COX18

Summary

COX18 (cytochrome c oxidase assembly factor COX18, HGNC:26801) is a protein-coding gene on chromosome 4q13.3, encoding Cytochrome c oxidase assembly protein COX18, mitochondrial (Q8N8Q8). Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT-CO2/COX2) across the mitochondrial inner membrane. It is a selective cancer dependency (DepMap: 19.5% of cell lines).

This gene encodes a cytochrome c oxidase assembly protein. The encoded protein is essential for integral membrane protein insertion into the mitochondrial inner membrane. It is also required for cytochrome c oxidase assembly and activity. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 285521 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 74 total — 3 pathogenic
• Phenotypes (HPO): 57
• Cancer dependency (DepMap): dependent in 19.5% of screened cell lines
• MANE Select transcript: NM_001297732

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26801
Approved symbol	COX18
Name	cytochrome c oxidase assembly factor COX18
Location	4q13.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ38991, OXA1L2
Ensembl gene	ENSG00000163626
Ensembl biotype	protein_coding
OMIM	610428
Entrez	285521

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 4 protein_coding, 2 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000295890, ENST00000421792, ENST00000449739, ENST00000507544, ENST00000510031, ENST00000942827, ENST00000942828

RefSeq mRNA: 4 — MANE Select: NM_001297732 NM_001297732, NM_001297733, NM_001300729, NM_173827

CCDS: CCDS3554, CCDS75139

Canonical transcript exons

ENST00000507544 — 6 exons

Exon	Start	End
ENSE00001218554	73068029	73068129
ENSE00002046699	73069317	73069716
ENSE00002420283	73064778	73064902
ENSE00003464182	73061813	73061920
ENSE00003504249	73065250	73065413
ENSE00003902824	73052362	73058287

Expression profiles

Bgee: expression breadth ubiquitous, 254 present calls, max score 91.18.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 14.6640 / max 66.4794, expressed in 1809 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
52464	14.6640	1809

Top tissues by expression

258 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibia	UBERON:0000979	91.18	gold quality
pigmented layer of retina	UBERON:0001782	90.98	gold quality
retina	UBERON:0000966	90.95	gold quality
jejunal mucosa	UBERON:0000399	88.66	gold quality
oviduct epithelium	UBERON:0004804	88.61	gold quality
oral cavity	UBERON:0000167	88.44	gold quality
upper arm skin	UBERON:0004263	87.85	gold quality
germinal epithelium of ovary	UBERON:0001304	87.82	gold quality
left ventricle myocardium	UBERON:0006566	87.55	gold quality
bronchial epithelial cell	CL:0002328	87.46	gold quality
kidney epithelium	UBERON:0004819	87.27	gold quality
corpus epididymis	UBERON:0004359	87.25	gold quality
palpebral conjunctiva	UBERON:0001812	87.18	gold quality
seminal vesicle	UBERON:0000998	87.06	gold quality
bronchus	UBERON:0002185	87.05	gold quality
trabecular bone tissue	UBERON:0002483	86.97	gold quality
adult organism	UBERON:0007023	86.88	gold quality
epithelium of nasopharynx	UBERON:0001951	85.99	gold quality
parotid gland	UBERON:0001831	85.96	gold quality
caput epididymis	UBERON:0004358	85.71	gold quality
myocardium	UBERON:0002349	85.10	gold quality
mucosa of sigmoid colon	UBERON:0004993	84.86	gold quality
esophagus squamous epithelium	UBERON:0006920	84.74	gold quality
colonic mucosa	UBERON:0000317	84.51	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	84.02	gold quality
biceps brachii	UBERON:0001507	83.67	gold quality
epithelial cell of pancreas	CL:0000083	83.63	silver quality
duodenum	UBERON:0002114	83.47	gold quality
cardiac muscle of right atrium	UBERON:0003379	83.41	gold quality
monocyte	CL:0000576	83.35	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.68

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

104 targeting COX18, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-141-3P	99.94	72.79	2421
HSA-MIR-200A-3P	99.94	72.68	2420
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-338-5P	99.92	72.34	2951
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-3681-3P	99.88	70.46	2254

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 19.5% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 4)

• Both hCox18p and hCox19p present significant amino acid identity with the corresponding yeast polypeptides and reveal highly conserved functional domains. (PMID:16212937)
• COX18 mutations may be very rare or associated with other phenotypes than isolated COX deficiency in infancy. (PMID:19373256)
• COX20 stabilizes COX2 during insertion of its N-proximal transmembrane domain, and subsequently, COX18 transiently interacts with COX2 to promote translocation across the inner membrane of the COX2 C-tail that contains the apo-CuA site. The release of COX18 from this complex coincides with the binding of the SCO1-SCO2-COA6 copper metallation module to COX2-COX20 to finalize COX2 biogenesis. (PMID:28330871)
• A biallelic variant in COX18 cause isolated Complex IV deficiency associated with neonatal encephalo-cardio-myopathy and axonal sensory neuropathy. (PMID:37468577)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	cox18	ENSDARG00000102463
mus_musculus	Cox18	ENSMUSG00000035505
rattus_norvegicus	Cox18	ENSRNOG00000003052
drosophila_melanogaster	CG4942	FBGN0035960

Paralogs (1): OXA1L (ENSG00000155463)

Protein

Protein identifiers

Cytochrome c oxidase assembly protein COX18, mitochondrial — Q8N8Q8 (reviewed: Q8N8Q8)

Alternative names: Cytochrome c oxidase assembly protein 18

All UniProt accessions (2): B7ZL88, Q8N8Q8

UniProt curated annotations — full annotation on UniProt →

Function. Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT-CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT-CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase).

Subunit / interactions. Found in a complex with TMEM177, COA6, MT-CO2/COX2, COX20, SCO1 and SCO2. Interacts transiently with MT-CO2/COX2 during its maturation. Interacts with COX20 in a MT-CO2/COX2-dependent manner.

Subcellular location. Mitochondrion inner membrane.

Similarity. Belongs to the OXA1/ALB3/YidC family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q8N8Q8-1	1, Hs1	yes
Q8N8Q8-2	2, Hs2
Q8N8Q8-3	3, Hs3
Q8N8Q8-4	4

RefSeq proteins (4): NP_001284661, NP_001284662, NP_001287658, NP_776188 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001708	YidC/ALB3/OXA1/COX18	Family
IPR028055	YidC/Oxa/ALB_C	Domain

Pfam: PF02096

UniProt features (16 total): splice variant 6, topological domain 4, transmembrane region 3, transit peptide 1, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N8Q8-F1	83.42	0.68

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9864848	Complex IV assembly

MSigDB gene sets: 157 (showing top): GOBP_RESPIRATORY_CHAIN_COMPLEX_IV_ASSEMBLY, GOBP_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_ASSEMBLY, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE, GOBP_CYTOCHROME_COMPLEX_ASSEMBLY, chr4q13, GOBP_INNER_MITOCHONDRIAL_MEMBRANE_ORGANIZATION, MORI_SMALL_PRE_BII_LYMPHOCYTE_DN, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE, GOCC_MITOCHONDRIAL_ENVELOPE, GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE, WONG_MITOCHONDRIA_GENE_MODULE, GOBP_MEMBRANE_ORGANIZATION, GOBP_PROTEIN_LOCALIZATION_TO_MITOCHONDRION, GOBP_LOCALIZATION_WITHIN_MEMBRANE, GOBP_PROTEIN_INSERTION_INTO_MEMBRANE

GO Biological Process (5): respiratory chain complex IV assembly (GO:0008535), protein insertion into mitochondrial inner membrane from matrix (GO:0032979), mitochondrial respiratory chain complex IV assembly (GO:0033617), protein insertion into mitochondrial membrane (GO:0051204), protein insertion into membrane (GO:0051205)

GO Molecular Function (2): membrane insertase activity (GO:0032977), protein binding (GO:0005515)

GO Cellular Component (3): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Respiratory electron transport	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
establishment of protein localization to membrane	2
cytochrome complex assembly	1
inner mitochondrial membrane organization	1
protein insertion into mitochondrial membrane	1
mitochondrion	1
respiratory chain complex IV assembly	1
mitochondrial respiratory chain complex assembly	1
mitochondrial membrane organization	1
protein insertion into membrane	1
establishment of localization in cell	1
protein localization to mitochondrion	1
establishment of protein localization to organelle	1
intracellular protein localization	1
membrane organization	1
protein carrier activity	1
binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
cellular anatomical structure	1

Protein interactions and networks

STRING

2336 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
COX18	MT-CO2	P00403	933
COX18	COX20	Q5RI15	807
COX18	IMMT	Q16891	805
COX18	COX16	Q9P0S2	744
COX18	SCO1	O75880	702
COX18	COA6	Q5JTJ3	697
COX18	COX11	Q9Y6N1	675
COX18	COX15	Q7KZN9	668
COX18	COX17	Q14061	667
COX18	COX10	Q12887	633
COX18	COX14	Q96I36	625
COX18	SCO2	O43819	622
COX18	PET117	Q6UWS5	593
COX18	PET100	P0DJ07	588
COX18	TIMM21	Q9BVV7	571

IntAct

9 interactions, top by confidence:

A	B	Type	Score
FAM241A	NRP1	psi-mi:“MI:0914”(association)	0.530
CFTR	COX18	psi-mi:“MI:0915”(physical association)	0.370
VNN2	ATP2A1	psi-mi:“MI:0914”(association)	0.350
CHRNA4	TMEM223	psi-mi:“MI:0914”(association)	0.350
VNN1	SMAD7	psi-mi:“MI:0914”(association)	0.350
FCER1A	STX6	psi-mi:“MI:0914”(association)	0.350
GP5	SLC19A2	psi-mi:“MI:0914”(association)	0.350

BioGRID (8): COX18 (Affinity Capture-MS), COX18 (Affinity Capture-MS), COX18 (Affinity Capture-MS), COX18 (Affinity Capture-MS), COX18 (Affinity Capture-MS), COX18 (Affinity Capture-MS), COX18 (Affinity Capture-MS), COX18 (PCA)

ESM2 similar proteins: A5GZW8, A6H773, A6QPI4, D3ZAW2, O14521, O75208, P09925, Q05B67, Q08BI9, Q12887, Q15070, Q15526, Q2KHV4, Q2NL34, Q3B8P0, Q3SYV3, Q3TD49, Q4KLZ1, Q5EA03, Q5G2C6, Q5PQL3, Q5R460, Q5R5H4, Q5R7D0, Q5RC29, Q5RE99, Q5T6X4, Q5XIJ4, Q5XJY4, Q5ZIS0, Q5ZLJ4, Q68FN7, Q68FT1, Q6AZR3, Q6AZV0, Q6DGM2, Q6P355, Q6PCT8, Q800L1, Q8BSF4

Diamond homologs: A1U7J4, B4RJJ2, O94587, Q5F4W6, Q5R7D0, Q8BGA9, Q8N8Q8, Q8VC74, A4W485, C4LDZ4, O13375, O43092, P0DC86, P0DC87, P65631, Q01625, Q15070, Q3SYV3, Q42191, Q5XDY9, Q73JM1, Q82YV1, Q8DN93, Q8DVX3, Q8P2P8, Q926Q5, Q97NI6, Q9M3B7, Q9SKD3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

74 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	3
Likely pathogenic	0
Uncertain significance	56
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (3)

Variant ID	HGVS	Classification
4688185	NM_001297732.2(COX18):c.328G>C (p.Ala110Pro)	Pathogenic
4688186	NM_001297732.2(COX18):c.893G>C (p.Arg298Pro)	Pathogenic
4709507	NM_001297732.2(COX18):c.435-6A>G	Pathogenic

SpliceAI

1181 predictions. Top by Δscore:

Variant	Effect	Δscore
4:73061807:A:AC	donor_gain	1.0000
4:73061808:C:CC	donor_gain	1.0000
4:73061808:CTCA:C	donor_gain	1.0000
4:73061811:A:AC	donor_gain	1.0000
4:73061812:C:CC	donor_gain	1.0000
4:73065248:ACCTT:A	donor_loss	1.0000
4:73065249:C:CA	donor_loss	1.0000
4:73065249:CCTT:C	donor_gain	1.0000
4:73065409:TGAGC:T	acceptor_gain	1.0000
4:73065425:T:C	acceptor_gain	1.0000
4:73065425:T:TC	acceptor_gain	1.0000
4:73068554:ATT:A	donor_gain	1.0000
4:73068556:T:TA	donor_gain	1.0000
4:73068576:T:TA	donor_gain	1.0000
4:73058288:C:CC	acceptor_gain	0.9900
4:73061808:CT:C	donor_gain	0.9900
4:73061916:CAAAT:C	acceptor_gain	0.9900
4:73065276:AAATT:A	donor_gain	0.9900
4:73065410:GAGC:G	acceptor_gain	0.9900
4:73065411:AGC:A	acceptor_gain	0.9900
4:73065412:GC:G	acceptor_gain	0.9900
4:73065413:CC:C	acceptor_gain	0.9900
4:73065414:C:CC	acceptor_gain	0.9900
4:73065415:T:A	acceptor_loss	0.9900
4:73065419:T:TC	acceptor_gain	0.9900
4:73065424:G:C	acceptor_gain	0.9900
4:73065424:G:GC	acceptor_gain	0.9900
4:73068130:CTAG:C	acceptor_gain	0.9900
4:73068561:C:A	donor_gain	0.9900
4:73068592:A:AC	donor_gain	0.9900

AlphaMissense

2116 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:73058258:G:C	S286R	0.990
4:73058258:G:T	S286R	0.990
4:73058260:T:G	S286R	0.990
4:73065307:A:G	W181R	0.985
4:73065307:A:T	W181R	0.985
4:73065341:T:A	K169N	0.983
4:73065341:T:G	K169N	0.983
4:73065325:A:G	W175R	0.979
4:73065325:A:T	W175R	0.979
4:73061838:A:T	I268K	0.978
4:73058272:A:G	W282R	0.977
4:73058272:A:T	W282R	0.977
4:73064858:A:G	W214R	0.977
4:73064858:A:T	W214R	0.977
4:73064804:C:G	G232R	0.973
4:73061838:A:C	I268R	0.972
4:73064803:C:T	G232D	0.971
4:73069403:A:G	W83R	0.971
4:73069403:A:T	W83R	0.971
4:73061829:G:T	A271D	0.968
4:73069406:A:G	W82R	0.963
4:73069406:A:T	W82R	0.963
4:73065363:C:G	R162P	0.962
4:73065282:C:G	R189P	0.957
4:73065353:G:C	C165W	0.955
4:73065288:G:T	A187D	0.952
4:73064815:G:C	P228R	0.948
4:73065342:T:A	K169I	0.948
4:73064793:A:C	N235K	0.945
4:73064793:A:T	N235K	0.945

dbSNP variants (sampled 300 via entrez): RS1000028337 (4:73069276 G>A,C,T), RS1000220295 (4:73069059 C>A,G,T), RS1000592815 (4:73070624 A>G), RS1000653198 (4:73070378 G>A,C), RS1000758973 (4:73051975 A>C), RS1000905965 (4:73057694 C>A,T), RS1000924886 (4:73064392 T>G), RS1000957407 (4:73058936 CTCA>C), RS1001164192 (4:73065045 G>A,T), RS1001213901 (4:73052245 C>T), RS1001379432 (4:73063316 C>A), RS1001515170 (4:73063003 T>C), RS1001537376 (4:73069727 G>A,C,T), RS1001986676 (4:73069591 G>A,T), RS1002287144 (4:73064602 C>T)

Disease associations

OMIM: gene MIM:610428 | disease phenotypes: MIM:220110, MIM:621487, MIM:621488

GenCC curated gene-disease

Mondo (4): mitochondrial complex IV deficiency, nuclear type 1 (MONDO:0700250), mitochondrial complex 4 deficiency, nuclear type 25 (MONDO:0980970), charcot-marie-tooth disease, axonal, type 2MM (MONDO:0980971), sensorineural hearing loss disorder (MONDO:0020678)

Orphanet (0):

HPO phenotypes

57 total (30 of 57 shown, HPO-id order):

HPO	Term
HP:0000007	Autosomal recessive inheritance
HP:0000473	Torticollis
HP:0000716	Depression
HP:0001263	Global developmental delay
HP:0001271	Polyneuropathy
HP:0001272	Cerebellar atrophy
HP:0001276	Hypertonia
HP:0001290	Generalized hypotonia
HP:0001639	Hypertrophic cardiomyopathy
HP:0001712	Left ventricular hypertrophy
HP:0001716	Wolff-Parkinson-White syndrome
HP:0001761	Pes cavus
HP:0001765	Hammertoe
HP:0002015	Dysphagia
HP:0002033	Poor suck
HP:0002064	Spastic gait
HP:0002151	Increased circulating lactate concentration
HP:0002166	Impaired vibration sensation in the lower limbs
HP:0002359	Frequent falls
HP:0002421	Poor head control
HP:0003348	Hyperalaninemia
HP:0003438	Absent Achilles reflex
HP:0003487	Babinski sign
HP:0003542	Increased circulating pyruvate concentration
HP:0003596	Middle age onset
HP:0003621	Juvenile onset
HP:0003688	Cytochrome C oxidase-negative muscle fibers
HP:0004696	Talipes cavus equinovarus
HP:0005978	Type II diabetes mellitus
HP:0006858	Impaired distal proprioception

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST001066_3	Dialysis-related mortality	1.000000e-06
GCST001942_8	Prostate cancer	5.000000e-13
GCST002606_10	Prostate cancer	2.000000e-10
GCST002606_29	Prostate cancer	2.000000e-10
GCST007836_5	Glycine levels	7.000000e-13
GCST007838_4	Glycine levels	1.000000e-11
GCST008839_258	Height	3.000000e-32
GCST008839_558	Height	3.000000e-11
GCST009391_1368	Metabolite levels	8.000000e-06

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0009767	glycine measurement
EFO:0010366	lysophosphatidylethanolamine 16:0 measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression	2
GSK-J4	decreases expression	1
triphenyl phosphate	affects expression	1
glycidyl methacrylate	increases expression	1
sodium arsenite	decreases expression	1
butyraldehyde	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
Sunitinib	decreases expression	1
Acetaminophen	decreases expression	1
Air Pollutants	affects expression, increases abundance	1
Vehicle Emissions	increases expression	1
Benzo(a)pyrene	increases methylation	1
Doxorubicin	decreases expression	1
Formaldehyde	decreases expression	1
Ketoconazole	affects expression	1
Ozone	increases abundance, affects expression	1
Phenobarbital	affects expression	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	decreases expression	1
Urethane	decreases expression	1
Cyclosporine	decreases expression	1
Aflatoxin B1	decreases methylation	1
Okadaic Acid	decreases expression	1
Copper Sulfate	decreases expression	1

Clinical trials (associated diseases)

89 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT01655212	PHASE3	TERMINATED	Congenital Cytomegalovirus: Efficacy of Antiviral Treatment in a Randomized Controlled Trial
NCT02005822	PHASE3	COMPLETED	Congenital Cytomegalovirus: Efficacy of Antiviral Treatment
NCT03374514	PHASE3	UNKNOWN	Cochlear Electrical Impedance and the Effect of Topical Dexamethasone on Cochlear Implant Surgery
NCT02497690	PHASE2	COMPLETED	Effectiveness of Therapy Via Telemedicine Following Cochlear Implants
NCT03107871	PHASE2	ACTIVE_NOT_RECRUITING	Randomized Controlled Trial of Valganciclovir for Cytomegalovirus Infected Hearing Impaired Infants
NCT04120116	PHASE2	COMPLETED	FX-322 in Adults With Stable Sensorineural Hearing Loss
NCT05061758	PHASE2	WITHDRAWN	A Trial of LY3056480 in Patients With SNLH
NCT07364747	PHASE2	RECRUITING	Protective Effect of Acetylcysteine Against Cisplatinum-Induced Ototoxicity: A Randomized Controlled Trial
NCT02259595	PHASE1	COMPLETED	Study to Determine the Safety, Tolerability, and Pharmacokinetic Profile of HPN-07 and HPN-07 Plus NAC
NCT02693704	PHASE2/PHASE3	COMPLETED	Evaluation of a Binaural Spatialization Method for Hearing Aids
NCT02882477	PHASE2/PHASE3	UNKNOWN	Treatment of Wolfram Syndrome Type 2 With the Chelator Deferiprone and Incretin Based Therapy
NCT01267994	PHASE1/PHASE2	COMPLETED	A Clinical Trial of Anakinra for Steroid-Resistant Autoimmune Inner Ear Disease
NCT01902914	PHASE1/PHASE2	UNKNOWN	Effectiveness of P02 Digital Hearing Aids
NCT02038972	PHASE1/PHASE2	COMPLETED	Safety of Autologous Stem Cell Infusion for Children With Acquired Hearing Loss
NCT02616172	PHASE1/PHASE2	SUSPENDED	Autologous Bone Marrow Harvest and Transplant for Sensorineural Hearing Loss
NCT03616223	PHASE1/PHASE2	COMPLETED	FX-322 in Sensorineural Hearing Loss
NCT04129775	PHASE1/PHASE2	COMPLETED	OTO-413 in Subjects With Speech-in-Noise Hearing Impairment
NCT04462198	PHASE1/PHASE2	COMPLETED	Phase I/IIa Study Evaluating Safety and Efficacy of an Intratympanic Dose of PIPE-505 in Subjects With Hearing Loss
NCT07032038	PHASE1/PHASE2	NOT_YET_RECRUITING	First In Human Randomised Trial of Rincell-1 in Adults With a Cochlear Implant
NCT06025097	EARLY_PHASE1	COMPLETED	Intra-Tympanic Steroid With PRP Combination in Sensorineural Hearing Loss and Tinnitus.
NCT06707389	EARLY_PHASE1	NOT_YET_RECRUITING	Autologous Blood Monocyte Vesicles for the Treatment of Sudden Deafness
NCT07472023	EARLY_PHASE1	ENROLLING_BY_INVITATION	Regenerative Medicine and Stem Cell-Based Interventions for Inner Ear Trauma, Tinnitus, and Sensorineural Hearing Loss
NCT00023036	Not specified	COMPLETED	Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts
NCT00023049	Not specified	COMPLETED	Genetic Analysis of Hereditary Disorders of Hearing and Balance
NCT00261768	Not specified	COMPLETED	Efficacy of Digital Noise Reduction Strategies: A Hearing Aid Trial
NCT00589511	Not specified	COMPLETED	Nucleus Freedom Cochlear Implant System Pediatric Post-approval Study
NCT00678899	Not specified	COMPLETED	Evaluation of the Nucleus Hybrid™ L24 Cochlear Implant System
NCT00787189	Not specified	COMPLETED	Study of Low Level Laser Therapy and Word Recognition in Hearing Impaired Individuals
NCT01184248	Not specified	COMPLETED	The Effect of Sound Stimulation on Pure-tone Hearing Threshold
NCT01434446	Not specified	COMPLETED	The Effect of Sound Stimulation on Hearing Ability
NCT01749592	Not specified	COMPLETED	Single-sided Deafness and Cochlear Implants
NCT01781039	Not specified	COMPLETED	Investigation of Anatomical Correlates of Speech Discrimination
NCT02082431	Not specified	COMPLETED	Determine the Incidence of Long QT Amongst a Large Cohort of Subjects Diagnosed With Unilateral or Bilateral Sensorineural Hearing Loss.
NCT02093806	Not specified	UNKNOWN	Clinical Applications of Round Window Imaging Anatomy in Cochlear Implant Surgery
NCT02252601	Not specified	UNKNOWN	Evaluation of the High Frequency Digit Triplet Test in Cystic Fibrosis
NCT02584361	Not specified	UNKNOWN	Cochlear Implant and Vestibular Function.
NCT02638883	Not specified	COMPLETED	Implantation of the Cochlear™ Nucleus® Hybrid S Round Window (S-RW) in Adults
NCT02689349	Not specified	COMPLETED	Esteem New Subject Enrollment Post Approval Study
NCT02698787	Not specified	COMPLETED	Fundamental Asynchronous Stimulus Timing Sound Coding Study
NCT02798783	Not specified	COMPLETED	Enlarged Vestibular Aqueduct Registry