CORO6

Summary

CORO6 (coronin 6, HGNC:21356) is a protein-coding gene on chromosome 17q11.2, encoding Coronin-6 (Q6QEF8).

Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and cell migration.

Source: NCBI Gene 84940 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 94 total
• MANE Select transcript: NM_032854

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21356
Approved symbol	CORO6
Name	coronin 6
Location	17q11.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ14871, ClipinE
Ensembl gene	ENSG00000167549
Ensembl biotype	protein_coding
Entrez	84940

Gene structure

Transcript identifiers

Ensembl transcripts: 48 — 39 protein_coding, 5 retained_intron, 3 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000345068, ENST00000388767, ENST00000459686, ENST00000467534, ENST00000469090, ENST00000480954, ENST00000492276, ENST00000577909, ENST00000579388, ENST00000580212, ENST00000584602, ENST00000584969, ENST00000682159, ENST00000683068, ENST00000683607, ENST00000683819, ENST00000892807, ENST00000892808, ENST00000892809, ENST00000892810, ENST00000892811, ENST00000892812, ENST00000892813, ENST00000892814, ENST00000892815, ENST00000892816, ENST00000892817, ENST00000892818, ENST00000919721, ENST00000967496, ENST00000967497, ENST00000967498, ENST00000967499, ENST00000967500, ENST00000967501, ENST00000967502, ENST00000967503, ENST00000967504, ENST00000967505, ENST00000967506, ENST00000967507, ENST00000967508, ENST00000967509, ENST00000967510, ENST00000967511, ENST00000967512, ENST00000967513, ENST00000967514

RefSeq mRNA: 10 — MANE Select: NM_032854 NM_001351301, NM_001351302, NM_001388431, NM_001388433, NM_001388434, NM_001388435, NM_001388436, NM_001388437, NM_001388438, NM_032854

CCDS: CCDS11252

Canonical transcript exons

ENST00000388767 — 11 exons

Exon	Start	End
ENSE00001503890	29617500	29617619
ENSE00001817530	29621224	29621484
ENSE00002707121	29614762	29615857
ENSE00002709670	29622688	29622912
ENSE00003496446	29615945	29616175
ENSE00003580829	29619060	29619189
ENSE00003588128	29616279	29616336
ENSE00003623153	29616938	29617042
ENSE00003675548	29618790	29618971
ENSE00003677594	29619651	29619773
ENSE00003683286	29616702	29616847

Expression profiles

Bgee: expression breadth ubiquitous, 212 present calls, max score 99.34.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.8259 / max 473.8357, expressed in 1213 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
165160	4.2493	1119
165159	3.5765	599

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	99.34	gold quality
hindlimb stylopod muscle	UBERON:0004252	98.96	gold quality
mucosa of stomach	UBERON:0001199	98.93	gold quality
muscle of leg	UBERON:0001383	98.31	gold quality
apex of heart	UBERON:0002098	98.19	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	97.95	gold quality
left lobe of thyroid gland	UBERON:0001120	97.76	gold quality
skeletal muscle tissue	UBERON:0001134	97.35	gold quality
right atrium auricular region	UBERON:0006631	97.31	gold quality
right lobe of thyroid gland	UBERON:0001119	97.10	gold quality
cardiac atrium	UBERON:0002081	96.95	gold quality
quadriceps femoris	UBERON:0001377	96.91	gold quality
vastus lateralis	UBERON:0001379	96.85	gold quality
lower esophagus muscularis layer	UBERON:0035833	96.76	gold quality
lower esophagus	UBERON:0013473	96.71	gold quality
right frontal lobe	UBERON:0002810	96.42	gold quality
thyroid gland	UBERON:0002046	96.28	gold quality
biceps brachii	UBERON:0001507	95.95	gold quality
heart left ventricle	UBERON:0002084	95.93	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	95.78	gold quality
muscle tissue	UBERON:0002385	95.68	gold quality
cardiac ventricle	UBERON:0002082	95.38	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	95.38	gold quality
Brodmann (1909) area 9	UBERON:0013540	95.11	gold quality
heart	UBERON:0000948	94.67	gold quality
body of tongue	UBERON:0011876	94.63	gold quality
primary visual cortex	UBERON:0002436	94.61	gold quality
left uterine tube	UBERON:0001303	93.53	gold quality
muscle layer of sigmoid colon	UBERON:0035805	93.19	gold quality
right hemisphere of cerebellum	UBERON:0014890	92.93	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.32
E-MTAB-6678	yes	6.29

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

20 targeting CORO6, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-6752-3P	99.72	66.71	1587
HSA-MIR-3158-5P	99.65	67.51	1763
HSA-MIR-6751-5P	99.56	64.99	1145
HSA-MIR-486-3P	99.51	66.82	1901
HSA-MIR-1275	99.47	67.90	2749
HSA-MIR-3612	99.45	66.02	1333
HSA-MIR-650	99.45	65.77	1309
HSA-MIR-223-5P	99.24	68.82	1206
HSA-MIR-6803-5P	99.19	63.90	1026
HSA-MIR-7109-5P	99.18	66.13	1057
HSA-MIR-3160-3P	99.07	64.78	955
HSA-MIR-6846-5P	98.81	65.86	1121
HSA-MIR-6848-5P	98.81	65.49	1126
HSA-MIR-2467-3P	98.65	67.18	1969
HSA-MIR-6887-5P	98.56	68.49	1295
HSA-MIR-6795-5P	98.52	68.51	1277
HSA-MIR-615-5P	98.10	63.76	591
HSA-MIR-1225-3P	97.29	64.60	876

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	coro6	ENSDARG00000102272
mus_musculus	Coro6	ENSMUSG00000020836
rattus_norvegicus	Coro6	ENSRNOG00000014496
drosophila_melanogaster	coro	FBGN0265935
caenorhabditis_elegans		WBGENE00000768

Paralogs (6): CORO1A (ENSG00000102879), CORO2B (ENSG00000103647), CORO2A (ENSG00000106789), CORO1C (ENSG00000110880), CORO1B (ENSG00000172725), CORO7 (ENSG00000262246)

Protein

Protein identifiers

Coronin-6 — Q6QEF8 (reviewed: Q6QEF8)

Alternative names: Coronin-like protein E

All UniProt accessions (9): A0A804HHT2, A0A804HI92, A0A804HLC9, Q6QEF8, J3KSS5, J3QLV6, J3QRV4, J3QSC1, K7ERF4

UniProt curated annotations — full annotation on UniProt →

Isoforms (5)

UniProt ID	Names	Canonical?
Q6QEF8-1	1	yes
Q6QEF8-2	2
Q6QEF8-3	3
Q6QEF8-4	4
Q6QEF8-5	5

RefSeq proteins (9): NP_001338230, NP_001375360, NP_001375362, NP_001375363, NP_001375364, NP_001375365, NP_001375366, NP_001375367, NP_116243* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR015048	DUF1899	Domain
IPR015505	Coronin	Family
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR019775	WD40_repeat_CS	Conserved_site
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily

Pfam: PF00400, PF08953, PF16300

UniProt features (55 total): strand 30, repeat 6, turn 5, helix 5, splice variant 4, chain 1, sequence conflict 1, region of interest 1, coiled-coil region 1, compositionally biased region 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
7KYX	X-RAY DIFFRACTION	1.63

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6QEF8-F1	91.55	0.83

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 102 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, TGGTGCT_MIR29A_MIR29B_MIR29C, RNGTGGGC_UNKNOWN, BENPORATH_ES_WITH_H3K27ME3, PAX4_01, chr17q11, GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION, MODULE_205, ATF1_Q6, GOBP_ACTIN_FILAMENT_ORGANIZATION, GGCKCATGS_UNKNOWN, ATF3_Q6, CCCNNNNNNAAGWT_UNKNOWN, ELK1_01, CREB_Q3

GO Biological Process (3): actin filament organization (GO:0007015), cell migration (GO:0016477), negative regulation of cellular component organization (GO:0051129)

GO Molecular Function (2): actin filament binding (GO:0051015), protein binding (GO:0005515)

GO Cellular Component (1): lamellipodium (GO:0030027)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
actin cytoskeleton organization	1
supramolecular fiber organization	1
cell motility	1
cellular component organization	1
negative regulation of cellular process	1
regulation of cellular component organization	1
actin binding	1
protein-containing complex binding	1
binding	1
cell leading edge	1
plasma membrane bounded cell projection	1

Protein interactions and networks

STRING

2038 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CORO6	KLHL35	Q6PF15	505
CORO6	ARHGEF5	Q12774	483
CORO6	MAP6D1	Q9H9H5	436
CORO6	RBM24	Q9BX46	434
CORO6	CFL2	Q9Y281	424
CORO6	IRGQ	Q8WZA9	424
CORO6	CFL1	P23528	398
CORO6	A0A3B3ITS8	A0A3B3ITS8	396
CORO6	ZSCAN18	Q8TBC5	392
CORO6	ELMO2	Q96JJ3	386
CORO6	DOK4	Q8TEW6	371
CORO6	ATP5MC2	Q06055	364
CORO6	SCUBE3	Q8IX30	363
CORO6	ARHGAP28	Q9P2N2	359
CORO6	PCMTD2	Q9NV79	357

IntAct

18 interactions, top by confidence:

A	B	Type	Score
BLOC1S6	CORO6	psi-mi:“MI:0915”(physical association)	0.560
CORO6	BLOC1S6	psi-mi:“MI:0915”(physical association)	0.560
KLHL10	PXDNL	psi-mi:“MI:0914”(association)	0.530
C8orf44	CORO6	psi-mi:“MI:0915”(physical association)	0.400
CORO6	FXR1	psi-mi:“MI:0915”(physical association)	0.370
CORO6	CORO1A	psi-mi:“MI:0914”(association)	0.350
BTF3	VPS37C	psi-mi:“MI:0914”(association)	0.350
RAB24	AIP	psi-mi:“MI:0914”(association)	0.350
CORO1A	PSMD9	psi-mi:“MI:0914”(association)	0.350
PILRA	PIK3C2A	psi-mi:“MI:0914”(association)	0.350
LPAR2	EI24	psi-mi:“MI:0914”(association)	0.350
CORO6	PPP1R12A	psi-mi:“MI:0914”(association)	0.350
ABRA	SPTBN2	psi-mi:“MI:0914”(association)	0.350
MRPS6	MRPS14	psi-mi:“MI:0914”(association)	0.350
POLG2	VSIG8	psi-mi:“MI:0914”(association)	0.350
MAGEE1	FYN	psi-mi:“MI:0914”(association)	0.350

BioGRID (56): CORO6 (Two-hybrid), CORO6 (Affinity Capture-MS), CORO6 (Two-hybrid), CORO1A (Affinity Capture-MS), CORO1C (Affinity Capture-MS), UACA (Affinity Capture-MS), TRIOBP (Affinity Capture-MS), TACC3 (Affinity Capture-MS), NBR1 (Affinity Capture-MS), CORO1B (Affinity Capture-MS), POC1A (Affinity Capture-MS), CSRP2BP (Affinity Capture-MS), C9orf16 (Affinity Capture-MS), TIGD5 (Affinity Capture-MS), PCGF6 (Affinity Capture-MS)

ESM2 similar proteins: A1L3L9, A2X2K3, B0R0D7, B6VA23, O35142, O55029, P35606, P36876, P36877, P50410, P54614, P56932, P63150, P63151, P97888, Q00005, Q00006, Q0D2F4, Q0E2P1, Q29090, Q38821, Q39247, Q4R4I8, Q4R7Z4, Q4R8L3, Q5E9Q7, Q5R4A2, Q5R664, Q5Z8Z7, Q5ZIY5, Q66LE6, Q6AY57, Q6DIY3, Q6NY64, Q6P1F6, Q6QEF8, Q6ZWR4, Q7ZWU5, Q7ZX64, Q80W47

Diamond homologs: A8WGE3, B0R0D7, O13923, O89046, O89053, P27133, P31146, P57737, Q06440, Q21624, Q32LP9, Q4R4J2, Q54JS5, Q5NVK4, Q6DJD8, Q6QEF8, Q7K0L4, Q8BH44, Q8C0P5, Q91ZN1, Q920J3, Q920M5, Q92176, Q92828, Q9BR76, Q9ULV4, Q9UQ03, Q9WUM3, Q9WUM4, Q9XS70, A6ZPA9, A7TMF9, B3RNR8, B6QC56, B8N9H4, C5FWH1, C7Z6H2, F1LTR1, G0S8H7, O13637

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

94 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	81
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2169 predictions. Top by Δscore:

Variant	Effect	Δscore
17:29615717:G:A	donor_gain	1.0000
17:29615939:TCTTA:T	donor_loss	1.0000
17:29615940:CTTAC:C	donor_loss	1.0000
17:29615941:TTACC:T	donor_loss	1.0000
17:29615942:TACC:T	donor_loss	1.0000
17:29615943:A:AC	donor_gain	1.0000
17:29615943:A:C	donor_loss	1.0000
17:29615944:C:CC	donor_gain	1.0000
17:29615944:CCGA:C	donor_gain	1.0000
17:29616172:CTGA:C	acceptor_gain	1.0000
17:29616173:TGA:T	acceptor_gain	1.0000
17:29616176:C:CC	acceptor_gain	1.0000
17:29616176:C:CG	acceptor_loss	1.0000
17:29616179:C:CT	acceptor_gain	1.0000
17:29616180:G:T	acceptor_gain	1.0000
17:29616184:G:C	acceptor_gain	1.0000
17:29616184:G:GC	acceptor_gain	1.0000
17:29616714:CA:C	donor_gain	1.0000
17:29617615:CTCTC:C	acceptor_gain	1.0000
17:29617617:CTCCT:C	acceptor_loss	1.0000
17:29617620:CTG:C	acceptor_loss	1.0000
17:29617621:T:A	acceptor_loss	1.0000
17:29618783:CACT:C	donor_loss	1.0000
17:29618784:ACTC:A	donor_loss	1.0000
17:29618785:CTCA:C	donor_loss	1.0000
17:29618786:TCACC:T	donor_loss	1.0000
17:29618787:CACCG:C	donor_loss	1.0000
17:29618788:A:AC	donor_gain	1.0000
17:29618788:A:C	donor_loss	1.0000
17:29618788:ACCG:A	donor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000003705 (17:29624223 C>A,T), RS1000039998 (17:29623807 A>G), RS1000050372 (17:29621785 G>A,T), RS1000990246 (17:29622768 G>C,T), RS1000993857 (17:29618314 C>T), RS1001042631 (17:29622637 C>T), RS1001216804 (17:29624595 A>G), RS1001391567 (17:29618157 C>T), RS1001741096 (17:29618431 G>A), RS1002209514 (17:29623015 G>A,C,T), RS1002700346 (17:29622233 C>T), RS1002798560 (17:29617005 T>G), RS1003008742 (17:29620143 A>G,T), RS1003720409 (17:29620719 T>C), RS1004103774 (17:29619354 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (1): breast ductal adenocarcinoma (MONDO:0005590)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST005194_160	Coronary artery disease	5.000000e-10
GCST005195_69	Coronary artery disease	3.000000e-10
GCST005196_23	Coronary artery disease	6.000000e-10
GCST006979_527	Heel bone mineral density	3.000000e-29
GCST010703_115	Brain morphology (MOSTest)	1.000000e-28

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0009270	heel bone mineral density
EFO:0004346	neuroimaging measurement

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D018270	Carcinoma, Ductal, Breast	C04.557.470.200.025.232.500; C04.557.470.615.132.500; C04.588.180.390; C17.800.090.500.390

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	affects expression, increases abundance, decreases expression	2
Estradiol	affects expression, affects cotreatment, increases expression	2
Valproic Acid	increases expression, affects expression	2
urushiol	increases expression	1
triphenyl phosphate	affects expression	1
propionaldehyde	increases expression	1
ethyl-p-hydroxybenzoate	decreases expression	1
sulforaphane	decreases expression	1
butyraldehyde	increases expression	1
perfluorooctanoic acid	decreases expression	1
tobacco tar	decreases reaction, decreases expression	1
diallyl disulfide	decreases expression, decreases reaction	1
4-aminophenylarsenoxide	affects binding, decreases reaction	1
ICG 001	decreases expression	1
bisphenol S	affects cotreatment, decreases expression	1
jinfukang	increases expression, affects cotreatment	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Temozolomide	decreases expression	1
Sunitinib	decreases expression	1
Arsenic Trioxide	affects binding, decreases reaction	1
Vehicle Emissions	increases abundance, increases expression	1
Benzo(a)pyrene	increases methylation	1
Cisplatin	affects cotreatment, increases expression	1
DDT	increases expression	1
Dexamethasone	affects cotreatment, decreases expression	1
Indomethacin	affects cotreatment, decreases expression	1
Ozone	affects expression, increases abundance	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Triclosan	decreases expression	1

Clinical trials (associated diseases)

11 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT03414970	PHASE3	ACTIVE_NOT_RECRUITING	Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer
NCT00461344	PHASE2	TERMINATED	Docetaxel + Doxorubicin as Neoadjuvant Chemotherapy in Patients With Breast Cancer
NCT07499999	PHASE2	NOT_YET_RECRUITING	Randomized Double-Blind Phase II Trial of Baby Exemestane Versus Baby Tamoxifen in Post-Menopausal Women at High Risk for Breast Cancer
NCT00637364	PHASE1/PHASE2	SUSPENDED	High Intensity Focused Ultrasound Tumor Treatment for Pancreatic Cancer Pain
NCT02779855	PHASE1/PHASE2	COMPLETED	Talimogene Laherparepvec in Combination With Neoadjuvant Chemotherapy in Triple Negative Breast Cancer
NCT01753908	EARLY_PHASE1	COMPLETED	Broccoli Sprout Extract in Treating Patients With Breast Cancer
NCT01796041	EARLY_PHASE1	COMPLETED	Intraoperative Imaging of Breast Cancer With Indocyanine Green
NCT01208974	Not specified	ACTIVE_NOT_RECRUITING	Nipple-Areola Complex (NAC) Irradiation After Nipple-Sparing Mastectomy and Reconstruction
NCT01875198	Not specified	TERMINATED	Oncologic Impact of Splenectomy-omitting Radical Pancreatectomy in Well-selected Left-sided Pancreatic Cancer
NCT03543397	Not specified	UNKNOWN	MRI in Ductal Carcinoma in Situ (DCIS)
NCT03834532	Not specified	COMPLETED	Living Well After Breast Surgery