COX10-DT

Summary

COX10-DT (COX10 divergent transcript, HGNC:38873) is a long non-coding RNA gene on chromosome 17p12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38873
Approved symbol	COX10-DT
Name	COX10 divergent transcript
Location	17p12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000236088
Ensembl biotype	lncRNA
Entrez	100874058
RNAcentral	URS000075D03D — lncRNA, 1944 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 84 — 83 lncRNA, 1 TEC

ENST00000423323, ENST00000449363, ENST00000457609, ENST00000577798, ENST00000582752, ENST00000602539, ENST00000602743, ENST00000623598, ENST00000652924, ENST00000653162, ENST00000655970, ENST00000656685, ENST00000656960, ENST00000656963, ENST00000659114, ENST00000660804, ENST00000661551, ENST00000662986, ENST00000664394, ENST00000664612, ENST00000686296, ENST00000686809, ENST00000690301, ENST00000701067, ENST00000701579, ENST00000701610, ENST00000701670, ENST00000717564, ENST00000792907, ENST00000792908, ENST00000792909, ENST00000792910, ENST00000792911, ENST00000792912, ENST00000792913, ENST00000792914, ENST00000792915, ENST00000792916, ENST00000792917, ENST00000792918, ENST00000792919, ENST00000792920, ENST00000792921, ENST00000792922, ENST00000792923, ENST00000792924, ENST00000792925, ENST00000792926, ENST00000792927, ENST00000792928, ENST00000792929, ENST00000792930, ENST00000792931, ENST00000792932, ENST00000792933, ENST00000792934, ENST00000792935, ENST00000792936, ENST00000792937, ENST00000792938, ENST00000792939, ENST00000792940, ENST00000792941, ENST00000792942, ENST00000792943, ENST00000792944, ENST00000792945, ENST00000792946, ENST00000792947, ENST00000792948, ENST00000792949, ENST00000792950, ENST00000792951, ENST00000792952, ENST00000792953, ENST00000792954, ENST00000792955, ENST00000792956, ENST00000792957, ENST00000792958, ENST00000792959, ENST00000792960, ENST00000792961, ENST00000792962

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000423323 — 2 exons

Exon	Start	End
ENSE00001666236	13790269	13792550
ENSE00001689622	13776632	13777349

Expression profiles

Bgee: expression breadth ubiquitous, 168 present calls, max score 85.73.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.2942 / max 83.2028, expressed in 1608 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
164659	5.6497	1579
164658	0.6445	387

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	85.73	gold quality
right lobe of liver	UBERON:0001114	83.24	gold quality
skin of abdomen	UBERON:0001416	82.35	gold quality
endothelial cell	CL:0000115	82.26	gold quality
ectocervix	UBERON:0012249	81.26	gold quality
esophagus mucosa	UBERON:0002469	81.25	gold quality
endocervix	UBERON:0000458	81.21	gold quality
sural nerve	UBERON:0015488	81.15	gold quality
skin of leg	UBERON:0001511	80.78	gold quality
ganglionic eminence	UBERON:0004023	80.36	gold quality
ventricular zone	UBERON:0003053	79.96	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	79.89	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.84	gold quality
cortical plate	UBERON:0005343	79.79	gold quality
right adrenal gland cortex	UBERON:0035827	79.45	gold quality
descending thoracic aorta	UBERON:0002345	79.42	gold quality
calcaneal tendon	UBERON:0003701	78.99	gold quality
right adrenal gland	UBERON:0001233	78.72	gold quality
zone of skin	UBERON:0000014	78.61	gold quality
esophagus	UBERON:0001043	78.52	gold quality
left ovary	UBERON:0002119	78.48	gold quality
left adrenal gland	UBERON:0001234	78.11	gold quality
bone marrow cell	CL:0002092	77.95	gold quality
right ovary	UBERON:0002118	77.84	gold quality
left adrenal gland cortex	UBERON:0035825	77.82	gold quality
adenohypophysis	UBERON:0002196	77.71	gold quality
granulocyte	CL:0000094	77.67	gold quality
spleen	UBERON:0002106	77.60	gold quality
mucosa of transverse colon	UBERON:0004991	77.49	gold quality
ascending aorta	UBERON:0001496	77.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	5.27

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Regulating COX10-AS1 / miR-142-5p / PAICS axis inhibits the proliferation of non-small cell lung cancer. (PMID:34323174)
• Long Non-coding RNA COX10-AS1 Promotes Glioma Progression by Competitively Binding miR-1-3p to Regulate ORC6 Expression. (PMID:38244670)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.