COX7A2

Summary

COX7A2 (cytochrome c oxidase subunit 7A2, HGNC:2288) is a protein-coding gene on chromosome 6q14.1, encoding Cytochrome c oxidase subunit 7A2, mitochondrial (P14406). Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14.

Source: NCBI Gene 1347 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 34 total — 1 pathogenic
• MANE Select transcript: NM_001366293

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:2288
Approved symbol	COX7A2
Name	cytochrome c oxidase subunit 7A2
Location	6q14.1
Locus type	gene with protein product
Status	Approved
Aliases	COXVIIa-L, COX7AL
Ensembl gene	ENSG00000112695
Ensembl biotype	protein_coding
OMIM	123996
Entrez	1347

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 20 protein_coding, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000370081, ENST00000370089, ENST00000377978, ENST00000459637, ENST00000460985, ENST00000472311, ENST00000481061, ENST00000509698, ENST00000684430, ENST00000899321, ENST00000899322, ENST00000899323, ENST00000899324, ENST00000940716, ENST00000940717, ENST00000940718, ENST00000940719, ENST00000940720, ENST00000940721, ENST00000940722, ENST00000940723, ENST00000940724

RefSeq mRNA: 3 — MANE Select: NM_001366293 NM_001366292, NM_001366293, NM_001865

CCDS: CCDS34486

Canonical transcript exons

ENST00000684430 — 4 exons

Exon	Start	End
ENSE00001878090	75243717	75243801
ENSE00002040866	75241176	75241265
ENSE00003617043	75237787	75237988
ENSE00003789817	75240301	75240385

Expression profiles

Bgee: expression breadth ubiquitous, 295 present calls, max score 99.95.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 92.5621 / max 679.9277, expressed in 1822 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
74459	92.5421	1822
74460	0.0150	3
74461	0.0050	3

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endothelial cell	CL:0000115	99.95	gold quality
left testis	UBERON:0004533	99.84	gold quality
right testis	UBERON:0004534	99.84	gold quality
adult organism	UBERON:0007023	99.80	gold quality
pancreatic ductal cell	CL:0002079	99.76	gold quality
heart right ventricle	UBERON:0002080	99.73	gold quality
Brodmann (1909) area 23	UBERON:0013554	99.69	gold quality
sperm	CL:0000019	99.64	gold quality
male germ cell	CL:0000015	99.62	gold quality
apex of heart	UBERON:0002098	99.61	gold quality
primary visual cortex	UBERON:0002436	99.61	gold quality
esophagus squamous epithelium	UBERON:0006920	99.61	gold quality
colonic mucosa	UBERON:0000317	99.56	gold quality
prefrontal cortex	UBERON:0000451	99.56	gold quality
lateral nuclear group of thalamus	UBERON:0002736	99.56	gold quality
mucosa of sigmoid colon	UBERON:0004993	99.55	gold quality
jejunal mucosa	UBERON:0000399	99.53	gold quality
mucosa of transverse colon	UBERON:0004991	99.53	gold quality
palpebral conjunctiva	UBERON:0001812	99.50	gold quality
oral cavity	UBERON:0000167	99.49	gold quality
rectum	UBERON:0001052	99.49	gold quality
gingival epithelium	UBERON:0001949	99.49	gold quality
hair follicle	UBERON:0002073	99.48	gold quality
cardiac ventricle	UBERON:0002082	99.48	gold quality
heart left ventricle	UBERON:0002084	99.48	gold quality
islet of Langerhans	UBERON:0000006	99.47	gold quality
epithelium of esophagus	UBERON:0001976	99.47	gold quality
amygdala	UBERON:0001876	99.46	gold quality
epithelium of nasopharynx	UBERON:0001951	99.46	gold quality
occipital lobe	UBERON:0002021	99.46	gold quality

Single-cell (SCXA)

Detected in 17 experiment(s), a significant marker in 9.

Experiment	Marker?	Max mean expression
E-GEOD-134144	yes	6092.53
E-MTAB-8410	yes	45.16
E-HCAD-1	yes	39.25
E-MTAB-9467	yes	30.45
E-MTAB-7316	yes	22.32
E-HCAD-11	yes	19.61
E-MTAB-10042	yes	11.50
E-MTAB-8142	yes	10.58
E-HCAD-5	no	1959.01
E-MTAB-7303	no	1676.07
E-MTAB-10596	no	990.75
E-MTAB-8060	no	979.00
E-GEOD-83139	no	770.64
E-CURD-53	no	548.71
E-HCAD-30	no	315.29

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

32 targeting COX7A2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-7152-3P	99.97	67.47	849
HSA-MIR-106A-5P	99.90	73.94	2683
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-17-5P	99.89	73.83	2665
HSA-MIR-106B-5P	99.88	74.72	2795
HSA-MIR-20A-5P	99.88	74.76	2769
HSA-MIR-20B-5P	99.88	74.01	2621
HSA-MIR-519D-3P	99.88	73.97	2607
HSA-MIR-526B-3P	99.88	74.06	2587
HSA-MIR-93-5P	99.88	73.98	2606
HSA-MIR-548AU-3P	99.70	68.22	1373
HSA-MIR-3609	99.52	69.89	2587
HSA-MIR-548AH-5P	99.52	69.73	2626
HSA-MIR-4460	99.37	68.52	615
HSA-MIR-6882-5P	99.35	71.13	1206
HSA-MIR-3160-5P	99.28	69.07	1938
HSA-MIR-3688-5P	99.12	69.67	1091
HSA-MIR-4796-3P	99.08	68.38	1681
HSA-MIR-3160-3P	99.07	64.78	955
HSA-MIR-4478	99.07	65.16	2320
HSA-MIR-4738-3P	98.98	67.98	1846
HSA-MIR-361-5P	98.95	70.16	1340
HSA-MIR-374A-3P	98.87	67.82	1531
HSA-MIR-4724-5P	98.87	67.75	1324
HSA-MIR-5197-3P	98.71	67.05	1905
HSA-MIR-640	98.44	66.93	644
HSA-MIR-224-5P	98.33	70.12	1256
HSA-MIR-4642	97.52	67.60	916
HSA-MIR-4727-3P	96.75	64.97	415

Literature-anchored findings (GeneRIF, showing 2)

• COX7A2, TAGLN2 and S100-A10 as novel prognostic markers in Barrett’s adenocarcinoma. (PMID:22365974)
• Overexpression of COX7A2 is associated with a good prognosis in patients with glioma. Results suggest that COX7A2 could be served as a valuable prognostic marker of glioma. (PMID:29079956)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	cox7a2a	ENSDARG00000053217
danio_rerio	COX7A2	ENSDARG00000110700
mus_musculus	Cox7a2	ENSMUSG00000032330
rattus_norvegicus	AABR07012587.1	ENSRNOG00000002223
rattus_norvegicus	Cox7a2	ENSRNOG00000042903
drosophila_melanogaster	COX7AL	FBGN0037579
drosophila_melanogaster	COX7AL2	FBGN0085201

Paralogs (2): COX7A2L (ENSG00000115944), COX7A1 (ENSG00000161281)

Protein

Protein identifiers

Cytochrome c oxidase subunit 7A2, mitochondrial — P14406 (reviewed: P14406)

Alternative names: Cytochrome c oxidase subunit VIIa-liver/heart

All UniProt accessions (7): P14406, D6R9C3, D6RA35, D6RGV5, D6RIE3, H0UI06, H0Y8S6

UniProt curated annotations — full annotation on UniProt →

Function. Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Subunit / interactions. Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I1 (or COX4I2), COX5A, COX5B, COX6A1 (or COX6A2), COX6B1 (or COX6B2), COX6C, COX7A2 (or COX7A1), COX7B, COX7C, COX8A and COXFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with PET100.

Subcellular location. Mitochondrion inner membrane.

Pathway. Energy metabolism; oxidative phosphorylation.

Similarity. Belongs to the cytochrome c oxidase VIIa family.

RefSeq proteins (3): NP_001353221, NP_001353222, NP_001856 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003177	Cytc_oxidase_su7a_met	Family
IPR036539	Cyt_c_oxidase_su7a_sf	Homologous_superfamily
IPR039297	COX7a	Family

Pfam: PF02238

UniProt features (7 total): topological domain 2, transit peptide 1, chain 1, transmembrane region 1, modified residue 1, sequence variant 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
9I6F	ELECTRON MICROSCOPY	2.95
9I7U	ELECTRON MICROSCOPY	3.15
5Z62	ELECTRON MICROSCOPY	3.6

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P14406-F1	87.99	0.63

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 33

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-5628897	TP53 Regulates Metabolic Genes
R-HSA-611105	Respiratory electron transport
R-HSA-9707564	Cytoprotection by HMOX1
R-HSA-9864848	Complex IV assembly

MSigDB gene sets: 198 (showing top): MODULE_93, MODULE_151, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, HSIAO_HOUSEKEEPING_GENES, GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY, GGAANCGGAANY_UNKNOWN, GOBP_OXIDATIVE_PHOSPHORYLATION, WCTCNATGGY_UNKNOWN, GOBP_ELECTRON_TRANSPORT_CHAIN, KEGG_HUNTINGTONS_DISEASE, MODULE_307, GOCC_MITOCHONDRIAL_ENVELOPE, SCHLOSSER_SERUM_RESPONSE_DN, WONG_MITOCHONDRIA_GENE_MODULE, GOBP_CELLULAR_RESPIRATION

GO Biological Process (4): oxidative phosphorylation (GO:0006119), mitochondrial electron transport, cytochrome c to oxygen (GO:0006123), cellular respiration (GO:0045333), proton transmembrane transport (GO:1902600)

GO Molecular Function (3): oxidoreductase activity (GO:0016491), cytochrome-c oxidase activity (GO:0004129), protein binding (GO:0005515)

GO Cellular Component (6): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial membrane (GO:0031966), respiratory chain complex IV (GO:0045277), respiratory chain complex (GO:0098803), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
Transcriptional Regulation by TP53	1
Aerobic respiration and respiratory electron transport	1
Cellular response to chemical stress	1
Respiratory electron transport	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
aerobic respiration	1
proton motive force-driven ATP synthesis	1
aerobic electron transport chain	1
mitochondrial ATP synthesis coupled electron transport	1
energy derivation by oxidation of organic compounds	1
monoatomic cation transmembrane transport	1
catalytic activity	1
electron transfer activity	1
proton transmembrane transporter activity	1
oxidoreduction-driven active transmembrane transporter activity	1
oxidoreductase activity, acting on a heme group of donors	1
active monoatomic ion transmembrane transporter activity	1
binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
mitochondrion	1
mitochondrial envelope	1
organelle membrane	1
cytochrome complex	1
respiratory chain complex	1
transmembrane transporter complex	1
oxidoreductase complex	1
protein-containing complex	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1781 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
COX7A2	COX6A1	P12074	927
COX7A2	COX6B1	P14854	805
COX7A2	COX5B	P10606	779
COX7A2	COXFA4	O00483	755
COX7A2	COX6C	P09669	735
COX7A2	COX8A	P10176	705
COX7A2	COX7B	P24311	687
COX7A2	UQCRH	P07919	678
COX7A2	COX4I1	P13073	678
COX7A2	ATP5ME	P56385	654
COX7A2	COX8C	Q7Z4L0	652
COX7A2	COX4I2	Q96KJ9	649
COX7A2	COX7C	P15954	647
COX7A2	COX5A	P20674	642
COX7A2	NDUFAB1	O14561	631

IntAct

81 interactions, top by confidence:

A	B	Type	Score
NDUFS3	NDUFS8	psi-mi:“MI:0914”(association)	0.730
COX7A2	COX6B1	psi-mi:“MI:0914”(association)	0.640
COX7A2	MEOX2	psi-mi:“MI:0915”(physical association)	0.560
MT-CO2	COX6C	psi-mi:“MI:0915”(physical association)	0.560
CNDP1	POTEF	psi-mi:“MI:0914”(association)	0.530
UQCRFS1	NDUFAB1	psi-mi:“MI:0914”(association)	0.530
COX5B	COX7A2L	psi-mi:“MI:0914”(association)	0.530
COX7A2	COX4I1	psi-mi:“MI:0914”(association)	0.480
FOXH1	DDX39A	psi-mi:“MI:0914”(association)	0.350
HSCB	RBP5	psi-mi:“MI:0914”(association)	0.350
K8.1	EXOC5	psi-mi:“MI:0914”(association)	0.350
COX15	SNRPGP15	psi-mi:“MI:0914”(association)	0.350
SOAT1	SNRPGP15	psi-mi:“MI:0914”(association)	0.350
VDAC1	SNRPGP15	psi-mi:“MI:0914”(association)	0.350
Prdm16	ESYT2	psi-mi:“MI:0914”(association)	0.350
Mecom	ESYT2	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
CD177	MYO1G	psi-mi:“MI:0914”(association)	0.350
NMES1	NDUFS8	psi-mi:“MI:0914”(association)	0.350
CHCHD10	TIMM44	psi-mi:“MI:0914”(association)	0.350
CISD3	POLRMT	psi-mi:“MI:0914”(association)	0.350
COX6B1	COX7A2L	psi-mi:“MI:0914”(association)	0.350
NDUFA4	NUDT19	psi-mi:“MI:0914”(association)	0.350
NDUFS3	ACOT7	psi-mi:“MI:0914”(association)	0.350
PTPMT1	TIMM44	psi-mi:“MI:0914”(association)	0.350
COX6B1	NDUFS4	psi-mi:“MI:0914”(association)	0.350

BioGRID (134): COX7A2 (Affinity Capture-MS), COX7A2 (Affinity Capture-MS), COX7A2 (Affinity Capture-RNA), COX7A2 (Affinity Capture-MS), COX7A2 (Affinity Capture-MS), COX7A2 (Affinity Capture-MS), COX7A2 (Affinity Capture-MS), COX7A2 (Affinity Capture-MS), COX7A2 (Affinity Capture-MS), COX7A2 (Affinity Capture-MS), COX7A2 (Affinity Capture-MS), COX7A2 (Affinity Capture-MS), COX7A2 (Affinity Capture-MS), COX7A2 (Affinity Capture-MS), COX6B1 (Affinity Capture-MS)

ESM2 similar proteins: A1XQS2, A4IJ20, F6QZ15, O14548, O60397, P0CU26, P13183, P14406, P24310, P34660, P46269, P56392, Q0V9J0, Q17ED3, Q290M9, Q2KI08, Q2M2S2, Q3T061, Q4QQV3, Q4R6H1, Q4VC39, Q5R504, Q5RE99, Q5REP2, Q5XIJ4, Q5XKA2, Q5ZML6, Q61387, Q64445, Q7JX57, Q7QHP6, Q7SXI1, Q7Z4L0, Q8BGY7, Q8BTC1, Q91W29, Q91Y94, Q99KD6, Q9BUB7, Q9BVV7

Diamond homologs: O14548, O60397, P07470, P13184, P14406, P24310, P35171, P48771, P56392, Q08CE7, Q3T061, Q53CF6, Q61387, Q7SXI1, Q8SPJ9, Q99KD6, Q9N234, Q9TR29, Q9VHS2, Q9TR28, Q9TR30, Q9TRZ8, P80333

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
COX7A2	“form complex”	“Cytochrome c oxidase-Mitochondrial respiratory chain complex IV”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 94 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Complex IV assembly	9	28.9×	4e-09
Cytoprotection by HMOX1	8	20.8×	6e-07
Respiratory electron transport	12	16.1×	4e-09
TP53 Regulates Metabolic Genes	7	12.8×	1e-04
Complex I biogenesis	5	11.7×	6e-03

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial electron transport, cytochrome c to oxygen	8	73.8×	7e-11
cellular respiration	6	31.2×	2e-05
mitochondrial electron transport, NADH to ubiquinone	5	21.6×	1e-03
positive regulation of miRNA transcription	5	17.5×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

34 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	20
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
625706	GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367)	Pathogenic

SpliceAI

965 predictions. Top by Δscore:

Variant	Effect	Δscore
6:75240392:T:C	acceptor_gain	1.0000
6:75237986:TTCC:T	acceptor_loss	0.9900
6:75237987:TCC:T	acceptor_loss	0.9900
6:75237988:CCT:C	acceptor_loss	0.9900
6:75237989:C:CA	acceptor_loss	0.9900
6:75237989:C:CC	acceptor_gain	0.9900
6:75240258:CTA:C	donor_gain	0.9900
6:75240259:TAT:T	donor_gain	0.9900
6:75240294:GCCTT:G	donor_loss	0.9900
6:75240295:CCTTA:C	donor_loss	0.9900
6:75240296:CTTAC:C	donor_loss	0.9900
6:75240297:TTA:T	donor_loss	0.9900
6:75240298:T:TA	donor_loss	0.9900
6:75240299:A:G	donor_loss	0.9900
6:75240300:C:CT	donor_gain	0.9900
6:75240300:C:T	donor_loss	0.9900
6:75240300:CCA:C	donor_gain	0.9900
6:75240381:TCCTC:T	acceptor_gain	0.9900
6:75240382:CCTCC:C	acceptor_gain	0.9900
6:75240384:TCCTA:T	acceptor_loss	0.9900
6:75240386:C:CA	acceptor_loss	0.9900
6:75240387:T:C	acceptor_loss	0.9900
6:75240391:T:TC	acceptor_gain	0.9900
6:75240392:T:TC	acceptor_gain	0.9900
6:75241174:A:AG	donor_loss	0.9900
6:75241175:CCT:C	donor_loss	0.9900
6:75241176:C:G	donor_loss	0.9900
6:75241263:AGCC:A	acceptor_loss	0.9900
6:75241264:GCC:G	acceptor_loss	0.9900
6:75241266:C:CC	acceptor_gain	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000423744 (6:75243162 T>A,C), RS1000610325 (6:75247761 C>A), RS1001183423 (6:75243657 C>A,T), RS1001350484 (6:75249974 A>T), RS1001418760 (6:75248430 C>G), RS1001470430 (6:75249807 G>A), RS1001671718 (6:75238068 T>C), RS1002114334 (6:75237303 AG>A), RS1002205914 (6:75237534 G>A), RS1002399741 (6:75248811 G>A), RS1002612316 (6:75251340 A>G), RS1002685119 (6:75249700 T>C), RS1002855318 (6:75244824 C>A,G), RS1003244002 (6:75245109 A>G), RS1003296108 (6:75244875 C>T)

Disease associations

OMIM: gene MIM:123996 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

44 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects cotreatment, decreases expression, increases expression	4
Acetaminophen	affects cotreatment, decreases expression, increases expression	3
bisphenol A	decreases expression	2
tris(2-butoxyethyl) phosphate	increases abundance, increases expression, decreases expression	2
Air Pollutants	decreases expression, increases abundance	2
Tretinoin	affects cotreatment, decreases expression, increases expression	2
Particulate Matter	increases abundance, decreases expression	2
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	affects expression, affects response to substance	1
arsenite	affects binding, increases reaction	1
perfluorooctanoic acid	decreases expression	1
tris(chloroethyl)phosphate	decreases expression, increases abundance	1
arsenic trichloride	affects cotreatment, decreases expression, increases abundance	1
CD 437	decreases expression	1
chloropicrin	affects expression	1
corosolic acid	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
3-(4’-hydroxy-3’-adamantylbiphenyl-4-yl)acrylic acid	decreases expression	1
ICG 001	increases expression	1
bisphenol B	increases expression	1
LDN 193189	affects cotreatment, decreases expression	1
bisphenol AF	increases expression	1
Sunitinib	decreases expression	1
Arsenic	decreases expression, increases abundance, affects cotreatment	1
Atrazine	decreases expression	1
Benzo(a)pyrene	affects methylation	1
Copper	decreases expression, increases abundance, affects cotreatment	1
Cyclophosphamide	decreases expression	1
Doxorubicin	affects expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2V2	Abcam HEK293T COX7A2 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.