COA7

Summary

COA7 (cytochrome c oxidase assembly factor 7, HGNC:25716) is a protein-coding gene on chromosome 1p32.3, encoding Cytochrome c oxidase assembly factor 7 (Q96BR5). Required for assembly of mitochondrial respiratory chain complex I and complex IV. It is a selective cancer dependency (DepMap: 42.1% of cell lines).

Enables protein-disulfide reductase activity. Involved in respiratory chain complex IV assembly. Located in mitochondrion and nucleoplasm. Is active in mitochondrial intermembrane space. Implicated in spinocerebellar ataxia with axonal neuropathy type 3.

Source: NCBI Gene 65260 — RefSeq curated summary.

At a glance

• Gene–disease (curated): mitochondrial disease (Definitive, ClinGen) — +1 more curated relationship
• Clinical variants (ClinVar): 80 total — 4 pathogenic, 6 likely-pathogenic
• Phenotypes (HPO): 23
• Cancer dependency (DepMap): dependent in 42.1% of screened cell lines
• MANE Select transcript: NM_023077

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25716
Approved symbol	COA7
Name	cytochrome c oxidase assembly factor 7
Location	1p32.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ12439, RESA1
Ensembl gene	ENSG00000162377
Ensembl biotype	protein_coding
OMIM	615623
Entrez	65260

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000371538, ENST00000486918, ENST00000939652

RefSeq mRNA: 1 — MANE Select: NM_023077 NM_023077

CCDS: CCDS570

Canonical transcript exons

ENST00000371538 — 3 exons

Exon	Start	End
ENSE00001455475	52684449	52688168
ENSE00001455476	52698221	52698347
ENSE00003657086	52692727	52692867

Expression profiles

Bgee: expression breadth ubiquitous, 262 present calls, max score 91.27.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.1649 / max 177.2784, expressed in 1770 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
12373	11.1649	1770

Top tissues by expression

281 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
type B pancreatic cell	CL:0000169	91.27	gold quality
olfactory bulb	UBERON:0002264	91.13	gold quality
secondary oocyte	CL:0000655	89.76	gold quality
cortical plate	UBERON:0005343	88.76	gold quality
vastus lateralis	UBERON:0001379	88.15	silver quality
quadriceps femoris	UBERON:0001377	87.27	silver quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	87.19	gold quality
mucosa of sigmoid colon	UBERON:0004993	86.88	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	86.87	gold quality
gastrocnemius	UBERON:0001388	86.41	gold quality
colonic mucosa	UBERON:0000317	86.20	gold quality
muscle organ	UBERON:0001630	86.03	gold quality
biceps brachii	UBERON:0001507	85.89	gold quality
muscle of leg	UBERON:0001383	85.76	gold quality
skeletal muscle tissue	UBERON:0001134	85.72	gold quality
gingival epithelium	UBERON:0001949	85.38	silver quality
hindlimb stylopod muscle	UBERON:0004252	85.02	gold quality
gingiva	UBERON:0001828	84.95	gold quality
islet of Langerhans	UBERON:0000006	84.88	gold quality
heart right ventricle	UBERON:0002080	84.34	gold quality
muscle tissue	UBERON:0002385	84.03	gold quality
cervix squamous epithelium	UBERON:0006922	83.64	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.58	gold quality
prefrontal cortex	UBERON:0000451	83.29	gold quality
diaphragm	UBERON:0001103	83.07	silver quality
Brodmann (1909) area 23	UBERON:0013554	82.89	gold quality
body of tongue	UBERON:0011876	82.87	gold quality
pons	UBERON:0000988	82.56	gold quality
stromal cell of endometrium	CL:0002255	82.44	gold quality
smooth muscle tissue	UBERON:0001135	82.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.35

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

51 targeting COA7, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-22-3P	99.93	68.13	917
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-548E-5P	99.89	72.73	4486
HSA-MIR-129-5P	99.88	70.26	3273
HSA-LET-7A-2-3P	99.87	70.53	1921
HSA-LET-7G-3P	99.85	70.43	1929
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-498-5P	99.76	69.64	1807
HSA-MIR-4677-5P	99.70	70.09	1940
HSA-MIR-4530	99.69	66.47	1509
HSA-MIR-6757-3P	99.63	66.88	1089
HSA-MIR-508-5P	99.41	64.25	1248
HSA-MIR-584-3P	99.35	67.69	1082
HSA-MIR-542-3P	99.34	67.58	1270
HSA-MIR-1272	99.34	68.79	878
HSA-MIR-2116-5P	99.32	69.34	1273
HSA-MIR-488-5P	99.28	68.12	821
HSA-MIR-5584-3P	99.23	68.79	1351
HSA-MIR-661	99.09	65.94	2062
HSA-MIR-3619-5P	99.00	68.87	2308

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 42.1% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 6)

• C1orf163 is a novel factor important for the assembly of respiratory chain complexes in human mitochondria. (PMID:24333015)
• The first patient carrying pathogenic mutations of COA7, causative of isolated COX deficiency and progressive neurological impairment is reported. It is also shown that COA7 is a soluble protein localized to the matrix, rather than in the intermembrane space as previously suggested. (PMID:27683825)
• The results of this study suggest that loss-of-function COA7 mutation is responsible for the phenotype of the presented patients, and this new entity of disease would be referred to as spinocerebellar ataxia with axonal neuropathy type 3. (PMID:29718187)
• pathogenic mutant versions of COA7 are imported slower than the wild-type protein, and mislocalized proteins are degraded in the cytosol by the proteasome. (PMID:30885959)
• Mitochondrial COA7 is a heme-binding protein with disulfide reductase activity, which acts in the early stages of complex IV assembly. (PMID:35210360)
• Dystonia and Parkinsonism in COA7-related disorders: expanding the phenotypic spectrum. (PMID:37750949)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	coa7	ENSDARG00000019355
mus_musculus	Coa7	ENSMUSG00000048351
rattus_norvegicus	Coa7	ENSRNOG00000010636
drosophila_melanogaster	Coa7	FBGN0039965
caenorhabditis_elegans		WBGENE00013925

Protein

Protein identifiers

Cytochrome c oxidase assembly factor 7 — Q96BR5 (reviewed: Q96BR5)

Alternative names: Beta-lactamase hcp-like protein, Respiratory chain assembly factor 1, Sel1 repeat-containing protein 1

All UniProt accessions (1): Q96BR5

UniProt curated annotations — full annotation on UniProt →

Function. Required for assembly of mitochondrial respiratory chain complex I and complex IV.

Subunit / interactions. Interacts with CHCHD4/MIA40 through transient intermolecular disulfide bonds.

Subcellular location. Mitochondrion intermembrane space.

Disease relevance. Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 3 (SCAN3) [MIM:618387] A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAN3 is an autosomal recessive disorder characterized by onset in the first decade of slowly progressive distal muscle weakness and atrophy and distal sensory impairment due to an axonal peripheral neuropathy. Affected individuals have gait disturbances and sometimes manual dexterity difficulties, as well as cerebellar ataxia associated with cerebellar atrophy on brain imaging. The disease is caused by variants affecting the gene represented in this entry.

Similarity. Belongs to the hcp beta-lactamase family.

RefSeq proteins (1): NP_075565* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006597	Sel1-like	Repeat
IPR011990	TPR-like_helical_dom_sf	Homologous_superfamily
IPR040239	HcpB-like	Family

Pfam: PF08238

UniProt features (28 total): helix 12, sequence variant 5, repeat 5, initiator methionine 1, chain 1, sequence conflict 1, turn 1, strand 1, modified residue 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
7MQZ	X-RAY DIFFRACTION	2.39

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96BR5-F1	95.47	0.93

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 2

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 143 (showing top): RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOBP_RESPIRATORY_CHAIN_COMPLEX_IV_ASSEMBLY, MAZ_Q6, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, GOBP_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_ASSEMBLY, GOBP_CYTOCHROME_COMPLEX_ASSEMBLY, MODULE_301, GOCC_MITOCHONDRIAL_ENVELOPE, DODD_NASOPHARYNGEAL_CARCINOMA_UP, MODULE_188, HAMAI_APOPTOSIS_VIA_TRAIL_DN, SHEN_SMARCA2_TARGETS_DN, MARSON_BOUND_BY_FOXP3_STIMULATED, GOCC_ORGANELLE_ENVELOPE_LUMEN

GO Biological Process (1): respiratory chain complex IV assembly (GO:0008535)

GO Molecular Function (2): protein-disulfide reductase activity (GO:0015035), protein binding (GO:0005515)

GO Cellular Component (3): nucleoplasm (GO:0005654), mitochondrion (GO:0005739), mitochondrial intermembrane space (GO:0005758)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytochrome complex assembly	1
disulfide oxidoreductase activity	1
catalytic activity, acting on a protein	1
binding	1
nuclear lumen	1
cellular anatomical structure	1
cytoplasm	1
intracellular membrane-bounded organelle	1
mitochondrial envelope	1
organelle envelope lumen	1

Protein interactions and networks

STRING

1118 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
COA7	COA6	Q5JTJ3	603
COA7	COA5	Q86WW8	602
COA7	COX17	Q14061	598
COA7	COA4	Q9NYJ1	598
COA7	SETX	Q7Z333	581
COA7	SAMM50	Q9Y512	573
COA7	COX8A	P10176	557
COA7	SYVN1	Q86TM6	551
COA7	CHCHD4	Q8N4Q1	549
COA7	COX6B1	P14854	536
COA7	ATP23	Q9Y6H3	531
COA7	TIMM9	Q9Y5J7	525
COA7	TIMM8A	O60220	522
COA7	SEL1L	Q9UBV2	498
COA7	TIMM10	P62072	494

IntAct

141 interactions, top by confidence:

A	B	Type	Score
RIN1	NRAS	psi-mi:“MI:0914”(association)	0.840
B3GNT3	PGRMC1	psi-mi:“MI:0914”(association)	0.670
HSPB2	BAG3	psi-mi:“MI:0914”(association)	0.670
CRHBP	CCNB2	psi-mi:“MI:0914”(association)	0.640
CHCHD4	SSNA1	psi-mi:“MI:0914”(association)	0.640
CRIPTO	AIP	psi-mi:“MI:0914”(association)	0.640
MPPED1	CLUH	psi-mi:“MI:0914”(association)	0.640
PDK4	PDK2	psi-mi:“MI:0914”(association)	0.640
SNRPB	COA7	psi-mi:“MI:0915”(physical association)	0.560
SUOX	COA7	psi-mi:“MI:0915”(physical association)	0.560
COA7	GPSM3	psi-mi:“MI:0915”(physical association)	0.560
TLE5	COA7	psi-mi:“MI:0915”(physical association)	0.560
COA7	ENKD1	psi-mi:“MI:0915”(physical association)	0.560
COA7	CASP6	psi-mi:“MI:0915”(physical association)	0.560
COA7	DMWD	psi-mi:“MI:0915”(physical association)	0.560
COA7		psi-mi:“MI:0915”(physical association)	0.560
COA7	FGFR3	psi-mi:“MI:0915”(physical association)	0.560
COA7	GSN	psi-mi:“MI:0915”(physical association)	0.560
COA7	HMOX2	psi-mi:“MI:0915”(physical association)	0.560
COA7	LAMP2	psi-mi:“MI:0915”(physical association)	0.560
COA7	PMP22	psi-mi:“MI:0915”(physical association)	0.560
COA7	RAN	psi-mi:“MI:0915”(physical association)	0.560
COA7	CYCS	psi-mi:“MI:0915”(physical association)	0.560
COA7	PRPF40A	psi-mi:“MI:0915”(physical association)	0.560
COA7	SPRED1	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (141): COA7 (Affinity Capture-MS), COA7 (Co-fractionation), COA7 (Affinity Capture-MS), COA7 (Affinity Capture-MS), COA7 (Affinity Capture-MS), COA7 (Affinity Capture-MS), COA7 (Affinity Capture-MS), COA7 (Affinity Capture-MS), COA7 (Affinity Capture-MS), COA7 (Affinity Capture-MS), COA7 (Proximity Label-MS), COA7 (Proximity Label-MS), COA7 (Proximity Label-MS), COA7 (Proximity Label-MS), COA7 (Proximity Label-MS)

ESM2 similar proteins: A1CP31, A1D1Y5, A2QAQ3, A2QQE8, G5EEN4, J9VSG5, O42632, P0CQ16, P0CQ17, P17885, P23231, P36583, P46822, P87253, Q00078, Q01317, Q0D0A1, Q0UXL8, Q20168, Q2U0M4, Q2URJ0, Q338B9, Q4IQC1, Q4QR29, Q4WKB2, Q4WVF4, Q4WVG0, Q4X0I8, Q52DF3, Q5AZT7, Q5BD89, Q5BFB1, Q5BGN7, Q5BH69, Q5M7J9, Q5TYQ3, Q5ZIK9, Q62018, Q6DEU9, Q6INS3

Diamond homologs: Q0V9D9, Q23450, Q5FWY3, Q5TYQ3, Q66KY0, Q921H9, Q96BR5, Q9W5N0

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 130 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Complex IV assembly	7	17.8×	4e-05
Cytoprotection by HMOX1	5	10.2×	8e-03
Mitochondrial protein degradation	7	8.9×	2e-03
Respiratory electron transport	8	8.5×	9e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

80 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	4
Likely pathogenic	6
Uncertain significance	34
Likely benign	29
Benign	7

Top pathogenic / likely-pathogenic (10)

Variant ID	HGVS	Classification
438350	NM_023077.3(COA7):c.410A>G (p.Tyr137Cys)	Pathogenic
438351	NM_023077.3(COA7):c.247+1G>T	Pathogenic
625459	NM_023077.3(COA7):c.446G>T (p.Ser149Ile)	Pathogenic
625461	NM_023077.3(COA7):c.431del (p.Gly144fs)	Pathogenic
1335810	NM_023077.3(COA7):c.107-2A>G	Likely pathogenic
2585171	NM_023077.3(COA7):c.97del (p.Asp33fs)	Likely pathogenic
4819770	NM_023077.3(COA7):c.106+2T>G	Likely pathogenic
625460	NM_023077.3(COA7):c.17A>G (p.Asp6Gly)	Likely pathogenic
806136	NM_023077.3(COA7):c.574C>T (p.Arg192Cys)	Likely pathogenic
806137	NM_023077.3(COA7):c.540_550dup (p.Ile184fs)	Likely pathogenic

SpliceAI

380 predictions. Top by Δscore:

Variant	Effect	Δscore
1:52692721:CCTTA:C	donor_loss	1.0000
1:52692722:CTTA:C	donor_loss	1.0000
1:52692723:TTACC:T	donor_loss	1.0000
1:52692724:TA:T	donor_loss	1.0000
1:52692725:A:AC	donor_gain	1.0000
1:52692725:A:C	donor_loss	1.0000
1:52692726:C:CC	donor_gain	1.0000
1:52692863:GCAAC:G	acceptor_gain	1.0000
1:52692864:CAAC:C	acceptor_gain	1.0000
1:52692864:CAACC:C	acceptor_gain	1.0000
1:52692865:AAC:A	acceptor_gain	1.0000
1:52692866:ACCT:A	acceptor_loss	1.0000
1:52692868:C:CC	acceptor_gain	1.0000
1:52692868:CTG:C	acceptor_loss	1.0000
1:52692869:T:C	acceptor_loss	1.0000
1:52698180:C:A	donor_gain	1.0000
1:52692725:AC:A	donor_gain	0.9900
1:52692726:CC:C	donor_gain	0.9900
1:52692726:CCTT:C	donor_gain	0.9900
1:52692799:TCAAC:T	donor_gain	0.9900
1:52692866:AC:A	acceptor_gain	0.9900
1:52692867:CC:C	acceptor_gain	0.9900
1:52692872:G:T	acceptor_gain	0.9900
1:52698131:T:TA	donor_gain	0.9900
1:52698216:CTCA:C	donor_loss	0.9900
1:52698217:TCA:T	donor_loss	0.9900
1:52698218:CA:C	donor_loss	0.9900
1:52698219:A:AC	donor_gain	0.9900
1:52698219:A:C	donor_loss	0.9900
1:52698219:ACCGT:A	donor_gain	0.9900

AlphaMissense

1547 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:52687969:A:C	S149R	0.998
1:52687969:A:T	S149R	0.998
1:52687971:T:G	S149R	0.998
1:52687954:A:C	S154R	0.997
1:52687954:A:T	S154R	0.997
1:52687956:T:G	S154R	0.997
1:52692764:G:C	S70R	0.995
1:52692764:G:T	S70R	0.995
1:52692766:T:G	S70R	0.995
1:52692751:C:A	G75W	0.993
1:52687958:A:G	L153P	0.992
1:52687841:C:G	R192P	0.991
1:52688072:C:T	G115D	0.991
1:52687848:C:G	A190P	0.990
1:52692750:C:T	G75E	0.989
1:52687880:C:T	C179Y	0.988
1:52687963:G:C	F151L	0.988
1:52687963:G:T	F151L	0.988
1:52687965:A:G	F151L	0.988
1:52687843:A:C	S191R	0.987
1:52687843:A:T	S191R	0.987
1:52687845:T:G	S191R	0.987
1:52687991:C:T	C142Y	0.987
1:52688073:C:G	G115R	0.987
1:52692751:C:G	G75R	0.987
1:52692751:C:T	G75R	0.987
1:52687797:C:G	A207P	0.985
1:52687893:A:G	S175P	0.984
1:52692791:G:C	N61K	0.984
1:52692791:G:T	N61K	0.984

dbSNP variants (sampled 300 via entrez): RS1000003548 (1:52693686 C>G,T), RS1000030772 (1:52684441 C>T), RS1000054882 (1:52694180 T>C,G), RS1000241546 (1:52687410 C>G), RS1000593398 (1:52687826 C>T), RS1000981086 (1:52689195 G>A), RS1001045285 (1:52692747 GC>G), RS1001090274 (1:52686282 C>G), RS1001192141 (1:52686621 G>C), RS1001574947 (1:52697586 T>A), RS1001852248 (1:52685244 TAA>T), RS1001893439 (1:52689208 T>G), RS1002286907 (1:52699186 G>T), RS1002577204 (1:52698920 A>G), RS1003023052 (1:52689927 T>A)

Disease associations

OMIM: gene MIM:615623 | disease phenotypes: MIM:618387

GenCC curated gene-disease

Disease	Classification	Inheritance
spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 3	Strong	Autosomal recessive

ClinGen Gene-Disease Validity (1)

Expert-panel classifications — Definitive > Strong > Moderate > Limited > Disputed > Refuted.

Disease	Classification	Inheritance
mitochondrial disease	Definitive	AR

Mondo (1): spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 3 (MONDO:0020770)

Orphanet (0):

HPO phenotypes

23 total (23 of 23 shown, HPO-id order):

HPO	Term
HP:0000007	Autosomal recessive inheritance
HP:0001251	Ataxia
HP:0001260	Dysarthria
HP:0001263	Global developmental delay
HP:0001265	Hyporeflexia
HP:0001272	Cerebellar atrophy
HP:0001310	Dysmetria
HP:0001337	Tremor
HP:0001761	Pes cavus
HP:0001765	Hammertoe
HP:0002066	Gait ataxia
HP:0002352	Leukoencephalopathy
HP:0002460	Distal muscle weakness
HP:0002936	Distal sensory impairment
HP:0003236	Elevated circulating creatine kinase concentration
HP:0003376	Steppage gait
HP:0003477	Peripheral axonal neuropathy
HP:0003677	Slowly progressive
HP:0003690	Limb muscle weakness
HP:0003693	Distal amyotrophy
HP:0009027	Foot dorsiflexor weakness
HP:0011402	Demyelinating sensory neuropathy
HP:0011463	Childhood onset

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

48 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, affects cotreatment, increases abundance, increases expression	2
(+)-JQ1 compound	decreases expression	2
Estradiol	increases expression	2
Ethyl Methanesulfonate	decreases expression	2
Methyl Methanesulfonate	decreases expression	2
Oxygen	decreases expression	2
aristolochic acid I	increases expression	1
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
ginger extract	decreases reaction, increases abundance, increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	increases expression, decreases reaction, increases abundance	1
salinomycin	decreases expression	1
trichostatin A	affects expression	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
nivalenol	increases expression	1
di-n-butylphosphoric acid	affects expression	1
cylindrospermopsin	increases expression	1
corosolic acid	decreases expression	1
abrine	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Temozolomide	increases expression	1
Sunitinib	decreases expression	1
Acetaminophen	decreases expression	1
Adenine	decreases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Atrazine	decreases expression	1
Cisplatin	decreases expression	1
Colchicine	decreases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Dimethyl Sulfoxide	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.