COPE

Summary

COPE (coat protein complex I subunit epsilon, HGNC:2234) is a protein-coding gene on chromosome 19p13.11, encoding Coatomer subunit epsilon (O14579). The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. It is a common-essential gene (DepMap: required in 95.2% of cancer cell lines).

The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta’, gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.

Source: NCBI Gene 11316 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 72 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 95.2% of screened cell lines (common-essential)
• MANE Select transcript: NM_007263

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:2234
Approved symbol	COPE
Name	coat protein complex I subunit epsilon
Location	19p13.11
Locus type	gene with protein product
Status	Approved
Aliases	epsilon-COP
Ensembl gene	ENSG00000105669
Ensembl biotype	protein_coding
OMIM	606942
Entrez	11316

Gene structure

Transcript identifiers

Ensembl transcripts: 45 — 38 protein_coding, 5 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000262812, ENST00000349893, ENST00000351079, ENST00000593827, ENST00000595984, ENST00000597026, ENST00000597646, ENST00000598969, ENST00000599964, ENST00000600528, ENST00000600932, ENST00000871093, ENST00000871094, ENST00000871095, ENST00000871096, ENST00000871097, ENST00000871098, ENST00000871099, ENST00000871100, ENST00000871101, ENST00000871102, ENST00000871103, ENST00000871104, ENST00000871105, ENST00000871106, ENST00000871107, ENST00000916152, ENST00000916153, ENST00000916154, ENST00000916155, ENST00000916156, ENST00000916157, ENST00000916158, ENST00000916159, ENST00000916160, ENST00000916161, ENST00000916162, ENST00000916163, ENST00000966210, ENST00000966211, ENST00000966212, ENST00000966213, ENST00000966214, ENST00000966215, ENST00000966216

RefSeq mRNA: 4 — MANE Select: NM_007263 NM_001330469, NM_007263, NM_199442, NM_199444

CCDS: CCDS12387, CCDS12388, CCDS12389, CCDS82321

Canonical transcript exons

ENST00000262812 — 10 exons

Exon	Start	End
ENSE00000690629	18905576	18905629
ENSE00000866156	18919223	18919387
ENSE00000866168	18899514	18899726
ENSE00001113522	18906960	18907112
ENSE00003465338	18912984	18913046
ENSE00003490718	18899873	18899947
ENSE00003503486	18903268	18903423
ENSE00003540431	18900381	18900449
ENSE00003658011	18904771	18904852
ENSE00003667255	18910971	18911071

Expression profiles

Bgee: expression breadth ubiquitous, 282 present calls, max score 99.00.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 133.1989 / max 450.7584, expressed in 1826 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
180112	132.4814	1826
180108	0.4424	225
180107	0.2752	113

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	99.00	gold quality
left testis	UBERON:0004533	98.99	gold quality
adenohypophysis	UBERON:0002196	98.69	gold quality
granulocyte	CL:0000094	98.59	gold quality
endometrium epithelium	UBERON:0004811	98.50	gold quality
mucosa of transverse colon	UBERON:0004991	98.36	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	98.34	gold quality
pituitary gland	UBERON:0000007	98.32	gold quality
left adrenal gland	UBERON:0001234	98.32	gold quality
right adrenal gland	UBERON:0001233	98.31	gold quality
lower esophagus mucosa	UBERON:0035834	98.31	gold quality
left adrenal gland cortex	UBERON:0035825	98.28	gold quality
right lobe of thyroid gland	UBERON:0001119	98.20	gold quality
right adrenal gland cortex	UBERON:0035827	98.20	gold quality
left lobe of thyroid gland	UBERON:0001120	98.10	gold quality
body of stomach	UBERON:0001161	98.05	gold quality
body of pancreas	UBERON:0001150	97.96	gold quality
minor salivary gland	UBERON:0001830	97.93	gold quality
apex of heart	UBERON:0002098	97.93	gold quality
cingulate cortex	UBERON:0003027	97.93	gold quality
anterior cingulate cortex	UBERON:0009835	97.93	gold quality
testis	UBERON:0000473	97.92	gold quality
stromal cell of endometrium	CL:0002255	97.90	gold quality
monocyte	CL:0000576	97.85	gold quality
right frontal lobe	UBERON:0002810	97.85	gold quality
metanephros cortex	UBERON:0010533	97.80	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	97.78	gold quality
adrenal cortex	UBERON:0001235	97.76	gold quality
skin of leg	UBERON:0001511	97.71	gold quality
prefrontal cortex	UBERON:0000451	97.69	gold quality

Single-cell (SCXA)

Detected in 7 experiment(s), a significant marker in 7.

Experiment	Marker?	Max mean expression
E-GEOD-134144	yes	3730.76
E-GEOD-124263	yes	1933.97
E-HCAD-1	yes	43.39
E-CURD-122	yes	24.41
E-CURD-46	yes	21.31
E-HCAD-9	yes	19.63
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

9 targeting COPE, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-6842-5P	99.80	67.54	1587
HSA-MIR-7110-5P	99.80	67.84	1712
HSA-MIR-6752-5P	99.59	67.32	1243
HSA-MIR-6803-5P	99.19	63.90	1026
HSA-MIR-3145-3P	98.85	69.07	2031
HSA-MIR-3620-3P	97.78	64.88	772
HSA-MIR-4653-3P	96.26	67.03	725

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 95.2% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 2)

• Ubiquitylation of epsilon-COP by PIRH2; overexpression of the wild type of PIRH2 in prostate cancer cells causes downregulation of the secretion of prostate-specific antigen. (PMID:17721809)
• Data show that iPLA(1)gamma is a novel membrane transport factor that contributes to a specific Golgi-to-ER retrograde pathway distinct from presently characterized COPI- and Rab6-dependent pathways. (PMID:19632984)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	cope	ENSDARG00000018562
mus_musculus	Cope	ENSMUSG00000055681
rattus_norvegicus	Cope	ENSRNOG00000020178
drosophila_melanogaster	epsilonCOP	FBGN0027496
caenorhabditis_elegans		WBGENE00009732

Protein

Protein identifiers

Coatomer subunit epsilon — O14579 (reviewed: O14579)

Alternative names: Epsilon-coat protein

All UniProt accessions (3): O14579, M0QXB4, M0R061

UniProt curated annotations — full annotation on UniProt →

Function. The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

Subunit / interactions. Oligomeric complex that consists of at least the alpha, beta, beta’, gamma, delta, epsilon and zeta subunits.

Subcellular location. Cytoplasm. Golgi apparatus membrane. Cytoplasmic vesicle. COPI-coated vesicle membrane.

Post-translational modifications. Phosphorylated by PKA. Polyubiquitinated by RCHY1 in the presence of androgen, leading to proteasomal degradation.

Similarity. Belongs to the COPE family.

Isoforms (3)

UniProt ID	Names	Canonical?
O14579-1	1	yes
O14579-2	2
O14579-3	3

RefSeq proteins (4): NP_001317398, NP_009194, NP_955474, NP_955476 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006822	Coatomer_esu	Family
IPR011990	TPR-like_helical_dom_sf	Homologous_superfamily

Pfam: PF04733

UniProt features (29 total): helix 18, modified residue 3, splice variant 3, sequence variant 2, initiator methionine 1, chain 1, turn 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
6U3V	X-RAY DIFFRACTION	2.96
6TZT	X-RAY DIFFRACTION	3.06

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O14579-F1	90.20	0.78

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 13, 45, 99

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-6807878	COPI-mediated anterograde transport
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic

MSigDB gene sets: 155 (showing top): MODULE_255, ENK_UV_RESPONSE_KERATINOCYTE_UP, MORF_HDAC1, MODULE_317, GOBP_VESICLE_MEDIATED_TRANSPORT, REACTOME_MEMBRANE_TRAFFICKING, GOBP_INTRA_GOLGI_VESICLE_MEDIATED_TRANSPORT, MORF_SKP1A, GOBP_ENDOPLASMIC_RETICULUM_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT, GROSS_ELK3_TARGETS_DN, GOCC_COATED_VESICLE, GOCC_GOLGI_ASSOCIATED_VESICLE, GOCC_VESICLE_COAT, MORF_GPX4, MODULE_207

GO Biological Process (6): endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888), retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum (GO:0006890), intra-Golgi vesicle-mediated transport (GO:0006891), protein transport (GO:0015031), protein localization to axon (GO:0099612), vesicle-mediated transport (GO:0016192)

GO Molecular Function (2): structural molecule activity (GO:0005198), protein binding (GO:0005515)

GO Cellular Component (12): Golgi membrane (GO:0000139), nucleoplasm (GO:0005654), endoplasmic reticulum membrane (GO:0005789), Golgi apparatus (GO:0005794), cytosol (GO:0005829), COPI vesicle coat (GO:0030126), transport vesicle (GO:0030133), cytoplasm (GO:0005737), membrane (GO:0016020), COPI-coated vesicle (GO:0030137), COPI-coated vesicle membrane (GO:0030663), cytoplasmic vesicle (GO:0031410)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
ER to Golgi Anterograde Transport	1
Golgi-to-ER retrograde transport	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	4
cellular anatomical structure	4
Golgi vesicle transport	3
transport	2
intracellular protein localization	2
Golgi apparatus	2
endomembrane system	2
intercellular transport	1
intracellular transport	1
establishment of protein localization	1
cellular process	1
molecular_function	1
binding	1
bounding membrane of organelle	1
nuclear lumen	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
intracellular membrane-bounded organelle	1
vesicle coat	1
COPI-coated vesicle membrane	1
cytoplasmic vesicle	1
intracellular anatomical structure	1
Golgi-associated vesicle	1
coated vesicle	1
COPI-coated vesicle	1
Golgi-associated vesicle membrane	1
coated vesicle membrane	1
intracellular vesicle	1

Protein interactions and networks

STRING

2112 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
COPE	COPB2	P35606	999
COPE	COPA	P53621	999
COPE	COPB1	P53618	998
COPE	ARCN1	P48444	998
COPE	COPZ1	P61923	996
COPE	COPG1	Q9Y678	772
COPE	SEC13	P55735	671
COPE	ARF1	P10947	661
COPE	RER1	O15258	566
COPE	COPZ2	Q9P299	562
COPE	COPG2	Q9UBF2	517
COPE	GOLPH3	Q9H4A6	505
COPE	PREB	Q9HCU5	500
COPE	BET1	O15155	463
COPE	SEC31A	O94979	455

IntAct

133 interactions, top by confidence:

A	B	Type	Score
COPE	EFHC2	psi-mi:“MI:0915”(physical association)	0.720
EFHC2	COPE	psi-mi:“MI:0915”(physical association)	0.720
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
COPG1	COPE	psi-mi:“MI:0914”(association)	0.640
SACM1L	COPE	psi-mi:“MI:0914”(association)	0.640
CFTR	HAX1	psi-mi:“MI:0914”(association)	0.610
INSR	PIK3R2	psi-mi:“MI:2364”(proximity)	0.570
COPE	CDC42EP3	psi-mi:“MI:0915”(physical association)	0.560
Copa	COPE	psi-mi:“MI:0915”(physical association)	0.560
PPM1G	COPE	psi-mi:“MI:0914”(association)	0.530
COPZ1	COPE	psi-mi:“MI:0914”(association)	0.530
COPE	COPB2	psi-mi:“MI:0914”(association)	0.530
TGOLN2	PGRMC1	psi-mi:“MI:0914”(association)	0.420
TNFAIP3	LRRIQ3	psi-mi:“MI:2364”(proximity)	0.420
COPE	TSG101	psi-mi:“MI:0915”(physical association)	0.370
COPE	MBD1	psi-mi:“MI:0915”(physical association)	0.370
MYH6	ELOC	psi-mi:“MI:0914”(association)	0.350
Copa	BCAP29	psi-mi:“MI:0914”(association)	0.350
Sacm1l	COPE	psi-mi:“MI:0914”(association)	0.350
Erp44	MEN1	psi-mi:“MI:0914”(association)	0.350

BioGRID (446): EFHC2 (Two-hybrid), COPE (Affinity Capture-RNA), COPE (Affinity Capture-MS), COPA (Co-fractionation), COPE (Co-fractionation), COPE (Co-fractionation), COPE (Co-fractionation), COPE (Co-fractionation), COPE (Co-fractionation), COPE (Co-fractionation), COPE (Co-fractionation), COPE (Co-fractionation), COPG1 (Co-fractionation), COPG2 (Co-fractionation), DTNBP1 (Co-fractionation)

ESM2 similar proteins: A2AKQ8, A2VE45, A2XY73, A4R796, A6H739, A8JA42, A8XBR9, B2RYD6, B3P0R4, E9Q6P5, O14579, O62246, O64748, O75843, O76094, P0C541, P33731, Q03560, Q0HA38, Q16JL4, Q20938, Q23049, Q28104, Q29L58, Q2HBQ2, Q4P7J4, Q4QQS2, Q5DM57, Q5R5M2, Q5RFR8, Q5ZIK9, Q6INC1, Q75AI5, Q7PRA4, Q7S519, Q7Z4L5, Q84K16, Q86TV6, Q86WT1, Q8C0S4

Diamond homologs: A2XY73, O14579, O62246, O64748, O89079, P0C541, Q28104, Q55FU2, Q5RFR8, Q5ZIK9, Q60445, Q9MAX6, Q9SA78

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
RCHY1	“down-regulates quantity by destabilization”	COPE	polyubiquitination

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 130 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
COPI-dependent Golgi-to-ER retrograde traffic	7	9.5×	3e-03
COPI-mediated anterograde transport	7	9.4×	3e-03

GO biological processes:

GO term	Partners	Fold	FDR
intra-Golgi vesicle-mediated transport	6	31.9×	3e-05
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	20.4×	2e-04
cell surface receptor protein tyrosine kinase signaling pathway	7	12.3×	6e-04
protein autophosphorylation	6	8.8×	9e-03
intracellular protein transport	10	6.5×	8e-04
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	8	6.3×	8e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

72 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	53
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2028 predictions. Top by Δscore:

Variant	Effect	Δscore
19:18899868:CTCA:C	donor_loss	1.0000
19:18899869:TCA:T	donor_loss	1.0000
19:18899870:CACC:C	donor_loss	1.0000
19:18899872:C:CG	donor_loss	1.0000
19:18899887:C:CA	donor_gain	1.0000
19:18899945:CAC:C	acceptor_gain	1.0000
19:18899948:C:CC	acceptor_gain	1.0000
19:18899948:CTGC:C	acceptor_loss	1.0000
19:18899949:T:A	acceptor_loss	1.0000
19:18900375:GCTTA:G	donor_loss	1.0000
19:18900376:CTTAC:C	donor_loss	1.0000
19:18900377:TTAC:T	donor_loss	1.0000
19:18900378:TACC:T	donor_loss	1.0000
19:18900379:A:AC	donor_gain	1.0000
19:18900380:C:CC	donor_gain	1.0000
19:18900380:CCT:C	donor_gain	1.0000
19:18900445:CTATC:C	acceptor_gain	1.0000
19:18900446:TATC:T	acceptor_gain	1.0000
19:18900448:TC:T	acceptor_gain	1.0000
19:18900449:CC:C	acceptor_gain	1.0000
19:18900450:C:CA	acceptor_loss	1.0000
19:18900450:C:CC	acceptor_gain	1.0000
19:18900451:T:C	acceptor_loss	1.0000
19:18900457:C:CT	acceptor_gain	1.0000
19:18900459:C:CT	acceptor_gain	1.0000
19:18900460:A:T	acceptor_gain	1.0000
19:18903263:CCTA:C	donor_loss	1.0000
19:18903264:CTAC:C	donor_loss	1.0000
19:18903265:TA:T	donor_loss	1.0000
19:18903266:A:AC	donor_gain	1.0000

AlphaMissense

2013 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:18904790:G:T	A187D	0.999
19:18904791:C:G	A187P	0.998
19:18904799:A:G	L184P	0.998
19:18905579:G:T	A165D	0.998
19:18905591:C:G	R161P	0.998
19:18912997:G:T	A59E	0.998
19:18919247:G:C	C34W	0.998
19:18899922:A:G	L277P	0.997
19:18906996:G:T	A136D	0.997
19:18910998:G:T	A88D	0.997
19:18911055:A:T	V69D	0.997
19:18912998:C:G	A59P	0.997
19:18903336:C:G	A223P	0.996
19:18905592:G:T	R161S	0.996
19:18919237:C:G	A38P	0.996
19:18919248:C:T	C34Y	0.996
19:18900420:G:C	N255K	0.995
19:18900420:G:T	N255K	0.995
19:18904797:C:G	A185P	0.995
19:18906993:A:G	L137P	0.995
19:18907032:G:T	A124D	0.995
19:18919249:A:G	C34R	0.995
19:18903279:C:G	A242P	0.993
19:18904818:C:G	D178H	0.993
19:18907035:G:T	A123D	0.993
19:18907036:C:G	A123P	0.993
19:18910999:C:G	A88P	0.993
19:18919236:G:T	A38E	0.993
19:18919245:A:T	I35K	0.993
19:18919263:C:T	G29D	0.993

dbSNP variants (sampled 300 via entrez): RS1000006766 (19:18906682 G>A), RS1000111607 (19:18907876 T>C), RS1000142790 (19:18908146 A>G), RS1000229723 (19:18901735 A>C), RS1000244 (19:18919658 A>C,G), RS1000245 (19:18920278 C>G), RS1000453351 (19:18918589 A>C), RS1000580467 (19:18901928 C>T), RS1000646321 (19:18912094 G>A), RS1000872946 (19:18915348 C>A,T), RS1000912655 (19:18910559 CTG>C), RS1001006293 (19:18905794 C>CGCTCA), RS1001201204 (19:18911745 G>A), RS1001253566 (19:18911953 T>C), RS1001317211 (19:18901996 C>A,G)

Disease associations

OMIM: gene MIM:606942 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067056 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

4 potent at pChembl≥5 of 4 total, top 4 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
6.90	Kd	126.2	nM	CHEMBL5653589
6.90	ED50	126.2	nM	CHEMBL5653589
6.10	Kd	786.7	nM	CHEMBL3752910
6.10	ED50	786.7	nM	CHEMBL3752910

PubChem BioAssay actives

2 with measured affinity, of 4 total; 2 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148117: Binding affinity to human COPE incubated for 45 mins by Kinobead based pull down assay	kd	0.1262	uM
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148117: Binding affinity to human COPE incubated for 45 mins by Kinobead based pull down assay	kd	0.7867	uM

CTD chemical–gene interactions

41 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases abundance, increases expression	4
Cyclosporine	increases expression	3
Particulate Matter	decreases expression, increases abundance, affects cotreatment, increases expression	3
cobaltous chloride	decreases expression	2
Valproic Acid	increases methylation, affects cotreatment, increases expression	2
FR900359	increases phosphorylation	1
bisphenol F	increases expression	1
2,4,6-tribromophenol	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	increases expression	1
tetrabromobisphenol A	decreases expression	1
bufalin	decreases expression	1
coumarin	increases phosphorylation	1
ICG 001	decreases expression	1
14-deoxy-11,12-didehydroandrographolide	decreases expression	1
hexabrominated diphenyl ether 153	decreases expression	1
bisphenol AF	increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Sunitinib	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	increases abundance, increases expression	1
Vehicle Emissions	increases expression	1
Caffeine	increases phosphorylation	1
Dinitrochlorobenzene	affects binding	1
Gasoline	affects cotreatment, increases abundance, increases expression	1
Hydralazine	affects cotreatment, increases expression	1
Ivermectin	decreases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Polycyclic Aromatic Hydrocarbons	affects cotreatment, increases abundance, increases expression	1
Quercetin	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651159	Binding	Binding affinity to human COPE incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.