COL1A2-AS1

Summary

COL1A2-AS1 (COL1A2 antisense RNA 1, HGNC:53133) is a long non-coding RNA gene on chromosome 7q21.3.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53133
Approved symbol	COL1A2-AS1
Name	COL1A2 antisense RNA 1
Location	7q21.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	TCONS_00013888, lncRNA8975-1
Entrez	101927525
RNAcentral	URS0000BC4488 — lncRNA, 559 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• the long non-coding RNA lncRNA8975-1 is upregulated in hypertrophic scar fibroblasts. (PMID:27866191)
• In conclusion, our study demonstrated that COL1A2-AS1/miR-21/Smad pathway plays an important role in inhibiting hypertrophic scar formation, and suggested this novel pathway may be a new target for hypertrophic scar treatment. (PMID:29117538)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000171796 (7:94387294 A>G), RS1000181762 (7:94381678 CTCTT>C,CTCTTTCTT), RS1000462796 (7:94369013 T>C), RS1000482437 (7:94381678 C>G,T), RS1000535746 (7:94381911 T>A,C), RS1000598363 (7:94380068 G>A), RS1000723765 (7:94368572 G>A), RS1000904498 (7:94368800 G>A,T), RS1000912875 (7:94388717 C>T), RS1001120945 (7:94374630 C>T), RS1001231590 (7:94385563 T>C), RS1001553684 (7:94374928 T>C), RS1001641206 (7:94372199 C>A,G,T), RS1001693348 (7:94372536 C>A,T), RS1001848385 (7:94366829 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.