COL6A5

Summary

COL6A5 (collagen type VI alpha 5 chain, HGNC:26674) is a protein-coding gene on chromosome 3q22.1, encoding Collagen alpha-5(VI) chain (A8TX70). Collagen VI acts as a cell-binding protein.

This gene encodes a member of the collagen superfamily of proteins. The encoded protein contains multiple von Willebrand factor A-like domains and may interact with the alpha 1 and alpha 2 chains of collagen VI to form the complete collagen VI trimer. Polymorphisms in this gene may be linked to dermal phenotypes, such as eczema. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 256076 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 406 total
• Druggable target: yes
• Dosage sensitivity (ClinGen): haploinsufficiency dosage sensitivity unlikely, triplosensitivity no evidence
• MANE Select transcript: NM_001278298

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26674
Approved symbol	COL6A5
Name	collagen type VI alpha 5 chain
Location	3q22.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ35880, VWA4
Ensembl gene	ENSG00000172752
Ensembl biotype	protein_coding
OMIM	611916
Entrez	256076

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 3 protein_coding, 1 nonsense_mediated_decay

ENST00000312481, ENST00000373157, ENST00000512482, ENST00000512836

RefSeq mRNA: 3 — MANE Select: NM_001278298 NM_001278298, NM_001412157, NM_153264

CCDS: CCDS93384, CCDS93385

Canonical transcript exons

ENST00000373157 — 41 exons

Exon	Start	End
ENSE00001194266	130470871	130470967
ENSE00001194273	130468795	130469481
ENSE00001194278	130455455	130455666
ENSE00001194287	130443476	130443566
ENSE00001379257	130440166	130440825
ENSE00001531459	130439522	130439615
ENSE00001531461	130431465	130431949
ENSE00001547997	130421325	130421360
ENSE00001548142	130409326	130409388
ENSE00001548940	130405993	130406019
ENSE00001551288	130401031	130401173
ENSE00001552037	130415645	130415707
ENSE00001552649	130398030	130398111
ENSE00001553178	130410009	130410074
ENSE00001553245	130416757	130416819
ENSE00001553637	130414069	130414131
ENSE00001553744	130418869	130418931
ENSE00001553925	130423838	130423900
ENSE00001554307	130373611	130373705
ENSE00001555371	130406131	130406175
ENSE00001556081	130405588	130405659
ENSE00001557802	130391179	130391754
ENSE00001559014	130426367	130426403
ENSE00001559270	130397583	130397923
ENSE00001559767	130403609	130403662
ENSE00001560348	130379418	130380050
ENSE00001560961	130422720	130422782
ENSE00001561139	130413545	130413580
ENSE00001561816	130410471	130410524
ENSE00001562090	130406268	130406321
ENSE00001562324	130376237	130376836
ENSE00001562534	130394890	130395465
ENSE00001562755	130401762	130401854
ENSE00001563783	130426214	130426249
ENSE00001564067	130388580	130389134
ENSE00001564082	130421153	130421203
ENSE00001564320	130384804	130385364
ENSE00001634300	130471682	130471926
ENSE00002055710	130484035	130484846
ENSE00002421519	130429573	130429584
ENSE00003970013	130345672	130345981

Expression profiles

Bgee: expression breadth broad, 58 present calls, max score 86.11.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0560 / max 11.2069, expressed in 33 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
38580	0.0560	33

Top tissues by expression

227 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
upper leg skin	UBERON:0004262	86.11	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.93	gold quality
upper lobe of left lung	UBERON:0008952	74.24	gold quality
upper lobe of lung	UBERON:0008948	73.38	gold quality
skin of hip	UBERON:0001554	70.21	gold quality
lung	UBERON:0002048	69.83	gold quality
right lung	UBERON:0002167	68.26	gold quality
lower lobe of lung	UBERON:0008949	67.51	silver quality
duodenum	UBERON:0002114	61.61	gold quality
skin of abdomen	UBERON:0001416	60.14	gold quality
lower esophagus mucosa	UBERON:0035834	59.35	gold quality
visceral pleura	UBERON:0002401	58.72	gold quality
colonic epithelium	UBERON:0000397	55.64	gold quality
zone of skin	UBERON:0000014	55.39	gold quality
jejunal mucosa	UBERON:0000399	55.09	gold quality
cardia of stomach	UBERON:0001162	53.77	gold quality
esophagus mucosa	UBERON:0002469	53.39	gold quality
left testis	UBERON:0004533	52.64	gold quality
testis	UBERON:0000473	51.83	gold quality
urinary bladder	UBERON:0001255	51.67	gold quality
bone marrow cell	CL:0002092	50.49	gold quality
skin of leg	UBERON:0001511	50.40	gold quality
right testis	UBERON:0004534	49.53	gold quality
vermiform appendix	UBERON:0001154	49.44	gold quality
fundus of stomach	UBERON:0001160	49.36	gold quality
caecum	UBERON:0001153	48.57	gold quality
jejunum	UBERON:0002115	48.29	gold quality
stomach	UBERON:0000945	47.35	gold quality
rectum	UBERON:0001052	47.35	gold quality
bone marrow	UBERON:0002371	46.01	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.66

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

50 targeting COL6A5, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4692	100.00	67.32	2066
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-6793-5P	99.97	65.95	758
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-145-5P	99.92	71.13	1836
HSA-MIR-5195-3P	99.92	70.92	1877
HSA-MIR-4697-3P	99.89	67.09	1123
HSA-MIR-221-3P	99.86	71.56	1329
HSA-MIR-222-3P	99.86	71.35	1337
HSA-MIR-4516	99.61	67.78	3390
HSA-MIR-3120-3P	99.54	70.28	2669
HSA-MIR-143-3P	99.49	69.05	1457
HSA-MIR-4770	99.49	69.09	1451
HSA-MIR-330-3P	99.41	69.95	2521
HSA-MIR-5683	99.36	68.59	2083
HSA-MIR-6088	99.29	68.45	1284
HSA-MIR-4279	99.19	66.70	2437
HSA-MIR-4434	99.10	67.01	1984
HSA-MIR-5703	99.10	67.09	2053
HSA-MIR-7151-3P	99.04	69.72	2370

Functional genomics

ClinGen dosage: haploinsufficiency 40 (dosage sensitivity unlikely), triplosensitivity 0 (no evidence). ClinGen Gene Dosage Map

Literature-anchored findings (GeneRIF, showing 13)

• To identify the underlying atopic dermatitis disease gene, a dense map of microsatellite markers and single nucleotide polymorphisms was used, and association with AD was detected. (PMID:17850181)
• The discovery of three additional collagen VI chains doubles the collagen VI family and adds a layer of complexity to collagen VI assembly and function in the extracellular matrix. (PMID:18400749)
• unlike eczema, genetic variation at COL29A1 and IL31 loci is unlikely to impact inflammatory bowel disease risk (PMID:18839421)
• The role of the COL29A1 gene as an atopic dermatitis gene was not supported. Also, COL29A1 did not play a substantial role in the pathogenesis of chronic obstructive pulmonary disease or asthma. (PMID:20649719)
• localization of alpha5, and to a lesser extent alpha6, is restricted to the papillary dermis, where the protein mainly colocalizes with collagen fibrils; both chains were found around blood vessels (PMID:20882040)
• Our results suggest that COL29A1 is unlikely to contain genetic variants that have a major effect on eczema or atopy susceptibility. (PMID:21353297)
• The collagen VI alpha5 chain is selectively localized at the basement membrane of myotendinous junctions. (PMID:22226732)
• This study demonstrated that an association between COL6A5 gene and familiar chronic itch, suggesting a new contributor to the pathogenesis of neuropathic itch. (PMID:28073787)
• The longitudinal EWAS for the recessive model showed that a novel SNV, rs11917356 of COL6A5, was significantly associated with systolic blood pressure, and the derived allele at the SNV may have spread throughout East Asia in recent evolutionary time. (PMID:29217820)
• three polymorphisms located in COL6A5, COL8A1, and COL10A1 were investigated as potential susceptibility biomarkers for atopic eczema. (PMID:31275967)
• Collagen type VI alpha5 gene variations may predict the risk of lung cancer development in Chinese Han population. (PMID:32193401)
• RNAseq-Based Prioritization Revealed COL6A5, COL8A1, COL10A1 and MIR146A as Common and Differential Susceptibility Biomarkers for Psoriasis and Psoriatic Arthritis: Confirmation from Genotyping Analysis of 1417 Italian Subjects. (PMID:32326527)
• Rare functional genetic variants in COL7A1, COL6A5, COL1A2 and COL5A2 frequently occur in Chiari Malformation Type 1. (PMID:33974636)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Col6a5	ENSMUSG00000091345
rattus_norvegicus	Col6a5	ENSRNOG00000010663
caenorhabditis_elegans		WBGENE00003497
caenorhabditis_elegans		WBGENE00007800

Paralogs (12): COCH (ENSG00000100473), COL12A1 (ENSG00000111799), MATN4 (ENSG00000124159), MATN3 (ENSG00000132031), MATN2 (ENSG00000132561), MATN1 (ENSG00000162510), COL6A3 (ENSG00000163359), VWA2 (ENSG00000165816), VWA1 (ENSG00000179403), COL14A1 (ENSG00000187955), VIT (ENSG00000205221), COL6A6 (ENSG00000206384)

Protein

Protein identifiers

Collagen alpha-5(VI) chain — A8TX70 (reviewed: A8TX70)

Alternative names: Collagen alpha-1(XXIX) chain, von Willebrand factor A domain-containing protein 4

All UniProt accessions (4): A8TX70, H0Y393, H0Y935, H0Y9T2

UniProt curated annotations — full annotation on UniProt →

Function. Collagen VI acts as a cell-binding protein.

Subunit / interactions. Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-5(VI) or alpha-6(VI).

Subcellular location. Secreted. Extracellular space. Extracellular matrix.

Tissue specificity. Expressed in skin, followed by lung, small intestine, colon and testis. In skin, it is expressed in the epidermis with strongest staining in suprabasal viable layers. In ATOD patients, it is absent in the most differentiated upper spinous and granular layers (at protein level).

Post-translational modifications. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Disease relevance. Patients affected by atopic dermatitis display an abnormal distribution of COL29A1 mRNA and protein in skin suggesting that COL29A1 may be involved in the pathogenesis of the disease.

Similarity. Belongs to the type VI collagen family.

Isoforms (2)

UniProt ID	Names	Canonical?
A8TX70-1	1	yes
A8TX70-2	2

RefSeq proteins (3): NP_001265227, NP_001399086, NP_694996 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002035	VWF_A	Domain
IPR008160	Collagen	Repeat
IPR036465	vWFA_dom_sf	Homologous_superfamily
IPR050525	ECM_Assembly_Org	Family

Pfam: PF00092, PF01391

UniProt features (46 total): domain 16, sequence variant 11, region of interest 4, glycosylation site 4, compositionally biased region 3, sequence conflict 3, splice variant 2, signal peptide 1, chain 1, short sequence motif 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A8TX70-F1	70.94	0.17

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (4): 201, 260, 835, 2509

Function

Pathways and Gene Ontology

Reactome pathways

8 pathways

ID	Pathway
R-HSA-1442490	Collagen degradation
R-HSA-1650814	Collagen biosynthesis and modifying enzymes
R-HSA-186797	Signaling by PDGF
R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures
R-HSA-216083	Integrin cell surface interactions
R-HSA-3000178	ECM proteoglycans
R-HSA-419037	NCAM1 interactions
R-HSA-8948216	Collagen chain trimerization

MSigDB gene sets: 66 (showing top): GOCC_COLLAGEN_TRIMER, REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH, GOMF_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT, chr3q22, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS, GOCC_COMPLEX_OF_COLLAGEN_TRIMERS, GOMF_STRUCTURAL_MOLECULE_ACTIVITY, REACTOME_SIGNALING_BY_PDGF, GOCC_SUPRAMOLECULAR_COMPLEX, GOMF_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT_CONFERRING_TENSILE_STRENGTH, REACTOME_COLLAGEN_DEGRADATION, REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES, REACTOME_ASSEMBLY_OF_COLLAGEN_FIBRILS_AND_OTHER_MULTIMERIC_STRUCTURES, REACTOME_ECM_PROTEOGLYCANS

GO Biological Process (2): cell adhesion (GO:0007155), extracellular matrix organization (GO:0030198)

GO Molecular Function (2): extracellular matrix structural constituent conferring tensile strength (GO:0030020), protein binding (GO:0005515)

GO Cellular Component (4): extracellular region (GO:0005576), collagen type VI trimer (GO:0005589), extracellular matrix (GO:0031012), collagen trimer (GO:0005581)

Reactome top-level categories

Rollup of top-6 pathways:

Category	Pathways
Collagen formation	2
Extracellular matrix organization	2
Degradation of the extracellular matrix	1
Signaling by Receptor Tyrosine Kinases	1
NCAM signaling for neurite out-growth	1
Collagen biosynthesis and modifying enzymes	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular process	1
extracellular structure organization	1
external encapsulating structure organization	1
extracellular matrix structural constituent	1
binding	1
cellular anatomical structure	1
collagen beaded filament	1
von-Willerbrand-factor-A-domain-rich collagen trimer	1
extracellular protein-containing complex	1
external encapsulating structure	1
protein-containing complex	1

Protein interactions and networks

STRING

1080 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
COL6A5	CSTA	P01040	884
COL6A5	MS4A2	Q01362	767
COL6A5	CMA1	P23946	650
COL6A5	COL6A2	P12110	564
COL6A5	COL5A2	P05997	485
COL6A5	COL5A1	P20908	484
COL6A5	COL6A1	P12109	482
COL6A5	ARMH1	Q6PIY5	470
COL6A5	ACAD10	Q6JQN1	469
COL6A5	COL1A2	P02464	466
COL6A5	ADAMTS2	O95450	440
COL6A5	COL8A1	P27658	436
COL6A5	COL2A1	P02458	416
COL6A5	F2RL2	O00254	402
COL6A5	CLCA2	Q9UQC9	396

IntAct

0 interactions, top by confidence:

BioGRID (6): COL6A5 (Affinity Capture-MS), COL6A5 (Affinity Capture-MS), COL6A5 (Reconstituted Complex), COL6A5 (Affinity Capture-Western), USP3 (Affinity Capture-Western), YWHAE (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A2AX52, A6H584, A6NMZ7, A6X935, A8TX70, E1BMV3, E7FF10, O00339, O02668, O08746, O55123, O89029, P05099, P06681, P12111, P15989, P19823, P19827, P21180, P21941, P51942, P79263, P97278, P97279, Q0IIH7, Q0V8T0, Q0V8T5, Q0V8T6, Q0V8T7, Q0VCM5, Q14624, Q21540, Q29052, Q3SYW2, Q3T052, Q5GFL6, Q61702, Q61703, Q6DCQ6, Q70UZ7

Diamond homologs: A2AX52, A6H584, A6NMZ7, A6QLN9, A8TX70, E7FF10, O00339, O08746, O42401, O75578, O89029, P05099, P05555, P11215, P12111, P15989, P20701, P20702, P34576, P51942, P61625, Q02388, Q13349, Q21281, Q21540, Q28902, Q3V0T4, Q63870, Q642A6, Q6PCB0, Q6UXI7, Q8C6K9, Q8NFW1, Q8R2Z5, Q90615, Q91145, Q923P0, Q95LI2, Q96P44, Q9P218

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

406 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	321
Likely benign	55
Benign	12

Top pathogenic / likely-pathogenic (0)

SpliceAI

6467 predictions. Top by Δscore:

Variant	Effect	Δscore
3:130345977:GCTGG:G	donor_gain	1.0000
3:130345979:TGGG:T	donor_loss	1.0000
3:130345980:GG:G	donor_gain	1.0000
3:130345981:GG:G	donor_gain	1.0000
3:130345982:GTAA:G	donor_loss	1.0000
3:130345983:T:A	donor_loss	1.0000
3:130376223:T:G	acceptor_gain	1.0000
3:130376227:A:AG	acceptor_gain	1.0000
3:130376227:ATTTT:A	acceptor_gain	1.0000
3:130376228:T:G	acceptor_gain	1.0000
3:130376231:T:A	acceptor_gain	1.0000
3:130376235:A:AG	acceptor_gain	1.0000
3:130376235:AG:A	acceptor_gain	1.0000
3:130376235:AGG:A	acceptor_gain	1.0000
3:130376236:G:GA	acceptor_gain	1.0000
3:130376236:GG:G	acceptor_gain	1.0000
3:130376236:GGG:G	acceptor_gain	1.0000
3:130376236:GGGC:G	acceptor_gain	1.0000
3:130376236:GGGCC:G	acceptor_gain	1.0000
3:130391613:G:GG	donor_gain	1.0000
3:130394886:GCA:G	acceptor_loss	1.0000
3:130394887:CA:C	acceptor_loss	1.0000
3:130394888:A:AG	acceptor_gain	1.0000
3:130394888:AGTCT:A	acceptor_gain	1.0000
3:130394889:G:GA	acceptor_gain	1.0000
3:130394889:GT:G	acceptor_gain	1.0000
3:130394889:GTC:G	acceptor_gain	1.0000
3:130394889:GTCT:G	acceptor_gain	1.0000
3:130394889:GTCTG:G	acceptor_gain	1.0000
3:130395462:ACCA:A	donor_gain	1.0000

AlphaMissense

17346 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:130376267:T:C	F33S	0.986
3:130376413:T:C	F82L	0.986
3:130376415:C:A	F82L	0.986
3:130376415:C:G	F82L	0.986
3:130388732:T:C	F672L	0.985
3:130388734:C:A	F672L	0.985
3:130388734:C:G	F672L	0.985
3:130376270:T:C	L34P	0.984
3:130469013:G:C	A2337P	0.984
3:130376278:A:C	S37R	0.983
3:130376280:C:A	S37R	0.983
3:130376280:C:G	S37R	0.983
3:130376377:G:C	A70P	0.983
3:130376588:T:A	V140D	0.983
3:130376510:T:C	L114P	0.982
3:130379577:T:C	L276P	0.981
3:130440225:G:C	D1963H	0.981
3:130440723:A:C	S2129R	0.981
3:130440725:C:A	S2129R	0.981
3:130440725:C:G	S2129R	0.981
3:130376381:T:C	L71P	0.980
3:130388913:T:C	L732P	0.980
3:130376275:G:C	D36H	0.978
3:130376383:G:C	A72P	0.978
3:130440654:T:A	C2106S	0.978
3:130440655:G:C	C2106S	0.978
3:130379466:T:C	F239S	0.977
3:130388621:A:C	S635R	0.977
3:130388623:T:A	S635R	0.977
3:130388623:T:G	S635R	0.977

dbSNP variants (sampled 300 via entrez): RS1000011069 (3:130477402 C>G,T), RS1000030150 (3:130459395 G>A), RS1000055271 (3:130392593 T>G), RS1000058199 (3:130452890 A>G), RS1000060714 (3:130381657 C>T), RS1000077444 (3:130388285 C>T), RS1000099240 (3:130344243 A>G), RS1000110166 (3:130472241 C>T), RS1000138548 (3:130430107 G>A), RS1000159622 (3:130374910 AG>A), RS1000160525 (3:130418137 T>C), RS1000232022 (3:130478778 G>C,T), RS1000256703 (3:130394314 T>C), RS1000292961 (3:130423452 G>C), RS1000358008 (3:130361110 C>A)

Disease associations

OMIM: gene MIM:611916 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST002301_3	Body mass index	1.000000e-08
GCST004748_85	Lung cancer	8.000000e-06
GCST008158_145	Body mass index	7.000000e-06
GCST010477_4	Hypertension	4.000000e-07
GCST010478_1	Chronic kidney disease	5.000000e-09
GCST012490_588	Femur bone mineral density x serum urate levels interaction	8.000000e-11
GCST90020028_1720	Hip circumference adjusted for BMI	3.000000e-08

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index
EFO:0004531	urate measurement
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL2364188 (PROTEIN COMPLEX GROUP)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

12 total (human), top 12 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Nickel	increases expression	2
bisphenol A	increases methylation	1
sodium arsenite	increases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
bisphenol S	affects cotreatment, increases methylation	1
MT19c compound	decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Acetaminophen	decreases expression	1
Benzo(a)pyrene	affects methylation	1
Lipopolysaccharides	affects response to substance, increases expression	1
Triclosan	increases expression	1
Aflatoxin B1	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.