COMMD10

Summary

COMMD10 (COMM domain containing 10, HGNC:30201) is a protein-coding gene on chromosome 5q23.1, encoding COMM domain-containing protein 10 (Q9Y6G5). Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex.

Predicted to be involved in endocytic recycling. Located in nucleoplasm. Part of protein-containing complex.

Source: NCBI Gene 51397 — automated summary from GO annotations (Alliance of Genome Resources).

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 49 total
• GTEx eGene: eQTL in 47 tissues, sQTL in 22 (q < 0.05)
• Constraint (gnomAD): pLI 0.00 (LoF-tolerant), LOEUF 1.81 (unconstrained)
• MANE Select transcript: NM_016144

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30201
Approved symbol	COMMD10
Name	COMM domain containing 10
Location	5q23.1
Locus type	gene with protein product
Status	Approved
Aliases	PTD002
Ensembl gene	ENSG00000145781
Ensembl biotype	protein_coding
OMIM	616704
Entrez	51397

Gene structure

Transcript identifiers

Ensembl transcripts: 33 — 17 nonsense_mediated_decay, 14 protein_coding, 2 protein_coding_CDS_not_defined

MANE Select: ENST00000274458

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 1: 2, TSL 3: 2, TSL 4: 1, TSL 5: 2

ENST00000274458, ENST00000503424, ENST00000506589, ENST00000507356, ENST00000508250, ENST00000515539, ENST00000632434, ENST00000908482, ENST00000978975, ENST00000978976, ENST00000978977, ENST00000978978, ENST00000978979, ENST00001029419, ENST00001029420, ENST00001029421, ENST00001059085, ENST00001059087, ENST00001099345, ENST00001099346, ENST00001099347, ENST00001109390, ENST00001109391, ENST00001119338, ENST00001119339, ENST00001119340, ENST00001119341, ENST00001119342, ENST00001119343, ENST00001127439, ENST00001127440, ENST00001127441, ENST00001136593

RefSeq mRNA: 2 — MANE Select: NM_016144 NM_001308080, NM_016144

CCDS: CCDS34215, CCDS78049

Canonical transcript exons

ENST00000274458 — 7 exons

Exon	Start	End
ENSE00000972237	116091079	116091189
ENSE00001005662	116092545	116092700
ENSE00001274247	116292451	116293287
ENSE00002029861	116085025	116085093
ENSE00003470480	116087497	116087587
ENSE00003537569	116291517	116291576
ENSE00003543802	116134068	116134178

Expression profiles

Bgee: expression breadth ubiquitous, 278 present calls, max score 98.80.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 22.0947 / max 224.4737, expressed in 1801 samples.

Highest expression (Bgee): oocyte, secondary oocyte, adrenal tissue, monocyte, mononuclear cell.

Genetic regulation across tissues (GTEx eQTL / sQTL)

COMMD10 is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 47 tissues and its splicing (sQTL) in 22 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

showing 20 of 69 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Muscle Skeletal	eqtl	1.2e-57	+0.69	5:116298321:T:C
Brain Spinal cord cervical c-1	eqtl	5.3e-20	+0.66	5:116187584:C:A
Heart Atrial Appendage	eqtl	8.0e-19	+0.46	5:116304165:G:A
Cells EBV-transformed lymphocytes	eqtl	1.5e-18	+0.70	5:116298321:T:C
Adipose Subcutaneous	eqtl	2.8e-15	+0.34	5:116291873:A:G
Cells Cultured fibroblasts	eqtl	7.7e-15	+0.24	5:116306400:C:G
Brain Cerebellar Hemisphere	eqtl	9.4e-15	-0.42	5:116235454:G:C
Brain Cerebellum	eqtl	2.5e-13	-0.50	5:116218524:T:C
Breast Mammary Tissue	eqtl	4.6e-11	+0.29	5:116298321:T:C
Brain Hypothalamus	eqtl	7.3e-11	+0.47	5:116088173:G:A
Testis	sqtl	2.4e-10	+0.71	5:116317237:C:G
Brain Frontal Cortex BA9	eqtl	2.4e-10	+0.38	5:116258211:G:A
Esophagus Muscularis	eqtl	3.2e-10	+0.22	5:116306816:T:C
Heart Left Ventricle	eqtl	7.9e-10	+0.31	5:116298321:T:C
Thyroid	sqtl	1.4e-09	+0.54	5:116108736:A:AAAAC
Skin Sun Exposed Lower leg	eqtl	1.5e-09	-0.74	5:116112547:C:A
Brain Substantia nigra	eqtl	2.0e-09	+0.50	5:116206253:A:G
Lung	sqtl	5.4e-09	+1.56	5:116412768:C:G
Thyroid	eqtl	7.8e-09	+0.20	5:116253780:C:T
Brain Hippocampus	eqtl	1.8e-08	+0.41	5:116272528:T:A

FANTOM5 promoters

3 alternative TSS:

Promoter ID	TPM avg	Samples expressed
58075	21.4347	1801
203664	0.6448	426
58077	0.0152	1

Top tissues by expression

showing 100 of 290 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oocyte	CL:0000023	98.80	gold quality
secondary oocyte	CL:0000655	98.38	gold quality
adrenal tissue	UBERON:0018303	93.66	gold quality
monocyte	CL:0000576	92.92	gold quality
mononuclear cell	CL:0000842	92.87	gold quality
leukocyte	CL:0000738	92.57	gold quality
buccal mucosa cell	CL:0002336	92.21	silver quality
ventricular zone	UBERON:0003053	92.05	gold quality
rectum	UBERON:0001052	91.08	gold quality
parotid gland	UBERON:0001831	91.01	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	90.86	gold quality
islet of Langerhans	UBERON:0000006	90.85	gold quality
right adrenal gland cortex	UBERON:0035827	90.76	gold quality
gall bladder	UBERON:0002110	90.49	gold quality
ganglionic eminence	UBERON:0004023	90.35	gold quality
heart left ventricle	UBERON:0002084	90.07	gold quality
right adrenal gland	UBERON:0001233	90.04	gold quality
right atrium auricular region	UBERON:0006631	90.03	gold quality
cardiac ventricle	UBERON:0002082	89.89	gold quality
left adrenal gland	UBERON:0001234	89.86	gold quality
heart	UBERON:0000948	89.64	gold quality
left adrenal gland cortex	UBERON:0035825	89.64	gold quality
adrenal gland	UBERON:0002369	89.62	gold quality
cardiac atrium	UBERON:0002081	89.56	gold quality
pigmented layer of retina	UBERON:0001782	89.48	gold quality
calcaneal tendon	UBERON:0003701	89.40	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.33	gold quality
bone marrow cell	CL:0002092	89.30	gold quality
left lobe of thyroid gland	UBERON:0001120	89.19	gold quality
embryo	UBERON:0000922	89.08	gold quality
body of pancreas	UBERON:0001150	89.07	gold quality
thyroid gland	UBERON:0002046	89.06	gold quality
adrenal cortex	UBERON:0001235	88.93	gold quality
pancreas	UBERON:0001264	88.92	gold quality
left ventricle myocardium	UBERON:0006566	88.86	gold quality
heart right ventricle	UBERON:0002080	88.85	gold quality
saliva-secreting gland	UBERON:0001044	88.78	gold quality
popliteal artery	UBERON:0002250	88.74	gold quality
tibial artery	UBERON:0007610	88.73	gold quality
germinal epithelium of ovary	UBERON:0001304	88.41	gold quality
right lobe of thyroid gland	UBERON:0001119	88.36	gold quality
endocervix	UBERON:0000458	88.26	gold quality
ectocervix	UBERON:0012249	88.26	gold quality
minor salivary gland	UBERON:0001830	88.10	gold quality
lymph node	UBERON:0000029	88.09	gold quality
aorta	UBERON:0000947	88.09	gold quality
right coronary artery	UBERON:0001625	88.05	gold quality
metanephros cortex	UBERON:0010533	87.98	gold quality
omental fat pad	UBERON:0010414	87.97	gold quality
peritoneum	UBERON:0002358	87.92	gold quality
muscle layer of sigmoid colon	UBERON:0035805	87.86	gold quality
myocardium	UBERON:0002349	87.85	gold quality
body of stomach	UBERON:0001161	87.81	gold quality
tonsil	UBERON:0002372	87.79	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	87.79	gold quality
adult mammalian kidney	UBERON:0000082	87.78	gold quality
endometrium	UBERON:0001295	87.76	gold quality
lower esophagus	UBERON:0013473	87.75	gold quality
lower esophagus muscularis layer	UBERON:0035833	87.74	gold quality
left coronary artery	UBERON:0001626	87.73	gold quality
descending thoracic aorta	UBERON:0002345	87.72	gold quality
adipose tissue of abdominal region	UBERON:0007808	87.71	gold quality
left ovary	UBERON:0002119	87.68	gold quality
right ovary	UBERON:0002118	87.64	gold quality
eye	UBERON:0000970	87.60	gold quality
body of uterus	UBERON:0009853	87.44	gold quality
ascending aorta	UBERON:0001496	87.43	gold quality
thoracic aorta	UBERON:0001515	87.39	gold quality
ovary	UBERON:0000992	87.32	gold quality
adenohypophysis	UBERON:0002196	87.10	gold quality
hindlimb stylopod muscle	UBERON:0004252	87.08	gold quality
coronary artery	UBERON:0001621	87.01	gold quality
palpebral conjunctiva	UBERON:0001812	87.00	gold quality
lower esophagus mucosa	UBERON:0035834	86.99	gold quality
stomach	UBERON:0000945	86.98	gold quality
esophagus	UBERON:0001043	86.97	gold quality
adipose tissue	UBERON:0001013	86.95	gold quality
subcutaneous adipose tissue	UBERON:0002190	86.86	gold quality
bone marrow	UBERON:0002371	86.67	gold quality
spleen	UBERON:0002106	86.66	gold quality
right uterine tube	UBERON:0001302	86.65	gold quality
connective tissue	UBERON:0002384	86.63	gold quality
vagina	UBERON:0000996	86.61	gold quality
sural nerve	UBERON:0015488	86.57	gold quality
mouth mucosa	UBERON:0003729	86.55	gold quality
prostate gland	UBERON:0002367	86.54	gold quality
granulocyte	CL:0000094	86.45	gold quality
smooth muscle tissue	UBERON:0001135	86.40	gold quality
esophagus mucosa	UBERON:0002469	86.39	gold quality
right lobe of liver	UBERON:0001114	86.35	gold quality
pituitary gland	UBERON:0000007	86.33	gold quality
vermiform appendix	UBERON:0001154	86.29	gold quality
upper lobe of left lung	UBERON:0008952	86.21	gold quality
uterus	UBERON:0000995	86.19	gold quality
prefrontal cortex	UBERON:0000451	86.17	gold quality
muscle of leg	UBERON:0001383	86.17	gold quality
cardiac muscle of right atrium	UBERON:0003379	86.15	gold quality
parietal pleura	UBERON:0002400	86.12	gold quality
esophagus squamous epithelium	UBERON:0006920	86.11	gold quality
kidney	UBERON:0002113	86.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.16

HPA expression

RNA tissue specificity: Low tissue specificity

showing 60 of 79 HPA tissues / cells by nTPM:

Tissue / cell	Axis	nTPM	Protein (IHC)
Corpus callosum	tissue	62.1
Spinal cord	tissue	49.9
Midbrain	tissue	47.5
Thalamus	tissue	46.3
Pons	tissue	45.8
Medulla oblongata	tissue	45.3
Putamen	tissue	43.9
Substantia nigra	tissue	43.3
Cerebral cortex	tissue	41.1	low
Somatosensory cortex	tissue	41.1
Superior colliculi	tissue	40.7
Hippocampal formation	tissue	40.3
Occipital cortex	tissue	40.0
Periaqueductal gray	tissue	39.1
Motor cortex	tissue	37.9
Hypothalamus	tissue	37.9
Prefrontal cortex	tissue	37.2
Ventral forebrain	tissue	37.2
Septum	tissue	37.0
Retrosplenial and cingulate cortex	tissue	36.4
Entorhinal cortex	tissue	35.9
Retrosplenial cortex	tissue	35.7
Temporal cortex	tissue	35.4
Amygdala	tissue	34.6
Cerebellum	tissue	33.7	low
Olfactory bulb	tissue	33.6
Kidney	tissue	33.0	medium
Insular cortex	tissue	32.9
Frontal cortex	tissue	31.5
Epididymis	tissue	30.4	low
Basal ganglia	tissue	29.5	low
Heart muscle	tissue	29.3	low
Salivary gland	tissue	28.9	not detected
Caudate putamen	tissue	27.9
Thyroid gland	tissue	25.7	low
Parathyroid gland	tissue	23.8	low
Liver	tissue	22.9	low
Adrenal gland	tissue	22.8	low
Pancreas	tissue	22.7	medium
Breast	tissue	21.6	low
Lymph node	tissue	20.7	low
Prostate	tissue	19.4	not detected
Tonsil	tissue	19.0	low
Rectum	tissue	18.8	medium
Placenta	tissue	18.4	low
Smooth muscle	tissue	18.3	not detected
Adipose tissue	tissue	18.1	not detected
Cervix	tissue	18.0	low
Spleen	tissue	17.5	not detected
Choroid plexus	tissue	17.1
Urinary bladder	tissue	16.9	medium
Tongue	tissue	16.2
Gallbladder	tissue	16.2	medium
Seminal vesicle	tissue	16.0	not detected
Retina	tissue	15.9
Colon	tissue	15.9	medium
Endometrium 1	tissue	15.6	low
Ovary	tissue	15.5	low
Thymus	tissue	15.2
Esophagus	tissue	14.6	medium

Brain sub-regions (HPA Brain Atlas): detected in 190; highest nTPM — White matter (62.1), Ventral spinal cord (49.9), Dorsal spinal cord (44.4), Dorsal hippocampus (40.3), Subiculum (37.8).

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

Targeting COMMD10 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific).

showing 30 of 60 miRNAs:

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-548D-3P	99.87	70.67	4362
HSA-MIR-221-5P	99.86	65.45	1052
HSA-MIR-8073	99.86	65.21	1118
HSA-MIR-548BB-3P	99.86	70.58	4354
HSA-MIR-548AC	99.84	70.77	4351
HSA-MIR-548H-3P	99.84	70.80	4349
HSA-MIR-548Z	99.84	70.80	4349
HSA-MIR-4713-5P	99.78	67.80	1794
HSA-MIR-4645-3P	99.76	69.33	993
HSA-MIR-132-3P	99.73	70.56	1424

Functional genomics

gnomAD constraint: pLI 0.00395, LOEUF 1.81, missense Z -2.14 — population loss-of-function intolerance (pLI ≥ 0.9 = LoF-intolerant; lower LOEUF = more constrained). gnomAD

Regional missense constraint (gnomAD RMC): no regional variation along ENST00000274458 — one region, missense o/e 1.33.

Literature-anchored findings (GeneRIF, showing 5)

• Data demonstrate that the FMNL2/COMMD10/p65 NF kappaB axis acts as a critical regulator in the maintenance of metastatic phenotypes in colorectal cancer. (PMID:28817833)
• Expression profile and bioinformatics analysis of COMMD10 in BALB/C mice and human. (PMID:30787448)
• COMMD10 inhibits tumor progression and induces apoptosis by blocking NF-kappaB signal and values up BCLC staging in predicting overall survival in hepatocellular carcinoma. (PMID:34047468)
• COMMD10 inhibits HIF1alpha/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma. (PMID:35101526)
• Comprehensive analysis of COMMD10 as a novel prognostic biomarker for gastric cancer. (PMID:36919165)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Commd10	ENSMUSG00000042705
rattus_norvegicus	Commd10	ENSRNOG00000003958
drosophila_melanogaster	Vlet	FBGN0030323

Mouse-model phenotypes

Observed phenotypes of the mouse ortholog (MGI:1916706) from MGI (Alliance of Genome Resources) — knockout/mutant phenotypes, ranked by annotation count. 4 distinct phenotype terms.

Mouse phenotype (MP)	Records
abnormal placenta morphology	1
abnormal trophoblast layer morphology	1
lethality throughout fetal growth and development, complete penetrance	1
preweaning lethality, complete penetrance	1

Additional cross-species homologs

Sequence homologs in species beyond Ensembl Compara’s model organisms, by Diamond local protein alignment (% sequence identity; best hit per species). Lower-identity rows are more distant homologs. The matched accessions’ gene symbols aren’t in biobtree yet, so each row shows the UniProt accession.

Organism	UniProt	Identity	Method
Dictyostelium discoideum	Q554G3	32.5%	Diamond

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
LINCADL	ncRNA	107986443
AP3S1	protein-coding	1176
LVRN	protein-coding	206338
ARL14EPL	protein-coding	644100
MIR12130	ncRNA	113219464
SEMA6A-AS1	ncRNA	101927233
SEMA6A	protein-coding	57556
SEMA6A-AS2	ncRNA	105379132
LINC02214	ncRNA	102467223

Protein

Protein identifiers

COMM domain-containing protein 10 — Q9Y6G5 (reviewed: Q9Y6G5)

All UniProt accessions (4): D6RC04, D6RJ90, H0Y9N4, Q9Y6G5

UniProt curated annotations — full annotation on UniProt →

Function. Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B.

Subunit / interactions. Component of the commander complex consisting of the CCC subcomplex and the retriever subcomplex. Component of the CCC (COMMD/CCDC22/CCDC93) subcomplex consisting of COMMD1, COMMD2, COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8, COMMD9, COMMD10, CCDC22 and CCDC93; within the complex forms a heterodimer with COMMD5. Interacts with RELA, RELB, NFKB1/p105, NFKB2/p100. Interacts with CCDC22, CCDC93, SCNN1B, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL7.

Subcellular location. Cytoplasm. Nucleus.

Tissue specificity. Ubiquitous.

Similarity. Belongs to the COMM domain-containing protein 10 family.

RefSeq proteins (2): NP_001295009, NP_057228* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR017920	COMM	Domain
IPR037361	COMMD10	Family

Pfam: PF07258, PF21672

UniProt features (19 total): helix 7, strand 4, turn 2, modified residue 2, initiator methionine 1, chain 1, domain 1, sequence variant 1

Structure

Experimental structures (PDB)

6 structures by resolution:

PDB	Title	Method	Resolution (Å)
9ZMY	Crystal structure of the human Commd10 HN domain in domain swapped conformation	X-RAY DIFFRACTION	1.62
9ZN0	Crystal structure of the Commd10 S50E HN domain mutant in domain swapped conformation	X-RAY DIFFRACTION	2.12
8P0W	Structure of the human Commander complex COMMD ring	ELECTRON MICROSCOPY	2.9
8F2R	Human CCC complex	ELECTRON MICROSCOPY	3.12
8ESD	Crystal structure of COMMD7-COMMD9-COMMD5-COMMD10 tetramer	X-RAY DIFFRACTION	3.33
8F2U	Human CCC complex	ELECTRON MICROSCOPY	3.53

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y6G5-F1	84.19	0.49

Human Protein Atlas

Protein class: Predicted intracellular proteins

Protein evidence: Evidence at protein level

Subcellular location (HPA, imaging): nucleoplasm

Antibody reliability (HPA): IH approved · IF supported

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2)

Type	Positions
N-acetylalanine	2
Phosphoserine	155

Function

Pathways and Gene Ontology

Reactome pathways

1 curated (TAS) of 3; 0 disease pathways. Curated-first; evidence = TAS (manually curated) vs IEA (electronic inference).

3 pathways:

ID	Pathway	Evidence
R-HSA-8951664	Neddylation	curated
R-HSA-392499	Metabolism of proteins	—
R-HSA-597592	Post-translational protein modification	—

MSigDB gene sets: 115 (showing top): YAATNRNNNYNATT_UNKNOWN, GOBP_VESICLE_MEDIATED_TRANSPORT, IRF7_01, OCT1_07, TGANTCA_AP1_C, GOBP_ENDOCYTIC_RECYCLING, GOBP_LOCALIZATION_WITHIN_MEMBRANE, GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS, ACEVEDO_LIVER_CANCER_UP, IVANOVA_HEMATOPOIESIS_INTERMEDIATE_PROGENITOR, HOXA4_Q2, NKX3A_01, DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP, DURCHDEWALD_SKIN_CARCINOGENESIS_DN, PARENT_MTOR_SIGNALING_UP

GO Biological Process (2): DNA-templated transcription (GO:0006351), endocytic recycling (GO:0032456)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (6): nucleoplasm (GO:0005654), endosome membrane (GO:0010008), protein-containing complex (GO:0032991), nucleus (GO:0005634), cytoplasm (GO:0005737), endoplasmic reticulum membrane (GO:0005789)

Reactome top-level categories

2 top-level categories:

Category	Pathways
Post-translational protein modification	1
Metabolism of proteins	1

GO top-level categories

16 GO namespaces:

Category	Terms
cellular anatomical structure	2
gene expression	1
RNA biosynthetic process	1
endosomal transport	1
vesicle-mediated transport to the plasma membrane	1
binding	1
nuclear lumen	1
endosome	1
cytoplasmic vesicle membrane	1
bounding membrane of organelle	1
cellular_component	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1

Experimentally-supported GO annotations

GO terms backed by direct experimental evidence (ECO experimental codes) — 2 of 9 annotations. The rest are phylogenetic / computational / electronic (IEA).

2 experimentally-supported GO terms:

GO term	NS	Evidence
nucleoplasm	CC	direct assay
protein-containing complex	CC	direct assay

Protein interactions and networks

STRING

showing 15 of 1,147 interactions by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
COMMD10	COMMD2	Q86X83	789
COMMD10	COMMD1	Q8N668	777
COMMD10	COMMD9	Q9P000	749
COMMD10	A0A2R8Y455	A0A2R8Y455	741
COMMD10	COMMD7	Q86VX2	732
COMMD10	COMMD6	Q7Z4G1	727
COMMD10	COMMD5	Q9GZQ3	725
COMMD10	COMMD8	Q9NX08	697
COMMD10	COMMD3	Q9UBI1	683
COMMD10	COMMD4	Q9H0A8	672
COMMD10	CCDC93	Q567U6	647
COMMD10	CCDC22	O60826	613
COMMD10	VPS26C	O14972	539
COMMD10	VPS35L	Q7Z3J2	474
COMMD10	DENND10	Q8TCE6	457

IntAct

Human interaction partners of COMMD10 in IntAct, one row per partner (best MIscore; records = supporting IntAct interaction records).

12 partners by confidence:

Partner	Interaction type	MIscore	Records
CCDC22	association	0.940	3
COMMD5	physical association	0.870	5
CCDC93	physical association	0.850	1
COMMD1	physical association	0.830	1
FKBP1A	physical association	0.560	3
FOS	physical association	0.560	3
GATM	physical association	0.560	3
UQCRC1	physical association	0.560	3
VPS26C	association	0.530	2
COMMD7	association	0.530	1
MAGEA9	association	0.350	1
NFKB1	association	0.350	1

BioGRID (106 interactions; top human partners by supporting records): CCDC22 (Co-fractionation; 8 records), COMMD2 (Co-fractionation; 7 records), COMMD3 (Affinity Capture-MS; 6 records), CCDC93 (Co-fractionation; 5 records), COMMD1 (Co-fractionation; 5 records), COMMD4 (Affinity Capture-MS; 5 records), COMMD6 (Affinity Capture-MS; 5 records), COMMD5 (Co-fractionation; 4 records), COMMD8 (Affinity Capture-MS; 4 records), COMMD7 (Affinity Capture-MS; 3 records), DSCR3 (Affinity Capture-MS; 3 records), RELA (Affinity Capture-Western; 3 records), VPS29 (Affinity Capture-MS; 3 records), C11orf73 (Affinity Capture-MS; 2 records), C16orf62 (Affinity Capture-MS; 2 records)

Protein complexes (CORUM) (2)

Experimentally-characterized complexes this protein is a subunit of (★ = the complex contains a known drug target).

2 complexes by size:

Complex	Subunits	Members
CCC-Wash (WASH1, FAM21C) complex	15	COMMD3, COMMD4, CCDC22, COMMD1, COMMD8, WASHC1, WASHC2C, CCDC93, COMMD10, COMMD2, COMMD5, COMMD7, COMMD6, COMMD9, VPS35L
CCC complex	13	COMMD2, COMMD3, COMMD6, COMMD8, VPS35L, CCDC93, COMMD1, COMMD10, COMMD4, COMMD5, COMMD7, COMMD9, CCDC22

Disease & clinical

Genetic variants

Variant evidence for COMMD10: 49 ClinVar records (0 pathogenic / likely pathogenic); 5 GWAS associations.

ClinVar

49 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	36
Likely benign	3
Benign	2

SpliceAI

Top 10 splice-impact sites by Δscore (adjacent positions with the same effect merged into one range; 40 predictions of 1,130):

Position(s)	Effect	Δscore	Sites
5:116087495–116087496	acceptor_loss	1.0000	3
5:116091077–116091078	acceptor_loss	1.0000	6
5:116092541	acceptor_gain	1.0000
5:116092543–116092544	acceptor_loss	1.0000	6
5:116092701–116092702	donor_loss	1.0000	5
5:116134179–116134180	donor_loss	1.0000	4
5:116291514	acceptor_gain	1.0000
5:116291515–116291516	acceptor_loss	1.0000	5
5:116291577	donor_loss	1.0000	3
5:116085094–116085095	donor_loss	0.9900	6

AlphaMissense

282 missense substitutions predicted likely pathogenic (of 1,324 scored), across 101 residues. Top 20 hotspot residues, ranked by the number of likely-pathogenic substitutions (of those reachable by a single-nucleotide change), then by mean score:

Residue	Likely-pathogenic substitutions	Mean am_pathogenicity	Max am_pathogenicity
D199	8	0.912	0.958
F49	8	0.896	0.979
W113	7	0.922	0.991
W139	7	0.912	0.993
E192	7	0.844	0.934
E53	7	0.823	0.896
F61	7	0.733	0.882
F30	6	0.851	0.954
Q195	6	0.849	0.972
F179	6	0.815	0.934
F109	6	0.722	0.835
M145	6	0.710	0.806
L57	5	0.866	0.993
R36	5	0.819	0.983
K56	5	0.749	0.809
F187	5	0.733	0.934
L34	4	0.873	0.972
Y188	4	0.857	0.953
F124	4	0.828	0.856
L184	4	0.828	0.977

HPA cancer prognostics

RNA cancer specificity: Low cancer specificity

Human Protein Atlas survival analysis — favorable = higher expression predicts better survival.

2 prognostic cancer types:

Cancer	Prognostic	p-value
Kidney Renal Clear Cell Carcinoma (TCGA)	favorable	3.52e-07
Stomach Adenocarcinoma (TCGA)	unfavorable	0.000151

Disease associations

OMIM: gene MIM:616704 | disease phenotypes:

GWAS associations

5 associations:

Study	Trait	p-value
GCST009136_1	Ankle-brachial index	3e-9
GCST001371_17	Inflammatory biomarkers	7e-7
GCST002119_7	Metabolite levels (X-11787)	4e-6
GCST002519_2	Asthma or chronic obstructive pulmonary disease	4e-6
GCST001567_10	Bipolar disorder and schizophrenia	8e-6

EFO canonical traits (from GWAS)

2 canonical traits:

EFO ID	Trait name
EFO:0005276	hydroxy-leucine measurement
EFO:0003912	ankle brachial index

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (CPIC guideline: no)

CTD chemical–gene interactions

39 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases expression, decreases methylation	4
sodium arsenite	decreases expression, increases expression	2
Cisplatin	affects cotreatment, decreases expression	2
Smoke	decreases expression, increases abundance, decreases reaction	2
Valproic Acid	decreases expression	2
aristolochic acid I	decreases expression	1
dicrotophos	decreases expression	1
methyleugenol	decreases expression	1
bisphenol A	affects cotreatment, increases expression	1
arsenite	affects binding, increases reaction	1
ochratoxin A	decreases expression	1
cupric chloride	decreases expression	1
glycidamide	increases expression	1
jinfukang	affects cotreatment, decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Decitabine	decreases expression, decreases reaction	1
Air Pollutants	decreases expression, increases abundance	1
Carcinogens	decreases expression	1
Coal	decreases expression, increases abundance	1
Dexamethasone	affects cotreatment, increases expression	1
Ethyl Methanesulfonate	decreases expression	1
Formaldehyde	increases expression	1
Indomethacin	increases expression, affects cotreatment	1
Methyl Methanesulfonate	decreases expression	1
Mustard Gas	decreases expression	1
Mutagens	decreases expression	1
Plant Extracts	increases expression, affects cotreatment	1
Quercetin	decreases expression	1
Tetrachlorodibenzodioxin	decreases expression	1
Tobacco Smoke Pollution	increases expression	1

Clinical trials (associated diseases)

Via MONDO — disease-level, not drug-specific.