CPEB2-DT

Summary

CPEB2-DT (CPEB2 divergent transcript, HGNC:49082) is a long non-coding RNA gene on chromosome 4p15.33-p15.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49082
Approved symbol	CPEB2-DT
Name	CPEB2 divergent transcript
Location	4p15.33-p15.32
Locus type	RNA, long non-coding
Status	Approved
Aliases	DRAIR
Ensembl gene	ENSG00000247624
Ensembl biotype	lncRNA
Entrez	441009
RNAcentral	URS000075EC33 — lncRNA, 1644 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 lncRNA

ENST00000500394, ENST00000501916, ENST00000825730, ENST00000825731, ENST00000825732, ENST00000825733, ENST00000825734, ENST00000825735

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000500394 — 8 exons

Exon	Start	End
ENSE00001959784	15001938	15002045
ENSE00001962382	15001161	15001229
ENSE00001965240	15001626	15001725
ENSE00001967356	14990454	14990554
ENSE00001975415	14992712	14992902
ENSE00001981474	14995254	14995350
ENSE00001986620	14985221	14985376
ENSE00001989175	14909961	14910768

Expression profiles

Bgee: expression breadth ubiquitous, 124 present calls, max score 76.99.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2932 / max 31.3550, expressed in 109 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
51435	0.2409	83
51434	0.0523	21

Top tissues by expression

124 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.99	gold quality
right testis	UBERON:0004534	76.19	gold quality
left testis	UBERON:0004533	75.96	gold quality
testis	UBERON:0000473	75.40	gold quality
cortical plate	UBERON:0005343	62.04	silver quality
ventricular zone	UBERON:0003053	61.49	gold quality
sural nerve	UBERON:0015488	58.62	silver quality
ganglionic eminence	UBERON:0004023	58.17	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	56.13	gold quality
calcaneal tendon	UBERON:0003701	56.02	gold quality
hindlimb stylopod muscle	UBERON:0004252	54.79	gold quality
right hemisphere of cerebellum	UBERON:0014890	54.35	gold quality
corpus callosum	UBERON:0002336	53.74	gold quality
blood	UBERON:0000178	53.50	silver quality
cerebellar cortex	UBERON:0002129	53.47	gold quality
cerebellar hemisphere	UBERON:0002245	53.42	gold quality
cerebellum	UBERON:0002037	53.39	gold quality
granulocyte	CL:0000094	52.80	gold quality
monocyte	CL:0000576	52.61	silver quality
ascending aorta	UBERON:0001496	52.60	gold quality
thoracic aorta	UBERON:0001515	52.28	gold quality
skeletal muscle tissue	UBERON:0001134	52.27	silver quality
liver	UBERON:0002107	50.23	silver quality
cortex of kidney	UBERON:0001225	50.16	gold quality
prefrontal cortex	UBERON:0000451	49.95	gold quality
popliteal artery	UBERON:0002250	49.89	gold quality
gall bladder	UBERON:0002110	49.84	gold quality
fundus of stomach	UBERON:0001160	49.83	gold quality
tibial artery	UBERON:0007610	49.83	gold quality
kidney	UBERON:0002113	49.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.64

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• lncRNA DRAIR is downregulated in diabetic monocytes and modulates the inflammatory phenotype via epigenetic mechanisms. (PMID:33945509)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.