CORO2B

Summary

CORO2B (coronin 2B, HGNC:2256) is a protein-coding gene on chromosome 15q23, encoding Coronin-2B (Q9UQ03). May play a role in the reorganization of neuronal actin structure.

Enables talin binding activity and vinculin binding activity. Acts upstream of or within several processes, including negative regulation of cell-substrate adhesion; regulation of actin cytoskeleton organization; and regulation of establishment of protein localization. Located in focal adhesion.

Source: NCBI Gene 10391 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 68 total
• MANE Select transcript: NM_006091

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:2256
Approved symbol	CORO2B
Name	coronin 2B
Location	15q23
Locus type	gene with protein product
Status	Approved
Aliases	ClipinC, KIAA0925
Ensembl gene	ENSG00000103647
Ensembl biotype	protein_coding
OMIM	605002
Entrez	10391

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 protein_coding

ENST00000261861, ENST00000540068, ENST00000543950, ENST00000972054, ENST00000972055

RefSeq mRNA: 5 — MANE Select: NM_006091 NM_001190456, NM_001190457, NM_001324014, NM_001324015, NM_006091

CCDS: CCDS10229, CCDS53952

Canonical transcript exons

ENST00000261861 — 12 exons

Exon	Start	End
ENSE00000449772	68695140	68695256
ENSE00000696033	68714559	68714663
ENSE00000696037	68713925	68714041
ENSE00000696042	68711542	68711706
ENSE00000696046	68710732	68710881
ENSE00001027034	68719144	68719234
ENSE00001027050	68719413	68719552
ENSE00001027055	68715215	68715311
ENSE00001251788	68718698	68718810
ENSE00001405057	68578993	68579277
ENSE00001550990	68725843	68727806
ENSE00003758263	68645160	68645360

Expression profiles

Bgee: expression breadth ubiquitous, 229 present calls, max score 97.79.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 19.2836 / max 548.2872, expressed in 1257 samples.

FANTOM5 promoters (12 alternative TSS)

Promoter ID	TPM avg	Samples expressed
147405	5.5540	978
147409	5.2323	1016
147410	5.1006	952
147403	0.6612	341
147408	0.6351	216
147404	0.5464	306
147413	0.4523	150
147407	0.3886	157
147412	0.2735	91
147406	0.2714	117

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	97.79	gold quality
middle frontal gyrus	UBERON:0002702	97.19	gold quality
Brodmann (1909) area 10	UBERON:0013541	96.52	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	96.40	gold quality
right hemisphere of cerebellum	UBERON:0014890	96.28	gold quality
inferior olivary complex	UBERON:0002127	96.27	gold quality
Brodmann (1909) area 46	UBERON:0006483	96.16	gold quality
prefrontal cortex	UBERON:0000451	96.08	gold quality
cerebellar hemisphere	UBERON:0002245	95.95	gold quality
cerebellar cortex	UBERON:0002129	95.94	gold quality
spinal cord	UBERON:0002240	95.93	gold quality
caudate nucleus	UBERON:0001873	95.91	gold quality
postcentral gyrus	UBERON:0002581	95.87	gold quality
CA1 field of hippocampus	UBERON:0003881	95.85	gold quality
inferior vagus X ganglion	UBERON:0005363	95.80	gold quality
parietal lobe	UBERON:0001872	95.70	gold quality
lateral nuclear group of thalamus	UBERON:0002736	95.68	gold quality
cerebellum	UBERON:0002037	95.67	gold quality
right frontal lobe	UBERON:0002810	95.58	gold quality
cortical plate	UBERON:0005343	95.54	gold quality
putamen	UBERON:0001874	95.36	gold quality
nucleus accumbens	UBERON:0001882	95.36	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	95.36	gold quality
frontal pole	UBERON:0002795	95.24	gold quality
frontal cortex	UBERON:0001870	95.22	gold quality
subthalamic nucleus	UBERON:0001906	95.21	gold quality
superior frontal gyrus	UBERON:0002661	95.05	gold quality
neocortex	UBERON:0001950	94.85	gold quality
Brodmann (1909) area 9	UBERON:0013540	94.79	gold quality
paraflocculus	UBERON:0005351	94.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.25

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

163 targeting CORO2B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-6888-3P	99.97	65.95	1170
HSA-MIR-7152-3P	99.97	67.47	849
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-8082	99.95	67.27	1170
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-145-5P	99.92	71.13	1836
HSA-MIR-5195-3P	99.92	70.92	1877
HSA-MIR-106A-5P	99.90	73.94	2683
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-345-3P	99.89	70.23	1421
HSA-MIR-17-5P	99.89	73.83	2665
HSA-MIR-302A-3P	99.89	71.23	1777

Literature-anchored findings (GeneRIF, showing 2)

• CORO2B is a novel podocyte enriched protein influencing cytoskeletal plasticity and stress adaptation. (PMID:29162887)
• Coro2b, a podocyte protein downregulated in human diabetic nephropathy, is involved in the development of protamine sulphate-induced foot process effacement. (PMID:31221975)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	coro2bb	ENSDARG00000063604
danio_rerio	coro2ba	ENSDARG00000079440
mus_musculus	Coro2b	ENSMUSG00000041729
rattus_norvegicus	Coro2b	ENSRNOG00000015257
drosophila_melanogaster	coro	FBGN0265935
caenorhabditis_elegans		WBGENE00000768

Paralogs (6): CORO1A (ENSG00000102879), CORO2A (ENSG00000106789), CORO1C (ENSG00000110880), CORO6 (ENSG00000167549), CORO1B (ENSG00000172725), CORO7 (ENSG00000262246)

Protein

Protein identifiers

Coronin-2B — Q9UQ03 (reviewed: Q9UQ03)

Alternative names: Coronin-like protein C, Protein FC96

All UniProt accessions (1): Q9UQ03

UniProt curated annotations — full annotation on UniProt →

Function. May play a role in the reorganization of neuronal actin structure.

Subunit / interactions. Binds to F-actin and to vinculin.

Subcellular location. Cytoplasm. Cytoskeleton.

Tissue specificity. Expressed predominantly in brain.

Similarity. Belongs to the WD repeat coronin family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9UQ03-1	1	yes
Q9UQ03-2	2

RefSeq proteins (5): NP_001177385, NP_001177386, NP_001310943, NP_001310944, NP_006082* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR015048	DUF1899	Domain
IPR015505	Coronin	Family
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR019775	WD40_repeat_CS	Conserved_site
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily

Pfam: PF00400, PF08953, PF16300

UniProt features (13 total): repeat 7, sequence variant 2, chain 1, sequence conflict 1, coiled-coil region 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UQ03-F1	91.58	0.80

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 255 (showing top): GOBP_ACTIN_FILAMENT_BUNDLE_ORGANIZATION, GOBP_REGULATION_OF_BLOOD_PRESSURE, GOBP_CIRCULATORY_SYSTEM_PROCESS, GOBP_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_BLOOD_VOLUME, GOBP_FOCAL_ADHESION_ASSEMBLY, GOBP_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, CAGCTG_AP4_Q5, GOBP_REGULATION_OF_GLOMERULAR_FILTRATION, GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION, GOBP_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS, GOBP_NEGATIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION, GOBP_CELL_JUNCTION_ORGANIZATION, GOBP_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY, GOBP_ACTIN_FILAMENT_ORGANIZATION

GO Biological Process (9): regulation of glomerular filtration (GO:0003093), negative regulation of cell-substrate adhesion (GO:0010812), actin cytoskeleton organization (GO:0030036), regulation of actin cytoskeleton organization (GO:0032956), focal adhesion assembly (GO:0048041), negative regulation of stress fiber assembly (GO:0051497), regulation of cellular response to stress (GO:0080135), negative regulation of establishment of protein localization (GO:1904950), positive regulation of establishment of protein localization (GO:1904951)

GO Molecular Function (5): actin binding (GO:0003779), vinculin binding (GO:0017166), actin filament binding (GO:0051015), talin binding (GO:1990147), protein binding (GO:0005515)

GO Cellular Component (5): focal adhesion (GO:0005925), actin cytoskeleton (GO:0015629), membrane (GO:0016020), cytoplasm (GO:0005737), cytoskeleton (GO:0005856)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoskeletal protein binding	3
establishment of protein localization	2
regulation of establishment of protein localization	2
cellular anatomical structure	2
glomerular filtration	1
regulation of renal system process	1
negative regulation of cell adhesion	1
regulation of cell-substrate adhesion	1
cell-substrate adhesion	1
cytoskeleton organization	1
actin filament-based process	1
actin cytoskeleton organization	1
regulation of actin filament-based process	1
regulation of cytoskeleton organization	1
cell-substrate junction assembly	1
cell-matrix adhesion	1
negative regulation of actin filament bundle assembly	1
stress fiber assembly	1
regulation of stress fiber assembly	1
cellular response to stress	1
regulation of cellular process	1
regulation of response to stress	1
negative regulation of biological process	1
positive regulation of biological process	1
actin binding	1
protein-containing complex binding	1
binding	1
cell-substrate junction	1
cytoskeleton	1
intracellular anatomical structure	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

2200 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CORO2B	ITGA11	Q9UKX5	834
CORO2B	TLE3	Q04726	810
CORO2B	KIF23	Q02241	663
CORO2B	VCL	P18206	549
CORO2B	ZNF567	Q8N184	327
CORO2B	SYCE1L	A8MT33	321
CORO2B	RELL1	Q8IUW5	321
CORO2B	URB2	Q14146	317
CORO2B	CDV3	Q9UKY7	317
CORO2B	RABEPK	Q7Z6M1	316
CORO2B	ANKRD34B	A5PLL1	310
CORO2B	CDH24	Q86UP0	307
CORO2B	KLHL24	Q6TFL4	302
CORO2B	ZNF768	Q9H5H4	301
CORO2B	SS18L2	Q9UHA2	301

IntAct

41 interactions, top by confidence:

A	B	Type	Score
APPBP2	CORO2B	psi-mi:“MI:0915”(physical association)	0.720
CORO2B	APPBP2	psi-mi:“MI:0915”(physical association)	0.720
DBN1	SVIL	psi-mi:“MI:0914”(association)	0.530
SSH1	GSN	psi-mi:“MI:0914”(association)	0.530
CORO2A	BCLAF1	psi-mi:“MI:0914”(association)	0.500
CORO2B		psi-mi:“MI:0915”(physical association)	0.400
NUDC	CORO2B	psi-mi:“MI:0915”(physical association)	0.400
P		psi-mi:“MI:0914”(association)	0.350
CTBP1	TAF15	psi-mi:“MI:0914”(association)	0.350
DAPK1	MYO1C	psi-mi:“MI:0914”(association)	0.350
MAPT	SHTN1	psi-mi:“MI:0914”(association)	0.350
CEP63	CIBAR1	psi-mi:“MI:0914”(association)	0.350
ANK2	IGKV2-40	psi-mi:“MI:0914”(association)	0.350
DYRK1A	TEX13D	psi-mi:“MI:0914”(association)	0.350
ITM2B	ILVBL	psi-mi:“MI:0914”(association)	0.350
SYNGAP1	POTEF	psi-mi:“MI:0914”(association)	0.350
HCN1	POTEF	psi-mi:“MI:0914”(association)	0.350
CORO2B	SHC1	psi-mi:“MI:0914”(association)	0.350
CORO2A	YPEL5	psi-mi:“MI:0914”(association)	0.350
CORO2B	OBI1	psi-mi:“MI:0914”(association)	0.350
VCP	SHTN1	psi-mi:“MI:0914”(association)	0.350
VCP	FAM171A2	psi-mi:“MI:0914”(association)	0.350

BioGRID (30): APPBP2 (Two-hybrid), CORO2A (Affinity Capture-MS), PRKG1 (Affinity Capture-MS), SHC1 (Affinity Capture-MS), ARHGEF25 (Affinity Capture-MS), CORO2B (Two-hybrid), CORO2B (Two-hybrid), CORO2B (Affinity Capture-Western), CORO2B (Negative Genetic), CORO2B (Affinity Capture-MS), SHC1 (Affinity Capture-MS), CORO2A (Affinity Capture-MS), ARHGEF25 (Affinity Capture-MS), PRKG1 (Affinity Capture-MS), CORO2B (Affinity Capture-MS)

ESM2 similar proteins: A0A286ZK88, A1L1L6, A7MB28, A8WGF4, B8BJ39, D0G6S1, O00399, O54956, P11029, P11497, Q13085, Q148G7, Q28007, Q28943, Q28DR7, Q2HJF8, Q2RAK2, Q4R4U1, Q502J7, Q5FVD6, Q5R559, Q5R5F8, Q5R7D8, Q5R8Q7, Q5SWU9, Q5ZIT8, Q5ZM73, Q6AYR2, Q6NVC5, Q6NWV3, Q6P1X5, Q6PC62, Q7TPD1, Q7TSL3, Q86XK2, Q8BG51, Q8BH44, Q8C176, Q8CHR6, Q8IWZ6

Diamond homologs: A8WGE3, B0R0D7, O13923, O89046, O89053, P27133, P31146, P57737, Q06440, Q21624, Q32LP9, Q4R4J2, Q54JS5, Q5NVK4, Q6DJD8, Q6QEF8, Q7K0L4, Q8BH44, Q8C0P5, Q91ZN1, Q920J3, Q920M5, Q92176, Q92828, Q9BR76, Q9ULV4, Q9UQ03, Q9WUM3, Q9WUM4, Q9XS70, A6ZPA9, A7TMF9, B3RNR8, B6QC56, B8N9H4, C5FWH1, C7Z6H2, F1LTR1, G0S8H7, O13637

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 40 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
actin filament organization	5	16.9×	4e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

68 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	57
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2684 predictions. Top by Δscore:

Variant	Effect	Δscore
15:68579275:AAGG:A	donor_loss	1.0000
15:68579278:G:GA	donor_loss	1.0000
15:68579279:T:A	donor_loss	1.0000
15:68645157:C:G	acceptor_gain	1.0000
15:68645158:A:AG	acceptor_gain	1.0000
15:68645159:G:GA	acceptor_gain	1.0000
15:68645159:GA:G	acceptor_gain	1.0000
15:68645159:GAT:G	acceptor_gain	1.0000
15:68645357:GCAG:G	donor_gain	1.0000
15:68645358:CAGG:C	donor_loss	1.0000
15:68645361:G:GG	donor_gain	1.0000
15:68695135:T:TA	acceptor_gain	1.0000
15:68695137:CA:C	acceptor_loss	1.0000
15:68695138:A:AG	acceptor_gain	1.0000
15:68695138:A:G	acceptor_loss	1.0000
15:68695139:G:GG	acceptor_gain	1.0000
15:68695139:GA:G	acceptor_gain	1.0000
15:68695139:GAC:G	acceptor_gain	1.0000
15:68695139:GACA:G	acceptor_gain	1.0000
15:68695253:GTCG:G	donor_gain	1.0000
15:68695254:TCG:T	donor_gain	1.0000
15:68695257:G:GG	donor_gain	1.0000
15:68695257:GTGAG:G	donor_loss	1.0000
15:68695259:GAGCA:G	donor_loss	1.0000
15:68710727:TGCAG:T	acceptor_loss	1.0000
15:68710728:GCAGG:G	acceptor_loss	1.0000
15:68710729:CAGG:C	acceptor_loss	1.0000
15:68710730:A:AC	acceptor_loss	1.0000
15:68710731:G:A	acceptor_loss	1.0000
15:68710880:AG:A	donor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000010858 (15:68598844 G>A), RS1000025885 (15:68706707 ATTTT>A,ATTT,ATTTTT), RS1000076671 (15:68595192 T>G), RS1000077004 (15:68579669 G>C), RS1000079689 (15:68634805 C>T), RS1000081488 (15:68545137 G>A,C,T), RS1000084095 (15:68599045 G>A), RS1000108536 (15:68538478 T>A,C), RS1000115203 (15:68704794 G>A,C), RS1000132554 (15:68550943 T>A), RS1000141270 (15:68552967 A>G), RS1000155167 (15:68720915 C>T), RS1000161985 (15:68717132 T>A,C), RS1000166404 (15:68659529 A>G), RS1000169890 (15:68589757 C>T)

Disease associations

OMIM: gene MIM:605002 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST000477_44	Cognitive performance	1.000000e-07
GCST003670_1	Systolic blood pressure	3.000000e-08
GCST010320_28	PR interval	8.000000e-09
GCST010321_45	PR interval	1.000000e-08

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0003926	neuropsychological test
EFO:0006335	systolic blood pressure
EFO:0004462	PR interval

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

48 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases expression	3
bisphenol A	affects cotreatment, increases expression, decreases methylation	2
Tretinoin	increases expression	2
Cyclosporine	increases expression	2
FR900359	increases phosphorylation	1
bisphenol F	affects cotreatment, increases methylation	1
deoxynivalenol	decreases expression	1
sodium arsenate	decreases expression	1
tris(2-butoxyethyl) phosphate	affects expression	1
sodium arsenite	increases expression	1
butyraldehyde	increases expression	1
benzo(e)pyrene	increases methylation	1
potassium chromate(VI)	decreases expression	1
aflatoxin B2	decreases methylation	1
nickel sulfate	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, decreases expression	1
diallyl trisulfide	increases expression	1
CGP 52608	affects binding, increases reaction	1
2,2’,4,4’,5-brominated diphenyl ether	increases expression	1
clothianidin	decreases expression	1
jinfukang	affects cotreatment, decreases expression	1
Sunitinib	decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Vorinostat	decreases expression	1
Cisplatin	affects cotreatment, decreases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Endosulfan	increases expression	1
Estradiol	affects cotreatment, increases expression	1
Indomethacin	affects cotreatment, increases expression	1
Lipopolysaccharides	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.