COPDA1

Summary

COPDA1 (chronic obstructive pulmonary disease associated lncRNA 1, HGNC:53171) is a long non-coding RNA gene on chromosome 14q32.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53171
Approved symbol	COPDA1
Name	chronic obstructive pulmonary disease associated lncRNA 1
Location	14q32.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-731F5.2
Ensembl gene	ENSG00000253364
Ensembl biotype	lncRNA
Entrez	115253418
RNAcentral	URS00000C493D — lncRNA, 548 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000497397

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000497397 — 3 exons

Exon	Start	End
ENSE00001835464	105648326	105648467
ENSE00001912892	105647924	105648030
ENSE00001958685	105648759	105649057

Expression profiles

Bgee: expression breadth broad, 82 present calls, max score 70.77.

Top tissues by expression

82 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	70.77	gold quality
bone marrow cell	CL:0002092	67.80	silver quality
tonsil	UBERON:0002372	66.22	gold quality
vermiform appendix	UBERON:0001154	64.12	gold quality
spleen	UBERON:0002106	64.08	gold quality
blood	UBERON:0000178	63.30	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.26	gold quality
small intestine	UBERON:0002108	62.19	gold quality
bone marrow	UBERON:0002371	61.89	gold quality
granulocyte	CL:0000094	60.96	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	60.09	gold quality
sural nerve	UBERON:0015488	59.96	silver quality
urinary bladder	UBERON:0001255	59.75	gold quality
pancreas	UBERON:0001264	57.26	gold quality
leukocyte	CL:0000738	56.51	gold quality
duodenum	UBERON:0002114	54.32	gold quality
multicellular organism	UBERON:0000468	54.31	gold quality
monocyte	CL:0000576	53.89	gold quality
intestine	UBERON:0000160	53.68	gold quality
islet of Langerhans	UBERON:0000006	52.90	gold quality
prefrontal cortex	UBERON:0000451	52.65	gold quality
adrenal gland	UBERON:0002369	51.67	gold quality
gall bladder	UBERON:0002110	50.24	gold quality
liver	UBERON:0002107	49.45	silver quality
omental fat pad	UBERON:0010414	48.09	gold quality
adipose tissue	UBERON:0001013	47.96	gold quality
Ammon’s horn	UBERON:0001954	47.88	gold quality
right lobe of liver	UBERON:0001114	47.81	silver quality
muscle layer of sigmoid colon	UBERON:0035805	47.25	gold quality
lower esophagus mucosa	UBERON:0035834	46.95	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.39

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• lncRNA COPDA1 upregulated the expression of MS4A1 to increase store-operated calcium entry in the human bronchial smooth muscle cells (PMID:31050548)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.