COPS7B

Summary

COPS7B (COP9 signalosome subunit 7B, HGNC:16760) is a protein-coding gene on chromosome 2q37.1, encoding COP9 signalosome complex subunit 7b (Q9H9Q2). Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.

Involved in protein deneddylation. Located in nucleoplasm. Part of COP9 signalosome.

Source: NCBI Gene 64708 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 34 total
• Druggable target: yes
• MANE Select transcript: NM_022730

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16760
Approved symbol	COPS7B
Name	COP9 signalosome subunit 7B
Location	2q37.1
Locus type	gene with protein product
Status	Approved
Aliases	CSN7B
Ensembl gene	ENSG00000144524
Ensembl biotype	protein_coding
OMIM	616010
Entrez	64708

Gene structure

Transcript identifiers

Ensembl transcripts: 31 — 17 protein_coding, 7 nonsense_mediated_decay, 6 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000350033, ENST00000357490, ENST00000373608, ENST00000409091, ENST00000409295, ENST00000410017, ENST00000410024, ENST00000412591, ENST00000412922, ENST00000413197, ENST00000432387, ENST00000436564, ENST00000449174, ENST00000449784, ENST00000450501, ENST00000452375, ENST00000461350, ENST00000466901, ENST00000474042, ENST00000479430, ENST00000488111, ENST00000492423, ENST00000611614, ENST00000620578, ENST00000631349, ENST00000876254, ENST00000876255, ENST00000914093, ENST00000914094, ENST00000914095, ENST00000956209

RefSeq mRNA: 7 — MANE Select: NM_022730 NM_001282949, NM_001282950, NM_001282951, NM_001282952, NM_001308381, NM_001369483, NM_022730

CCDS: CCDS2488, CCDS63152, CCDS63153, CCDS63154, CCDS74668, CCDS77539

Canonical transcript exons

ENST00000350033 — 7 exons

Exon	Start	End
ENSE00003467265	231788555	231788732
ENSE00003567830	231794263	231794351
ENSE00003585607	231791733	231791808
ENSE00003592347	231807487	231809253
ENSE00003615938	231796106	231796308
ENSE00003654813	231798859	231798964
ENSE00003902322	231786445	231786538

Expression profiles

Bgee: expression breadth ubiquitous, 243 present calls, max score 94.56.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 22.8976 / max 214.7140, expressed in 1800 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
25939	15.5873	1786
25937	3.7551	1310
25936	3.4383	1283
25938	0.1169	33

Top tissues by expression

275 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	94.56	gold quality
right testis	UBERON:0004534	94.07	gold quality
left testis	UBERON:0004533	93.96	gold quality
body of uterus	UBERON:0009853	93.88	gold quality
cortical plate	UBERON:0005343	93.84	gold quality
adenohypophysis	UBERON:0002196	93.68	gold quality
right adrenal gland cortex	UBERON:0035827	93.67	gold quality
apex of heart	UBERON:0002098	93.58	gold quality
endocervix	UBERON:0000458	93.50	gold quality
right adrenal gland	UBERON:0001233	93.43	gold quality
pituitary gland	UBERON:0000007	93.26	gold quality
left adrenal gland	UBERON:0001234	93.14	gold quality
stromal cell of endometrium	CL:0002255	92.98	gold quality
left adrenal gland cortex	UBERON:0035825	92.92	gold quality
right lobe of thyroid gland	UBERON:0001119	92.90	gold quality
muscle layer of sigmoid colon	UBERON:0035805	92.89	gold quality
body of stomach	UBERON:0001161	92.85	gold quality
right coronary artery	UBERON:0001625	92.80	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	92.69	gold quality
metanephros cortex	UBERON:0010533	92.67	gold quality
minor salivary gland	UBERON:0001830	92.65	gold quality
lower esophagus	UBERON:0013473	92.65	gold quality
lower esophagus muscularis layer	UBERON:0035833	92.65	gold quality
tibial nerve	UBERON:0001323	92.62	gold quality
lower esophagus mucosa	UBERON:0035834	92.61	gold quality
left lobe of thyroid gland	UBERON:0001120	92.60	gold quality
right ovary	UBERON:0002118	92.52	gold quality
granulocyte	CL:0000094	92.40	gold quality
descending thoracic aorta	UBERON:0002345	92.31	gold quality
left ovary	UBERON:0002119	92.28	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.09
E-MTAB-6379	no	179.75

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

124 targeting COPS7B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-6856-5P	100.00	65.47	1298
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-767-5P	99.95	70.85	993
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-22-3P	99.93	68.13	917
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-7-1-3P	99.91	71.53	4384
HSA-MIR-7-2-3P	99.91	71.40	4394
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-362-3P	99.91	66.38	1267
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-424-5P	99.89	71.90	2641

Literature-anchored findings (GeneRIF, showing 2)

• CSN7B defines a variant COP9 signalosome complex with distinct function in DNA damage response. (PMID:33503427)
• The IGF2BP3-COPS7B Axis Facilitates mRNA Translation to Drive Colorectal Cancer Progression. (PMID:37560971)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Cops7b	ENSMUSG00000026240
rattus_norvegicus	Cops7b	ENSRNOG00000018723
drosophila_melanogaster	CSN7	FBGN0028836

Paralogs (2): COPS7A (ENSG00000111652), EIF3M (ENSG00000149100)

Protein

Protein identifiers

COP9 signalosome complex subunit 7b — Q9H9Q2 (reviewed: Q9H9Q2)

Alternative names: JAB1-containing signalosome subunit 7b

All UniProt accessions (12): Q9H9Q2, A0A087X1P5, J3KQ34, J3KQ41, J3KQV6, J3QT43, J3QT50, J3QT65, J3QT66, J3QT67, J3QT73, J3QT95

UniProt curated annotations — full annotation on UniProt →

Function. Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Subunit / interactions. Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8. Interacts with EIF3S6. (Microbial infection) Interacts with vaccinia virus protein C9L.

Subcellular location. Cytoplasm. Nucleus.

Similarity. Belongs to the CSN7/EIF3M family. CSN7 subfamily.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9H9Q2-1	1	yes
Q9H9Q2-2	2
Q9H9Q2-3	3

RefSeq proteins (7): NP_001269878, NP_001269879, NP_001269880, NP_001269881, NP_001295310, NP_001356412, NP_073567* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000717	PCI_dom	Domain
IPR041481	CSN7_helixI	Domain
IPR045237	COPS7/eIF3m	Family

Pfam: PF01399, PF18392, PF22061

UniProt features (12 total): modified residue 3, compositionally biased region 2, splice variant 2, initiator methionine 1, chain 1, domain 1, region of interest 1, coiled-coil region 1

Structure

Experimental structures (PDB)

25 structures.

PDB	Method	Resolution (Å)
9QO4	ELECTRON MICROSCOPY	2.95
9EFQ	ELECTRON MICROSCOPY	2.96
9PH4	ELECTRON MICROSCOPY	3
9QO6	ELECTRON MICROSCOPY	3
9EFV	ELECTRON MICROSCOPY	3.03
9EFM	ELECTRON MICROSCOPY	3.16
9QO1	ELECTRON MICROSCOPY	3.23
9QO0	ELECTRON MICROSCOPY	3.26
9E77	ELECTRON MICROSCOPY	3.3
9E81	ELECTRON MICROSCOPY	3.3
9EG8	ELECTRON MICROSCOPY	3.39
9E5Z	ELECTRON MICROSCOPY	3.4
9EG1	ELECTRON MICROSCOPY	3.52
9QO2	ELECTRON MICROSCOPY	3.8
9EGL	ELECTRON MICROSCOPY	3.93
9QO5	ELECTRON MICROSCOPY	4
8H38	ELECTRON MICROSCOPY	4.25
9QO3	ELECTRON MICROSCOPY	4.6
6R7I	ELECTRON MICROSCOPY	5.9
6R7N	ELECTRON MICROSCOPY	6.5
8H3F	ELECTRON MICROSCOPY	6.73
8H3A	ELECTRON MICROSCOPY	7.51
6R7F	ELECTRON MICROSCOPY	8.2
6R6H	ELECTRON MICROSCOPY	8.4
6R7H	ELECTRON MICROSCOPY	8.8

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H9Q2-F1	85.00	0.67

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 261, 263, 2

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-5696394	DNA Damage Recognition in GG-NER
R-HSA-6781823	Formation of TC-NER Pre-Incision Complex
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis
R-HSA-8951664	Neddylation

MSigDB gene sets: 199 (showing top): BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, GOBP_PROTEIN_NEDDYLATION, REACTOME_MEMBRANE_TRAFFICKING, GGGTGGRR_PAX4_03, GTACAGG_MIR486, GOBP_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_REMOVAL, CATTTCA_MIR203, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P, REACTOME_DNA_REPAIR, CAGCCTC_MIR4855P, GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN, MARSON_BOUND_BY_FOXP3_STIMULATED, MARSON_BOUND_BY_FOXP3_UNSTIMULATED

GO Biological Process (3): protein deneddylation (GO:0000338), COP9 signalosome assembly (GO:0010387), regulation of protein neddylation (GO:2000434)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (6): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), cytosol (GO:0005829), COP9 signalosome (GO:0008180), protein-containing complex (GO:0032991)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
Global Genome Nucleotide Excision Repair (GG-NER)	1
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	1
Clathrin-mediated endocytosis	1
Post-translational protein modification	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
protein modification by small protein removal	1
protein-containing complex assembly	1
protein neddylation	1
regulation of protein modification by small protein conjugation or removal	1
binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular anatomical structure	1
cytoplasm	1
nuclear protein-containing complex	1
cellular_component	1

Protein interactions and networks

STRING

1090 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
COPS7B	COPS8	Q99627	853
COPS7B	COPS4	Q9BT78	824
COPS7B	COPS6	Q7L5N1	822
COPS7B	COPS2	P61201	803
COPS7B	COPS3	Q9UNS2	775
COPS7B	GPS1	Q13098	749
COPS7B	COPS5	Q92905	731
COPS7B	NEDD8	Q15843	591
COPS7B	AAAS	Q9NRG9	457
COPS7B	C9orf153	Q5TBE3	418
COPS7B	WDR64	B1ANS9	416
COPS7B	NUP50	Q9UKX7	414
COPS7B	COPS7A	Q9UBW8	411
COPS7B	NUP210	Q8TEM1	408
COPS7B	PSMC1	P49014	407

IntAct

165 interactions, top by confidence:

A	B	Type	Score
CUL2	VHL	psi-mi:“MI:0914”(association)	0.940
COPS5	COPS2	psi-mi:“MI:0914”(association)	0.910
FBXO7	SKP1	psi-mi:“MI:0914”(association)	0.900
COPS3	COPS2	psi-mi:“MI:0914”(association)	0.870
GPS1	COPS2	psi-mi:“MI:0915”(physical association)	0.860
COPS8	COPS2	psi-mi:“MI:0914”(association)	0.850
CUL4B	COPS2	psi-mi:“MI:0914”(association)	0.790
NHERF2	PODXL	psi-mi:“MI:0914”(association)	0.770
COPS6	RHOBTB1	psi-mi:“MI:0914”(association)	0.730
COPS7B	NMI	psi-mi:“MI:0915”(physical association)	0.720
NMI	COPS7B	psi-mi:“MI:0915”(physical association)	0.720
CUL4A	COPS2	psi-mi:“MI:0914”(association)	0.640

BioGRID (306): COPS7B (Two-hybrid), COPS7B (Affinity Capture-MS), COPS7B (Affinity Capture-MS), COPS7B (Affinity Capture-MS), COPS7B (Affinity Capture-MS), COPS7B (Affinity Capture-MS), COPS7B (Affinity Capture-MS), COPS2 (Co-fractionation), COPS6 (Co-fractionation), COPS7B (Co-fractionation), COPS8 (Co-fractionation), COPS7B (Proximity Label-MS), COPS7B (Affinity Capture-MS), COPS7B (Affinity Capture-MS), COPS7B (Affinity Capture-MS)

ESM2 similar proteins: A0JN27, A2ADY9, D3K5L7, D3Z7P3, E2R222, G3MWR8, O70133, O94925, O94973, P13264, P18484, P97834, Q06AT3, Q08211, Q0VCK5, Q13042, Q13098, Q15645, Q28141, Q28F89, Q2KI56, Q2TBV5, Q3MHJ2, Q3UA06, Q497D6, Q5NVP9, Q5R874, Q5RBN9, Q5TDH0, Q5XHZ9, Q5XIT1, Q5ZJB7, Q6AYU1, Q6NRB5, Q6NRT5, Q6PER3, Q6TH22, Q7RTP6, Q7ZYA7, Q86TJ2

Diamond homologs: Q2KI56, Q55BD5, Q5R762, Q7SGS1, Q8BV13, Q94JU3, Q9CZ04, Q9H9Q2, Q9UBW8, Q9V4S8, Q00648, B4GDM5, B4JW83, B4KT65, P68395, Q0CPV5, Q292F0, Q2UDZ9, A8WQY8, Q94261

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
COPS7B	“form complex”	“COP9 signalosome variant 2”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 136 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
DNA Damage Recognition in GG-NER	11	32.0×	6e-12
RHOBTB1 GTPase cycle	6	29.1×	5e-06
Formation of TC-NER Pre-Incision Complex	11	23.7×	1e-10
Neddylation	31	15.0×	9e-26
Cargo recognition for clathrin-mediated endocytosis	9	9.6×	4e-05
Antigen processing: Ubiquitination & Proteasome degradation	18	6.8×	1e-08

GO biological processes:

GO term	Partners	Fold	FDR
protein neddylation	11	63.8×	2e-15
regulation of protein neddylation	8	61.9×	5e-11
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	6	18.6×	9e-05
intrinsic apoptotic signaling pathway	6	17.8×	1e-04
cellular response to UV	5	12.2×	4e-03
protein ubiquitination	32	10.9×	1e-21
G1/S transition of mitotic cell cycle	6	9.9×	3e-03
proteasome-mediated ubiquitin-dependent protein catabolic process	20	8.6×	4e-11

Disease & clinical

Clinical variants and AI predictions

ClinVar

34 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	29
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1154 predictions. Top by Δscore:

Variant	Effect	Δscore
2:231788729:GGAG:G	donor_gain	1.0000
2:231788730:GAGG:G	donor_gain	1.0000
2:231791731:A:AG	acceptor_gain	1.0000
2:231791732:G:GG	acceptor_gain	1.0000
2:231794234:T:A	acceptor_gain	1.0000
2:231794241:T:A	acceptor_gain	1.0000
2:231794243:T:TA	acceptor_gain	1.0000
2:231794244:G:A	acceptor_gain	1.0000
2:231794246:T:TA	acceptor_gain	1.0000
2:231794247:G:A	acceptor_gain	1.0000
2:231794250:T:TA	acceptor_gain	1.0000
2:231794251:G:A	acceptor_gain	1.0000
2:231794349:AAG:A	donor_loss	1.0000
2:231794352:GTAC:G	donor_loss	1.0000
2:231794353:T:A	donor_loss	1.0000
2:231796103:CA:C	acceptor_loss	1.0000
2:231796104:A:AG	acceptor_gain	1.0000
2:231796104:AGT:A	acceptor_gain	1.0000
2:231796105:G:A	acceptor_loss	1.0000
2:231796105:G:GA	acceptor_gain	1.0000
2:231796105:GT:G	acceptor_gain	1.0000
2:231796105:GTG:G	acceptor_gain	1.0000
2:231796105:GTGT:G	acceptor_gain	1.0000
2:231796105:GTGTA:G	acceptor_gain	1.0000
2:231796122:T:TA	acceptor_gain	1.0000
2:231796125:T:A	acceptor_gain	1.0000
2:231796128:T:A	acceptor_gain	1.0000
2:231796235:G:GT	donor_gain	1.0000
2:231796270:G:GT	donor_gain	1.0000
2:231796274:GA:G	donor_gain	1.0000

AlphaMissense

1714 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:231794311:T:C	L96P	1.000
2:231794320:T:C	L99P	1.000
2:231796170:T:C	L131P	1.000
2:231796181:G:C	A135P	1.000
2:231796307:T:A	W177R	1.000
2:231796307:T:C	W177R	1.000
2:231788697:T:C	F43L	0.999
2:231788699:T:A	F43L	0.999
2:231788699:T:G	F43L	0.999
2:231791778:T:C	F70L	0.999
2:231791780:T:A	F70L	0.999
2:231791780:T:G	F70L	0.999
2:231791782:C:A	A71D	0.999
2:231794307:A:G	K95E	0.999
2:231794309:G:C	K95N	0.999
2:231794309:G:T	K95N	0.999
2:231794311:T:A	L96Q	0.999
2:231794320:T:A	L99H	0.999
2:231794323:C:T	T100I	0.999
2:231794326:T:A	I101N	0.999
2:231794337:G:C	A105P	0.999
2:231794338:C:A	A105E	0.999
2:231796125:T:C	L116S	0.999
2:231796161:T:C	L128P	0.999
2:231796164:A:T	E129V	0.999
2:231796165:A:C	E129D	0.999
2:231796165:A:T	E129D	0.999
2:231796176:T:A	I133N	0.999
2:231796205:G:C	G143R	0.999
2:231796206:G:A	G143D	0.999

dbSNP variants (sampled 300 via entrez): RS1000205421 (2:231787546 C>A,T), RS1000345810 (2:231808903 T>A), RS1000638491 (2:231807210 C>T), RS1000660594 (2:231787341 A>G), RS1000801198 (2:231801092 A>G), RS1000938021 (2:231797926 T>A,G), RS1000938847 (2:231804397 G>A), RS1000947847 (2:231798193 A>T), RS1001145647 (2:231785525 T>A,C), RS1001243375 (2:231804181 G>T), RS1001396603 (2:231799999 TAA>T), RS1001501933 (2:231781793 A>G), RS1001541210 (2:231809749 C>G), RS1001681587 (2:231803039 A>G), RS1001763591 (2:231789497 T>G)

Disease associations

OMIM: gene MIM:616010 | disease phenotypes: MIM:267000, MIM:615665

GenCC curated gene-disease

Mondo (3): Perlman syndrome (MONDO:0009965), Joubert syndrome 22 (MONDO:0014297), skeletal dysplasia (MONDO:0018230)

Orphanet (3): Orofaciodigital syndrome type 6 (Orphanet:2754), Perlman syndrome (Orphanet:2849), Primary bone dysplasia (Orphanet:364526)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST000175_5	Height	1.000000e-06

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C536399	Nephroblastomatosis, fetal ascites, macrosomia and Wilms tumor (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5706 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, increases expression	2
dicrotophos	increases expression	1
2,4,6-tribromophenol	increases expression	1
sodium arsenite	decreases expression, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
LDN 193189	affects cotreatment, increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Air Pollutants	increases abundance, affects expression	1
Arsenic	increases abundance, decreases expression	1
Benzo(a)pyrene	affects methylation	1
Benzophenoneidum	increases expression	1
Caffeine	decreases phosphorylation	1
Cisplatin	increases expression	1
Doxorubicin	decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Gallic Acid	decreases expression	1
Ivermectin	decreases expression	1
Ozone	affects expression, increases abundance	1
Thimerosal	increases expression	1
Tretinoin	decreases expression	1
Aflatoxin B1	increases methylation	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL950406	Binding	Binding affinity to COP9 signalosome complex subunit 7b in human Jurkat cells at 10 uM after 24 hrs by 2D electrophoresis	Highly cytotoxic and neurotoxic acetogenins of the Annonaceae: new putative biological targets of squamocin detected by activity-based protein profiling. — Bioorg Med Chem Lett

Cellosaurus cell lines

3 cell lines: 2 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2UY	Abcam HEK293T COPS7B KO	Transformed cell line	Female
CVCL_SJ56	HAP1 COPS7B (-) 1	Cancer cell line	Male
CVCL_SJ57	HAP1 COPS7B (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

7 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT00001754	Not specified	COMPLETED	Study of Skeletal Disorders and Short Stature
NCT02762318	Not specified	TERMINATED	Identification and Characterization of Bone-related Genetic Variants in Families
NCT03548779	Not specified	COMPLETED	North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2
NCT05247645	Not specified	RECRUITING	Data Collection of Patients With Rare Bone Diseases
NCT05876416	Not specified	RECRUITING	Decoding the Genetic Landscape of Skeletal Diseases
NCT05991609	Not specified	ACTIVE_NOT_RECRUITING	Extreme Morphology and Metabolic Health
NCT06002373	Not specified	UNKNOWN	Assessment of Artificial Intelligence for Treatment Decision Recommendation of Adult Skeletal Class III Patients