COX8A

Summary

COX8A (cytochrome c oxidase subunit 8A, HGNC:2294) is a protein-coding gene on chromosome 11q13.1, encoding Cytochrome c oxidase subunit 8A, mitochondrial (P10176). Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits.

Source: NCBI Gene 1351 — RefSeq curated summary.

At a glance

• Gene–disease (curated): cytochrome-c oxidase deficiency disease (Supportive, GenCC) — +3 more curated relationships
• GWAS associations: 1
• Clinical variants (ClinVar): 36 total — 1 pathogenic
• Phenotypes (HPO): 24
• MANE Select transcript: NM_004074

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:2294
Approved symbol	COX8A
Name	cytochrome c oxidase subunit 8A
Location	11q13.1
Locus type	gene with protein product
Status	Approved
Aliases	COX8-2, COX8L, VIII-L, COX, VIII
Ensembl gene	ENSG00000176340
Ensembl biotype	protein_coding
OMIM	123870
Entrez	1351

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000314133

RefSeq mRNA: 1 — MANE Select: NM_004074 NM_004074

CCDS: CCDS8054

Canonical transcript exons

ENST00000314133 — 2 exons

Exon	Start	End
ENSE00001272060	63976225	63976543
ENSE00001325675	63974620	63974794

Expression profiles

Bgee: expression breadth ubiquitous, 302 present calls, max score 99.80.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 371.3660 / max 1834.2696, expressed in 1828 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
114846	332.8968	1828
114847	38.4693	1808

Top tissues by expression

302 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	99.80	gold quality
mucosa of transverse colon	UBERON:0004991	99.68	gold quality
heart left ventricle	UBERON:0002084	99.67	gold quality
cardiac ventricle	UBERON:0002082	99.66	gold quality
right atrium auricular region	UBERON:0006631	99.63	gold quality
renal medulla	UBERON:0000362	99.62	gold quality
cardiac atrium	UBERON:0002081	99.62	gold quality
left ventricle myocardium	UBERON:0006566	99.58	gold quality
gastrocnemius	UBERON:0001388	99.57	gold quality
hindlimb stylopod muscle	UBERON:0004252	99.55	gold quality
heart	UBERON:0000948	99.54	gold quality
metanephros cortex	UBERON:0010533	99.53	gold quality
adult mammalian kidney	UBERON:0000082	99.51	gold quality
triceps brachii	UBERON:0001509	99.51	gold quality
heart right ventricle	UBERON:0002080	99.51	gold quality
body of tongue	UBERON:0011876	99.50	gold quality
adenohypophysis	UBERON:0002196	99.49	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	99.49	gold quality
transverse colon	UBERON:0001157	99.48	gold quality
right frontal lobe	UBERON:0002810	99.48	gold quality
prefrontal cortex	UBERON:0000451	99.46	gold quality
pituitary gland	UBERON:0000007	99.45	gold quality
pharyngeal mucosa	UBERON:0000355	99.45	gold quality
body of stomach	UBERON:0001161	99.44	gold quality
biceps brachii	UBERON:0001507	99.44	gold quality
right adrenal gland	UBERON:0001233	99.43	gold quality
right hemisphere of cerebellum	UBERON:0014890	99.43	gold quality
nucleus accumbens	UBERON:0001882	99.42	gold quality
myocardium	UBERON:0002349	99.42	gold quality
caudate nucleus	UBERON:0001873	99.40	gold quality

Single-cell (SCXA)

Detected in 14 experiment(s), a significant marker in 11.

Experiment	Marker?	Max mean expression
E-HCAD-4	yes	71.89
E-HCAD-31	yes	36.36
E-CURD-122	yes	26.56
E-CURD-46	yes	25.26
E-MTAB-7316	yes	19.76
E-GEOD-81547	yes	19.68
E-MTAB-10042	yes	16.53
E-HCAD-10	yes	14.65
E-MTAB-10553	yes	7.57
E-CURD-88	yes	6.08
E-CURD-112	no	1020.77
E-MTAB-8271	no	645.07
E-HCAD-6	no	33.77
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): CREB1, NCOR1

miRNA regulators (miRDB)

13 targeting COX8A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-3681-3P	99.88	70.46	2254
HSA-MIR-3121-3P	99.82	71.96	3630
HSA-MIR-370-5P	99.78	66.81	706
HSA-MIR-3913-3P	99.74	66.53	938
HSA-MIR-298	99.63	67.56	1916
HSA-MIR-7854-3P	99.08	66.26	1117
HSA-MIR-5701	98.97	69.54	1502
HSA-MIR-6859-3P	97.26	64.69	428
HSA-MIR-3126-5P	96.87	65.83	912
HSA-MIR-6875-5P	96.87	65.49	958
HSA-MIR-6781-5P	94.61	59.49	155

Literature-anchored findings (GeneRIF, showing 2)

• COX8A is indispensable for function of human complex IV and its mutation causes Leigh-like syndrome and epilepsy. (PMID:26685157)
• Molecular and Functional Effects of Loss of Cytochrome c Oxidase Subunit 8A. (PMID:33705280)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	cox8a	ENSDARG00000095273
mus_musculus	Cox8a	ENSMUSG00000035885
rattus_norvegicus	Cox8a	ENSRNOG00000073321

Paralogs (1): COX8C (ENSG00000187581)

Protein

Protein identifiers

Cytochrome c oxidase subunit 8A, mitochondrial — P10176 (reviewed: P10176)

Alternative names: Cytochrome c oxidase polypeptide VIII-liver/heart, Cytochrome c oxidase subunit 8-2

All UniProt accessions (2): P10176, Q53XN1

UniProt curated annotations — full annotation on UniProt →

Function. Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Subunit / interactions. Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I1 (or COX4I2), COX5A, COX5B, COX6A1 (or COX6A2), COX6B1 (or COX6B2), COX6C, COX7A2 (or COX7A1), COX7B, COX7C, COX8A and COXFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).

Subcellular location. Mitochondrion inner membrane.

Tissue specificity. Widely expressed.

Post-translational modifications. In response to mitochondrial stress, the precursor protein is ubiquitinated by the SIFI complex in the cytoplasm before mitochondrial import, leading to its degradation. Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1.

Disease relevance. Mitochondrial complex IV deficiency, nuclear type 15 (MC4DN15) [MIM:619059] An autosomal recessive mitochondrial disorder with onset in infancy. MC4DN15 is characterized by global developmental delay, poor feeding, metabolic acidosis, short stature, microcephaly, proximal muscle weakness, and distal spasticity. Additional manifestations include scoliosis, primary pulmonary hypertension, refractory seizures, and inability to walk. Serum and CSF lactate levels are increased. Patient tissues show decreased levels and activity of mitochondrial respiratory complex IV. The disease may be caused by variants affecting the gene represented in this entry.

Pathway. Energy metabolism; oxidative phosphorylation.

Similarity. Belongs to the cytochrome c oxidase VIII family.

RefSeq proteins (1): NP_004065* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003205	Cyt_c_oxidase_su8	Family
IPR036548	Cyt_c_oxidase_su8_sf	Homologous_superfamily

Pfam: PF02285

UniProt features (8 total): topological domain 2, helix 2, transit peptide 1, chain 1, transmembrane region 1, short sequence motif 1

Structure

Experimental structures (PDB)

4 structures.

PDB	Method	Resolution (Å)
9I6F	ELECTRON MICROSCOPY	2.95
8D4T	ELECTRON MICROSCOPY	3.1
9I7U	ELECTRON MICROSCOPY	3.15
5Z62	ELECTRON MICROSCOPY	3.6

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P10176-F1	85.74	0.56

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-5628897	TP53 Regulates Metabolic Genes
R-HSA-611105	Respiratory electron transport
R-HSA-9707564	Cytoprotection by HMOX1
R-HSA-9864848	Complex IV assembly

MSigDB gene sets: 326 (showing top): YAATNRNNNYNATT_UNKNOWN, MODY_HIPPOCAMPUS_POSTNATAL, MORF_UBE2I, HSIAO_HOUSEKEEPING_GENES, TGACCTY_ERR1_Q2, chr11q13, RODWELL_AGING_KIDNEY_NO_BLOOD_DN, GOBP_MONOATOMIC_CATION_TRANSPORT, GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY, MORF_RAF1, GOBP_OXIDATIVE_PHOSPHORYLATION, WCTCNATGGY_UNKNOWN, GOBP_ELECTRON_TRANSPORT_CHAIN, KEGG_HUNTINGTONS_DISEASE, MODULE_307

GO Biological Process (5): generation of precursor metabolites and energy (GO:0006091), mitochondrial electron transport, cytochrome c to oxygen (GO:0006123), cellular respiration (GO:0045333), oxidative phosphorylation (GO:0006119), proton transmembrane transport (GO:1902600)

GO Molecular Function (2): cytochrome-c oxidase activity (GO:0004129), protein binding (GO:0005515)

GO Cellular Component (5): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial membrane (GO:0031966), respiratory chain complex IV (GO:0045277), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
Transcriptional Regulation by TP53	1
Aerobic respiration and respiratory electron transport	1
Cellular response to chemical stress	1
Respiratory electron transport	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
metabolic process	1
aerobic electron transport chain	1
mitochondrial ATP synthesis coupled electron transport	1
energy derivation by oxidation of organic compounds	1
aerobic respiration	1
proton motive force-driven ATP synthesis	1
monoatomic cation transmembrane transport	1
electron transfer activity	1
proton transmembrane transporter activity	1
oxidoreduction-driven active transmembrane transporter activity	1
oxidoreductase activity, acting on a heme group of donors	1
active monoatomic ion transmembrane transporter activity	1
binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
mitochondrion	1
mitochondrial envelope	1
organelle membrane	1
cytochrome complex	1
respiratory chain complex	1
transmembrane transporter complex	1
oxidoreductase complex	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1424 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
COX8A	COX5B	P10606	965
COX8A	COX6C	P09669	954
COX8A	COX7B	P24311	903
COX8A	COX7C	P15954	846
COX8A	COX5A	P20674	842
COX8A	COX6A1	P12074	838
COX8A	FTH1	P02794	788
COX8A	PYGM	P11217	775
COX8A	PLCB3	Q01970	769
COX8A	SF1	Q15637	769
COX8A	FKBP2	P26885	768
COX8A	AHNAK	Q09666	768
COX8A	ROM1	Q03395	767
COX8A	MAP3K11	Q16584	767
COX8A	MARK2	Q7KZI7	767

IntAct

22 interactions, top by confidence:

A	B	Type	Score
COX8A	NPM1	psi-mi:“MI:0915”(physical association)	0.560
COX8A	BATF	psi-mi:“MI:0915”(physical association)	0.560
COX8A	MAGEA4	psi-mi:“MI:0915”(physical association)	0.560
COX8A	EDDM3B	psi-mi:“MI:0915”(physical association)	0.560
PCNA	COX8A	psi-mi:“MI:0915”(physical association)	0.370
COX8A	AMBP	psi-mi:“MI:0915”(physical association)	0.370
K8.1	EXOC5	psi-mi:“MI:0914”(association)	0.350
NMES1	NDUFS8	psi-mi:“MI:0914”(association)	0.350
NDUFA4	NUDT19	psi-mi:“MI:0914”(association)	0.350
NDUFA4	NDUFS8	psi-mi:“MI:0914”(association)	0.350
NDUFA4	COX7A2L	psi-mi:“MI:0914”(association)	0.350
SLC35A3	STXBP3	psi-mi:“MI:0914”(association)	0.350
SLC35E3	TP53I11	psi-mi:“MI:0914”(association)	0.350
COX8A	BATF	psi-mi:“MI:0915”(physical association)	0.000
COX8A	MAGEA4	psi-mi:“MI:0915”(physical association)	0.000
COX8A	EDDM3B	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (329): NPM1 (Two-hybrid), COX8A (Affinity Capture-MS), COX8A (Affinity Capture-MS), COX8A (Affinity Capture-MS), COX8A (Co-fractionation), COX8A (Co-fractionation), ASPH (Co-fractionation), CANX (Co-fractionation), COX4I1 (Co-fractionation), COX5A (Co-fractionation), COX7B (Co-fractionation), COX7C (Co-fractionation), CTNNB1 (Co-fractionation), HADHA (Co-fractionation), HADHB (Co-fractionation)

ESM2 similar proteins: A5Z2X5, A6H666, A8WGU8, C0HK62, D6X268, O43677, P04039, P0CB69, P0CB70, P10175, P10176, P16221, P48772, P53507, P60181, P60182, P60183, Q02376, Q09774, Q0MQF5, Q0MQF6, Q17ED3, Q290M9, Q2V2P9, Q2V2Q3, Q3E870, Q3KQJ0, Q5SWH9, Q64445, Q6H611, Q7JX57, Q7QHP6, Q7TNN2, Q7YRF4, Q862Z8, Q862Z9, Q863F8, Q863F9, Q863G0, Q863G5

Diamond homologs: P10175, P10176, P14622, P16221, P48772, P60181, P60182, P60183, P80433, Q64445, Q862Z8, Q862Z9, Q863F8, Q863F9, Q863G0, Q863G1, Q863G2, Q863G3, Q863G4, Q863G5, Q863G6, Q863G7, Q863G8, Q863G9, Q8SPI5, Q8SQ78, Q8SQ79, Q7Z4L0, Q7YRF4, A6H666, Q7TNN2

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
COX8A	“form complex”	“Cytochrome c oxidase-Mitochondrial respiratory chain complex IV”	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

36 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	15
Likely benign	13
Benign	3

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
222973	NM_004074.3(COX8A):c.115-1G>C	Pathogenic

SpliceAI

378 predictions. Top by Δscore:

Variant	Effect	Δscore
11:63976308:G:GT	donor_gain	1.0000
11:63974779:G:GT	donor_gain	0.9900
11:63974779:G:T	donor_gain	0.9900
11:63974791:CATGG:C	donor_loss	0.9900
11:63974792:ATGG:A	donor_loss	0.9900
11:63974793:TGG:T	donor_loss	0.9900
11:63974793:TGGTG:T	donor_loss	0.9900
11:63974795:G:GG	donor_gain	0.9900
11:63974795:GTGAG:G	donor_loss	0.9900
11:63974796:T:G	donor_loss	0.9900
11:63974801:A:T	donor_gain	0.9900
11:63974797:GAG:G	donor_loss	0.9800
11:63974800:G:GT	donor_gain	0.9800
11:63976220:TGTAG:T	acceptor_loss	0.9800
11:63976221:GTAGG:G	acceptor_loss	0.9800
11:63976222:TAGG:T	acceptor_loss	0.9800
11:63976223:A:T	acceptor_loss	0.9800
11:63976322:GGG:G	donor_gain	0.9800
11:63976323:GGG:G	donor_gain	0.9800
11:63976213:T:TA	acceptor_gain	0.9700
11:63976219:GTGTA:G	acceptor_loss	0.9700
11:63976224:GGA:G	acceptor_gain	0.9700
11:63974774:G:GT	donor_gain	0.9600
11:63974793:TG:T	donor_gain	0.9600
11:63974794:GG:G	donor_gain	0.9600
11:63976223:A:AG	acceptor_gain	0.9600
11:63976223:AG:A	acceptor_gain	0.9600
11:63976224:G:GG	acceptor_gain	0.9600
11:63976224:GG:G	acceptor_gain	0.9600
11:63974811:G:GT	donor_gain	0.9500

AlphaMissense

418 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:63976249:T:C	C47R	0.986
11:63976271:C:G	P54R	0.972
11:63976238:G:A	G43E	0.964
11:63976237:G:A	G43R	0.960
11:63976237:G:C	G43R	0.960
11:63976235:T:A	V42D	0.957
11:63976271:C:A	P54Q	0.957
11:63976279:T:A	W57R	0.944
11:63976279:T:C	W57R	0.944
11:63976277:G:A	G56D	0.939
11:63976241:T:C	L44P	0.938
11:63976276:G:C	G56R	0.938
11:63976232:C:A	A41D	0.929
11:63976256:T:A	V49E	0.923
11:63976268:T:G	L53R	0.923
11:63976283:T:C	I58T	0.904
11:63976281:G:C	W57C	0.894
11:63976281:G:T	W57C	0.894
11:63976265:T:G	L52R	0.887
11:63976241:T:A	L44H	0.881
11:63976274:C:A	A55E	0.878
11:63976241:T:G	L44R	0.869
11:63976270:C:T	P54S	0.859
11:63976283:T:G	I58S	0.853
11:63976268:T:A	L53Q	0.850
11:63976286:T:C	L59P	0.847
11:63976237:G:T	G43W	0.831
11:63976271:C:T	P54L	0.825
11:63976265:T:A	L52H	0.818
11:63976283:T:A	I58N	0.815

dbSNP variants (sampled 300 via entrez): RS1001707448 (11:63976386 C>A,T), RS1002159789 (11:63976994 T>TC), RS1003160916 (11:63975289 C>T), RS1005259418 (11:63972788 G>A), RS1005606391 (11:63976934 G>C), RS1007117852 (11:63976395 T>G), RS1007176344 (11:63973144 G>A), RS1008095683 (11:63974534 A>G), RS1008711394 (11:63975232 G>T), RS1008800633 (11:63973988 G>A), RS1009097617 (11:63973208 A>G), RS1009131725 (11:63973527 A>C,G), RS1010906569 (11:63973169 G>A), RS1010960582 (11:63973404 G>A), RS1011255086 (11:63974293 C>A,G,T)

Disease associations

OMIM: gene MIM:123870 | disease phenotypes: MIM:220110, MIM:619059

GenCC curated gene-disease

Disease	Classification	Inheritance
cytochrome-c oxidase deficiency disease	Supportive	Autosomal recessive
mitochondrial complex IV deficiency, nuclear type 15	Limited	Autosomal recessive

ClinGen Gene-Disease Validity (2)

Expert-panel classifications — Definitive > Strong > Moderate > Limited > Disputed > Refuted.

Disease	Classification	Inheritance
Leigh syndrome	Limited	AR
mitochondrial disease	Limited	AR

Mondo (3): mitochondrial complex IV deficiency, nuclear type 1 (MONDO:0700250), mitochondrial complex IV deficiency, nuclear type 15 (MONDO:0033650), (MONDO:0009068)

Orphanet (0):

HPO phenotypes

24 total (24 of 24 shown, HPO-id order):

HPO	Term
HP:0000007	Autosomal recessive inheritance
HP:0000252	Microcephaly
HP:0000490	Deeply set eye
HP:0000580	Pigmentary retinopathy
HP:0001257	Spasticity
HP:0001263	Global developmental delay
HP:0001265	Hyporeflexia
HP:0002092	Pulmonary arterial hypertension
HP:0002119	Ventriculomegaly
HP:0002151	Increased circulating lactate concentration
HP:0002154	Hyperglycinemia
HP:0002490	Increased CSF lactate
HP:0002650	Scoliosis
HP:0002827	Hip dislocation
HP:0003128	Lactic acidosis
HP:0003348	Hyperalaninemia
HP:0004322	Short stature
HP:0010819	Atonic seizure
HP:0011421	Death in adolescence
HP:0011470	Nasogastric tube feeding in infancy
HP:0012444	Brain atrophy
HP:0025190	Bilateral tonic-clonic seizure with generalized onset
HP:0032794	Myoclonic seizure
HP:0100806	Sepsis

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST008103_34	Bipolar disorder	6.000000e-08

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression	3
bisphenol A	affects expression, decreases expression	2
sodium arsenite	decreases expression, increases expression	2
Acetaminophen	increases expression	2
aristolochic acid I	increases expression	1
triphenyl phosphate	affects expression	1
tris(2-butoxyethyl) phosphate	decreases expression, increases abundance	1
arsenite	affects binding, increases reaction	1
methylparaben	decreases expression	1
ochratoxin A	increases expression	1
tris(chloroethyl)phosphate	decreases expression, increases abundance	1
azoxystrobin	increases expression	1
chloropicrin	decreases expression	1
K 7174	decreases expression	1
pyrimidifen	increases expression	1
XCT790	decreases expression	1
pyrachlostrobin	increases expression	1
carfilzomib	decreases expression	1
picoxystrobin	increases expression	1
(+)-JQ1 compound	decreases expression	1
Bortezomib	decreases expression	1
Cisplatin	increases expression	1
Diazinon	increases methylation	1
Diuron	decreases expression	1
Doxorubicin	increases expression	1
Flame Retardants	decreases expression, increases abundance	1
Rotenone	increases expression	1
Smoke	decreases expression	1
Tunicamycin	decreases expression	1
Sodium Selenite	increases expression	1

Cellosaurus cell lines

5 cell lines: 4 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2V3	Abcam HEK293T COX8A KO	Transformed cell line	Female
CVCL_C8HA	RAW-Kb-Mito gB30-694	Cancer cell line	Male
CVCL_C8HD	RAW-Kb-Mito gB30-694 Sting1 KO	Cancer cell line	Male
CVCL_C8HF	RAW-Kb-Mito gB30-694 Xbp1 KO	Cancer cell line	Male
CVCL_F0LD	RAW-Kb-Mito gB30-694 Cd14 KO	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.