CORO1C

Summary

CORO1C (coronin 1C, HGNC:2254) is a protein-coding gene on chromosome 12q24.11, encoding Coronin-1C (Q9ULV4). Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1.

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene.

Source: NCBI Gene 23603 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 53 total
• Druggable target: yes
• MANE Select transcript: NM_014325

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:2254
Approved symbol	CORO1C
Name	coronin 1C
Location	12q24.11
Locus type	gene with protein product
Status	Approved
Aliases	coronin-3, HCRNN4
Ensembl gene	ENSG00000110880
Ensembl biotype	protein_coding
OMIM	605269
Entrez	23603

Gene structure

Transcript identifiers

Ensembl transcripts: 44 — 37 protein_coding, 4 retained_intron, 2 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000261401, ENST00000420959, ENST00000421578, ENST00000541050, ENST00000546571, ENST00000546705, ENST00000547170, ENST00000547294, ENST00000547361, ENST00000549384, ENST00000549387, ENST00000549772, ENST00000550032, ENST00000550542, ENST00000551044, ENST00000551059, ENST00000551550, ENST00000552030, ENST00000552871, ENST00000878546, ENST00000878547, ENST00000878548, ENST00000878549, ENST00000878550, ENST00000878551, ENST00000878552, ENST00000878553, ENST00000878554, ENST00000878555, ENST00000878556, ENST00000878557, ENST00000878558, ENST00000878559, ENST00000937033, ENST00000937034, ENST00000937035, ENST00000937036, ENST00000937037, ENST00000937038, ENST00000937039, ENST00000937040, ENST00000958760, ENST00000958761, ENST00000958762

RefSeq mRNA: 3 — MANE Select: NM_014325 NM_001105237, NM_001276471, NM_014325

CCDS: CCDS61236, CCDS9120

Canonical transcript exons

ENST00000261401 — 11 exons

Exon	Start	End
ENSE00000754666	108658738	108658919
ENSE00000754668	108662029	108662158
ENSE00000818391	108645109	108647522
ENSE00001245949	108731429	108731518
ENSE00003490068	108654306	108654410
ENSE00003491942	108648963	108649020
ENSE00003531501	108678272	108678394
ENSE00003570790	108701124	108701323
ENSE00003595798	108657304	108657423
ENSE00003607197	108648605	108648850
ENSE00003617618	108652272	108652417

Expression profiles

Bgee: expression breadth ubiquitous, 291 present calls, max score 99.23.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 93.6416 / max 1174.4692, expressed in 1826 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
133161	90.1684	1826
133160	3.1420	1419
133162	0.2930	119
133156	0.0382	6

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
saphenous vein	UBERON:0007318	99.23	gold quality
tendon of biceps brachii	UBERON:0008188	99.13	gold quality
ganglionic eminence	UBERON:0004023	98.80	gold quality
tendon	UBERON:0000043	98.55	gold quality
synovial joint	UBERON:0002217	98.55	gold quality
calcaneal tendon	UBERON:0003701	98.53	gold quality
stromal cell of endometrium	CL:0002255	98.37	gold quality
colonic epithelium	UBERON:0000397	98.20	gold quality
urethra	UBERON:0000057	98.16	gold quality
popliteal artery	UBERON:0002250	98.05	gold quality
tibial artery	UBERON:0007610	98.04	gold quality
penis	UBERON:0000989	98.02	gold quality
smooth muscle tissue	UBERON:0001135	98.02	gold quality
amniotic fluid	UBERON:0000173	97.98	gold quality
myometrium	UBERON:0001296	97.98	gold quality
nipple	UBERON:0002030	97.98	gold quality
cauda epididymis	UBERON:0004360	97.88	gold quality
lower esophagus muscularis layer	UBERON:0035833	97.88	gold quality
lower esophagus	UBERON:0013473	97.87	gold quality
muscle layer of sigmoid colon	UBERON:0035805	97.86	gold quality
right coronary artery	UBERON:0001625	97.85	gold quality
body of uterus	UBERON:0009853	97.80	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	97.72	gold quality
aorta	UBERON:0000947	97.69	gold quality
monocyte	CL:0000576	97.46	gold quality
coronary artery	UBERON:0001621	97.46	gold quality
left coronary artery	UBERON:0001626	97.44	gold quality
mononuclear cell	CL:0000842	97.34	gold quality
left uterine tube	UBERON:0001303	97.30	gold quality
mucosa of stomach	UBERON:0001199	97.21	gold quality

Single-cell (SCXA)

Detected in 7 experiment(s), a significant marker in 6.

Experiment	Marker?	Max mean expression
E-HCAD-5	yes	22.14
E-HCAD-10	yes	15.74
E-CURD-122	yes	11.77
E-CURD-46	yes	9.98
E-MTAB-9388	yes	7.78
E-GEOD-93593	no	7.45
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): F2R, F2RL1, MYOD1, NR1I2

miRNA regulators (miRDB)

122 targeting CORO1C, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-96-5P	99.95	72.80	2140
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-1-3P	99.93	72.35	1914
HSA-MIR-206	99.93	72.50	1893
HSA-MIR-218-5P	99.93	72.22	2103
HSA-MIR-6508-5P	99.92	70.67	2465
HSA-MIR-12133	99.92	71.82	2006
HSA-MIR-613	99.91	71.50	1710
HSA-MIR-1271-5P	99.91	71.99	1972
HSA-MIR-7-1-3P	99.91	71.53	4384
HSA-MIR-7-2-3P	99.91	71.40	4394
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-182-5P	99.87	74.03	2589

Literature-anchored findings (GeneRIF, showing 26)

• oligomerization, F-actin interaction and membrane association are mediated by carboxyl terminus (PMID:12377779)
• We show that coronin 3 similar to other coronins interacts with the Arp2/3-complex and cofilin indicating that this family in general is involved in regulating Arp2/3-mediated events. (PMID:17274980)
• Fndings postulate a role for CRN2 isoforms in the structural and functional organization of F-actin in highly ordered protein complexes. (PMID:19651142)
• Coronin 1C negatively regulates epithelial cell migration via FAK-mediated inhibition of cell-matrix adhesion. (PMID:19913511)
• Patients with higher coronin-1C expression had a more advanced stage of hepatocellular carcinoma. (PMID:20678442)
• There is a strong expression of both SELPLG and coronin-1C in the majority of primary effusion lymphomas, irrespective of their gene dosage. SELPLG is critical for cell migration and chemotaxis, while CORO1C regulates actin-dependent processes. (PMID:20690162)
• Coronin 3 promotes gastric cancer metastasis via the up-regulation of MMP-9 and cathepsin K. (PMID:22974233)
• Coronin-1C overexpression is associated withand hepatocellular carcinoma growth through enhancement of tumor cell proliferation and migration, which are correlated with Rac-1 activation. (PMID:23292607)
• Data indicate that coronin 1C protein (CORO1C) was a direct target of the microRNA miR-1/133a cluster in EBC-1 CORO1C was a direct target of the miR-1/133a cluster in lung-squamous cell carcinoma cell line EBC-1. (PMID:25518741)
• Coro1C mediated Rac1 trafficking through actin-rich vesicles. (PMID:25862165)
• findings emphasize the power of genetic modifiers, PLS3 and CORO1C, to unravel the cellular pathomechanisms underlying spinal muscular atrophy (SMA)–and the power of combinatorial therapy based on splice correction of SMN2 and endocytosis improvement to efficiently treat SMA (PMID:27499521)
• It would appear that YB-1 could regulate cell invasion and migration via downregulation of its indirect target coronin-1C. The association between YB-1 and coronin-1C offers a novel approach by which metastasis of breast cancer cells could be targeted and abrogated. (PMID:28302118)
• circBIRC6 and circCORO1C are functionally associated with the pluripotent state in undifferentiated human embryonic stem cells (PMID:29074849)
• These results identify coronin 1C as a novel player of the multi-faceted mechanism responsible for invadopodia formation, MT1-MMP surface exposure and invasiveness in breast cancer cells. (PMID:30065298)
• Coronin 1c protein and F-actin protein are highly expressed in breast cancer and their expression may be related to the metastasis of breast cancer cells. (PMID:30150608)
• CORO1C promoted both proliferation and metastasis, stimulated cellular mitosis and inhibited cell apoptosis in gastric cancer cells. Gastric cancer patients with positive CORO1C expression were associated with poor prognosis and lower survival rate. (PMID:30974047)
• miR-26 suppresses renal cell cancer via down-regulating coronin-3. (PMID:31595425)
• MiR-206 may suppress non-small lung cancer metastasis by targeting CORO1C. (PMID:32206066)
• Circ_0003998 Regulates the Progression and Docetaxel Sensitivity of DTX-Resistant Non-Small Cell Lung Cancer Cells by the miR-136-5p/CORO1C Axis. (PMID:33511909)
• Cytoplasmic RAD23B interacts with CORO1C to synergistically promote colorectal cancer progression and metastasis. (PMID:34062216)
• A peptide CORO1C-47aa encoded by the circular noncoding RNA circ-0000437 functions as a negative regulator in endometrium tumor angiogenesis. (PMID:34534547)
• Circ_0025039 acts an oncogenic role in the progression of non-small cell lung cancer through miR-636-dependent regulation of CORO1C. (PMID:35034254)
• CircRNA CORO1C Regulates miR-654-3p/USP7 Axis to Mediate Laryngeal Squamous Cell Carcinoma Progression. (PMID:35064359)
• Circ_0020123 plays an oncogenic role in non-small cell lung cancer depending on the regulation of miR-512-3p/CORO1C. (PMID:35388975)
• CORO1C, a novel PAK4 binding protein, recruits phospho-PAK4 at serine 99 to the leading edge and promotes the migration of gastric cancer cells. (PMID:35593474)
• Coronin 1C, Regulated by Multiple microRNAs, Facilitates Cancer Cell Aggressiveness in Pancreatic Ductal Adenocarcinoma. (PMID:37239355)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	coro1cb	ENSDARG00000021193
danio_rerio	coro1ca	ENSDARG00000035598
mus_musculus	Coro1c	ENSMUSG00000004530
rattus_norvegicus	Coro1c	ENSRNOG00000000697
drosophila_melanogaster	coro	FBGN0265935
caenorhabditis_elegans		WBGENE00000768

Paralogs (6): CORO1A (ENSG00000102879), CORO2B (ENSG00000103647), CORO2A (ENSG00000106789), CORO6 (ENSG00000167549), CORO1B (ENSG00000172725), CORO7 (ENSG00000262246)

Protein

Protein identifiers

Coronin-1C — Q9ULV4 (reviewed: Q9ULV4)

Alternative names: Coronin-3, hCRNN4

All UniProt accessions (10): B4E3S0, Q9ULV4, F8VRE9, F8VSA4, F8VTT6, F8VUX3, F8VV53, F8VVB7, F8W1H8, H0YHL7

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1. Increases the presence of activated RAC1 at the leading edge of migrating cells. Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments. Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission. Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. Required for normal cell proliferation, cell migration, and normal formation of lamellipodia. Required for normal distribution of mitochondria within cells. Interacts with GDP-bound RAB44 in bone marrow macrophages to promote osteoclastogenesis. Involved in the migration and chemotaxis of macrophages. Involved in myogenic differentiation.

Subunit / interactions. Binds F-actin. Interacts with RCC2. Interacts preferentially with nucleotide-free and GDP-bound RAC1. Interacts with VIM (via head domain). Isoform 1 and isoform 2 appear as homotrimers, while isoform 3 seems to exist as monomers. Interacts with MICAL2; this interaction recruits MICAL2 to the actin filaments. Interacts with RAB44 (GDP-bound); the interaction promotes osteoclastogenesis.

Subcellular location. Cell membrane. Cell projection. Lamellipodium. Ruffle membrane. Cytoplasm. Cytoskeleton. Cell cortex. Endosome membrane Cell membrane. Sarcolemma. Myofibril. Sarcomere. Synapse.

Tissue specificity. Ubiquitous.

Domain organisation. The C-terminal coiled-coil domain is essential for cortical membrane localization and oligomerization.

Miscellaneous. Exclusively expressed in well-differentiated myoblasts as well as in mature skeletal muscle.

Similarity. Belongs to the WD repeat coronin family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9ULV4-1	1	yes
Q9ULV4-2	2, CRN2i2
Q9ULV4-3	3, CRN2i3

RefSeq proteins (3): NP_001098707, NP_001263400, NP_055140* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR015048	DUF1899	Domain
IPR015505	Coronin	Family
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR019775	WD40_repeat_CS	Conserved_site
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily

Pfam: PF00400, PF08953, PF16300

UniProt features (53 total): strand 32, repeat 6, helix 6, turn 4, splice variant 2, chain 1, coiled-coil region 1, modified residue 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
7STY	X-RAY DIFFRACTION	2

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9ULV4-F1	91.10	0.84

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 446

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 504 (showing top): GOBP_MYELOID_CELL_DIFFERENTIATION, RNGTGGGC_UNKNOWN, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, GOBP_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION, GOBP_POSITIVE_REGULATION_OF_HEMOPOIESIS, GOBP_REGULATION_OF_CELL_MORPHOGENESIS, GOBP_ENDOSOME_ORGANIZATION, GOBP_MYELOID_LEUKOCYTE_MIGRATION, GOBP_CELL_CHEMOTAXIS, GOBP_REGULATION_OF_PHOSPHORYLATION, GOBP_NEGATIVE_REGULATION_OF_KINASE_ACTIVITY, GOBP_VESICLE_ORGANIZATION, GOBP_ACTIVATION_OF_GTPASE_ACTIVITY, GOBP_FOCAL_ADHESION_ASSEMBLY, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP

GO Biological Process (27): neural crest cell migration (GO:0001755), regulation of protein phosphorylation (GO:0001932), negative regulation of protein phosphorylation (GO:0001933), phagocytosis (GO:0006909), actin filament organization (GO:0007015), signal transduction (GO:0007165), regulation of epithelial cell migration (GO:0010632), negative regulation of epithelial cell migration (GO:0010633), regulation of fibroblast migration (GO:0010762), endosomal transport (GO:0016197), ventricular system development (GO:0021591), corpus callosum development (GO:0022038), negative regulation of protein kinase activity by regulation of protein phosphorylation (GO:0044387), establishment of protein localization (GO:0045184), positive regulation of osteoclast differentiation (GO:0045672), macrophage chemotaxis (GO:0048246), regulation of focal adhesion assembly (GO:0051893), negative regulation of focal adhesion assembly (GO:0051895), membrane fission (GO:0090148), activation of GTPase activity (GO:0090630), endosome membrane tubulation (GO:0097750), endosome fission (GO:0140285), regulation of substrate adhesion-dependent cell spreading (GO:1900024), negative regulation of substrate adhesion-dependent cell spreading (GO:1900025), regulation of ruffle assembly (GO:1900027), positive regulation of lamellipodium morphogenesis (GO:2000394), negative regulation of cellular component organization (GO:0051129)

GO Molecular Function (4): small GTPase binding (GO:0031267), actin filament binding (GO:0051015), actin binding (GO:0003779), protein binding (GO:0005515)

GO Cellular Component (19): actin filament (GO:0005884), focal adhesion (GO:0005925), cell cortex (GO:0005938), endosome membrane (GO:0010008), actin cytoskeleton (GO:0015629), lateral plasma membrane (GO:0016328), flotillin complex (GO:0016600), sarcomere (GO:0030017), lamellipodium (GO:0030027), ruffle membrane (GO:0032587), sarcolemma (GO:0042383), synapse (GO:0045202), cytoplasm (GO:0005737), endosome (GO:0005768), cytoskeleton (GO:0005856), plasma membrane (GO:0005886), membrane (GO:0016020), vesicle (GO:0031982), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	5
protein phosphorylation	2
epithelial cell migration	2
regulation of cell migration	2
focal adhesion assembly	2
cell periphery	2
plasma membrane	2
neural crest cell development	1
mesenchymal cell migration	1
regulation of protein modification process	1
regulation of phosphorylation	1
regulation of protein phosphorylation	1
negative regulation of protein modification process	1
negative regulation of phosphorylation	1
endocytosis	1
actin cytoskeleton organization	1
supramolecular fiber organization	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
regulation of multicellular organismal process	1
regulation of epithelial cell migration	1
negative regulation of cell migration	1
negative regulation of multicellular organismal process	1
fibroblast migration	1
vesicle-mediated transport	1
intracellular transport	1
brain development	1
system development	1
telencephalon development	1
anatomical structure development	1
negative regulation of protein kinase activity	1
establishment of localization	1
positive regulation of myeloid leukocyte differentiation	1
osteoclast differentiation	1
regulation of osteoclast differentiation	1
leukocyte chemotaxis	1
macrophage migration	1

Protein interactions and networks

STRING

2550 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CORO1C	PLS3	P13797	795
CORO1C	ACTR2	P61160	650
CORO1C	TMCC1	O94876	639
CORO1C	RAB27A	P51159	580
CORO1C	TWF1	Q12792	558
CORO1C	RCC2	Q9P258	542
CORO1C	IQGAP1	P46940	527
CORO1C	ACTN4	O43707	522
CORO1C	ARPC3	O15145	517
CORO1C	FLNA	P21333	506
CORO1C	CAPZB	P47756	505
CORO1C	ACTN1	P12814	483
CORO1C	DBNL	P84070	480
CORO1C	RHOBTB3	O94955	453
CORO1C	CFL1	P23528	447

IntAct

185 interactions, top by confidence:

A	B	Type	Score
MED4	MED19	psi-mi:“MI:0914”(association)	0.900
MED20	MED19	psi-mi:“MI:0914”(association)	0.840
CORO1B	CORO1C	psi-mi:“MI:0915”(physical association)	0.740
DLGAP5	KPNB1	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
MAPK7	PFDN6	psi-mi:“MI:0914”(association)	0.640
DAPK1	MYO1B	psi-mi:“MI:0914”(association)	0.530
CORO1C	GTPBP1	psi-mi:“MI:0914”(association)	0.530
CORO1A	VARS1	psi-mi:“MI:0914”(association)	0.530
TWF1	MYO1C	psi-mi:“MI:0914”(association)	0.530
CST1	CTSV	psi-mi:“MI:0914”(association)	0.530
VCAM1	PSMD11	psi-mi:“MI:0914”(association)	0.530
CFTR	PLEKHG3	psi-mi:“MI:0914”(association)	0.480
CFTR	CNOT1	psi-mi:“MI:0914”(association)	0.480
EVPL	CORO1C	psi-mi:“MI:0915”(physical association)	0.400
DNAH6	CORO1C	psi-mi:“MI:0915”(physical association)	0.400
IRAG2	CORO1C	psi-mi:“MI:0915”(physical association)	0.400
ANKRD26	CORO1C	psi-mi:“MI:0915”(physical association)	0.400
Cdk1		psi-mi:“MI:0915”(physical association)	0.400

BioGRID (428): CORO1C (Affinity Capture-MS), CORO1C (Affinity Capture-MS), CORO1C (Affinity Capture-MS), CORO1C (Affinity Capture-MS), CORO1C (Affinity Capture-MS), CORO1C (Affinity Capture-MS), ACTB (Co-fractionation), ACTG1 (Co-fractionation), ACTR2 (Co-fractionation), ACTR3 (Co-fractionation), AIMP1 (Co-fractionation), ATP6V1F (Co-fractionation), CORO1C (Co-fractionation), CORO1C (Co-fractionation), CORO1C (Co-fractionation)

ESM2 similar proteins: A0A1S4A695, A0CDD4, A2VE01, A8IU92, B0R0D7, D3ZRP6, O88958, O97556, P46926, P48454, P50397, P50399, P62495, P62496, P62497, P62498, Q0VCX5, Q1W377, Q24208, Q259G4, Q3SYW1, Q499T7, Q4R7R3, Q503E1, Q5PQL4, Q5R4C7, Q5R8T8, Q5U2Q7, Q5ZHP3, Q5ZJL4, Q61598, Q64422, Q6B857, Q6GL74, Q6GPY6, Q6PBJ2, Q6Q7J2, Q7XPW5, Q8BTU1, Q8BWY3

Diamond homologs: A1C6X5, A1DHK2, A2QBZ0, A3GFK8, A4RD35, A5DB75, A5DTX3, O13637, P38968, Q0CYG9, Q0ULF5, Q1DX43, Q2GVT8, Q2UF60, Q4P2B6, Q4X0M4, Q5AAU3, Q5AZM3, Q5S580, Q6BRR2, Q6C414, Q6CL75, Q6FNU4, Q75A30, Q80ZK9, Q873A1, Q8N5D0, Q9ULV4, Q9WUM4, A1CH75, A1CXL0, A2QI22, A3LQ86, A4R2Q6, A5DL92, A5DST9, A6R3K5, A6S0T8, A6ZPA9, A7ECP3

SIGNOR signaling

3 interactions.

A	Effect	B	Mechanism
CSNK2A1	up-regulates	CORO1C	phosphorylation
F2RL1	“up-regulates quantity by expression”	CORO1C	“transcriptional regulation”
F2R	“up-regulates quantity by expression”	CORO1C	“transcriptional regulation”

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 200 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
RHO GTPases activate PAKs	7	28.8×	6e-07
Parasite infection	8	21.0×	6e-07
Leishmania phagocytosis	8	21.0×	6e-07
Fcgamma receptor (FCGR) dependent phagocytosis	8	16.9×	3e-06
RHO GTPases Activate WASPs and WAVEs	7	16.8×	1e-05
RHO GTPases activate IQGAPs	6	15.7×	1e-04
FCGR3A-mediated phagocytosis	10	14.2×	6e-07
Sensory processing of sound	6	14.0×	2e-04

GO biological processes:

GO term	Partners	Fold	FDR
platelet aggregation	6	11.7×	4e-03
establishment or maintenance of cell polarity	5	11.6×	9e-03
mitotic spindle organization	6	9.4×	9e-03
protein dephosphorylation	7	9.0×	4e-03
actin filament organization	11	7.5×	4e-04
actin cytoskeleton organization	11	5.0×	4e-03
cell migration	14	5.0×	7e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

53 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	41
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2387 predictions. Top by Δscore:

Variant	Effect	Δscore
12:108647518:TTTTG:T	acceptor_gain	1.0000
12:108647519:TTTG:T	acceptor_gain	1.0000
12:108647520:TTG:T	acceptor_gain	1.0000
12:108647521:TG:T	acceptor_gain	1.0000
12:108647523:C:CC	acceptor_gain	1.0000
12:108648604:CCACA:C	donor_gain	1.0000
12:108652323:ATC:A	donor_gain	1.0000
12:108652325:C:A	donor_gain	1.0000
12:108653085:A:C	acceptor_gain	1.0000
12:108654302:TTACC:T	donor_loss	1.0000
12:108654304:A:C	donor_loss	1.0000
12:108654406:TTTTT:T	acceptor_gain	1.0000
12:108654407:TTTT:T	acceptor_gain	1.0000
12:108654408:TTT:T	acceptor_gain	1.0000
12:108654409:TTC:T	acceptor_loss	1.0000
12:108654411:C:CA	acceptor_loss	1.0000
12:108654411:C:CC	acceptor_gain	1.0000
12:108657297:GGCGT:G	donor_loss	1.0000
12:108657298:GCGTA:G	donor_loss	1.0000
12:108657299:CGTA:C	donor_loss	1.0000
12:108657300:GTA:G	donor_loss	1.0000
12:108657301:TAC:T	donor_loss	1.0000
12:108657302:A:AC	donor_gain	1.0000
12:108657302:ACC:A	donor_loss	1.0000
12:108657303:C:CC	donor_gain	1.0000
12:108657421:CTC:C	acceptor_gain	1.0000
12:108657423:CCTG:C	acceptor_loss	1.0000
12:108657424:C:CA	acceptor_loss	1.0000
12:108657424:C:CC	acceptor_gain	1.0000
12:108657425:T:A	acceptor_loss	1.0000

AlphaMissense

3180 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:108648828:A:G	L361P	1.000
12:108648963:C:A	K353N	1.000
12:108648963:C:G	K353N	1.000
12:108648965:T:C	K353E	1.000
12:108648966:C:A	R352S	1.000
12:108648966:C:G	R352S	1.000
12:108648967:C:A	R352M	1.000
12:108648967:C:G	R352T	1.000
12:108648968:T:C	R352G	1.000
12:108648970:G:T	P351H	1.000
12:108648973:A:T	V350D	1.000
12:108652414:C:G	D287H	1.000
12:108652416:C:T	G286D	1.000
12:108652417:C:G	G286R	1.000
12:108654361:C:T	G267E	1.000
12:108654362:C:A	G267W	1.000
12:108657326:C:G	R243P	1.000
12:108657343:G:C	F237L	1.000
12:108657343:G:T	F237L	1.000
12:108657345:A:G	F237L	1.000
12:108657347:C:T	G236E	1.000
12:108657348:C:A	G236W	1.000
12:108657395:C:G	R220T	1.000
12:108658896:A:G	W158R	1.000
12:108658896:A:T	W158R	1.000
12:108662033:A:C	S148R	1.000
12:108662033:A:T	S148R	1.000
12:108662035:T:G	S148R	1.000
12:108662065:A:G	W138R	1.000
12:108662065:A:T	W138R	1.000

dbSNP variants (sampled 300 via entrez): RS1000004618 (12:108728119 C>T), RS1000015425 (12:108708557 G>T), RS1000048968 (12:108687456 C>T), RS1000054860 (12:108671332 GAAAGA>G), RS1000069126 (12:108708933 A>T), RS1000111901 (12:108722812 GTATGA>G), RS1000144378 (12:108723165 C>G,T), RS1000195498 (12:108690663 G>C), RS1000202795 (12:108724958 A>G), RS1000236766 (12:108677397 T>C,G), RS1000248410 (12:108729891 G>C), RS1000301703 (12:108684381 A>C,G,T), RS1000310672 (12:108669738 A>G), RS1000439506 (12:108664651 G>A), RS1000460406 (12:108721319 C>T)

Disease associations

OMIM: gene MIM:605269 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST002408_11	Response to methotrexate in juvenile idiopathic arthritis	4.000000e-06
GCST002481_2	Acne (severe)	5.000000e-06
GCST003391_8	Low high density lipoprotein cholesterol levels	3.000000e-07
GCST007546_1	Coronary artery disease and LDL cholesterol levels (multivariate analysis)	3.000000e-09
GCST010703_222	Brain morphology (MOSTest)	6.000000e-13
GCST012489_46	Heel bone mineral density x serum urate levels interaction	5.000000e-09
GCST90002384_314	Hemoglobin	5.000000e-09
GCST90002387_124	Immature fraction of reticulocytes	1.000000e-10

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0004612	high density lipoprotein cholesterol measurement
EFO:0004611	low density lipoprotein cholesterol measurement
EFO:0004346	neuroimaging measurement
EFO:0004531	urate measurement
EFO:0009270	heel bone mineral density
EFO:0004509	hemoglobin measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067092 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

63 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, affects cotreatment, increases expression	8
bisphenol A	affects cotreatment, increases methylation, decreases expression, decreases methylation, increases expression	4
Benzo(a)pyrene	affects methylation, decreases expression, affects cotreatment, increases expression	3
Cisplatin	increases expression, affects response to substance, affects cotreatment, decreases expression	3
bisphenol S	decreases methylation, increases expression	2
Air Pollutants	increases expression, decreases expression, affects cotreatment, increases abundance	2
Smoke	decreases expression, increases expression	2
Tobacco Smoke Pollution	affects expression, increases expression	2
Particulate Matter	decreases expression, increases abundance, affects cotreatment, increases expression	2
bisphenol F	affects cotreatment, increases expression	1
beauvericin	affects cotreatment, increases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases expression, increases abundance	1
pirinixic acid	increases activity, affects binding, decreases expression	1
pyrogallol 1,3-dimethyl ether	affects cotreatment, affects localization, increases expression, decreases expression	1
decabromobiphenyl ether	decreases expression	1
beta-lapachone	increases expression	1
sodium bichromate	decreases expression	1
cobaltous chloride	decreases expression	1
1-nitropyrene	increases expression	1
methacrylaldehyde	increases abundance, affects cotreatment, increases expression	1
perfluorooctane sulfonic acid	decreases expression	1
CGP 52608	affects binding, increases reaction	1
enniatins	affects cotreatment, increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
ICG 001	decreases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
jinfukang	affects cotreatment, decreases expression	1
bisphenol AF	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651168	Binding	Binding affinity to human CORO1C incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2V1	Abcam HEK293T CORO1C KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.