COX7B

Summary

COX7B (cytochrome c oxidase subunit 7B, HGNC:2291) is a protein-coding gene on chromosome Xq21.1, encoding Cytochrome c oxidase subunit 7B, mitochondrial (P24311). Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. It is a selective cancer dependency (DepMap: 70.8% of cell lines).

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2, 20 and 22.

Source: NCBI Gene 1349 — RefSeq curated summary.

At a glance

• Gene–disease (curated): linear skin defects with multiple congenital anomalies 2 (Definitive, GenCC) — +2 more curated relationships
• Clinical variants (ClinVar): 53 total — 4 pathogenic, 1 likely-pathogenic
• Phenotypes (HPO): 120
• Cancer dependency (DepMap): dependent in 70.8% of screened cell lines
• MANE Select transcript: NM_001866

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:2291
Approved symbol	COX7B
Name	cytochrome c oxidase subunit 7B
Location	Xq21.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000131174
Ensembl biotype	protein_coding
OMIM	300885
Entrez	1349

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 protein_coding

ENST00000373335, ENST00000475465, ENST00000647835, ENST00000650309, ENST00000857759, ENST00000912755, ENST00000912756

RefSeq mRNA: 1 — MANE Select: NM_001866 NM_001866

CCDS: CCDS14437

Canonical transcript exons

ENST00000650309 — 3 exons

Exon	Start	End
ENSE00003582133	77902643	77902767
ENSE00003834652	77899468	77899593
ENSE00003850148	77905184	77907376

Expression profiles

Bgee: expression breadth ubiquitous, 295 present calls, max score 99.85.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 152.1559 / max 1027.8190, expressed in 1826 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
196775	152.1559	1826

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart right ventricle	UBERON:0002080	99.85	gold quality
apex of heart	UBERON:0002098	99.68	gold quality
biceps brachii	UBERON:0001507	99.62	gold quality
body of tongue	UBERON:0011876	99.62	gold quality
hindlimb stylopod muscle	UBERON:0004252	99.60	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	99.56	gold quality
diaphragm	UBERON:0001103	99.55	gold quality
mucosa of sigmoid colon	UBERON:0004993	99.54	gold quality
right atrium auricular region	UBERON:0006631	99.53	gold quality
renal medulla	UBERON:0000362	99.51	gold quality
cardiac ventricle	UBERON:0002082	99.51	gold quality
heart left ventricle	UBERON:0002084	99.50	gold quality
vena cava	UBERON:0004087	99.47	gold quality
triceps brachii	UBERON:0001509	99.45	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	99.45	gold quality
pharyngeal mucosa	UBERON:0000355	99.42	gold quality
colonic mucosa	UBERON:0000317	99.41	gold quality
tongue	UBERON:0001723	99.40	gold quality
mucosa of transverse colon	UBERON:0004991	99.40	gold quality
jejunum	UBERON:0002115	99.31	gold quality
upper leg skin	UBERON:0004262	99.27	gold quality
superior surface of tongue	UBERON:0007371	99.23	gold quality
oral cavity	UBERON:0000167	99.22	gold quality
jejunal mucosa	UBERON:0000399	99.22	gold quality
heart	UBERON:0000948	99.14	gold quality
mammalian vulva	UBERON:0000997	99.13	gold quality
gingival epithelium	UBERON:0001949	99.12	gold quality
sigmoid colon	UBERON:0001159	99.11	gold quality
gingiva	UBERON:0001828	99.11	gold quality
gastrocnemius	UBERON:0001388	99.08	gold quality

Single-cell (SCXA)

Detected in 10 experiment(s), a significant marker in 6.

Experiment	Marker?	Max mean expression
E-MTAB-7008	yes	550.23
E-MTAB-8410	yes	46.35
E-MTAB-7316	yes	23.73
E-HCAD-10	yes	12.24
E-MTAB-10042	yes	10.01
E-MTAB-9388	no	1566.55
E-MTAB-10596	no	1324.63
E-MTAB-8271	no	8.99
E-HCAD-13	no	3.09
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

11 targeting COX7B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-4659A-3P	99.80	72.62	4248
HSA-MIR-4659B-3P	99.80	72.62	4248
HSA-MIR-12129	99.72	67.45	1311
HSA-MIR-4506	99.34	67.47	526
HSA-MIR-664A-3P	99.22	71.08	2696
HSA-MIR-556-5P	97.75	66.17	473
HSA-MIR-4642	97.52	67.60	916
HSA-MIR-1225-5P	96.76	66.85	417

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 70.8% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 4)

• Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 7b (PMID:20307258)
• Data indicate that recombinant (r)IL-24 stimulated the mitochondrial apoptotic pathway genes Bax, Bid, Casp8, COX6C, COX7B after 36 h. (PMID:22860893)
• study analyzed the X-linked COX7B and found deleterious de novo mutations in two simplex cases of microphthalmia with linear skin lesions and a nonsense mutation, which segregates with the disease, in a familial case (PMID:23122588)
• Our results offer a new transcriptome landscape of platinum-resistance that provides valuable insights into chemosensitivity and drug resistance in cancers, and we identify a novel platinum resistance gene, COX7B, and a surrogate marker, CD63. (PMID:30367559)

Cross-species orthologs

0 orthologs

Paralogs (1): COX7B2 (ENSG00000170516)

Protein

Protein identifiers

Cytochrome c oxidase subunit 7B, mitochondrial — P24311 (reviewed: P24311)

Alternative names: Cytochrome c oxidase polypeptide VIIb

All UniProt accessions (4): A0A3B3IRN8, A0A3B3ISY5, A0A3B3ITX0, P24311

UniProt curated annotations — full annotation on UniProt →

Function. Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Plays a role in proper central nervous system (CNS) development in vertebrates.

Subunit / interactions. Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I1 (or COX4I2), COX5A, COX5B, COX6A1 (or COX6A2), COX6B1 (or COX6B2), COX6C, COX7A2 (or COX7A1), COX7B, COX7C, COX8A and COXFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).

Subcellular location. Mitochondrion inner membrane.

Disease relevance. Linear skin defects with multiple congenital anomalies 2 (LSDMCA2) [MIM:300887] A distinct form of aplasia cutis congenita presenting as multiple linear skin defects on the face and neck associated with poor growth, microcephaly, and facial dysmorphism. Additional features include intellectual disability, nail dystrophy, short stature and cardiac abnormalities. The disease is caused by variants affecting the gene represented in this entry.

Pathway. Energy metabolism; oxidative phosphorylation.

Similarity. Belongs to the cytochrome c oxidase VIIb family.

RefSeq proteins (1): NP_001857* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR008433	Cyt_c_oxidase_suVIIB	Family
IPR023272	Cyt_c_oxidase_suVIIB_dom_sf	Homologous_superfamily

Pfam: PF05392

UniProt features (6 total): topological domain 2, transit peptide 1, chain 1, transmembrane region 1, sequence conflict 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
9I6F	ELECTRON MICROSCOPY	2.95
9I7U	ELECTRON MICROSCOPY	3.15
5Z62	ELECTRON MICROSCOPY	3.6

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P24311-F1	90.15	0.56

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-5628897	TP53 Regulates Metabolic Genes
R-HSA-611105	Respiratory electron transport
R-HSA-9707564	Cytoprotection by HMOX1
R-HSA-9864848	Complex IV assembly

MSigDB gene sets: 432 (showing top): MODULE_93, MODULE_52, HORIUCHI_WTAP_TARGETS_DN, MODULE_151, MORF_RAD21, AACYNNNNTTCCS_UNKNOWN, TGACCTY_ERR1_Q2, MODULE_16, RODWELL_AGING_KIDNEY_NO_BLOOD_DN, GOBP_MONOATOMIC_CATION_TRANSPORT, PUJANA_CHEK2_PCC_NETWORK, OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_UP, GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY, MORF_SKP1A, GOBP_OXIDATIVE_PHOSPHORYLATION

GO Biological Process (5): mitochondrial electron transport, cytochrome c to oxygen (GO:0006123), central nervous system development (GO:0007417), cellular respiration (GO:0045333), oxidative phosphorylation (GO:0006119), proton transmembrane transport (GO:1902600)

GO Molecular Function (2): cytochrome-c oxidase activity (GO:0004129), protein binding (GO:0005515)

GO Cellular Component (5): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial membrane (GO:0031966), respiratory chain complex IV (GO:0045277), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
Transcriptional Regulation by TP53	1
Aerobic respiration and respiratory electron transport	1
Cellular response to chemical stress	1
Respiratory electron transport	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
aerobic electron transport chain	1
mitochondrial ATP synthesis coupled electron transport	1
nervous system development	1
system development	1
energy derivation by oxidation of organic compounds	1
aerobic respiration	1
proton motive force-driven ATP synthesis	1
monoatomic cation transmembrane transport	1
electron transfer activity	1
proton transmembrane transporter activity	1
oxidoreduction-driven active transmembrane transporter activity	1
oxidoreductase activity, acting on a heme group of donors	1
active monoatomic ion transmembrane transporter activity	1
binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
mitochondrion	1
mitochondrial envelope	1
organelle membrane	1
cytochrome complex	1
respiratory chain complex	1
transmembrane transporter complex	1
oxidoreductase complex	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1102 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
COX7B	COX5B	P10606	970
COX7B	COX6C	P09669	961
COX7B	COX7C	P15954	948
COX7B	COX8A	P10176	903
COX7B	COX6A1	P12074	837
COX7B	COX6B1	P14854	801
COX7B	COX6A2	Q02221	794
COX7B	COXFA4	O00483	765
COX7B	COX5A	P20674	745
COX7B	NDUFA1	O15239	730
COX7B	COX7A1	P24310	705
COX7B	COX7A2	P14406	687
COX7B	NDUFB9	Q9Y6M9	683
COX7B	UQCR11	O14957	681
COX7B	NDUFA11	Q86Y39	675

IntAct

8 interactions, top by confidence:

A	B	Type	Score
COX7B	GNMT	psi-mi:“MI:0915”(physical association)	0.560
COX7B	COX4I1	psi-mi:“MI:0915”(physical association)	0.400
HSCB	RBP5	psi-mi:“MI:0914”(association)	0.350
MT-CO2	NDUFA4	psi-mi:“MI:0914”(association)	0.350
GNMT	COX7B	psi-mi:“MI:0915”(physical association)	0.000
MYB	COX7B	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (25): COX7B (Affinity Capture-RNA), COX7B (Synthetic Lethality), BCAP31 (Co-fractionation), NDUFB9 (Co-fractionation), COX7B (Co-fractionation), COX7B (Co-fractionation), COX7B (Co-fractionation), COX7B (Co-fractionation), AUH (Co-fractionation), CTNNB1 (Co-fractionation), CYFIP2 (Co-fractionation), SMDT1 (Co-fractionation), VCP (Co-fractionation), COX7B (Co-fractionation), COX7B (Co-fractionation)

ESM2 similar proteins: A1L2P2, A1XQR7, A8E7D3, A8MTT3, L0R6Q1, O48832, O64497, O82803, P11951, P13183, P14790, P24311, P43883, P46270, P80977, Q148H0, Q1LUK1, Q1MTD4, Q1RMH3, Q21154, Q28EM2, Q2ACH7, Q41112, Q4V8S3, Q5BKW8, Q5CZQ0, Q5R987, Q5XFV8, Q5XKP0, Q63ZZ0, Q68EV8, Q7SGT7, Q7YRK0, Q7YRK1, Q810Q5, Q84K90, Q8BH51, Q8BTE5, Q8R404, Q8VCR3

Diamond homologs: P13183, P24311, P56393, P80431, Q4R648, Q5R9K2, Q8TF08

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
COX7B	“form complex”	“Cytochrome c oxidase-Mitochondrial respiratory chain complex IV”	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

53 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	4
Likely pathogenic	1
Uncertain significance	13
Likely benign	18
Benign	4

Top pathogenic / likely-pathogenic (5)

Variant ID	HGVS	Classification
39767	NM_001866.3(COX7B):c.196del (p.Leu66fs)	Pathogenic
39768	NM_001866.3(COX7B):c.41-2A>G	Pathogenic
39769	NM_001866.2(COX7B):c.55C>T (p.Gln19Ter)	Pathogenic
58660	GRCh38/hg38 Xq21.1(chrX:77829855-77902263)x2	Pathogenic
449642	NM_001866.3(COX7B):c.40+5G>C	Likely pathogenic

SpliceAI

550 predictions. Top by Δscore:

Variant	Effect	Δscore
X:77899591:AAGGT:A	donor_loss	1.0000
X:77899593:GGTG:G	donor_loss	1.0000
X:77899595:T:A	donor_loss	1.0000
X:77902404:T:G	donor_gain	1.0000
X:77902629:C:A	acceptor_gain	1.0000
X:77902637:T:A	acceptor_gain	1.0000
X:77902640:A:AG	acceptor_gain	1.0000
X:77902641:A:G	acceptor_gain	1.0000
X:77902642:G:GG	acceptor_gain	1.0000
X:77899594:G:GG	donor_gain	0.9900
X:77902319:A:AG	acceptor_gain	0.9900
X:77902322:A:AG	acceptor_gain	0.9900
X:77902766:ATG:A	donor_loss	0.9900
X:77902767:TGTA:T	donor_loss	0.9900
X:77902768:G:GG	donor_gain	0.9900
X:77902769:T:A	donor_loss	0.9900
X:77902770:A:AC	donor_loss	0.9900
X:77902771:AG:A	donor_loss	0.9900
X:77902772:G:C	donor_loss	0.9900
X:77902320:A:G	acceptor_gain	0.9800
X:77902323:C:G	acceptor_gain	0.9800
X:77902638:GTAA:G	acceptor_loss	0.9800
X:77902640:AAG:A	acceptor_loss	0.9800
X:77902642:G:GA	acceptor_loss	0.9800
X:77902642:GTTC:G	acceptor_gain	0.9800
X:77902718:ATGCT:A	donor_loss	0.9800
X:77902765:TAT:T	donor_gain	0.9800
X:77905183:GGTA:G	acceptor_gain	0.9800
X:77905257:A:AG	donor_gain	0.9800
X:77905258:G:GG	donor_gain	0.9800

AlphaMissense

522 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:77902699:T:C	F33L	0.953
X:77902701:T:A	F33L	0.953
X:77902701:T:G	F33L	0.953
X:77905249:G:C	W77C	0.910
X:77905249:G:T	W77C	0.910
X:77905208:T:A	W64R	0.904
X:77905208:T:C	W64R	0.904
X:77905247:T:A	W77R	0.902
X:77905247:T:C	W77R	0.902
X:77902747:T:C	C49R	0.890
X:77905210:G:C	W64C	0.877
X:77905210:G:T	W64C	0.877
X:77902759:T:A	W53R	0.873
X:77902759:T:C	W53R	0.873
X:77902700:T:C	F33S	0.827
X:77902700:T:G	F33C	0.824
X:77902732:A:C	S44R	0.814
X:77902734:T:A	S44R	0.814
X:77902734:T:G	S44R	0.814
X:77902730:C:A	A43D	0.781
X:77902715:G:T	G38V	0.778
X:77902744:T:C	F48L	0.777
X:77902746:C:A	F48L	0.777
X:77902746:C:G	F48L	0.777
X:77902724:T:A	V41E	0.770
X:77902727:T:C	L42S	0.767
X:77902754:T:A	V51D	0.758
X:77902736:G:A	G45E	0.739
X:77902749:T:G	C49W	0.733
X:77905248:G:C	W77S	0.733

dbSNP variants (sampled 300 via entrez): RS1000220144 (X:77903384 G>A), RS1000572276 (X:77902913 G>C), RS1001391728 (X:77903792 C>T), RS1002488087 (X:77902244 A>G), RS1002787070 (X:77901778 G>A,T), RS1003057262 (X:77905947 G>A), RS1004328684 (X:77902355 T>G), RS1006021772 (X:77904267 G>T), RS1007192450 (X:77904955 A>G), RS1007655319 (X:77905508 T>G), RS1008001891 (X:77899770 A>T), RS1008034507 (X:77900272 C>G), RS1008914359 (X:77907329 A>C,G), RS1009278157 (X:77906991 G>T), RS1010180957 (X:77903437 G>A,T)

Disease associations

OMIM: gene MIM:300885 | disease phenotypes: MIM:300887, MIM:300853

GenCC curated gene-disease

Disease	Classification	Inheritance
linear skin defects with multiple congenital anomalies 2	Definitive	X-linked
linear skin defects with multiple congenital anomalies	Supportive	X-linked

ClinGen Gene-Disease Validity (1)

Expert-panel classifications — Definitive > Strong > Moderate > Limited > Disputed > Refuted.

Disease	Classification	Inheritance
mitochondrial disease	Limited	XL

Mondo (3): linear skin defects with multiple congenital anomalies 2 (MONDO:0010474), X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia (MONDO:0010455), linear skin defects with multiple congenital anomalies (MONDO:0010672)

Orphanet (2): Microphthalmia with linear skin defects syndrome (Orphanet:2556), XMEN (Orphanet:317476)

HPO phenotypes

120 total (30 of 120 shown, HPO-id order):

HPO	Term
HP:0000013	Hypoplasia of the uterus
HP:0000035	Abnormal testis morphology
HP:0000036	Abnormal penis morphology
HP:0000037	Male pseudohermaphroditism
HP:0000039	Epispadias
HP:0000041	Chordee
HP:0000047	Hypospadias
HP:0000054	Micropenis
HP:0000062	Ambiguous genitalia
HP:0000175	Cleft palate
HP:0000238	Hydrocephalus
HP:0000252	Microcephaly
HP:0000278	Retrognathia
HP:0000316	Hypertelorism
HP:0000331	Short chin
HP:0000343	Long philtrum
HP:0000347	Micrognathia
HP:0000348	High forehead
HP:0000358	Posteriorly rotated ears
HP:0000363	Abnormal earlobe morphology
HP:0000365	Hearing impairment
HP:0000431	Wide nasal bridge
HP:0000445	Wide nose
HP:0000492	Abnormal eyelid morphology
HP:0000499	Abnormal eyelash morphology
HP:0000501	Glaucoma
HP:0000505	Visual impairment
HP:0000518	Cataract
HP:0000528	Anophthalmia
HP:0000543	Optic disc pallor

GWAS associations

0 associations (top):

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C537466	Microphthalmia, syndromic 7 (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

65 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	decreases expression, affects cotreatment, increases abundance, increases oxidation, affects expression	5
Valproic Acid	affects cotreatment, increases expression, affects expression	4
Particulate Matter	decreases expression, increases abundance	4
Acetaminophen	decreases expression, increases expression, affects cotreatment	3
bisphenol A	decreases expression, affects expression	2
sodium arsenite	decreases expression, increases expression	2
Atrazine	decreases expression	2
Ozone	increases oxidation, increases abundance, affects expression, affects cotreatment	2
Zidovudine	decreases expression, increases expression	2
Cyclosporine	decreases expression	2
bisphenol F	affects cotreatment, increases expression	1
dicrotophos	decreases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
arsenite	affects binding, increases reaction	1
methylparaben	decreases expression	1
cobaltous chloride	decreases expression	1
zinc chromate	increases abundance, increases expression	1
bleomycetin	decreases expression	1
potassium chromate(VI)	decreases expression	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
1-methyl-4-phenyl-2,3-dihydropyridinium	decreases expression	1
beta-methylcholine	affects expression	1
chromium hexavalent ion	increases abundance, increases expression	1
CD 437	decreases expression	1
chloropicrin	increases expression	1
OSW 1	increases expression	1
corosolic acid	decreases expression	1
K 7174	decreases expression	1

Clinical trials (associated diseases)

1 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT02496676	PHASE1/PHASE2	COMPLETED	Magnesium Supplementation in People With XMEN Syndrome