COQ3

Summary

COQ3 (coenzyme Q3, methyltransferase, HGNC:18175) is a protein-coding gene on chromosome 6q16.2, encoding Ubiquinone biosynthesis O-methyltransferase, mitochondrial (Q9NZJ6). O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis.

Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.

Source: NCBI Gene 51805 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 70 total — 1 likely-pathogenic
• MANE Select transcript: NM_017421

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18175
Approved symbol	COQ3
Name	coenzyme Q3, methyltransferase
Location	6q16.2
Locus type	gene with protein product
Status	Approved
Aliases	bA9819.1
Ensembl gene	ENSG00000132423
Ensembl biotype	protein_coding
OMIM	605196
Entrez	51805

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 6 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000254759, ENST00000369240, ENST00000479163, ENST00000876256, ENST00000876257, ENST00000926084, ENST00000961104

RefSeq mRNA: 1 — MANE Select: NM_017421 NM_017421

CCDS: CCDS5042

Canonical transcript exons

ENST00000254759 — 7 exons

Exon	Start	End
ENSE00000904085	99369401	99369820
ENSE00000904086	99371428	99371587
ENSE00000904087	99375940	99376182
ENSE00003463911	99394074	99394195
ENSE00003612461	99383698	99383824
ENSE00003653990	99380189	99380341
ENSE00003730517	99377386	99377485

Expression profiles

Bgee: expression breadth ubiquitous, 270 present calls, max score 93.19.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.5894 / max 66.4794, expressed in 1558 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
74793	4.5894	1558

Top tissues by expression

286 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
biceps brachii	UBERON:0001507	93.19	gold quality
heart right ventricle	UBERON:0002080	92.90	gold quality
vastus lateralis	UBERON:0001379	92.54	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	92.13	gold quality
quadriceps femoris	UBERON:0001377	91.79	gold quality
heart left ventricle	UBERON:0002084	91.47	gold quality
cardiac ventricle	UBERON:0002082	91.35	gold quality
triceps brachii	UBERON:0001509	91.31	gold quality
deltoid	UBERON:0001476	90.22	gold quality
hindlimb stylopod muscle	UBERON:0004252	90.17	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	90.11	gold quality
apex of heart	UBERON:0002098	89.73	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.70	gold quality
skeletal muscle tissue	UBERON:0001134	89.28	gold quality
left ventricle myocardium	UBERON:0006566	89.12	gold quality
muscle organ	UBERON:0001630	89.03	gold quality
skeletal muscle organ	UBERON:0014892	89.03	gold quality
diaphragm	UBERON:0001103	89.02	silver quality
heart	UBERON:0000948	88.55	gold quality
muscle of leg	UBERON:0001383	88.20	gold quality
muscle tissue	UBERON:0002385	88.12	gold quality
gastrocnemius	UBERON:0001388	87.86	gold quality
myocardium	UBERON:0002349	87.86	gold quality
right atrium auricular region	UBERON:0006631	87.73	gold quality
cortical plate	UBERON:0005343	87.70	gold quality
gluteal muscle	UBERON:0002000	87.48	silver quality
cardiac atrium	UBERON:0002081	87.27	gold quality
mucosa of transverse colon	UBERON:0004991	87.24	gold quality
middle temporal gyrus	UBERON:0002771	87.04	gold quality
cerebellar hemisphere	UBERON:0002245	86.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.24

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

10 targeting COQ3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-6817-3P	99.79	68.35	2126
HSA-MIR-510-3P	99.54	70.06	2965
HSA-MIR-129-1-3P	98.86	68.41	779
HSA-MIR-129-2-3P	98.86	68.41	779
HSA-MIR-625-3P	97.32	66.55	554

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	coq3	ENSDARG00000069857
mus_musculus	Coq3	ENSMUSG00000028247
rattus_norvegicus	Coq3	ENSRNOG00000009974
drosophila_melanogaster	Coq3	FBGN0032922
caenorhabditis_elegans		WBGENE00000763

Protein

Protein identifiers

Ubiquinone biosynthesis O-methyltransferase, mitochondrial — Q9NZJ6 (reviewed: Q9NZJ6)

Alternative names: 3-demethylubiquinol 3-O-methyltransferase, 3-demethylubiquinone 3-O-methyltransferase, Polyprenyldihydroxybenzoate methyltransferase

All UniProt accessions (2): Q9NZJ6, F6WGP0

UniProt curated annotations — full annotation on UniProt →

Function. O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-decaprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-decaprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol-10 into ubiquinol-10.

Subunit / interactions. Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.

Subcellular location. Mitochondrion inner membrane.

Pathway. Cofactor biosynthesis; ubiquinone biosynthesis.

Similarity. Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.

RefSeq proteins (1): NP_059117* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR010233	UbiG_MeTrfase	Family
IPR029063	SAM-dependent_MTases_sf	Homologous_superfamily

Pfam: PF13489

Enzyme classification (BRENDA):

• EC 2.1.1.114 — polyprenyldihydroxybenzoate methyltransferase (BRENDA: 6 organisms, 10 substrates, 0 inhibitors, 0 Km, 0 kcat entries)
• EC 2.1.1.222 — 2-polyprenyl-6-hydroxyphenol methylase (BRENDA: 7 organisms, 12 substrates, 0 inhibitors, 0 Km, 0 kcat entries)
• EC 2.1.1.64 — 3-demethylubiquinol 3-O-methyltransferase (BRENDA: 5 organisms, 14 substrates, 0 inhibitors, 2 Km, 0 kcat entries)

Substrate kinetics (BRENDA)

1 substrates with measured Km, best-characterized 1. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
S-ADENOSYL-L-METHIONINE	0.022	1

Catalyzed reactions (Rhea), 3 shown:

• 3-demethylubiquinol-10 + S-adenosyl-L-methionine = ubiquinol-10 + S-adenosyl-L-homocysteine + H(+) (RHEA:44412)
• 3,4-dihydroxy-5-(all-trans-decaprenyl)benzoate + S-adenosyl-L-methionine = 4-hydroxy-3-methoxy-5-(all-trans-decaprenyl)benzoate + S-adenosyl-L-homocysteine + H(+) (RHEA:44492)
• a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine (RHEA:81215)

UniProt features (19 total): binding site 7, sequence conflict 4, modified residue 3, sequence variant 3, transit peptide 1, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NZJ6-F1	71.17	0.43

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (7): 124; 154; 175; 222; 223; 226; 227

Post-translational modifications (3): 149, 196, 143

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-2142789	Ubiquinol biosynthesis

MSigDB gene sets: 151 (showing top): HORIUCHI_WTAP_TARGETS_DN, TGCGCANK_UNKNOWN, GOBP_POLYOL_METABOLIC_PROCESS, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, GOBP_KETONE_METABOLIC_PROCESS, WEI_MYCN_TARGETS_WITH_E_BOX, GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS, GOBP_CARBOHYDRATE_METABOLIC_PROCESS, GOCC_MITOCHONDRIAL_ENVELOPE, ZHOU_INFLAMMATORY_RESPONSE_LIVE_DN, GOBP_KETONE_BIOSYNTHETIC_PROCESS, WONG_MITOCHONDRIA_GENE_MODULE, GOBP_METHYLATION, GOBP_QUINONE_METABOLIC_PROCESS

GO Biological Process (3): glycerol metabolic process (GO:0006071), ubiquinone biosynthetic process (GO:0006744), methylation (GO:0032259)

GO Molecular Function (7): O-methyltransferase activity (GO:0008171), polyprenyldihydroxybenzoate methyltransferase activity (GO:0010420), 3-demethylubiquinol 3-O-methyltransferase activity (GO:0061542), 3-demethylubiquinone 3-O-methyltransferase activity (GO:0120537), protein binding (GO:0005515), methyltransferase activity (GO:0008168), transferase activity (GO:0016740)

GO Cellular Component (6): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial matrix (GO:0005759), extrinsic component of mitochondrial inner membrane (GO:0031314), ubiquinone biosynthesis complex (GO:0110142), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Metabolism of cofactors	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
ubiquinone biosynthetic process	3
S-adenosylmethionine-dependent methyltransferase activity	3
O-methyltransferase activity	2
carbohydrate metabolic process	1
polyol metabolic process	1
ubiquinone metabolic process	1
quinone biosynthetic process	1
metabolic process	1
methyltransferase activity	1
binding	1
transferase activity, transferring one-carbon groups	1
catalytic activity	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
mitochondrion	1
intracellular organelle lumen	1
mitochondrial inner membrane	1
extrinsic component of organelle membrane	1
catalytic complex	1
cellular anatomical structure	1

Protein interactions and networks

STRING

2912 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
COQ3	COQ9	O75208	984
COQ3	COQ5	Q5HYK3	982
COQ3	COQ6	Q9Y2Z9	976
COQ3	COQ7	Q99807	961
COQ3	COQ4	Q9Y3A0	953
COQ3	COQ8A	Q8NI60	877
COQ3	PDSS1	Q5T2R2	864
COQ3	COQ8B	Q96D53	858
COQ3	COQ2	Q96H96	856
COQ3	PDSS2	Q86YH6	794
COQ3	COQ10A	Q96MF6	728
COQ3	NDUFA9	Q16795	693
COQ3	COQ10B	Q9H8M1	679
COQ3	ADCK2	Q7Z695	638
COQ3	ADCK1	Q86TW2	619

IntAct

49 interactions, top by confidence:

A	B	Type	Score
COQ8A	COQ9	psi-mi:“MI:0914”(association)	0.670
COQ3	COQ7	psi-mi:“MI:0407”(direct interaction)	0.590
COQ7	COQ3	psi-mi:“MI:0407”(direct interaction)	0.590
COQ9	COQ5	psi-mi:“MI:0915”(physical association)	0.590
COQ7	COQ9	psi-mi:“MI:0915”(physical association)	0.590
COQ5	COQ9	psi-mi:“MI:0914”(association)	0.590
PTPN9	COQ3	psi-mi:“MI:0915”(physical association)	0.560
SNX1	COQ3	psi-mi:“MI:0915”(physical association)	0.560
TTPA	COQ3	psi-mi:“MI:0915”(physical association)	0.560
COQ3	NDRG4	psi-mi:“MI:0915”(physical association)	0.560
COQ3	COQ4	psi-mi:“MI:0407”(direct interaction)	0.520
COQ3	COQ5	psi-mi:“MI:0407”(direct interaction)	0.520
COQ3	COQ6	psi-mi:“MI:0407”(direct interaction)	0.520
COQ4	COQ3	psi-mi:“MI:0407”(direct interaction)	0.520
COQ5	COQ3	psi-mi:“MI:0407”(direct interaction)	0.520
COQ6	COQ3	psi-mi:“MI:0407”(direct interaction)	0.520
COQ4	COQ5	psi-mi:“MI:0914”(association)	0.520
COQ3	NFS1	psi-mi:“MI:0915”(physical association)	0.500
COQ3	COQ9	psi-mi:“MI:0914”(association)	0.500
COQ4	COQ9	psi-mi:“MI:0914”(association)	0.500
COQ3	VPS28	psi-mi:“MI:0915”(physical association)	0.400
ECE1	COQ3	psi-mi:“MI:0915”(physical association)	0.370
COQ5	ACOT7	psi-mi:“MI:0914”(association)	0.350
COQ9	NDUFS8	psi-mi:“MI:0914”(association)	0.350
COQ3	COQ8B	psi-mi:“MI:0914”(association)	0.350

BioGRID (62): VPS28 (Affinity Capture-MS), COQ3 (Co-fractionation), COQ3 (Co-fractionation), NOVA1 (Co-fractionation), COQ6 (Reconstituted Complex), COQ3 (Reconstituted Complex), COQ3 (Affinity Capture-MS), COQ3 (Affinity Capture-MS), COQ3 (Affinity Capture-MS), COQ3 (Affinity Capture-MS), NFS1 (Affinity Capture-MS), COQ9 (Affinity Capture-MS), COQ3 (Affinity Capture-MS), COQ5 (Affinity Capture-MS), COQ6 (Affinity Capture-MS)

ESM2 similar proteins: A0A067XMT3, A0A075D5I4, A0A075D654, A0A075D657, A0A075D6M1, A0A1B4XBK1, A0A1B5L8S2, A0A1D6NER6, A0A1W5SKE9, A0A2I2F2M2, A0A411KUP5, A0A482NB13, A0A8X8M4T9, A0A8X8M4W6, A0A8X8M501, A0A8X8M505, A2XMJ1, C8YTM5, F4J2K2, F4K2A1, H2E7T5, H2E7T6, H2E7T7, H2E7T8, H2E7T9, H2E7U0, O49196, O81027, P74388, P9WEU0, Q03606, Q05763, Q0CXW9, Q0UI02, Q0WVD6, Q1JPN0, Q38932, Q3T131, Q6ZIK0, Q7X7H9

Diamond homologs: A1K8Q1, A1U3K1, A1URT5, A3PNM3, A4JCG7, A4SM99, A4VLX7, A4WW91, A4YKT6, A5VSK3, A5W7G3, A6UCF6, A6V2Q4, A6WXQ0, A7HTX8, A8HVC4, A8LQ43, A9ADW3, A9IQF4, A9M8K8, B0CIC6, B0KTX4, B0SW81, B0U3W1, B0UAV0, B1J5G4, B1Y2L3, B1YV26, B2I705, B2JEZ6, B2S828, B3H0C8, B3PP83, B3QCF3, B5ZRR7, B7V9J5, B8EI29, B8H209, B8IUB0, B9JB78

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
COQ3	“form complex”	“CoQ biosynthetic complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 22 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
ubiquinone biosynthetic process	7	327.7×	3e-15

Disease & clinical

Clinical variants and AI predictions

ClinVar

70 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	49
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
1807771	GRCh37/hg19 6q16.1-16.2(chr6:97904220-99964434)x1	Likely pathogenic

SpliceAI

1532 predictions. Top by Δscore:

Variant	Effect	Δscore
6:99371426:A:AC	donor_gain	1.0000
6:99371427:C:CC	donor_gain	1.0000
6:99375938:A:AC	donor_gain	1.0000
6:99375939:C:CC	donor_gain	1.0000
6:99369817:CCAT:C	acceptor_gain	0.9900
6:99369818:CAT:C	acceptor_gain	0.9900
6:99369818:CATC:C	acceptor_gain	0.9900
6:99371420:ATACT:A	donor_loss	0.9900
6:99371421:TACTT:T	donor_loss	0.9900
6:99371422:ACTTA:A	donor_loss	0.9900
6:99371423:CTT:C	donor_loss	0.9900
6:99371424:TTAC:T	donor_loss	0.9900
6:99371425:TACTT:T	donor_loss	0.9900
6:99371427:CTTGA:C	donor_gain	0.9900
6:99375941:TTTA:T	donor_gain	0.9900
6:99375983:A:C	donor_gain	0.9900
6:99376001:T:TA	donor_gain	0.9900
6:99377384:A:AC	donor_gain	0.9900
6:99377385:C:CC	donor_gain	0.9900
6:99377485:CCT:C	acceptor_gain	0.9900
6:99377491:T:C	acceptor_gain	0.9900
6:99377491:T:TC	acceptor_gain	0.9900
6:99380240:C:CA	donor_gain	0.9900
6:99383821:TAAA:T	acceptor_gain	0.9900
6:99383825:C:CC	acceptor_gain	0.9900
6:99369821:C:CA	acceptor_loss	0.9800
6:99369821:C:CC	acceptor_gain	0.9800
6:99371427:CTT:C	donor_gain	0.9800
6:99371583:CCGGG:C	acceptor_gain	0.9800
6:99371584:CGGGC:C	acceptor_gain	0.9800

AlphaMissense

2394 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:99376172:C:G	R166P	0.989
6:99380203:C:A	R124S	0.987
6:99380203:C:G	R124S	0.987
6:99380251:C:A	W108C	0.987
6:99380251:C:G	W108C	0.987
6:99376151:C:T	G173E	0.985
6:99380256:A:G	W107R	0.984
6:99380256:A:T	W107R	0.984
6:99369731:C:G	A327P	0.982
6:99377409:A:G	C155R	0.982
6:99376013:A:T	V219D	0.980
6:99376157:A:T	V171D	0.980
6:99380204:C:G	R124T	0.980
6:99377407:A:C	C155W	0.979
6:99380253:A:G	W108R	0.979
6:99380253:A:T	W108R	0.979
6:99376110:G:C	H187D	0.978
6:99376118:G:T	A184E	0.977
6:99377399:C:T	G158E	0.977
6:99369730:G:T	A327E	0.976
6:99380212:A:C	N121K	0.976
6:99380212:A:T	N121K	0.976
6:99371448:A:G	L290P	0.975
6:99377411:C:T	G154D	0.975
6:99376001:T:A	E223V	0.974
6:99377420:A:G	L151P	0.974
6:99380254:C:A	W107C	0.974
6:99380254:C:G	W107C	0.974
6:99369764:A:G	W316R	0.973
6:99369764:A:T	W316R	0.973

dbSNP variants (sampled 300 via entrez): RS1000078027 (6:99371394 C>T), RS1000131477 (6:99370953 A>C), RS1000228330 (6:99389272 C>A,T), RS1000381799 (6:99395205 T>C,G), RS1000452915 (6:99375721 A>G), RS1000578907 (6:99389559 C>A), RS1000640560 (6:99383270 A>G), RS1000646030 (6:99395448 A>T), RS1000852580 (6:99389411 C>T), RS1000881938 (6:99382240 T>C), RS1000916744 (6:99376927 C>A,T), RS1001089271 (6:99369634 G>C), RS1001141652 (6:99369281 A>C), RS1001245258 (6:99384544 T>C), RS1001253539 (6:99390464 G>T)

Disease associations

OMIM: gene MIM:605196 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST006922_14	Regular attendance at a religious group	2.000000e-08

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0009592	social interaction measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs11548336	COQ3		0.00	0

CTD chemical–gene interactions

40 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression	3
Cadmium Chloride	increases expression, decreases expression, increases abundance	2
Particulate Matter	increases abundance, affects cotreatment, decreases expression	2
aristolochic acid I	decreases expression	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases methylation	1
quercitrin	decreases expression	1
arsenite	affects binding, increases reaction	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
sodium arsenite	affects cotreatment, increases abundance, increases expression	1
isobutyl alcohol	affects cotreatment, decreases expression, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
erucylphospho-N,N,N-trimethylpropylammonium	decreases expression	1
Sunitinib	decreases expression	1
Zoledronic Acid	decreases expression	1
Vorinostat	increases expression	1
Acetaminophen	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	increases expression, affects cotreatment, increases abundance	1
Atrazine	decreases expression	1
Benzo(a)pyrene	increases methylation	1
Cadmium	increases abundance, increases expression	1
Calcitriol	decreases expression, affects cotreatment	1
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	decreases expression	1
Cisplatin	increases expression	1
Gasoline	affects cotreatment, decreases expression, increases abundance	1
Oxygen	decreases expression	1
Polycyclic Aromatic Hydrocarbons	increases abundance, affects cotreatment, decreases expression	1
Quercetin	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E1UA	HAP1 COQ3 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.