COPG2

Summary

COPG2 (coat protein complex I subunit gamma 2, HGNC:2237) is a protein-coding gene on chromosome 7q32.2, encoding Coatomer subunit gamma-2 (Q9UBF2). The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

Predicted to enable structural molecule activity. Involved in intra-Golgi vesicle-mediated transport. Part of COPI vesicle coat.

Source: NCBI Gene 26958 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 47 total
• Druggable target: yes
• MANE Select transcript: NM_012133

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:2237
Approved symbol	COPG2
Name	coat protein complex I subunit gamma 2
Location	7q32.2
Locus type	gene with protein product
Status	Approved
Aliases	2-COP
Ensembl gene	ENSG00000158623
Ensembl biotype	protein_coding
OMIM	604355
Entrez	26958

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding, 1 retained_intron

ENST00000330992, ENST00000425248, ENST00000617523

RefSeq mRNA: 2 — MANE Select: NM_012133 NM_001290033, NM_012133

CCDS: CCDS75662, CCDS78275

Canonical transcript exons

ENST00000425248 — 24 exons

Exon	Start	End
ENSE00001293825	130507685	130507823
ENSE00001299244	130508562	130508659
ENSE00001365015	130666849	130666929
ENSE00001366018	130612152	130612238
ENSE00001369605	130662967	130663038
ENSE00001372340	130652869	130652948
ENSE00001376012	130667482	130667534
ENSE00001377828	130616990	130617065
ENSE00001388747	130613544	130613636
ENSE00001701959	130668632	130668748
ENSE00001737345	130610953	130611110
ENSE00001800878	130506238	130506806
ENSE00003520841	130507274	130507372
ENSE00003712041	130551241	130551344
ENSE00003712077	130554481	130554724
ENSE00003715027	130555037	130555132
ENSE00003715470	130563269	130563336
ENSE00003733925	130561033	130561221
ENSE00003737364	130564260	130564393
ENSE00003740037	130548403	130548542
ENSE00003742173	130552355	130552430
ENSE00003743590	130549314	130549376
ENSE00003745238	130550524	130550649
ENSE00003751230	130547674	130547845

Expression profiles

Bgee: expression breadth ubiquitous, 199 present calls, max score 92.76.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 22.0781 / max 494.4929, expressed in 1795 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
86159	22.0781	1795

Top tissues by expression

239 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	92.76	gold quality
ganglionic eminence	UBERON:0004023	92.00	gold quality
ventricular zone	UBERON:0003053	91.81	gold quality
right adrenal gland	UBERON:0001233	90.06	gold quality
right adrenal gland cortex	UBERON:0035827	89.86	gold quality
left adrenal gland	UBERON:0001234	89.08	gold quality
left ovary	UBERON:0002119	89.06	gold quality
islet of Langerhans	UBERON:0000006	88.85	gold quality
left adrenal gland cortex	UBERON:0035825	88.69	gold quality
right testis	UBERON:0004534	87.66	gold quality
right ovary	UBERON:0002118	87.37	gold quality
adrenal gland	UBERON:0002369	87.29	gold quality
adrenal cortex	UBERON:0001235	87.08	gold quality
ovary	UBERON:0000992	86.50	gold quality
left testis	UBERON:0004533	86.34	gold quality
gastrocnemius	UBERON:0001388	85.84	gold quality
stromal cell of endometrium	CL:0002255	85.83	gold quality
muscle of leg	UBERON:0001383	85.66	gold quality
skin of leg	UBERON:0001511	85.59	gold quality
smooth muscle tissue	UBERON:0001135	85.50	gold quality
ectocervix	UBERON:0012249	85.44	gold quality
skin of abdomen	UBERON:0001416	85.25	gold quality
hindlimb stylopod muscle	UBERON:0004252	85.21	gold quality
testis	UBERON:0000473	85.19	gold quality
cerebellar hemisphere	UBERON:0002245	84.96	gold quality
monocyte	CL:0000576	84.95	gold quality
cerebellar cortex	UBERON:0002129	84.95	gold quality
leukocyte	CL:0000738	84.85	gold quality
rectum	UBERON:0001052	84.63	gold quality
gall bladder	UBERON:0002110	84.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	5.09

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

45 targeting COPG2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-320A-3P	99.77	69.73	2107
HSA-MIR-320B	99.77	69.73	2107
HSA-MIR-320C	99.77	69.73	2107
HSA-MIR-320D	99.77	69.73	2107
HSA-MIR-4429	99.77	69.62	2111
HSA-MIR-6885-3P	99.75	70.36	3187
HSA-MIR-6505-5P	99.73	69.25	1595
HSA-MIR-6887-3P	99.66	67.83	1778
HSA-MIR-24-3P	99.59	69.97	1934
HSA-MIR-7159-3P	99.51	70.17	1920
HSA-MIR-4643	99.49	67.63	1791
HSA-MIR-519D-5P	99.41	69.30	2057
HSA-MIR-5580-5P	99.38	66.96	1139
HSA-MIR-6507-5P	99.36	70.46	2524
HSA-MIR-6128	99.33	67.83	1581
HSA-MIR-3692-5P	99.29	67.04	1421
HSA-MIR-4504	99.10	69.14	1328
HSA-MIR-6506-5P	99.04	65.66	1386
HSA-MIR-4738-3P	98.98	67.98	1846
HSA-MIR-3926	98.95	69.26	1438
HSA-MIR-4711-5P	98.89	68.00	965
HSA-MIR-5006-5P	98.79	66.92	1246

Literature-anchored findings (GeneRIF, showing 3)

• Mutation sscreening and imprinting analysis of candidate genes for autism in the 7q32 region (PMID:11920156)
• In cortices, the MEST promoter was hemimethylated, as expected for a differentially methylated imprinting control region, whereas the COPG2 and TSGA14 promoters were completely demethylated, typical for transcriptionally active non-imprinted genes. (PMID:22456293)
• SCYL1 arginine methylation by PRMT1 is essential for neurite outgrowth via Golgi morphogenesis. (PMID:32583741)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	copg2	ENSDARG00000034823
mus_musculus	Copg2	ENSMUSG00000025607
rattus_norvegicus	Copg2	ENSRNOG00000011014
drosophila_melanogaster	gammaCOP	FBGN0028968
caenorhabditis_elegans		WBGENE00011775

Paralogs (1): COPG1 (ENSG00000181789)

Protein

Protein identifiers

Coatomer subunit gamma-2 — Q9UBF2 (reviewed: Q9UBF2)

Alternative names: Gamma-2-coat protein

All UniProt accessions (2): A0A140VK12, Q9UBF2

UniProt curated annotations — full annotation on UniProt →

Function. The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

Subunit / interactions. Oligomeric complex. Binds to CDC42. Interacts with JAGN1. Interacts with TMED10 (via cytoplasmic domain).

Subcellular location. Cytoplasm. Cytosol. Golgi apparatus membrane. Cytoplasmic vesicle. COPI-coated vesicle membrane.

Similarity. Belongs to the COPG family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9UBF2-1	1	yes
Q9UBF2-2	2

RefSeq proteins (2): NP_001276962, NP_036265* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002553	Clathrin/coatomer_adapt-like_N	Domain
IPR009028	Coatomer/calthrin_app_sub_C	Homologous_superfamily
IPR011989	ARM-like	Homologous_superfamily
IPR012295	TBP_dom_sf	Homologous_superfamily
IPR013040	Coatomer_gsu_app_Ig-like_dom	Domain
IPR013041	Clathrin_app_Ig-like_sf	Homologous_superfamily
IPR016024	ARM-type_fold	Homologous_superfamily
IPR017106	Coatomer_gsu	Family
IPR032154	Coatomer_g_Cpla	Domain
IPR037067	Coatomer_gsu_app_sf	Homologous_superfamily

Pfam: PF01602, PF08752, PF16381

UniProt features (14 total): repeat 6, splice variant 2, sequence variant 2, chain 1, region of interest 1, compositionally biased region 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UBF2-F1	87.98	0.58

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 594

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-6807878	COPI-mediated anterograde transport
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic

MSigDB gene sets: 163 (showing top): GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GOBP_VESICLE_MEDIATED_TRANSPORT, REACTOME_MEMBRANE_TRAFFICKING, GOBP_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE, GOBP_INTRA_GOLGI_VESICLE_MEDIATED_TRANSPORT, GOBP_ENDOPLASMIC_RETICULUM_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT, NF1_Q6_01, GOCC_COATED_VESICLE, chr7q32, GOBP_SECRETION, GOCC_GOLGI_ASSOCIATED_VESICLE, GOCC_VESICLE_COAT, AACTTT_UNKNOWN, GOCC_NEURON_PROJECTION

GO Biological Process (8): intracellular protein transport (GO:0006886), endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888), retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum (GO:0006890), intra-Golgi vesicle-mediated transport (GO:0006891), protein secretion (GO:0009306), organelle transport along microtubule (GO:0072384), protein transport (GO:0015031), vesicle-mediated transport (GO:0016192)

GO Molecular Function (1): structural molecule activity (GO:0005198)

GO Cellular Component (16): Golgi membrane (GO:0000139), endoplasmic reticulum (GO:0005783), endoplasmic reticulum membrane (GO:0005789), endoplasmic reticulum-Golgi intermediate compartment (GO:0005793), cytosol (GO:0005829), COPI vesicle coat (GO:0030126), transport vesicle (GO:0030133), growth cone (GO:0030426), cytoplasm (GO:0005737), Golgi apparatus (GO:0005794), membrane (GO:0016020), membrane coat (GO:0030117), COPI-coated vesicle (GO:0030137), COPI-coated vesicle membrane (GO:0030663), cytoplasmic vesicle (GO:0031410), bounding membrane of organelle (GO:0098588)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
ER to Golgi Anterograde Transport	1
Golgi-to-ER retrograde transport	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	7
Golgi vesicle transport	3
endomembrane system	3
intracellular membrane-bounded organelle	3
cellular anatomical structure	3
intracellular protein localization	2
protein transport	2
intracellular transport	2
transport	2
Golgi apparatus	2
organelle membrane	2
intercellular transport	1
secretion by cell	1
establishment of protein localization to extracellular region	1
protein localization to extracellular region	1
transport along microtubule	1
establishment of organelle localization	1
establishment of protein localization	1
cellular process	1
molecular_function	1
bounding membrane of organelle	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
vesicle coat	1
COPI-coated vesicle membrane	1
cytoplasmic vesicle	1
site of polarized growth	1
distal axon	1
intracellular anatomical structure	1
coated membrane	1
membrane protein complex	1
Golgi-associated vesicle	1
coated vesicle	1
COPI-coated vesicle	1
Golgi-associated vesicle membrane	1
coated vesicle membrane	1
intracellular vesicle	1

Protein interactions and networks

STRING

1260 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
COPG2	COPB1	P53618	915
COPG2	COPB2	P35606	909
COPG2	MEST	Q5EB52	908
COPG2	ARCN1	P48444	818
COPG2	COPZ1	P61923	787
COPG2	GRB10	Q13322	775
COPG2	COPZ2	Q9P299	704
COPG2	IGF2	P01344	674
COPG2	SCYL1	Q96KG9	664
COPG2	TSGA13	Q96PP4	647
COPG2	DLK1	P15803	612
COPG2	CEP41	Q9BYV8	609
COPG2	CDKN1C	P49918	565
COPG2	ASB4	Q9Y574	563
COPG2	TMED10	P49755	536

IntAct

125 interactions, top by confidence:

A	B	Type	Score
COPG1	COPB2	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
SPTLC1	SPTLC2	psi-mi:“MI:0914”(association)	0.680
COPG1	COPE	psi-mi:“MI:0914”(association)	0.640
CANX	PGRMC1	psi-mi:“MI:0914”(association)	0.570
Copa	COPE	psi-mi:“MI:0915”(physical association)	0.560
	XPO1	psi-mi:“MI:0914”(association)	0.530
CD74	PGRMC1	psi-mi:“MI:0914”(association)	0.530
COPZ1	COPE	psi-mi:“MI:0914”(association)	0.530
COPE	COPB2	psi-mi:“MI:0914”(association)	0.530
	MYL12B	psi-mi:“MI:0914”(association)	0.460
TGOLN2	PGRMC1	psi-mi:“MI:0914”(association)	0.420
Copa	BCAP29	psi-mi:“MI:0914”(association)	0.350
Sacm1l	COPE	psi-mi:“MI:0914”(association)	0.350
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
MYC	ILVBL	psi-mi:“MI:0914”(association)	0.350
	TSPO	psi-mi:“MI:0914”(association)	0.350
NUDCD1	TUBAL3	psi-mi:“MI:0914”(association)	0.350
Prdm16	ESYT2	psi-mi:“MI:0914”(association)	0.350
Mecom	ESYT2	psi-mi:“MI:0914”(association)	0.350

BioGRID (228): COPG2 (Affinity Capture-RNA), COPG2 (Affinity Capture-MS), COPG2 (Affinity Capture-MS), COPG2 (Affinity Capture-MS), COPG2 (Co-fractionation), COPG2 (Co-fractionation), COPG2 (Affinity Capture-MS), COPG2 (Reconstituted Complex), COPG2 (Affinity Capture-MS), COPG2 (Affinity Capture-MS), COPG2 (Affinity Capture-MS), COPG2 (Affinity Capture-MS), COPG2 (Affinity Capture-MS), COPG2 (Affinity Capture-MS), COPG2 (Affinity Capture-MS)

ESM2 similar proteins: A1A5G0, A1A5K2, A2AGT5, A2VE21, A7MBJ5, D4ABY2, G5EEM5, O35643, O81742, P22892, P52303, P53620, P55060, P62944, P63009, P63010, P97536, Q08DS7, Q0WW26, Q10567, Q14008, Q1ZXQ8, Q29AE5, Q32PG1, Q4AEF8, Q4U0G1, Q5N749, Q5R6L5, Q5RHR0, Q66JI9, Q6DDM4, Q6DKD7, Q6GM65, Q6Z382, Q6ZQ38, Q7Z460, Q80TV8, Q86VP6, Q8H852, Q94FN2

Diamond homologs: A2VE21, D4ABY2, P32074, P53620, P87140, Q0WW26, Q22498, Q29AE5, Q4AEF8, Q54HL0, Q66JI9, Q6DKD7, Q6Z382, Q7PVF6, Q8H852, Q8I0G5, Q9I8E6, Q9PUE4, Q9QXK3, Q9QZE5, Q9UBF2, Q9Y678

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 138 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
COPI-dependent Golgi-to-ER retrograde traffic	9	10.6×	9e-05
COPI-mediated anterograde transport	8	9.3×	6e-04

GO biological processes:

GO term	Partners	Fold	FDR
intra-Golgi vesicle-mediated transport	5	22.9×	1e-03
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	17.6×	1e-03
endoplasmic reticulum to Golgi vesicle-mediated transport	7	8.3×	4e-03
mRNA splicing, via spliceosome	9	7.2×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

47 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	26
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1222 predictions. Top by Δscore:

Variant	Effect	Δscore
7:130611106:TGGTA:T	acceptor_gain	1.0000
7:130611107:GGTA:G	acceptor_gain	1.0000
7:130611108:GTA:G	acceptor_gain	1.0000
7:130611109:TA:T	acceptor_gain	1.0000
7:130611109:TAC:T	acceptor_loss	1.0000
7:130611111:C:A	acceptor_loss	1.0000
7:130611111:C:CC	acceptor_gain	1.0000
7:130611119:CA:C	acceptor_gain	1.0000
7:130611120:A:AC	acceptor_gain	1.0000
7:130611120:A:C	acceptor_gain	1.0000
7:130612146:CAATA:C	donor_loss	1.0000
7:130612147:AATAC:A	donor_loss	1.0000
7:130612148:ATACC:A	donor_loss	1.0000
7:130612149:TACCT:T	donor_loss	1.0000
7:130612150:A:C	donor_loss	1.0000
7:130612151:CCTG:C	donor_loss	1.0000
7:130612153:TGG:T	donor_gain	1.0000
7:130612167:A:AC	donor_gain	1.0000
7:130612234:ATGTG:A	acceptor_gain	1.0000
7:130612235:TGTG:T	acceptor_gain	1.0000
7:130612236:GTG:G	acceptor_gain	1.0000
7:130612237:TG:T	acceptor_gain	1.0000
7:130612237:TGC:T	acceptor_loss	1.0000
7:130612238:GCT:G	acceptor_loss	1.0000
7:130612239:C:CC	acceptor_gain	1.0000
7:130612239:C:T	acceptor_loss	1.0000
7:130612240:T:C	acceptor_loss	1.0000
7:130612243:A:AC	acceptor_gain	1.0000
7:130612243:A:C	acceptor_gain	1.0000
7:130612246:C:CT	acceptor_gain	1.0000

AlphaMissense

5775 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:130551315:C:G	R525P	1.000
7:130552427:G:T	A491D	1.000
7:130554504:A:G	L482P	1.000
7:130554512:C:A	R479S	1.000
7:130554512:C:G	R479S	1.000
7:130554513:C:A	R479M	1.000
7:130554513:C:G	R479T	1.000
7:130554515:A:C	N478K	1.000
7:130554515:A:T	N478K	1.000
7:130554582:A:G	L456P	1.000
7:130554614:G:C	D445E	1.000
7:130554614:G:T	D445E	1.000
7:130554615:T:G	D445A	1.000
7:130554616:C:G	D445H	1.000
7:130554633:A:G	L439P	1.000
7:130554707:C:A	K414N	1.000
7:130554707:C:G	K414N	1.000
7:130555047:A:G	L405P	1.000
7:130555104:A:G	L386P	1.000
7:130555117:C:G	A382P	1.000
7:130561082:A:G	L360P	1.000
7:130561115:A:G	L349P	1.000
7:130561115:A:T	L349H	1.000
7:130561118:A:G	L348P	1.000
7:130561118:A:T	L348H	1.000
7:130561121:G:T	T347K	1.000
7:130561127:A:T	I345N	1.000
7:130561130:G:T	A344D	1.000
7:130561131:C:G	A344P	1.000
7:130561139:G:T	A341D	1.000

dbSNP variants (sampled 300 via entrez): RS1000001258 (7:130626583 C>G,T), RS1000003477 (7:130648333 T>C), RS1000087734 (7:130551157 A>G), RS1000119418 (7:130510772 G>A), RS1000137422 (7:130665394 G>A), RS1000164306 (7:130571119 C>A), RS1000164642 (7:130623150 G>A), RS1000172401 (7:130511034 C>T), RS1000236361 (7:130528107 G>C), RS1000237688 (7:130533033 G>C), RS1000266901 (7:130629304 T>C), RS1000285996 (7:130598537 T>C), RS1000290212 (7:130532803 C>G,T), RS1000346168 (7:130577371 C>G), RS1000400986 (7:130589928 T>C)

Disease associations

OMIM: gene MIM:604355 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST002553_9	Pancreatic cancer	3.000000e-12
GCST005958_14	Waist-to-hip ratio adjusted for BMI (age >50)	1.000000e-07
GCST005962_34	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)	6.000000e-07
GCST90020024_122	A body shape index	2.000000e-09
GCST90020029_896	Waist circumference adjusted for body mass index	3.000000e-09

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0008007	age at assessment
EFO:0008343	sex interaction measurement
EFO:0007789	BMI-adjusted waist circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067321 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

4 potent at pChembl≥5 of 4 total, top 4 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.29	Kd	50.98	nM	CHEMBL5653589
7.29	ED50	50.98	nM	CHEMBL5653589
5.13	Kd	7486	nM	CHEMBL3752910
5.13	ED50	7486	nM	CHEMBL3752910

PubChem BioAssay actives

2 with measured affinity, of 4 total; 2 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148119: Binding affinity to human COPG2 incubated for 45 mins by Kinobead based pull down assay	kd	0.0510	uM
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148119: Binding affinity to human COPG2 incubated for 45 mins by Kinobead based pull down assay	kd	7.4864	uM

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, increases expression	3
Valproic Acid	decreases expression	2
aristolochic acid I	decreases expression	1
GSK-J4	decreases expression	1
2,4,6-tribromophenol	decreases expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
pirinixic acid	decreases expression, increases activity, affects binding	1
sodium arsenate	increases expression	1
decabromobiphenyl ether	decreases expression	1
sodium arsenite	decreases expression	1
tetrabromobisphenol A	decreases expression	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
beta-methylcholine	affects expression	1
CGP 52608	affects binding, increases reaction	1
abrine	decreases expression	1
pentabrominated diphenyl ether 100	decreases expression	1
hexabrominated diphenyl ether 153	decreases expression	1
bisphenol S	increases expression	1
Sunitinib	increases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Air Pollutants	affects cotreatment, increases abundance, increases oxidation	1
Benzo(a)pyrene	decreases expression	1
Doxorubicin	affects expression	1
Hydrogen Peroxide	affects expression	1
Ivermectin	decreases expression	1
Ozone	affects cotreatment, increases oxidation, increases abundance	1
Paraquat	decreases expression	1
Rotenone	decreases expression	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651161	Binding	Binding affinity to human COPG2 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.