COL18A1-AS1

Summary

COL18A1-AS1 (COL18A1 antisense RNA 1, HGNC:23132) is a long non-coding RNA gene on chromosome 21q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23132
Approved symbol	COL18A1-AS1
Name	COL18A1 antisense RNA 1
Location	21q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	PRED80
Ensembl gene	ENSG00000183535
Ensembl biotype	lncRNA
Entrez	378832
RNAcentral	URS0000203EE5 — lncRNA, 2341 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000397787, ENST00000485206

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000397787 — 3 exons

Exon	Start	End
ENSE00001530161	45419716	45421619
ENSE00001530162	45423770	45425040
ENSE00002084477	45422412	45422661

Expression profiles

Bgee: expression breadth broad, 68 present calls, max score 78.09.

Top tissues by expression

178 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	78.09	gold quality
sural nerve	UBERON:0015488	65.76	silver quality
colonic epithelium	UBERON:0000397	64.29	silver quality
cortical plate	UBERON:0005343	58.04	silver quality
adult mammalian kidney	UBERON:0000082	56.94	gold quality
kidney	UBERON:0002113	55.75	gold quality
tendon of biceps brachii	UBERON:0008188	55.68	gold quality
tendon	UBERON:0000043	53.41	gold quality
cortex of kidney	UBERON:0001225	51.80	gold quality
popliteal artery	UBERON:0002250	49.68	gold quality
tibial artery	UBERON:0007610	49.65	gold quality
right coronary artery	UBERON:0001625	48.19	gold quality
urinary bladder	UBERON:0001255	48.08	gold quality
stomach	UBERON:0000945	48.07	silver quality
medial globus pallidus	UBERON:0002477	48.04	gold quality
prefrontal cortex	UBERON:0000451	47.81	silver quality
aorta	UBERON:0000947	47.28	gold quality
tibial nerve	UBERON:0001323	47.16	silver quality
small intestine	UBERON:0002108	46.64	silver quality
globus pallidus	UBERON:0001875	46.23	gold quality
gastrocnemius	UBERON:0001388	46.11	silver quality
left coronary artery	UBERON:0001626	45.98	gold quality
pancreas	UBERON:0001264	45.94	gold quality
left ovary	UBERON:0002119	45.86	gold quality
coronary artery	UBERON:0001621	45.79	gold quality
ovary	UBERON:0000992	45.78	gold quality
metanephros cortex	UBERON:0010533	45.65	gold quality
right ovary	UBERON:0002118	45.15	silver quality
liver	UBERON:0002107	45.05	gold quality
amniotic fluid	UBERON:0000173	44.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.47

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The COL18A1-AS1/C21orf123 promoter is activated by serum depletion according to promoter reporter assays in HEK 293 cells. (PMID:20494980)
• Restoring the epigenetically silenced lncRNA COL18A1-AS1 represses ccRCC progression by lipid browning via miR-1286/KLF12 axis. (PMID:35787628)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.