	Endo/exonuclease/phosphatase	Domain
IPR032675	LRR_dom_sf	Homologous_superfamily
IPR034966	Cnot6	Domain
IPR036691	Endo/exonu/phosph_ase_sf	Homologous_superfamily
IPR050410	CCR4/nocturin_mRNA_transcr	Family

Pfam: PF03372, PF13855

UniProt features (62 total): strand 21, helix 19, binding site 9, turn 5, repeat 4, chain 1, mutagenesis site 1, region of interest 1, active site 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
7AX1	X-RAY DIFFRACTION	3.3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9ULM6-F1	89.51	0.76

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 412 (proton donor/acceptor)

Ligand- & substrate-binding residues (9): 361; 366; 412; 414; 481; 486; 240; 240; 276

Mutagenesis-validated functional residues (1):

Position	Phenotype
240	impairs deadenylation and decay of mrnai-targeted mrna.

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-429947	Deadenylation of mRNA
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
R-HSA-9820841	M-decay: degradation of maternal mRNAs by maternally stored factors

MSigDB gene sets: 482 (showing top): GOMF_RNA_NUCLEASE_ACTIVITY, GOBP_P_BODY_ASSEMBLY, GGTGTGT_MIR329, GOBP_TOLERANCE_INDUCTION, GOBP_CELL_CHEMOTAXIS, GOBP_REGULATION_OF_MRNA_CATABOLIC_PROCESS, GOBP_INFLAMMATORY_RESPONSE, GOBP_RESPONSE_TO_PEPTIDE, TGCACTT_MIR519C_MIR519B_MIR519A, GOMF_NUCLEASE_ACTIVITY, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOCC_CELL_SURFACE, GOBP_NEUROGENESIS

GO Biological Process (8): nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289), regulation of translation (GO:0006417), positive regulation of cell population proliferation (GO:0008284), positive regulation of cytoplasmic mRNA processing body assembly (GO:0010606), miRNA-mediated gene silencing by mRNA destabilization (GO:0035279), nuclear-transcribed mRNA catabolic process, no-go decay (GO:0070966), regulatory ncRNA-mediated gene silencing (GO:0031047), positive regulation of DNA-templated transcription (GO:0045893)

GO Molecular Function (11): 3’-5’-RNA exonuclease activity (GO:0000175), transcription coactivator activity (GO:0003713), RNA binding (GO:0003723), RNA exonuclease activity (GO:0004532), poly(A)-specific ribonuclease activity (GO:0004535), metal ion binding (GO:0046872), catalytic activity (GO:0003824), nuclease activity (GO:0004518), exonuclease activity (GO:0004527), protein binding (GO:0005515), hydrolase activity (GO:0016787)

GO Cellular Component (5): nucleus (GO:0005634), cytosol (GO:0005829), membrane (GO:0016020), CCR4-NOT complex (GO:0030014), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
Deadenylation-dependent mRNA decay	1
Activation of HOX genes during differentiation	1
TP53 Regulates Transcription of Cell Cycle Genes	1
Maternal to zygotic transition (MZT)	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
nuclear-transcribed mRNA catabolic process	2
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	1
translation	1
post-transcriptional regulation of gene expression	1
regulation of protein metabolic process	1
cell population proliferation	1
regulation of cell population proliferation	1
positive regulation of cellular process	1
regulation of cytoplasmic mRNA processing body assembly	1
P-body assembly	1
positive regulation of organelle assembly	1
miRNA-mediated post-transcriptional gene silencing	1
mRNA destabilization	1
negative regulation of gene expression	1
DNA-templated transcription	1
regulation of DNA-templated transcription	1
positive regulation of RNA biosynthetic process	1
3’-5’ exonuclease activity	1
RNA exonuclease activity, producing 5’-phosphomonoesters	1
transcription coregulator activity	1
positive regulation of DNA-templated transcription	1
nucleic acid binding	1
exonuclease activity	1
RNA nuclease activity	1
3’-5’-RNA exonuclease activity	1
cation binding	1
molecular_function	1
catalytic activity, acting on a nucleic acid	1
nuclease activity	1
hydrolase activity, acting on ester bonds	1
binding	1
catalytic activity	1
intracellular membrane-bounded organelle	1
cytoplasm	1
intracellular protein-containing complex	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1312 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CNOT6	CNOT9	Q92600	998
CNOT6	CNOT7	Q9UIV1	997
CNOT6	CNOT8	Q9UFF9	997
CNOT6	CNOT1	A5YKK6	995
CNOT6	CNOT3	O75175	987
CNOT6	CNOT2	Q9NZN8	981
CNOT6	CNOT6L	Q96LI5	972
CNOT6	CNOT10	Q9H9A5	961
CNOT6	CNOT11	Q9UKZ1	918
CNOT6	CNOT4	O95628	845
CNOT6	PARN	O95453	803
CNOT6	XRN1	Q8IZH2	668
CNOT6	DEDD	O75618	667
CNOT6	THRA	P10827	655
CNOT6	DCP2	Q8IU60	580

IntAct

90 interactions, top by confidence:

A	B	Type	Score
CNOT7	CNOT1	psi-mi:“MI:0914”(association)	0.880
CNOT7	CNOT6L	psi-mi:“MI:0914”(association)	0.880
CNOT6L	CNOT1	psi-mi:“MI:0914”(association)	0.810
PATL1	LSM1	psi-mi:“MI:0914”(association)	0.770
CNOT11	CNOT1	psi-mi:“MI:0914”(association)	0.770
CNOT6	CNOT1	psi-mi:“MI:0915”(physical association)	0.750
CNOT3	CNOT1	psi-mi:“MI:0914”(association)	0.740
TOB1	CNOT1	psi-mi:“MI:0914”(association)	0.710
CNOT6	CNOT7	psi-mi:“MI:0915”(physical association)	0.710
CNOT6	CNOT3	psi-mi:“MI:0915”(physical association)	0.670
HSP90AA1	CHUK	psi-mi:“MI:0914”(association)	0.670
CNOT6	CNOT10	psi-mi:“MI:0915”(physical association)	0.660
CAPZB	CNOT1	psi-mi:“MI:0914”(association)	0.640
CAPZA2	CNOT1	psi-mi:“MI:0914”(association)	0.640
CNOT8	CNOT6	psi-mi:“MI:0915”(physical association)	0.570
TNKS1BP1	CNOT6	psi-mi:“MI:0915”(physical association)	0.530

BioGRID (113): CNOT6 (Affinity Capture-Western), CNOT6 (Affinity Capture-Western), CNOT6 (Affinity Capture-MS), CNOT6 (Affinity Capture-MS), CNOT6 (Affinity Capture-MS), CNOT6 (Affinity Capture-Western), CNOT6 (Affinity Capture-Western), CNOT6 (Affinity Capture-Western), CNOT6 (Affinity Capture-Western), CNOT6 (Affinity Capture-MS), CNOT6 (Affinity Capture-MS), CNOT6 (Affinity Capture-MS), CNOT6 (Affinity Capture-MS), CNOT6 (Affinity Capture-Western), CNOT6 (Affinity Capture-Western)

ESM2 similar proteins: A1Z6E0, A2BHJ4, A8IU92, B0X9V1, B3MDR0, B3NRP1, B4F739, B4GBN7, B4HQ29, B4J6Q0, B4KNC5, B4LMQ3, B4MR59, B4P4K8, B4QE02, P00860, P0C2W1, P0CH38, P11926, P27117, P27119, P27120, P48455, P53041, P53042, Q0G819, Q16XV7, Q290L5, Q5BJ41, Q5E9X6, Q5VST6, Q5XH73, Q60676, Q68FK8, Q6AXU9, Q6AY17, Q6IR85, Q6NZ03, Q7M759, Q7QGL9

Diamond homologs: A1CIJ6, A1CW67, A2BHJ4, A2Q9L0, B7XK66, C4V7I7, O74874, P0CP22, P0CP23, P31384, Q0CT27, Q0U7W4, Q1EA11, Q2UUI3, Q4P9T3, Q4WQG5, Q5A761, Q5B778, Q5BJ41, Q5XH73, Q6AXU9, Q6BMM5, Q6CEJ6, Q6CJU4, Q6FRT2, Q6IR85, Q75BI3, Q8K3P5, Q8SU52, Q8VEG6, Q8W0Z9, Q96LI5, Q9C2R2, Q9M2F8, Q9ULM6, A8JQX3, B2RYM0, P79942, Q8K1C0, Q8VCU0

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
CNOT6	“form complex”	“CCR4-NOT complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 62 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	9	122.9×	1e-15
Deadenylation of mRNA	9	104.0×	6e-15
M-decay: degradation of maternal mRNAs by maternally stored factors	11	94.5×	1e-17
Estrogen-dependent gene expression	6	11.9×	2e-04

GO biological processes:

GO term	Partners	Fold	FDR
nuclear-transcribed mRNA poly(A) tail shortening	9	136.3×	2e-15
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	6	127.2×	4e-10
regulatory ncRNA-mediated gene silencing	9	114.5×	6e-15
regulation of translation	7	28.9×	3e-07
negative regulation of translation	6	22.2×	1e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

100 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	81
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
253599	GRCh37/hg19 3p24.1-22.3(chr3:29689082-34233218)x1	Pathogenic

SpliceAI

2826 predictions. Top by Δscore:

Variant	Effect	Δscore
5:180529273:A:AG	acceptor_gain	1.0000
5:180529273:A:G	acceptor_loss	1.0000
5:180529273:AG:A	acceptor_gain	1.0000
5:180529274:G:GT	acceptor_gain	1.0000
5:180529274:GG:G	acceptor_gain	1.0000
5:180529274:GGC:G	acceptor_gain	1.0000
5:180529274:GGCA:G	acceptor_gain	1.0000
5:180529274:GGCAT:G	acceptor_gain	1.0000
5:180529354:A:T	donor_gain	1.0000
5:180529382:A:AG	donor_gain	1.0000
5:180529386:GTG:G	donor_gain	1.0000
5:180529387:TGG:T	donor_loss	1.0000
5:180529389:G:GG	donor_gain	1.0000
5:180549925:TTACA:T	acceptor_loss	1.0000
5:180549926:TACA:T	acceptor_loss	1.0000
5:180549928:CA:C	acceptor_loss	1.0000
5:180549929:A:AC	acceptor_loss	1.0000
5:180549929:A:AG	acceptor_gain	1.0000
5:180549929:AG:A	acceptor_gain	1.0000
5:180549930:G:GG	acceptor_gain	1.0000
5:180549930:GG:G	acceptor_gain	1.0000
5:180549930:GGA:G	acceptor_gain	1.0000
5:180549930:GGAA:G	acceptor_gain	1.0000
5:180550114:TCAG:T	donor_loss	1.0000
5:180550115:CAGGT:C	donor_loss	1.0000
5:180550116:AG:A	donor_loss	1.0000
5:180550117:GGT:G	donor_loss	1.0000
5:180550118:G:GA	donor_loss	1.0000
5:180550119:T:A	donor_loss	1.0000
5:180564475:A:AG	acceptor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000017288 (5:180530581 G>T), RS1000084460 (5:180575255 T>A), RS1000173563 (5:180521253 C>T), RS1000174783 (5:180565468 C>T), RS1000209445 (5:180566551 A>G), RS1000232816 (5:180552898 C>T), RS1000240373 (5:180504687 T>C), RS1000261807 (5:180561448 CTTGG>C), RS1000340336 (5:180510771 G>A), RS1000369556 (5:180494769 C>G,T), RS1000434945 (5:180537664 C>T), RS1000458060 (5:180572120 T>C), RS1000480316 (5:180515875 AAGGAG>A), RS1000497825 (5:180557463 A>G), RS1000579231 (5:180514572 G>A)

Disease associations

OMIM: gene MIM:608951 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

12 associations (top):

Study	Trait	p-value
GCST000612_21	Celiac disease	3.000000e-09
GCST004682_2	Psychosis proneness (hypomanic personality scale and revised social anhedonia scale)	2.000000e-06
GCST004683_2	Psychosis proneness (perceptual aberration scale and revised social anhedonia scale)	6.000000e-07
GCST004684_1	Psychosis proneness (revised physical anhedonia scale and revised social anhedonia scale)	4.000000e-06
GCST004686_1	Psychosis proneness (revised social anhedonia scale)	7.000000e-07
GCST005523_13	Celiac disease	2.000000e-07
GCST005531_36	Multiple sclerosis	2.000000e-09
GCST007239_9	Ovarian cancer	5.000000e-06
GCST009798_68	Asthma	3.000000e-12
GCST012317_16	Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder	9.000000e-06
GCST90002396_316	Mean reticulocyte volume	2.000000e-11
GCST90002397_102	Mean spheric corpuscular volume	6.000000e-15

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0008337	psychosis predisposition measurement
EFO:0004530	triglyceride measurement
EFO:0010701	mean reticulocyte volume

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL3616363 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

19 total (human), top 19 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression, increases methylation	2
aristolochic acid I	decreases expression	1
triphenyl phosphate	affects expression	1
arsenite	affects binding, decreases reaction	1
sodium arsenite	decreases expression, increases abundance	1
butyraldehyde	decreases expression	1
benzo(e)pyrene	decreases methylation	1
perfluorooctane sulfonic acid	decreases expression	1
jinfukang	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Air Pollutants	increases abundance, decreases expression	1
Arsenic	decreases expression, increases abundance	1
Benzo(a)pyrene	increases methylation	1
Methapyrilene	decreases methylation	1
Plant Extracts	affects cotreatment, increases expression	1
Cyclosporine	decreases expression	1
Cadmium Chloride	decreases expression	1
Copper Sulfate	increases expression	1
Particulate Matter	decreases expression, increases abundance	1

ChEMBL screening assays

3 unique, capped per target: 3 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL3619399	Binding	Inhibition of Ccr4 (unknown origin) at 30 uM by fluorescence-based assay	Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1. — Bioorg Med Chem Lett

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B8DW	Abcam HCT 116 CNOT6 KO	Cancer cell line	Male
CVCL_B9G4	Abcam A-549 CNOT6 KO	Cancer cell line	Male
CVCL_D2EI	Abcam MCF-7 CNOT6 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.