CORO2B

Summary

CORO2B (coronin 2B, HGNC:2256) is a protein-coding gene on chromosome 15q23, encoding Coronin-2B (Q9UQ03). May play a role in the reorganization of neuronal actin structure.

Enables talin binding activity and vinculin binding activity. Acts upstream of or within several processes, including negative regulation of cell-substrate adhesion; regulation of actin cytoskeleton organization; and regulation of establishment of protein localization. Located in focal adhesion.

Source: NCBI Gene 10391 — automated summary from GO annotations (Alliance of Genome Resources).

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 68 total
• GTEx eGene: eQTL in 16 tissues, sQTL in 0 (q < 0.05)
• Constraint (gnomAD): pLI 0.02 (LoF-tolerant), LOEUF 0.63 (unconstrained)
• MANE Select transcript: NM_006091
• Notable: 68 clinical variants but no curated precision-oncology (CIViC) evidence yet

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:2256
Approved symbol	CORO2B
Name	coronin 2B
Location	15q23
Locus type	gene with protein product
Status	Approved
Aliases	ClipinC, KIAA0925
Ensembl gene	ENSG00000103647
Ensembl biotype	protein_coding
OMIM	605002
Entrez	10391

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 6 protein_coding, 1 nonsense_mediated_decay

MANE Select: ENST00000261861

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 1: 1, TSL 2: 1, TSL 5: 1

ENST00000261861, ENST00000540068, ENST00000543950, ENST00000972054, ENST00000972055, ENST00001048446, ENST00001063014

RefSeq mRNA: 5 — MANE Select: NM_006091 NM_001190456, NM_001190457, NM_001324014, NM_001324015, NM_006091

CCDS: CCDS10229, CCDS53952

Canonical transcript exons

ENST00000261861 — 12 exons

Exon	Start	End
ENSE00000449772	68695140	68695256
ENSE00000696033	68714559	68714663
ENSE00000696037	68713925	68714041
ENSE00000696042	68711542	68711706
ENSE00000696046	68710732	68710881
ENSE00001027034	68719144	68719234
ENSE00001027050	68719413	68719552
ENSE00001027055	68715215	68715311
ENSE00001251788	68718698	68718810
ENSE00001405057	68578993	68579277
ENSE00001550990	68725843	68727806
ENSE00003758263	68645160	68645360

Expression profiles

Bgee: expression breadth ubiquitous, 229 present calls, max score 97.79.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 19.2836 / max 548.2872, expressed in 1257 samples.

Highest expression (Bgee): ganglionic eminence, middle frontal gyrus, Brodmann (1909) area 10, C1 segment of cervical spinal cord, hemisphere of cerebellum.

Genetic regulation across tissues (GTEx eQTL / sQTL)

CORO2B is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 16 tissues and its splicing (sQTL) in 0 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

16 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Whole Blood	eqtl	2.5e-11	-0.28	15:68630871:G:C
Cells Cultured fibroblasts	eqtl	9.0e-06	-0.19	15:68623747:C:T
Brain Cerebellar Hemisphere	eqtl	9.7e-06	-0.27	15:68684923:C:G
Testis	eqtl	2.0e-03	-0.25	15:68722586:T:G
Muscle Skeletal	eqtl	3.4e-03	-0.32	15:68601932:T:G
Skin Not Sun Exposed Suprapubic	eqtl	5.1e-03	+0.12	15:68657224:T:A
Brain Cortex	eqtl	8.2e-03	+0.94	15:67948275:A:G
Esophagus Mucosa	eqtl	8.9e-03	-0.26	15:68369794:G:C
Thyroid	eqtl	1.2e-02	-0.12	15:68487097:A:C
Adipose Visceral Omentum	eqtl	1.3e-02	+0.18	15:68674395:C:G
Skin Sun Exposed Lower leg	eqtl	2.6e-02	+0.19	15:69092673:C:T
Nerve Tibial	eqtl	3.5e-02	+0.39	15:68663526:A:C
Adrenal Gland	eqtl	3.7e-02	+0.50	15:68732862:C:T
Brain Cerebellum	eqtl	4.4e-02	-0.23	15:68560321:T:A
Artery Aorta	eqtl	4.4e-02	+0.38	15:68715317:T:G
Spleen	eqtl	4.5e-02	-0.31	15:68587047:TATACACACAC:T

FANTOM5 promoters

showing 10 of 12 alternative TSS:

Promoter ID	TPM avg	Samples expressed
147405	5.5540	978
147409	5.2323	1016
147410	5.1006	952
147403	0.6612	341
147408	0.6351	216
147404	0.5464	306
147413	0.4523	150
147407	0.3886	157
147412	0.2735	91
147406	0.2714	117

Top tissues by expression

showing 100 of 295 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	97.79	gold quality
middle frontal gyrus	UBERON:0002702	97.19	gold quality
Brodmann (1909) area 10	UBERON:0013541	96.52	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	96.40	gold quality
right hemisphere of cerebellum	UBERON:0014890	96.28	gold quality
inferior olivary complex	UBERON:0002127	96.27	gold quality
Brodmann (1909) area 46	UBERON:0006483	96.16	gold quality
prefrontal cortex	UBERON:0000451	96.08	gold quality
cerebellar hemisphere	UBERON:0002245	95.95	gold quality
cerebellar cortex	UBERON:0002129	95.94	gold quality
spinal cord	UBERON:0002240	95.93	gold quality
caudate nucleus	UBERON:0001873	95.91	gold quality
postcentral gyrus	UBERON:0002581	95.87	gold quality
CA1 field of hippocampus	UBERON:0003881	95.85	gold quality
inferior vagus X ganglion	UBERON:0005363	95.80	gold quality
parietal lobe	UBERON:0001872	95.70	gold quality
lateral nuclear group of thalamus	UBERON:0002736	95.68	gold quality
cerebellum	UBERON:0002037	95.67	gold quality
right frontal lobe	UBERON:0002810	95.58	gold quality
cortical plate	UBERON:0005343	95.54	gold quality
putamen	UBERON:0001874	95.36	gold quality
nucleus accumbens	UBERON:0001882	95.36	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	95.36	gold quality
frontal pole	UBERON:0002795	95.24	gold quality
frontal cortex	UBERON:0001870	95.22	gold quality
subthalamic nucleus	UBERON:0001906	95.21	gold quality
superior frontal gyrus	UBERON:0002661	95.05	gold quality
neocortex	UBERON:0001950	94.85	gold quality
Brodmann (1909) area 9	UBERON:0013540	94.79	gold quality
paraflocculus	UBERON:0005351	94.78	gold quality
telencephalon	UBERON:0001893	94.59	gold quality
cerebral cortex	UBERON:0000956	94.49	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	94.47	gold quality
cingulate cortex	UBERON:0003027	94.17	gold quality
anterior cingulate cortex	UBERON:0009835	94.15	gold quality
Ammon’s horn	UBERON:0001954	94.13	gold quality
cerebellar vermis	UBERON:0004720	93.93	gold quality
dorsal plus ventral thalamus	UBERON:0001897	93.88	gold quality
lateral globus pallidus	UBERON:0002476	93.79	gold quality
entorhinal cortex	UBERON:0002728	93.65	gold quality
medulla oblongata	UBERON:0001896	93.60	gold quality
orbitofrontal cortex	UBERON:0004167	93.57	gold quality
occipital lobe	UBERON:0002021	93.46	gold quality
primary visual cortex	UBERON:0002436	93.37	gold quality
substantia nigra pars reticulata	UBERON:0001966	93.06	gold quality
substantia nigra	UBERON:0002038	93.04	gold quality
midbrain	UBERON:0001891	92.97	gold quality
central nervous system	UBERON:0001017	92.56	gold quality
globus pallidus	UBERON:0001875	92.53	gold quality
temporal lobe	UBERON:0001871	92.47	gold quality
brain	UBERON:0000955	92.45	gold quality
medial globus pallidus	UBERON:0002477	92.26	gold quality
hypothalamus	UBERON:0001898	92.00	gold quality
forebrain	UBERON:0001890	91.96	gold quality
middle temporal gyrus	UBERON:0002771	91.90	gold quality
corpus callosum	UBERON:0002336	91.81	gold quality
superior vestibular nucleus	UBERON:0007227	91.80	gold quality
substantia nigra pars compacta	UBERON:0001965	91.76	gold quality
ventral tegmental area	UBERON:0002691	91.71	gold quality
amygdala	UBERON:0001876	91.64	gold quality
pons	UBERON:0000988	91.38	gold quality
ventricular zone	UBERON:0003053	90.61	gold quality
Brodmann (1909) area 23	UBERON:0013554	88.60	gold quality
dorsal root ganglion	UBERON:0000044	88.49	gold quality
right uterine tube	UBERON:0001302	87.44	gold quality
pigmented layer of retina	UBERON:0001782	87.20	gold quality
retina	UBERON:0000966	87.19	gold quality
decidua	UBERON:0002450	86.08	gold quality
cranial nerve II	UBERON:0000941	85.70	gold quality
apex of heart	UBERON:0002098	84.62	gold quality
right ovary	UBERON:0002118	84.32	gold quality
metanephric glomerulus	UBERON:0004736	84.23	gold quality
renal glomerulus	UBERON:0000074	84.01	gold quality
right atrium auricular region	UBERON:0006631	83.98	gold quality
left uterine tube	UBERON:0001303	83.92	gold quality
trigeminal ganglion	UBERON:0001675	83.59	gold quality
cardiac atrium	UBERON:0002081	82.96	gold quality
left ovary	UBERON:0002119	82.30	gold quality
tibial nerve	UBERON:0001323	81.54	gold quality
omental fat pad	UBERON:0010414	80.52	gold quality
peritoneum	UBERON:0002358	80.48	gold quality
adipose tissue of abdominal region	UBERON:0007808	80.37	gold quality
ovary	UBERON:0000992	80.32	gold quality
stromal cell of endometrium	CL:0002255	79.26	gold quality
embryo	UBERON:0000922	79.06	gold quality
subcutaneous adipose tissue	UBERON:0002190	78.37	gold quality
heart	UBERON:0000948	78.14	gold quality
heart left ventricle	UBERON:0002084	78.03	gold quality
metanephros	UBERON:0000081	77.98	gold quality
adipose tissue	UBERON:0001013	77.74	gold quality
cardiac ventricle	UBERON:0002082	77.71	gold quality
body of uterus	UBERON:0009853	77.24	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	77.23	gold quality
left coronary artery	UBERON:0001626	77.15	gold quality
endocervix	UBERON:0000458	77.05	gold quality
lower esophagus muscularis layer	UBERON:0035833	77.05	gold quality
lower esophagus	UBERON:0013473	76.92	gold quality
sural nerve	UBERON:0015488	76.74	gold quality
coronary artery	UBERON:0001621	76.73	gold quality
connective tissue	UBERON:0002384	76.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.25

HPA expression

RNA tissue specificity: Tissue enhanced

showing 60 of 79 HPA tissues / cells by nTPM:

Tissue / cell	Axis	nTPM	Protein (IHC)
Corpus callosum	tissue	200.1
Putamen	tissue	194.8
Spinal cord	tissue	158.7
Basal ganglia	tissue	153.9	high
Medulla oblongata	tissue	130.6
Midbrain	tissue	130.4
Thalamus	tissue	121.7
Caudate putamen	tissue	119.2
Ventral forebrain	tissue	118.6
Postcentral gyrus	tissue	117.2
Cerebral cortex	tissue	114.0	medium
Somatosensory cortex	tissue	114.0
Occipital cortex	tissue	108.9
Hippocampal formation	tissue	106.0
Superior colliculi	tissue	105.6
Nucleus accumbens	tissue	102.5
Pons	tissue	99.1
Cerebellum	tissue	97.7	medium
Substantia nigra	tissue	93.9
Motor cortex	tissue	93.8
Frontal cortex	tissue	90.7
Prefrontal cortex	tissue	89.8
Septum	tissue	82.2
Retrosplenial and cingulate cortex	tissue	81.9
Retrosplenial cortex	tissue	81.7
Hippocampus	tissue	80.2	high
Entorhinal cortex	tissue	80.0
Temporal cortex	tissue	80.0
Insular cortex	tissue	78.9
Periaqueductal gray	tissue	67.9
Locus coeruleus	tissue	64.2
Amygdala	tissue	63.6
Olfactory bulb	tissue	63.1
Hypothalamus	tissue	54.9
Retina	tissue	41.9
Choroid plexus	tissue	39.7
Fallopian tube	tissue	25.9	medium
Ovary	tissue	13.5	low
Adipose tissue	tissue	8.6	not detected
Smooth muscle	tissue	5.9	low
Heart muscle	tissue	5.3	not detected
Endometrium 1	tissue	5.2	medium
Seminal vesicle	tissue	4.6	not detected
Gallbladder	tissue	4.4	low
Tongue	tissue	4.2
Cervix	tissue	4.1	low
Lung	tissue	4.1	medium
Skin 1	tissue	3.8	low
Vagina	tissue	3.8	low
Kidney	tissue	3.5	medium
Pituitary gland	tissue	3.4
Breast	tissue	3.0	medium
Placenta	tissue	3.0	medium
Thyroid gland	tissue	2.9	low
Adrenal gland	tissue	2.7	medium
Skeletal muscle	tissue	2.5	not detected
Spleen	tissue	2.3	low
Epididymis	tissue	2.1	low
Urinary bladder	tissue	2.0	low
Salivary gland	tissue	1.9	not detected

Brain sub-regions (HPA Brain Atlas): detected in 191; highest nTPM — White matter (200.1), Ventral spinal cord (158.7), Parieto-temporal junction (white matter) (149.2), Dorsal funiculus (white matter) (129.5), Corpus callosum, splenium (white matter) (123.3).

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

Targeting CORO2B by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific).

showing 30 of 163 miRNAs:

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-6888-3P	99.97	65.95	1170
HSA-MIR-7152-3P	99.97	67.47	849
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-8082	99.95	67.27	1170
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-145-5P	99.92	71.13	1836
HSA-MIR-5195-3P	99.92	70.92	1877
HSA-MIR-106A-5P	99.90	73.94	2683
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-345-3P	99.89	70.23	1421
HSA-MIR-17-5P	99.89	73.83	2665
HSA-MIR-302A-3P	99.89	71.23	1777

Functional genomics

gnomAD constraint: pLI 0.0154, LOEUF 0.633, missense Z 2.98 — population loss-of-function intolerance (pLI ≥ 0.9 = LoF-intolerant; lower LOEUF = more constrained). gnomAD

Regional missense constraint (gnomAD)

ENST00000261861 splits into 2 regions with different missense tolerance; 0 are missense-constrained. Missense variants in a constrained region (low observed/expected) are more likely to be pathogenic. gnomAD

Region (GRCh38)	Missense obs / exp	o/e	Constrained
15:68,579,263–68,719,436	352 / 543.0	0.65	no
15:68,719,437–68,725,971	108 / 102.1	1.06	no

Literature-anchored findings (GeneRIF, showing 2)

• CORO2B is a novel podocyte enriched protein influencing cytoskeletal plasticity and stress adaptation. (PMID:29162887)
• Coro2b, a podocyte protein downregulated in human diabetic nephropathy, is involved in the development of protamine sulphate-induced foot process effacement. (PMID:31221975)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	coro2bb	ENSDARG00000063604
danio_rerio	coro2ba	ENSDARG00000079440
mus_musculus	Coro2b	ENSMUSG00000041729
rattus_norvegicus	Coro2b	ENSRNOG00000015257
drosophila_melanogaster	coro	FBGN0265935
caenorhabditis_elegans		WBGENE00000768

Paralogs (6): CORO1A (ENSG00000102879), CORO2A (ENSG00000106789), CORO1C (ENSG00000110880), CORO6 (ENSG00000167549), CORO1B (ENSG00000172725), CORO7 (ENSG00000262246)

Mouse-model phenotypes

Observed phenotypes of the mouse ortholog (MGI:2444283) from MGI (Alliance of Genome Resources) — knockout/mutant phenotypes, ranked by annotation count. 5 distinct phenotype terms.

Mouse phenotype (MP)	Records
abnormal coat/hair pigmentation	1
decreased susceptibility to injury	1
abnormal renal glomerulus morphology	1
abnormal urine protein level	1
increased fibroblast adhesion	1

Additional cross-species homologs

Sequence homologs in species beyond Ensembl Compara’s model organisms, by Diamond local protein alignment (% sequence identity; best hit per species). Lower-identity rows are more distant homologs. The matched accessions’ gene symbols aren’t in biobtree yet, so each row shows the UniProt accession.

Organism	UniProt	Identity	Method
Macaca fascicularis	Q4R4J2	99.3%	Diamond
Pongo abelii	Q5NVK4	99.0%	Diamond
Xenopus tropicalis	A8WGE3	96.0%	Diamond
Xenopus laevis	Q6DJD8	96.0%	Diamond
Bos taurus	Q92176	95.4%	Diamond
Oryctolagus cuniculus	Q9XS70	91.2%	Diamond
Schizosaccharomyces pombe 972h-	O13923	56.5%	Diamond
Saccharomyces cerevisiae S288C	Q06440	56.5%	Diamond
Dictyostelium discoideum	P27133	52.9%	Diamond

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
MIR4312	ncRNA	100422971
ANP32A-IT1	ncRNA	80035
ANP32A	protein-coding	8125
ITGA11	protein-coding	22801
FEM1B	protein-coding	10116
SPESP1-NOX5	protein-coding	134826889
SPESP1	protein-coding	246777

Protein

Protein identifiers

Coronin-2B — Q9UQ03 (reviewed: Q9UQ03)

Alternative names: Coronin-like protein C, Protein FC96

All UniProt accessions (1): Q9UQ03

UniProt curated annotations — full annotation on UniProt →

Function. May play a role in the reorganization of neuronal actin structure.

Subunit / interactions. Binds to F-actin and to vinculin.

Subcellular location. Cytoplasm. Cytoskeleton.

Tissue specificity. Expressed predominantly in brain.

Similarity. Belongs to the WD repeat coronin family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9UQ03-1	1	yes
Q9UQ03-2	2

RefSeq proteins (5): NP_001177385, NP_001177386, NP_001310943, NP_001310944, NP_006082* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR015048	DUF1899	Domain
IPR015505	Coronin	Family
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR019775	WD40_repeat_CS	Conserved_site
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily

Pfam: PF00400, PF08953, PF16300

UniProt features (13 total): repeat 7, sequence variant 2, chain 1, sequence conflict 1, coiled-coil region 1, splice variant 1

Structure

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UQ03-F1	91.58	0.80

Human Protein Atlas

Protein class: Predicted intracellular proteins, Plasma proteins

Protein evidence: Evidence at protein level

Subcellular location (HPA, imaging): focal adhesion sites; plasma membrane

Antibody reliability (HPA): IH enhanced · IF approved

Function

Pathways and Gene Ontology

Reactome pathways

0 curated (TAS) of 0; 0 disease pathways. Curated-first; evidence = TAS (manually curated) vs IEA (electronic inference).

MSigDB gene sets: 255 (showing top): GOBP_ACTIN_FILAMENT_BUNDLE_ORGANIZATION, GOBP_REGULATION_OF_BLOOD_PRESSURE, GOBP_CIRCULATORY_SYSTEM_PROCESS, GOBP_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_BLOOD_VOLUME, GOBP_FOCAL_ADHESION_ASSEMBLY, GOBP_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, CAGCTG_AP4_Q5, GOBP_REGULATION_OF_GLOMERULAR_FILTRATION, GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION, GOBP_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS, GOBP_NEGATIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION, GOBP_CELL_JUNCTION_ORGANIZATION, GOBP_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY, GOBP_ACTIN_FILAMENT_ORGANIZATION

GO Biological Process (8): actin filament organization (GO:0007015), negative regulation of cell-substrate adhesion (GO:0010812), actin cytoskeleton organization (GO:0030036), regulation of actin cytoskeleton organization (GO:0032956), focal adhesion assembly (GO:0048041), regulation of cellular response to stress (GO:0080135), negative regulation of establishment of protein localization (GO:1904950), positive regulation of establishment of protein localization (GO:1904951)

GO Molecular Function (5): actin binding (GO:0003779), vinculin binding (GO:0017166), actin filament binding (GO:0051015), talin binding (GO:1990147), protein binding (GO:0005515)

GO Cellular Component (6): actin filament (GO:0005884), plasma membrane (GO:0005886), focal adhesion (GO:0005925), actin cytoskeleton (GO:0015629), membrane (GO:0016020), cytoskeleton (GO:0005856)

GO top-level categories

30 GO namespaces:

Category	Terms
cytoskeletal protein binding	3
actin cytoskeleton organization	2
establishment of protein localization	2
regulation of establishment of protein localization	2
supramolecular fiber organization	1
negative regulation of cell adhesion	1
regulation of cell-substrate adhesion	1
cell-substrate adhesion	1
cytoskeleton organization	1
actin filament-based process	1
regulation of actin filament-based process	1
regulation of cytoskeleton organization	1
cell-substrate junction assembly	1
cell-matrix adhesion	1
cellular response to stress	1
regulation of cellular process	1
regulation of response to stress	1
negative regulation of biological process	1
positive regulation of biological process	1
actin binding	1
protein-containing complex binding	1
binding	1
actin cytoskeleton	1
polymeric cytoskeletal fiber	1
membrane	1
cell periphery	1
cell-substrate junction	1
cytoskeleton	1
cellular anatomical structure	1
intracellular membraneless organelle	1

Experimentally-supported GO annotations

GO terms backed by direct experimental evidence (ECO experimental codes) — 8 of 19 annotations. The rest are phylogenetic / computational / electronic (IEA).

8 experimentally-supported GO terms:

GO term	NS	Evidence
negative regulation of cell-substrate adhesion	BP	direct assay
negative regulation of establishment of protein localization	BP	direct assay
positive regulation of establishment of protein localization	BP	direct assay
regulation of actin cytoskeleton organization	BP	direct assay
regulation of cellular response to stress	BP	direct assay
focal adhesion	CC	direct assay
talin binding	MF	direct assay
vinculin binding	MF	physical interaction

Protein interactions and networks

STRING

showing 15 of 1,120 interactions by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CORO2B	ITGA11	Q9UKX5	830
CORO2B	TLE3	Q04726	800
CORO2B	KIF23	Q02241	667
CORO2B	SDK1	Q7Z5N4	456
CORO2B	PARVB	Q9HBI1	370
CORO2B	RPL7L1	Q6DKI1	364
CORO2B	TGFB1I1	O43294	359
CORO2B	TMOD2	Q9NZR1	356
CORO2B	PHLDB1	Q86UU1	323
CORO2B	CHAMP1	Q96JM3	323
CORO2B	DBN1	Q16643	309
CORO2B	WDR7	Q9Y4E6	307
CORO2B	LRRIQ1	Q96JM4	290
CORO2B	MTCL2	O94964	278
CORO2B	CFL1	P23528	275

IntAct

Human interaction partners of CORO2B in IntAct, one row per partner (best MIscore; records = supporting IntAct interaction records).

7 partners by confidence:

Partner	Interaction type	MIscore	Records
APPBP2	physical association	0.720	6
NUDC	physical association	0.400	1
OBI1	association	0.350	1
PLEKHG3	association	0.350	1
SHC1	association	0.350	1
RSPH1	physical association	0.000	1
TSC22D1	physical association	0.000	1

BioGRID (31 interactions; top human partners by supporting records): CORO2A (Affinity Capture-MS; 3 records), APPBP2 (Two-hybrid; 2 records), ARHGEF25 (Affinity Capture-MS; 2 records), PRKG1 (Affinity Capture-MS; 2 records), SHC1 (Affinity Capture-MS; 2 records), ACACA (Negative Genetic), ANK2 (Affinity Capture-MS), ARPC1B (Affinity Capture-MS), BHLHE40 (Affinity Capture-Western), DAPK1 (Affinity Capture-MS), DYRK1A (Affinity Capture-MS), GATA4 (Affinity Capture-Western), HSPA5 (Affinity Capture-MS), KLHL20 (Affinity Capture-MS), MYC (Affinity Capture-MS)

Disease & clinical

Genetic variants

Variant evidence for CORO2B: 68 ClinVar records (0 pathogenic / likely pathogenic); 4 GWAS associations.

ClinVar

68 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	57
Likely benign	3
Benign	0

SpliceAI

Top 10 splice-impact sites by Δscore (adjacent positions with the same effect merged into one range; 30 predictions of 1,365):

Position(s)	Effect	Δscore	Sites
15:68579278–68579279	donor_loss	1.0000	3
15:68645157	acceptor_gain	1.0000
15:68645361	donor_loss	1.0000	2
15:68695138–68695139	acceptor_loss	1.0000	6
15:68695257–68695258	donor_loss	1.0000	5
15:68710730–68710731	acceptor_loss	1.0000	4
15:68710882–68710883	donor_loss	1.0000	2
15:68711531	acceptor_gain	1.0000
15:68711540–68711541	acceptor_loss	1.0000	5
15:68711668	donor_gain	1.0000

HPA cancer prognostics

RNA cancer specificity: Group enriched (Glioblastoma Multiforme, Skin Cutaneous Melanoma)

Human Protein Atlas survival analysis — favorable = higher expression predicts better survival.

2 prognostic cancer types:

Cancer	Prognostic	p-value
Kidney Renal Papillary Cell Carcinoma (TCGA)	favorable	2.47e-05
Skin Cutaneous Melanoma (TCGA)	unfavorable	0.00063

Disease associations

OMIM: gene MIM:605002 | disease phenotypes:

GWAS associations

4 associations:

Study	Trait	p-value
GCST010320_103	PR interval	8e-9
GCST010321_5	PR interval	1e-8
GCST003670_1	Systolic blood pressure	3e-8
GCST000477_44	Cognitive performance	1e-7

EFO canonical traits (from GWAS)

3 canonical traits:

EFO ID	Trait name
EFO:0003926	neuropsychological test
EFO:0006335	systolic blood pressure
EFO:0004462	PR interval

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (CPIC guideline: no)

CTD chemical–gene interactions

48 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases expression	3
bisphenol A	decreases methylation, affects cotreatment, increases expression	2
Tretinoin	increases expression	2
Cyclosporine	increases expression	2
FR900359	increases phosphorylation	1
bisphenol F	affects cotreatment, increases methylation	1
deoxynivalenol	decreases expression	1
sodium arsenate	decreases expression	1
tris(2-butoxyethyl) phosphate	affects expression	1
sodium arsenite	increases expression	1
butyraldehyde	increases expression	1
benzo(e)pyrene	increases methylation	1
potassium chromate(VI)	decreases expression	1
aflatoxin B2	decreases methylation	1
nickel sulfate	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	decreases expression, affects cotreatment	1
diallyl trisulfide	increases expression	1
CGP 52608	affects binding, increases reaction	1
2,2’,4,4’,5-brominated diphenyl ether	increases expression	1
clothianidin	decreases expression	1
jinfukang	affects cotreatment, decreases expression	1
Sunitinib	decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Vorinostat	decreases expression	1
Cisplatin	affects cotreatment, decreases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Endosulfan	increases expression	1
Estradiol	affects cotreatment, increases expression	1
Indomethacin	affects cotreatment, increases expression	1
Lipopolysaccharides	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

Via MONDO — disease-level, not drug-specific.