COX5B

Summary

COX5B (cytochrome c oxidase subunit 5B, HGNC:2269) is a protein-coding gene on chromosome 2q11.2, encoding Cytochrome c oxidase subunit 5B, mitochondrial (P10606). Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. It is a selective cancer dependency (DepMap: 53.1% of cell lines).

Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme.

Source: NCBI Gene 1329 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 23 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 53.1% of screened cell lines
• MANE Select transcript: NM_001862

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:2269
Approved symbol	COX5B
Name	cytochrome c oxidase subunit 5B
Location	2q11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000135940
Ensembl biotype	protein_coding
OMIM	123866
Entrez	1329

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 6 protein_coding, 2 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000258424, ENST00000464949, ENST00000491989, ENST00000494306, ENST00000867154, ENST00000867155, ENST00000867156, ENST00000923575, ENST00000961195

RefSeq mRNA: 1 — MANE Select: NM_001862 NM_001862

CCDS: CCDS2032

Canonical transcript exons

ENST00000258424 — 4 exons

Exon	Start	End
ENSE00000921817	97646062	97646189
ENSE00001907403	97647996	97648383
ENSE00003510308	97647344	97647443
ENSE00003633849	97647067	97647140

Expression profiles

Bgee: expression breadth ubiquitous, 295 present calls, max score 99.74.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 323.1226 / max 2689.2048, expressed in 1828 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
21506	320.2167	1828
21507	2.9059	557

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart right ventricle	UBERON:0002080	99.74	gold quality
apex of heart	UBERON:0002098	99.69	gold quality
vastus lateralis	UBERON:0001379	99.65	gold quality
cardiac ventricle	UBERON:0002082	99.64	gold quality
heart left ventricle	UBERON:0002084	99.63	gold quality
quadriceps femoris	UBERON:0001377	99.62	gold quality
biceps brachii	UBERON:0001507	99.62	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	99.62	gold quality
body of tongue	UBERON:0011876	99.62	gold quality
lateral nuclear group of thalamus	UBERON:0002736	99.60	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	99.60	gold quality
renal medulla	UBERON:0000362	99.57	gold quality
triceps brachii	UBERON:0001509	99.57	gold quality
right atrium auricular region	UBERON:0006631	99.57	gold quality
cardiac atrium	UBERON:0002081	99.55	gold quality
hindlimb stylopod muscle	UBERON:0004252	99.54	gold quality
skeletal muscle tissue	UBERON:0001134	99.53	gold quality
mucosa of transverse colon	UBERON:0004991	99.53	gold quality
vena cava	UBERON:0004087	99.52	gold quality
substantia nigra pars compacta	UBERON:0001965	99.49	gold quality
substantia nigra pars reticulata	UBERON:0001966	99.49	gold quality
mucosa of sigmoid colon	UBERON:0004993	99.49	gold quality
diaphragm	UBERON:0001103	99.47	gold quality
myocardium	UBERON:0002349	99.47	gold quality
heart	UBERON:0000948	99.45	gold quality
colonic mucosa	UBERON:0000317	99.44	gold quality
gastrocnemius	UBERON:0001388	99.43	gold quality
Brodmann (1909) area 9	UBERON:0013540	99.43	gold quality
deltoid	UBERON:0001476	99.41	gold quality
muscle organ	UBERON:0001630	99.41	gold quality

Single-cell (SCXA)

Detected in 8 experiment(s), a significant marker in 6.

Experiment	Marker?	Max mean expression
E-MTAB-8410	yes	55.83
E-HCAD-10	yes	31.18
E-MTAB-10042	yes	11.71
E-CURD-114	yes	10.28
E-MTAB-7316	yes	8.76
E-MTAB-6819	no	686.11
E-GEOD-110499	no	287.22
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): PPARGC1A, SP1, USF2, YY1

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 53.1% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 7)

• Data show that Bcl-2 expression positively influences the targeting of nuclear-encoded COX Va and Vb to the mitochondria of cancer cells. (PMID:19834492)
• Transfected the A549 cells with COX Vb small interfering or shRNA and observed a significant reduction of their COX activity, oxygen consumption, ATP and ability to grow in soft agar and as poorly differentiated tumors in athymic mice. (PMID:22917272)
• silence of COX5B leads to metabolic disorders, such as increased glucose uptake and decreased lactate secretion (PMID:26506233)
• Our results suggest that COX5B protein level might be associated with tumor size. COX5B overexpression indicated a worse DFS (p < 0.05) in breast cancer. (PMID:28592145)
• These experiments suggest that the FAD group of cytochrome b5 reductase increase its solvent exposition upon complex formation promoting an efficient electron transfer between the proteins. (PMID:29111436)
• Systematic expression analysis of the mitochondrial respiratory chain protein subunits identifies COX5B as a prognostic marker in clear cell renal cell carcinoma. (PMID:31280487)
• Heart proteomic profiling discovers MYH6 and COX5B as biomarkers for sudden unexplained death. (PMID:38971138)

Cross-species orthologs

8 orthologs

Organism	Symbol	Gene ID
danio_rerio	cox5ba	ENSDARG00000015978
danio_rerio	cox5b2	ENSDARG00000068738
danio_rerio	cox5bb	ENSDARG00000113254
mus_musculus	Cox5b	ENSMUSG00000061518
mus_musculus	Cox5b-ps	ENSMUSG00000079941
rattus_norvegicus	Cox5b	ENSRNOG00000016660
drosophila_melanogaster	COX5B	FBGN0031830
drosophila_melanogaster	COX5BL	FBGN0031831

Protein

Protein identifiers

Cytochrome c oxidase subunit 5B, mitochondrial — P10606 (reviewed: P10606)

Alternative names: Cytochrome c oxidase polypeptide Vb

All UniProt accessions (2): A0A384NL93, P10606

UniProt curated annotations — full annotation on UniProt →

Function. Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Subunit / interactions. Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I1 (or COX4I2), COX5A, COX5B, COX6A1 (or COX6A2), COX6B1 (or COX6B2), COX6C, COX7A2 (or COX7A1), COX7B, COX7C, COX8A and COXFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).

Subcellular location. Mitochondrion inner membrane.

Pathway. Energy metabolism; oxidative phosphorylation.

Similarity. Belongs to the cytochrome c oxidase subunit 5B family.

RefSeq proteins (1): NP_001853* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002124	Cyt_c_oxidase_su5b	Family
IPR036972	Cyt_c_oxidase_su5b_sf	Homologous_superfamily

Pfam: PF01215

UniProt features (11 total): binding site 4, modified residue 3, sequence conflict 2, transit peptide 1, chain 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
9I6F	ELECTRON MICROSCOPY	2.95
9I7U	ELECTRON MICROSCOPY	3.15
5Z62	ELECTRON MICROSCOPY	3.6

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P10606-F1	85.75	0.69

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 91; 93; 113; 116

Post-translational modifications (3): 68, 86, 121

Function

Pathways and Gene Ontology

Reactome pathways

5 pathways

ID	Pathway
R-HSA-5628897	TP53 Regulates Metabolic Genes
R-HSA-611105	Respiratory electron transport
R-HSA-9707564	Cytoprotection by HMOX1
R-HSA-9837999	Mitochondrial protein degradation
R-HSA-9864848	Complex IV assembly

MSigDB gene sets: 196 (showing top): MODULE_93, GOBP_RESPIRATORY_GASEOUS_EXCHANGE_BY_RESPIRATORY_SYSTEM, MODULE_151, ENK_UV_RESPONSE_KERATINOCYTE_UP, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, MORF_UBE2I, MORF_HDAC1, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN, THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN, DARWICHE_SKIN_TUMOR_PROMOTER_UP, DARWICHE_PAPILLOMA_RISK_LOW_UP, DARWICHE_PAPILLOMA_RISK_HIGH_UP, DARWICHE_SQUAMOUS_CELL_CARCINOMA_UP, TGACCTY_ERR1_Q2, GOBP_MONOATOMIC_CATION_TRANSPORT

GO Biological Process (5): mitochondrial electron transport, cytochrome c to oxygen (GO:0006123), respiratory gaseous exchange by respiratory system (GO:0007585), cellular respiration (GO:0045333), oxidative phosphorylation (GO:0006119), proton transmembrane transport (GO:1902600)

GO Molecular Function (3): cytochrome-c oxidase activity (GO:0004129), metal ion binding (GO:0046872), protein binding (GO:0005515)

GO Cellular Component (7): acrosomal vesicle (GO:0001669), mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial membrane (GO:0031966), respiratory chain complex IV (GO:0045277), mitochondrial envelope (GO:0005740), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
Transcriptional Regulation by TP53	1
Aerobic respiration and respiratory electron transport	1
Cellular response to chemical stress	1
Metabolism of proteins	1
Respiratory electron transport	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
mitochondrion	2
aerobic electron transport chain	1
mitochondrial ATP synthesis coupled electron transport	1
multicellular organismal process	1
energy derivation by oxidation of organic compounds	1
aerobic respiration	1
proton motive force-driven ATP synthesis	1
monoatomic cation transmembrane transport	1
electron transfer activity	1
proton transmembrane transporter activity	1
oxidoreduction-driven active transmembrane transporter activity	1
oxidoreductase activity, acting on a heme group of donors	1
active monoatomic ion transmembrane transporter activity	1
cation binding	1
binding	1
secretory granule	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
mitochondrial envelope	1
organelle membrane	1
cytochrome complex	1
respiratory chain complex	1
transmembrane transporter complex	1
oxidoreductase complex	1
organelle envelope	1
cellular anatomical structure	1

Protein interactions and networks

STRING

2348 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
COX5B	COX6C	P09669	991
COX5B	COX5A	P20674	988
COX5B	COX7C	P15954	983
COX5B	COX7B	P24311	970
COX5B	COX6B1	P14854	968
COX5B	COX6A1	P12074	966
COX5B	COX8A	P10176	965
COX5B	COX4I1	P13073	935
COX5B	COX6A2	Q02221	924
COX5B	COX7A1	P24310	883
COX5B	CYCS	P00001	880
COX5B	COX4I2	Q96KJ9	869
COX5B	UQCRC1	P31930	827
COX5B	ATP5PO	P48047	783
COX5B	MT-CO1	P00395	781

IntAct

215 interactions, top by confidence:

A	B	Type	Score
COX5B	CDR2	psi-mi:“MI:0915”(physical association)	0.780
CDR2	COX5B	psi-mi:“MI:0915”(physical association)	0.780
TRIM23	COX5B	psi-mi:“MI:0915”(physical association)	0.740
COX5B	TRIM23	psi-mi:“MI:0915”(physical association)	0.740
BHLHE40	COX5B	psi-mi:“MI:0915”(physical association)	0.670
COX5B	IHO1	psi-mi:“MI:0915”(physical association)	0.670
TFIP11	COX5B	psi-mi:“MI:0915”(physical association)	0.670
COX5B	BHLHE40	psi-mi:“MI:0915”(physical association)	0.670
COX5B	TFIP11	psi-mi:“MI:0915”(physical association)	0.670
COX5B	TASOR2	psi-mi:“MI:0915”(physical association)	0.670
COX5B	HTT	psi-mi:“MI:0915”(physical association)	0.670
RAC1	COX6C	psi-mi:“MI:0914”(association)	0.640
UQCRB	COX7A2L	psi-mi:“MI:0914”(association)	0.640

BioGRID (196): COX5B (Two-hybrid), COX5B (Two-hybrid), KRT15 (Two-hybrid), KRT31 (Two-hybrid), TRAF1 (Two-hybrid), BHLHE40 (Two-hybrid), PNMA1 (Two-hybrid), TFIP11 (Two-hybrid), CCDC36 (Two-hybrid), COX5B (Affinity Capture-RNA), COX5B (Affinity Capture-RNA), COX5B (Affinity Capture-RNA), COX5B (Co-fractionation), COX5B (Co-fractionation), COX5B (Co-fractionation)

ESM2 similar proteins: A3KMZ6, A5EAA0, A6QLP2, B3NYF7, B3QF26, B4H303, B4IMF6, B4PZ52, B4R3T1, B5DKJ8, C5DKX0, D3ZS74, O35658, O35796, P00257, P00258, P00428, P10606, P12075, P19516, P19536, P22185, P24483, P46656, P54150, P56939, Q07021, Q08C57, Q0V6R0, Q13CY3, Q19293, Q2IR93, Q32PH2, Q3T0B6, Q5R7U6, Q5REG2, Q5S3G4, Q68FL4, Q6P8I6, Q710D6

Diamond homologs: P00428, P04037, P06809, P10606, P12075, P19536, P79010, P80330, Q5REG2, Q5S3G4, Q710D6, Q9LW15, Q9SSB8, Q9SSS5, P29505

SIGNOR signaling

5 interactions.

A	Effect	B	Mechanism
PPARGC1A	“up-regulates quantity by expression”	COX5B	“transcriptional regulation”
COX5B	up-regulates	Oxidative_phosphorylation
COX5B	down-regulates	Skeletal_muscle_differentiation
COX5B	down-regulates	Cell_cycle_exit
COX5B	“form complex”	“Cytochrome c oxidase-Mitochondrial respiratory chain complex IV”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 135 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Complex IV assembly	11	28.9×	2e-11
Cytoprotection by HMOX1	8	16.9×	2e-06
Respiratory electron transport	15	16.4×	5e-12
TP53 Regulates Metabolic Genes	10	14.9×	2e-07
Mitochondrial protein degradation	9	11.8×	5e-06

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial electron transport, cytochrome c to oxygen	9	60.0×	1e-11
cellular respiration	9	33.8×	2e-09
generation of precursor metabolites and energy	5	14.9×	5e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

23 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	16
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

375 predictions. Top by Δscore:

Variant	Effect	Δscore
2:97647062:TTTAG:T	acceptor_loss	1.0000
2:97647064:TAGGT:T	acceptor_loss	1.0000
2:97647065:A:AG	acceptor_gain	1.0000
2:97647065:AGGT:A	acceptor_gain	1.0000
2:97647066:G:GC	acceptor_loss	1.0000
2:97647066:G:GG	acceptor_gain	1.0000
2:97647066:GGT:G	acceptor_gain	1.0000
2:97647066:GGTG:G	acceptor_gain	1.0000
2:97647136:GACTG:G	donor_gain	1.0000
2:97647138:CTGGT:C	donor_loss	1.0000
2:97647139:TGGT:T	donor_loss	1.0000
2:97647140:GGT:G	donor_loss	1.0000
2:97647141:G:GG	donor_gain	1.0000
2:97647141:GTAA:G	donor_loss	1.0000
2:97647142:T:A	donor_loss	1.0000
2:97647330:T:TA	acceptor_gain	1.0000
2:97647439:CATCT:C	donor_gain	1.0000
2:97647440:ATCTG:A	donor_loss	1.0000
2:97647441:TCT:T	donor_gain	1.0000
2:97647442:CT:C	donor_gain	1.0000
2:97647442:CTGTA:C	donor_loss	1.0000
2:97647443:TG:T	donor_loss	1.0000
2:97647444:G:A	donor_loss	1.0000
2:97647444:G:GG	donor_gain	1.0000
2:97647445:T:G	donor_loss	1.0000
2:97647446:AAGTA:A	donor_loss	1.0000
2:97646187:G:GT	donor_gain	0.9900
2:97646389:A:T	donor_gain	0.9900
2:97646404:G:GT	donor_gain	0.9900
2:97647065:AG:A	acceptor_gain	0.9900

AlphaMissense

816 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:97647405:T:A	V80D	0.991
2:97648025:T:C	F103L	0.986
2:97648027:T:A	F103L	0.986
2:97648027:T:G	F103L	0.986
2:97647093:G:C	A44P	0.985
2:97648022:T:A	W102R	0.983
2:97648022:T:C	W102R	0.983
2:97648026:T:C	F103S	0.978
2:97647427:A:C	R87S	0.976
2:97647427:A:T	R87S	0.976
2:97647435:G:A	G90D	0.976
2:97647437:T:A	C91S	0.976
2:97647438:G:C	C91S	0.976
2:97647410:T:C	S82P	0.971
2:97648055:T:C	C113R	0.970
2:97648024:G:C	W102C	0.967
2:97648024:G:T	W102C	0.967
2:97647432:T:A	V89E	0.966
2:97647100:G:A	G46E	0.965
2:97647437:T:C	C91R	0.965
2:97648076:T:G	Y120D	0.965
2:97648055:T:A	C113S	0.964
2:97648056:G:C	C113S	0.964
2:97648017:T:A	V100D	0.962
2:97648064:T:A	C116S	0.958
2:97648065:G:C	C116S	0.958
2:97647434:G:C	G90R	0.953
2:97648064:T:C	C116R	0.952
2:97647438:G:A	C91Y	0.950
2:97647411:C:T	S82F	0.946

dbSNP variants (sampled 300 via entrez): RS1000155022 (2:97646859 A>G), RS1001217359 (2:97645856 C>A,T), RS1001316585 (2:97644802 T>A), RS1001681184 (2:97645209 C>A), RS1002008531 (2:97646244 C>A), RS1002038180 (2:97644493 T>A), RS1002387531 (2:97644897 T>G), RS1002759779 (2:97648437 A>G), RS1002987268 (2:97646050 C>A,G,T), RS1003682933 (2:97647738 G>A,T), RS1004143280 (2:97646623 A>G), RS1004387017 (2:97647658 G>C), RS1004477477 (2:97648248 A>C,T), RS1004780628 (2:97647907 G>A,T), RS1006793582 (2:97645958 G>A,C)

Disease associations

OMIM: gene MIM:123866 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST008103_128	Bipolar disorder	2.000000e-06
GCST010697_1	Cortical surface area (min-P)	6.000000e-12
GCST010698_17	Subcortical volume (min-P)	9.000000e-09
GCST010699_105	Brain morphology (min-P)	2.000000e-11
GCST010700_9	Cortical thickness (MOSTest)	9.000000e-14
GCST010701_54	Cortical surface area (MOSTest)	2.000000e-16
GCST010702_79	Subcortical volume (MOSTest)	5.000000e-09
GCST010703_322	Brain morphology (MOSTest)	1.000000e-10

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004346	neuroimaging measurement
EFO:0004840	cortical thickness

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066966 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

46 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects expression, decreases expression, increases expression	3
tris(2-butoxyethyl) phosphate	increases expression, decreases expression, increases abundance	2
chloropicrin	affects expression, decreases expression	2
Vorinostat	increases expression	2
Atrazine	affects expression, decreases expression	2
Benzo(a)pyrene	decreases expression, decreases methylation	2
Cadmium	increases abundance, increases expression, decreases expression	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression, increases expression	2
Particulate Matter	affects expression, increases abundance, decreases expression	2
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
deoxynivalenol	decreases expression	1
trichostatin A	increases expression	1
arsenite	affects binding, increases reaction	1
methylparaben	decreases expression	1
tetrathiomolybdate	increases expression	1
perfluorooctanoic acid	decreases expression	1
ochratoxin A	increases expression	1
myricetin	increases expression	1
1-methyl-4-phenyl-2,3-dihydropyridinium	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
3-(4’-hydroxy-3’-adamantylbiphenyl-4-yl)acrylic acid	decreases expression	1
LDN 193189	affects cotreatment, decreases expression	1
bisphenol AF	increases expression	1
Temozolomide	decreases expression	1
Decitabine	increases expression	1
Air Pollutants	affects expression, increases abundance	1
Succimer	affects cotreatment, decreases expression	1
Environmental Pollutants	affects expression	1
Estradiol	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651172	Binding	Binding affinity to human COX5B incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.