COMETT

Summary

COMETT (cytosolic oncogenic antisense to MET transcript, HGNC:51196) is a long non-coding RNA gene on chromosome 7q31.2.

This gene encodes a natural antisense transcript highly expressed in papillary thyroid carcinomas harboring BRAF V600E mutation or RET gene rearrangements. This lncRNA induces the downstream MAPK pathway and is part of a co-expression network including different oncogenes belonging to the MAPK and PI3H/AKT pathways. In thyroid carcinomas, this gene has oncogenic properties associated with increased proliferation and drug resistance.

Source: NCBI Gene 100996266 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51196
Approved symbol	COMETT
Name	cytosolic oncogenic antisense to MET transcript
Location	7q31.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	COMET
Ensembl gene	ENSG00000231210
Ensembl biotype	lncRNA
Entrez	100996266
RNAcentral	URS0001981104 — lncRNA, 1195 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 19 lncRNA

ENST00000441991, ENST00000450063, ENST00000458082, ENST00000650435, ENST00000757593, ENST00000757594, ENST00000757595, ENST00000757596, ENST00000757597, ENST00000757598, ENST00000757599, ENST00000757600, ENST00000757601, ENST00000757602, ENST00000757603, ENST00000757604, ENST00000757605, ENST00000757606, ENST00000757607

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000441991 — 3 exons

Exon	Start	End
ENSE00001632523	116573441	116573744
ENSE00004108858	116570938	116571230
ENSE00004108871	116614599	116614785

Expression profiles

Bgee: expression breadth broad, 97 present calls, max score 88.63.

Top tissues by expression

97 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.63	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.41	silver quality
adult mammalian kidney	UBERON:0000082	86.15	gold quality
kidney	UBERON:0002113	84.07	gold quality
cortex of kidney	UBERON:0001225	78.64	gold quality
hindlimb stylopod muscle	UBERON:0004252	72.48	gold quality
metanephros cortex	UBERON:0010533	70.59	gold quality
right uterine tube	UBERON:0001302	59.93	gold quality
muscle tissue	UBERON:0002385	59.82	silver quality
monocyte	CL:0000576	59.64	gold quality
endometrium	UBERON:0001295	58.05	gold quality
islet of Langerhans	UBERON:0000006	57.29	gold quality
prefrontal cortex	UBERON:0000451	57.17	gold quality
liver	UBERON:0002107	55.68	gold quality
placenta	UBERON:0001987	55.59	gold quality
fallopian tube	UBERON:0003889	55.31	gold quality
pituitary gland	UBERON:0000007	54.44	gold quality
body of uterus	UBERON:0009853	54.27	gold quality
gall bladder	UBERON:0002110	54.26	gold quality
skeletal muscle tissue	UBERON:0001134	53.60	silver quality
muscle of leg	UBERON:0001383	52.32	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	52.27	gold quality
calcaneal tendon	UBERON:0003701	51.50	silver quality
primary visual cortex	UBERON:0002436	51.48	gold quality
gastrocnemius	UBERON:0001388	51.29	gold quality
right lobe of liver	UBERON:0001114	51.01	gold quality
fundus of stomach	UBERON:0001160	50.95	gold quality
blood	UBERON:0000178	50.91	gold quality
right atrium auricular region	UBERON:0006631	50.40	gold quality
heart	UBERON:0000948	49.73	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.24

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• Long non-coding RNA LINC01510 is down-regulated in renal cell carcinoma (RCC) and predicts poor prognosis. (PMID:30224058)
• Increased expression of LINC01510 predicts poor prognosis and promotes tumorigenesis in non-small cell lung cancer. (PMID:30399588)
• We demonstrated that low LINC01510 expression was associated with the progression of colorectal cancer (CRC) and could serve as a potential independent prognostic biomarker for patients with CRC. (PMID:30536314)
• High COMET expression is associated with Papillary Thyroid Carcinomas. (PMID:30862713)
• SOX2-induced upregulation of lncRNA LINC01510 promotes papillary thyroid carcinoma progression by modulating miR-335/SHH and activating Hedgehog pathway (PMID:31590919)
• Loss of KMT5C Promotes EGFR Inhibitor Resistance in NSCLC via LINC01510-Mediated Upregulation of MET. (PMID:35404406)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.