CPEB2

Summary

CPEB2 (cytoplasmic polyadenylation element binding protein 2, HGNC:21745) is a protein-coding gene on chromosome 4p15.32, encoding Cytoplasmic polyadenylation element-binding protein 2 (Q7Z5Q1). May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids.

The protein encoded by this gene is highly similar to cytoplasmic polyadenylation element binding protein (CPEB), an mRNA-binding protein that regulates cytoplasmic polyadenylation of mRNA as a trans factor in oogenesis and spermatogenesis. Studies of the similar gene in mice suggested a possible role of this protein in transcriptionally inactive haploid spermatids. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Source: NCBI Gene 132864 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 170 total
• GTEx eGene: eQTL in 14 tissues, sQTL in 5 (q < 0.05)
• Constraint (gnomAD): pLI 0.00 (LoF-tolerant), LOEUF 1.33 (unconstrained)
• MANE Select transcript: NM_001177382
• Notable: 170 clinical variants but no curated precision-oncology (CIViC) evidence yet

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21745
Approved symbol	CPEB2
Name	cytoplasmic polyadenylation element binding protein 2
Location	4p15.32
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000137449
Ensembl biotype	protein_coding
OMIM	610605
Entrez	132864

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 7 protein_coding, 1 retained_intron

MANE Select: ENST00000538197

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 1: 4, TSL 3: 2, TSL 5: 2

ENST00000538197, ENST00000345451, ENST00000382395, ENST00000382401, ENST00000442003, ENST00000503926, ENST00000507071, ENST00000509684

RefSeq mRNA: 6 — MANE Select: NM_001177382 NM_001177381, NM_001177382, NM_001177383, NM_001177384, NM_182485, NM_182646

CCDS: CCDS56325, CCDS56326, CCDS93479, CCDS93480

Canonical transcript exons

ENST00000538197 — 12 exons

Exon	Start	End
ENSE00000927352	15062079	15062260
ENSE00001293264	15052414	15052584
ENSE00001312682	15017188	15017278
ENSE00001318425	15054128	15054217
ENSE00001338033	15008338	15008427
ENSE00001338035	15033161	15033211
ENSE00001338038	15007305	15007586
ENSE00001491992	15040464	15040487
ENSE00001692146	15058421	15058539
ENSE00001718573	15059187	15059301
ENSE00002040018	15066153	15070151
ENSE00003908489	15002481	15004335

Expression profiles

Bgee: expression breadth ubiquitous, 256 present calls, max score 98.68.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 37.5769 / max 670.7050, expressed in 1803 samples.

Highest expression (Bgee): sperm, upper arm skin, buccal mucosa cell, endothelial cell, upper leg skin.

Genetic regulation across tissues (GTEx eQTL / sQTL)

CPEB2 is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 14 tissues and its splicing (sQTL) in 5 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

19 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Esophagus Mucosa	eqtl	8.0e-19	+0.28	4:15042115:G:A
Whole Blood	eqtl	1.6e-11	+0.14	4:15007608:C:T
Nerve Tibial	eqtl	1.1e-07	+0.15	4:15081256:T:C
Skin Sun Exposed Lower leg	eqtl	1.3e-05	-0.14	4:15023994:C:G
Testis	sqtl	2.1e-05	-0.31	4:14989265:T:G
Skin Not Sun Exposed Suprapubic	sqtl	2.5e-05	+0.33	4:15079063:T:C
Skin Not Sun Exposed Suprapubic	eqtl	7.7e-05	+0.16	4:15088829:C:T
Esophagus Muscularis	eqtl	8.2e-05	+0.18	4:14990530:C:T
Cells EBV-transformed lymphocytes	eqtl	1.3e-04	+0.24	4:15018602:A:G
Skin Sun Exposed Lower leg	sqtl	1.6e-03	+0.30	4:14968359:T:G
Artery Tibial	sqtl	8.0e-03	+0.28	4:15071954:A:G
Breast Mammary Tissue	eqtl	1.1e-02	+0.16	4:15114312:G:A
Brain Hippocampus	eqtl	1.6e-02	+1.38	4:14849808:G:C
Stomach	eqtl	3.2e-02	+0.39	4:15146624:A:G
Cells Cultured fibroblasts	eqtl	3.3e-02	-0.15	4:14108896:T:C
Brain Cerebellar Hemisphere	eqtl	3.3e-02	-0.20	4:15169420:G:A
Brain Cerebellum	eqtl	4.1e-02	-0.25	4:15169420:G:A
Nerve Tibial	sqtl	4.5e-02	-1.06	4:15479961:G:C
Thyroid	eqtl	4.6e-02	+0.23	4:15127607:G:T

FANTOM5 promoters

10 alternative TSS:

Promoter ID	TPM avg	Samples expressed
46967	21.5741	1753
46960	5.0416	1388
46963	3.8394	1239
46971	3.4597	1364
46966	1.3408	677
46964	1.2686	584
46962	0.3589	188
46965	0.2727	124
46961	0.2399	125
46970	0.1814	68

Top tissues by expression

showing 100 of 256 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	98.68	gold quality
upper arm skin	UBERON:0004263	97.90	gold quality
buccal mucosa cell	CL:0002336	97.55	gold quality
endothelial cell	CL:0000115	97.42	gold quality
upper leg skin	UBERON:0004262	97.29	gold quality
gingival epithelium	UBERON:0001949	97.28	gold quality
epithelial cell of pancreas	CL:0000083	96.91	gold quality
gingiva	UBERON:0001828	96.80	gold quality
oviduct epithelium	UBERON:0004804	96.43	gold quality
Brodmann (1909) area 23	UBERON:0013554	96.26	gold quality
inferior vagus X ganglion	UBERON:0005363	95.87	gold quality
subthalamic nucleus	UBERON:0001906	95.75	gold quality
corpus callosum	UBERON:0002336	95.51	gold quality
medulla oblongata	UBERON:0001896	95.37	gold quality
adult organism	UBERON:0007023	95.35	gold quality
saphenous vein	UBERON:0007318	95.34	gold quality
palpebral conjunctiva	UBERON:0001812	95.28	gold quality
penis	UBERON:0000989	95.11	gold quality
trigeminal ganglion	UBERON:0001675	95.09	gold quality
lateral globus pallidus	UBERON:0002476	95.03	gold quality
substantia nigra pars reticulata	UBERON:0001966	94.95	gold quality
skin of hip	UBERON:0001554	94.85	gold quality
entorhinal cortex	UBERON:0002728	94.81	gold quality
dorsal plus ventral thalamus	UBERON:0001897	94.75	gold quality
superior vestibular nucleus	UBERON:0007227	94.75	gold quality
cauda epididymis	UBERON:0004360	94.71	gold quality
mammalian vulva	UBERON:0000997	94.62	gold quality
substantia nigra pars compacta	UBERON:0001965	94.38	gold quality
amniotic fluid	UBERON:0000173	94.15	gold quality
left ventricle myocardium	UBERON:0006566	94.07	gold quality
Brodmann (1909) area 46	UBERON:0006483	93.76	gold quality
jejunal mucosa	UBERON:0000399	93.51	gold quality
postcentral gyrus	UBERON:0002581	93.39	gold quality
kidney epithelium	UBERON:0004819	93.39	gold quality
cardiac muscle of right atrium	UBERON:0003379	93.35	gold quality
pigmented layer of retina	UBERON:0001782	93.14	gold quality
dorsal root ganglion	UBERON:0000044	93.13	gold quality
nipple	UBERON:0002030	93.03	gold quality
seminal vesicle	UBERON:0000998	92.91	gold quality
parietal lobe	UBERON:0001872	92.89	gold quality
visceral pleura	UBERON:0002401	92.67	gold quality
lateral nuclear group of thalamus	UBERON:0002736	92.59	gold quality
corpus epididymis	UBERON:0004359	92.40	gold quality
superior frontal gyrus	UBERON:0002661	92.38	gold quality
esophagus squamous epithelium	UBERON:0006920	92.28	gold quality
ventral tegmental area	UBERON:0002691	92.18	gold quality
myocardium	UBERON:0002349	92.04	gold quality
middle temporal gyrus	UBERON:0002771	92.00	gold quality
renal medulla	UBERON:0000362	91.92	gold quality
layer of synovial tissue	UBERON:0007616	91.89	gold quality
globus pallidus	UBERON:0001875	91.76	gold quality
oral cavity	UBERON:0000167	91.75	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	91.62	gold quality
secondary oocyte	CL:0000655	91.52	gold quality
mucosa of sigmoid colon	UBERON:0004993	91.23	gold quality
pons	UBERON:0000988	91.19	gold quality
cardia of stomach	UBERON:0001162	91.02	gold quality
jejunum	UBERON:0002115	91.01	gold quality
mucosa of paranasal sinus	UBERON:0005030	91.01	gold quality
left testis	UBERON:0004533	90.83	gold quality
medial globus pallidus	UBERON:0002477	90.77	gold quality
biceps brachii	UBERON:0001507	90.74	gold quality
ileal mucosa	UBERON:0000331	90.70	gold quality
trabecular bone tissue	UBERON:0002483	90.60	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	90.60	gold quality
right testis	UBERON:0004534	90.54	gold quality
colonic mucosa	UBERON:0000317	90.48	gold quality
caput epididymis	UBERON:0004358	90.48	gold quality
deltoid	UBERON:0001476	90.38	gold quality
occipital lobe	UBERON:0002021	90.38	gold quality
testis	UBERON:0000473	90.30	gold quality
heart right ventricle	UBERON:0002080	90.25	gold quality
superficial temporal artery	UBERON:0001614	90.16	gold quality
primary visual cortex	UBERON:0002436	89.86	gold quality
urethra	UBERON:0000057	89.34	gold quality
parietal pleura	UBERON:0002400	89.20	gold quality
pancreatic ductal cell	CL:0002079	88.94	gold quality
zone of skin	UBERON:0000014	88.89	gold quality
lower lobe of lung	UBERON:0008949	88.87	gold quality
synovial joint	UBERON:0002217	88.64	gold quality
epithelium of mammary gland	UBERON:0003244	88.59	gold quality
mammary duct	UBERON:0001765	88.51	gold quality
germinal epithelium of ovary	UBERON:0001304	88.50	gold quality
tibialis anterior	UBERON:0001385	88.48	gold quality
bone marrow	UBERON:0002371	88.23	gold quality
skin of leg	UBERON:0001511	88.01	gold quality
temporal lobe	UBERON:0001871	88.01	gold quality
epithelium of nasopharynx	UBERON:0001951	87.95	gold quality
skin of abdomen	UBERON:0001416	87.79	gold quality
mammary gland	UBERON:0001911	87.73	gold quality
thoracic mammary gland	UBERON:0005200	87.65	gold quality
Ammon’s horn	UBERON:0001954	87.58	gold quality
spinal cord	UBERON:0002240	87.53	gold quality
calcaneal tendon	UBERON:0003701	87.06	gold quality
body of tongue	UBERON:0011876	86.82	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	86.70	gold quality
quadriceps femoris	UBERON:0001377	86.68	gold quality
vastus lateralis	UBERON:0001379	86.66	gold quality
midbrain	UBERON:0001891	86.62	gold quality
cerebellar vermis	UBERON:0004720	86.40	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-135922	yes	9.81
E-ANND-3	no	0.00

HPA expression

RNA tissue specificity: Low tissue specificity

showing 60 of 76 HPA tissues / cells by nTPM:

Tissue / cell	Axis	nTPM
Locus coeruleus	tissue	53.9
Nucleus accumbens	tissue	53.7
Corpus callosum	tissue	47.8
Hippocampus	tissue	41.9
Postcentral gyrus	tissue	38.5
Spinal cord	tissue	37.4
Thalamus	tissue	36.8
Midbrain	tissue	36.6
Medulla oblongata	tissue	36.2
Pons	tissue	35.6
Testis	tissue	35.4
Choroid plexus	tissue	33.2
Periaqueductal gray	tissue	31.8
Hypothalamus	tissue	31.6
Substantia nigra	tissue	31.3
Superior colliculi	tissue	30.5
Ventral forebrain	tissue	27.5
Septum	tissue	26.7
Cerebral cortex	tissue	25.8
Motor cortex	tissue	25.8
Putamen	tissue	25.5
Amygdala	tissue	25.3
Bone marrow	tissue	25.1
Retrosplenial cortex	tissue	24.9
Hippocampal formation	tissue	24.2
Retrosplenial and cingulate cortex	tissue	22.8
Prefrontal cortex	tissue	22.7
Insular cortex	tissue	22.6
Frontal cortex	tissue	21.4
Occipital cortex	tissue	21.4
Somatosensory cortex	tissue	21.0
Skin 1	tissue	20.4
Entorhinal cortex	tissue	20.1
Caudate putamen	tissue	20.1
Temporal cortex	tissue	20.0
Liver	tissue	16.4
Basal ganglia	tissue	16.0
Parathyroid gland	tissue	15.3
Cerebellum	tissue	15.0
Olfactory bulb	tissue	15.0
Retina	tissue	14.9
Breast	tissue	11.5
Kidney	tissue	11.2
Esophagus	tissue	10.9
Vagina	tissue	10.4
Seminal vesicle	tissue	10.1
Rectum	tissue	9.1
Gallbladder	tissue	8.9
Stomach 1	tissue	8.6
Adipose tissue	tissue	8.5
Small intestine	tissue	8.2
Smooth muscle	tissue	8.1
Lung	tissue	8.0
Duodenum	tissue	7.9
Prostate	tissue	7.9
Epididymis	tissue	7.8
Urinary bladder	tissue	7.3
Colon	tissue	7.1
Salivary gland	tissue	6.9
Heart muscle	tissue	6.8

Brain sub-regions (HPA Brain Atlas): detected in 189; highest nTPM — Parieto-temporal junction (white matter) (112.1), Corpus callosum, genu (white matter) (98.7), Corpus callosum, splenium (white matter) (96.4), Temporal white matter (87.2), Occipital cortex (white matter) (77.2).

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

Targeting CPEB2 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific).

showing 30 of 399 miRNAs:

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-3924	100.00	72.09	2394
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-33A-5P	99.99	68.62	1055
HSA-MIR-33B-5P	99.99	68.58	1062
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-520D-5P	99.98	73.34	4883

Functional genomics

gnomAD constraint: pLI 2.39e-16, LOEUF 1.33, missense Z -3.92 — population loss-of-function intolerance (pLI ≥ 0.9 = LoF-intolerant; lower LOEUF = more constrained). gnomAD

Regional missense constraint (gnomAD)

ENST00000538197 splits into 2 regions with different missense tolerance; 0 are missense-constrained. Missense variants in a constrained region (low observed/expected) are more likely to be pathogenic. gnomAD

Region (GRCh38)	Missense obs / exp	o/e	Constrained
4:15,002,674–15,052,509	1411 / 1056.0	1.34	no
4:15,052,510–15,066,377	168 / 339.1	0.50	no

Literature-anchored findings (GeneRIF, showing 13)

• Functional studies of the mouse homolog (PMID:12672660)
• findings demonstrate that the regulation of CPEB2 mRNA splicing is a key mechanism in AnR and a driving force in TNBC metastasis (PMID:26304115)
• CPEB1, 2, and 4, are essential to successful mitotic cell division. (PMID:26398195)
• Long non-coding RNA TUG1 mediates methotrexate resistance in colorectal cancer via miR-186/CPEB2 axis. (PMID:28302487)
• Our findings demonstrated the overexpression of miR-885-5p in liver metastasis and its roles in inducing CRC metastasis, potentiating development of miR-885-5p inhibitor to treat advanced CRC in the future. (PMID:28460469)
• Data demonstrated an increased occurrence of both SRSF3 and the CPEB2B isoform in triple negative breast cancer (TNBC), and identified a consensus binding motif for SRSF3 in the exon promoting the CPEB2B isoform. The study also suggests that the splicing event, which promotes the expression of CPEB2B, is driven by SRSF3 as well as linked to aggressive growth in metastatic TNBC. (PMID:31138601)
• CPEB2, presumably the isoform A, plays a key role in suppressing tumorigenesis in mammary epithelial cells by repressing EMT, migration, invasion, proliferation and stem-like cells phenotype, via multiple targets, including a newly-identified translational target p53. (PMID:31185986)
• A positive feedback self-regulatory loop between miR-210 and HIF-1alpha mediated by CPEB2 is involved in trophoblast syncytialization: implication of trophoblast malfunction in preeclampsiadagger. (PMID:31616934)
• The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer. (PMID:32440535)
• A p53/CPEB2 negative feedback loop regulates renal cancer cell proliferation and migration. (PMID:34362680)
• CPEB2 m6A methylation regulates blood-tumor barrier permeability by regulating splicing factor SRSF5 stability. (PMID:36064747)
• CPEB2 enhances cell growth and angiogenesis by upregulating ARPC5 mRNA stability in multiple myeloma. (PMID:37231521)
• CPEB2 inhibit cell proliferation through upregulating p21 mRNA stability in glioma. (PMID:38158431)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	cpeb2	ENSDARG00000052604
mus_musculus	Cpeb2	ENSMUSG00000039782
rattus_norvegicus	Cpeb2	ENSRNOG00000005043
drosophila_melanogaster	orb2	FBGN0264307
caenorhabditis_elegans		WBGENE00000770
caenorhabditis_elegans		WBGENE00000771

Paralogs (3): CPEB3 (ENSG00000107864), CPEB4 (ENSG00000113742), CPEB1 (ENSG00000214575)

Mouse-model phenotypes

Observed phenotypes of the mouse ortholog (MGI:2442640) from MGI (Alliance of Genome Resources) — knockout/mutant phenotypes, ranked by annotation count. 13 distinct phenotype terms.

Mouse phenotype (MP)	Records
abnormal parasympathetic neuron morphology	1
bronchoconstriction	1
abnormal breathing pattern	1
increased airway responsiveness	1
respiratory failure	1
apnea	1
abnormal whole-body plethysmography	1
decreased heart rate	1
decreased pulmonary respiratory rate	1
abnormal parasympathetic nervous system physiology	1
postnatal lethality, incomplete penetrance	1
increased brain choline acetyltransferase activity	1
increased acetylcholine level	1

Additional cross-species homologs

Sequence homologs in species beyond Ensembl Compara’s model organisms, by Diamond local protein alignment (% sequence identity; best hit per species). Lower-identity rows are more distant homologs. The matched accessions’ gene symbols aren’t in biobtree yet, so each row shows the UniProt accession.

Organism	UniProt	Identity	Method
Pongo abelii	Q5R733	98.4%	Diamond
Xenopus laevis	Q52KN7	96.8%	Diamond
Carassius auratus	Q9DED5	95.3%	Diamond
Xenopus tropicalis	Q28CH2	86.0%	Diamond
Caenorhabditis briggsae	Q6E3F3	72.0%	Diamond
Caenorhabditis remanei	Q6E3F2	71.3%	Diamond
Aplysia californica	Q967R6	66.8%	Diamond
Caenorhabditis japonica	Q6E3F0	65.4%	Diamond

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
C1QTNF7	protein-coding	114905
LINC00504	ncRNA	201853
FBXL5	protein-coding	26234
CPEB2-DT	ncRNA	441009
CC2D2A	protein-coding	57545
C1QTNF7-AS1	ncRNA	101929095
LINC01085	ncRNA	152742

Protein

Protein identifiers

Cytoplasmic polyadenylation element-binding protein 2 — Q7Z5Q1 (reviewed: Q7Z5Q1)

All UniProt accessions (6): A0A5K1VW61, A0A5K1VW71, A0A5K1VW79, A0A5K1VW93, Q7Z5Q1, H0Y9D9

UniProt curated annotations — full annotation on UniProt →

Function. May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers. Required for cell cycle progression, specifically for the transition from metaphase to anaphase.

Subunit / interactions. Interacts with TENT2/GLD2.

Subcellular location. Cytoplasm.

Similarity. Belongs to the RRM CPEB family.

Isoforms (8)

UniProt ID	Names	Canonical?
Q7Z5Q1-2	1	yes
Q7Z5Q1-3	2
Q7Z5Q1-4	3
Q7Z5Q1-5	4, CPEB2b
Q7Z5Q1-6	5
Q7Z5Q1-7	6
Q7Z5Q1-8	7
Q7Z5Q1-9	8

RefSeq proteins (6): NP_001170852, NP_001170853, NP_001170854, NP_001170855, NP_872291, NP_872587 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000504	RRM_dom	Domain
IPR012677	Nucleotide-bd_a/b_plait_sf	Homologous_superfamily
IPR032296	CEBP_ZZ	Domain
IPR034819	CPEB	Family
IPR035979	RBD_domain_sf	Homologous_superfamily
IPR038446	CEBP_ZZ_sf	Homologous_superfamily

Pfam: PF16366, PF16367

UniProt features (17 total): splice variant 5, compositionally biased region 5, domain 2, region of interest 2, chain 1, modified residue 1, sequence conflict 1

Structure

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7Z5Q1-F1	61.86	0.37

Human Protein Atlas

Protein class: Predicted intracellular proteins, UniProt - Evidence at transcript level

Protein evidence: Evidence at protein level

Subcellular location (HPA, imaging): cytosol

Antibody reliability (HPA): IF approved

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1)

Type	Positions
Phosphoserine	89

Function

Pathways and Gene Ontology

Reactome pathways

0 curated (TAS) of 0; 0 disease pathways. Curated-first; evidence = TAS (manually curated) vs IEA (electronic inference).

MSigDB gene sets: 399 (showing top): GOBP_CYTOPLASMIC_TRANSLATION, GOBP_RESPONSE_TO_NITROGEN_COMPOUND, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, TGCACTT_MIR519C_MIR519B_MIR519A, TTTGTAG_MIR520D, ATACCTC_MIR202, GOZGIT_ESR1_TARGETS_DN, GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_DN, GTTAAAG_MIR302B, GOBP_REGULATION_OF_TRANSLATIONAL_ELONGATION, GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, AATGGAG_MIR136, BONCI_TARGETS_OF_MIR15A_AND_MIR16_1, GOBP_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS, GOBP_NEGATIVE_REGULATION_OF_TRANSLATION

GO Biological Process (6): cellular response to insulin stimulus (GO:0032869), cellular response to hypoxia (GO:0071456), negative regulation of cytoplasmic translational elongation (GO:1900248), negative regulation of cytoplasmic translation (GO:2000766), translation (GO:0006412), regulation of translation (GO:0006417)

GO Molecular Function (11): mRNA regulatory element binding translation repressor activity (GO:0000900), RNA binding (GO:0003723), mRNA 3’-UTR binding (GO:0003730), GTPase inhibitor activity (GO:0005095), translation factor activity, RNA binding (GO:0008135), mRNA 3’-UTR AU-rich region binding (GO:0035925), ribosome binding (GO:0043022), ribosomal large subunit binding (GO:0043023), ribosomal small subunit binding (GO:0043024), nucleic acid binding (GO:0003676), translation regulator activity (GO:0045182)

GO Cellular Component (4): nucleus (GO:0005634), cytoplasm (GO:0005737), neuron projection (GO:0043005), synapse (GO:0045202)

GO top-level categories

41 GO namespaces:

Category	Terms
translation	2
mRNA binding	2
ribosome binding	2
response to insulin	1
cellular response to peptide hormone stimulus	1
response to hypoxia	1
cellular response to stress	1
cellular response to decreased oxygen levels	1
cytoplasmic translational elongation	1
negative regulation of translational elongation	1
regulation of cytoplasmic translational elongation	1
negative regulation of cytoplasmic translation	1
cytoplasmic translation	1
negative regulation of translation	1
regulation of cytoplasmic translation	1
peptidyltransferase activity	1
translational initiation	1
translational elongation	1
translational termination	1
macromolecule biosynthetic process	1
protein metabolic process	1
protein biosynthetic process	1
post-transcriptional regulation of gene expression	1
regulation of protein metabolic process	1
translation repressor activity	1
nucleic acid binding	1
GTPase activity	1
enzyme inhibitor activity	1
GTPase regulator activity	1
RNA binding	1
translation factor activity	1
mRNA 3’-UTR binding	1
ribonucleoprotein complex binding	1
binding	1
molecular_function	1
regulation of translation	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cellular anatomical structure	1
plasma membrane bounded cell projection	1
cell junction	1

Experimentally-supported GO annotations

GO terms backed by direct experimental evidence (ECO experimental codes) — 6 of 21 annotations. The rest are phylogenetic / computational / electronic (IEA).

6 experimentally-supported GO terms:

GO term	NS	Evidence
cellular response to hypoxia	BP	direct assay
cellular response to insulin stimulus	BP	direct assay
negative regulation of cytoplasmic translation	BP	mutant phenotype
cytoplasm	CC	direct assay
nucleus	CC	direct assay
RNA binding	MF	high-throughput assay

Protein interactions and networks

STRING

showing 15 of 678 interactions by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CPEB2	TENT2	Q6PIY7	565
CPEB2	FXR2	P51116	492
CPEB2	FXR1	P51114	477
CPEB2	FMR1	Q06787	474
CPEB2	PAPOLG	Q9BWT3	451
CPEB2	PAPOLB	Q9NRJ5	450
CPEB2	PAPOLA	P51003	448
CPEB2	NGDN	Q8NEJ9	435
CPEB2	SYMPK	Q92797	424
CPEB2	EIF4E	P06730	381
CPEB2	ZNF207	O43670	374
CPEB2	CISD3	P0C7P0	370
CPEB2	SPAG4	Q9NPE6	369
CPEB2	RSBN1	Q5VWQ0	368
CPEB2	TIA1	P31483	365

IntAct

Human interaction partners of CPEB2 in IntAct, one row per partner (best MIscore; records = supporting IntAct interaction records).

1 partners by confidence:

Partner	Interaction type	MIscore	Records
CPEB4	association	0.350	1

BioGRID (50 interactions; top human partners by supporting records): EEF2 (Two-hybrid; 3 records), GPX7 (Affinity Capture-Western; 3 records), ATG2A (Two-hybrid), ATP1B2 (Two-hybrid), ATP6 (Two-hybrid), BSCL2 (Two-hybrid), C2CD2L (Two-hybrid), CAPN15 (Two-hybrid), COPS7A (Two-hybrid), CPEB4 (Affinity Capture-MS), CSK (Synthetic Lethality), DMRTB1 (Two-hybrid), DYRK1A (Affinity Capture-MS), ERI3 (Two-hybrid), GAA (Two-hybrid)

Disease & clinical

Genetic variants

Variant evidence for CPEB2: 170 ClinVar records (0 pathogenic / likely pathogenic); 3 GWAS associations.

ClinVar

170 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	164
Likely benign	0
Benign	1

SpliceAI

Top 10 splice-impact sites by Δscore (adjacent positions with the same effect merged into one range; 28 predictions of 1,621):

Position(s)	Effect	Δscore	Sites
4:15007587–15007588	donor_loss	1.0000	4
4:15017186–15017187	acceptor_loss	1.0000	4
4:15017187	acceptor_gain	1.0000
4:15017279–15017280	donor_loss	1.0000	3
4:15052412–15052413	acceptor_loss	1.0000	5
4:15052582	donor_gain	1.0000
4:15052585–15052586	donor_loss	1.0000	3
4:15054126	acceptor_gain	1.0000
4:15058409	acceptor_gain	1.0000
4:15058540–15058541	donor_loss	1.0000	5

HPA cancer prognostics

RNA cancer specificity: Low cancer specificity

Human Protein Atlas survival analysis — favorable = higher expression predicts better survival.

2 prognostic cancer types:

Cancer	Prognostic	p-value
Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)	unfavorable	8e-05
Glioblastoma Multiforme (validation)	unfavorable	0.000337

Disease associations

OMIM: gene MIM:610605 | disease phenotypes:

GWAS associations

3 associations:

Study	Trait	p-value
GCST010244_141	Triglyceride levels	2e-8
GCST012042_1	Type 2 diabetes	3e-8
GCST006406_3	Cognitive flexibility	3e-7

EFO canonical traits (from GWAS)

2 canonical traits:

EFO ID	Trait name
EFO:0009332	executive function measurement
EFO:0004530	triglyceride measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (CPIC guideline: no)

CTD chemical–gene interactions

76 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
methylmercuric chloride	affects cotreatment, increases expression	3
Estradiol	affects cotreatment, increases expression	3
trichostatin A	affects cotreatment, increases expression	2
sodium arsenite	decreases expression, increases expression	2
potassium chromate(VI)	affects cotreatment, decreases expression	2
mercuric bromide	increases expression, affects cotreatment	2
chromium hexavalent ion	increases expression, decreases expression, increases abundance	2
Air Pollutants	affects expression, increases abundance, increases expression	2
Calcitriol	increases expression, affects cotreatment	2
Ozone	affects expression, increases abundance, increases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Tretinoin	increases expression	2
Cyclosporine	increases expression	2
p-Chloromercuribenzoic Acid	affects cotreatment, increases expression	2
aristolochic acid I	decreases expression	1
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
FR900359	affects phosphorylation	1
bisphenol F	affects cotreatment, decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	affects cotreatment, decreases expression	1
2-methyl-4-isothiazolin-3-one	increases expression	1
arsenite	decreases reaction, affects binding	1
sulforaphane	decreases methylation	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
butyraldehyde	decreases expression	1
zinc chromate	increases abundance, increases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
pentanal	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
pentabromodiphenyl ether	increases expression	1

Clinical trials (associated diseases)

Via MONDO — disease-level, not drug-specific.