CPNE8

Summary

CPNE8 (copine 8, HGNC:23498) is a protein-coding gene on chromosome 12q12, encoding Copine-8 (Q86YQ8). Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus.

Source: NCBI Gene 144402 — RefSeq curated summary.

At a glance

• GWAS associations: 21
• Clinical variants (ClinVar): 57 total
• MANE Select transcript: NM_153634

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23498
Approved symbol	CPNE8
Name	copine 8
Location	12q12
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000139117
Ensembl biotype	protein_coding
Entrez	144402

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 5 protein_coding, 5 protein_coding_CDS_not_defined

ENST00000331366, ENST00000360449, ENST00000538596, ENST00000546603, ENST00000547417, ENST00000549842, ENST00000550863, ENST00000551855, ENST00000552259, ENST00000862791

RefSeq mRNA: 1 — MANE Select: NM_153634 NM_153634

CCDS: CCDS8733

Canonical transcript exons

ENST00000331366 — 20 exons

Exon	Start	End
ENSE00001098349	38767635	38767738
ENSE00001326921	38905437	38905591
ENSE00001628967	38723772	38723833
ENSE00001678586	38685490	38685617
ENSE00002377339	38724846	38724899
ENSE00002394433	38652203	38654070
ENSE00003470844	38839916	38839955
ENSE00003483869	38675717	38675774
ENSE00003508238	38873004	38873050
ENSE00003566435	38848559	38848662
ENSE00003568665	38762112	38762216
ENSE00003587218	38874471	38874511
ENSE00003594426	38829379	38829455
ENSE00003610232	38760847	38760888
ENSE00003618238	38702875	38702921
ENSE00003619166	38776238	38776301
ENSE00003643056	38730283	38730358
ENSE00003650104	38693657	38693838
ENSE00003655783	38670729	38670802
ENSE00003659731	38677452	38677554

Expression profiles

Bgee: expression breadth ubiquitous, 233 present calls, max score 92.05.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 16.5059 / max 428.2626, expressed in 1577 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
130427	9.1617	1468
130428	5.6855	1424
130429	0.8082	418
130433	0.2684	117
130430	0.2507	112
130432	0.2145	87
130435	0.0860	25
130431	0.0308	11

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
epithelial cell of pancreas	CL:0000083	92.05	gold quality
calcaneal tendon	UBERON:0003701	90.69	gold quality
sperm	CL:0000019	90.43	gold quality
monocyte	CL:0000576	89.15	gold quality
leukocyte	CL:0000738	88.52	gold quality
right atrium auricular region	UBERON:0006631	87.37	gold quality
cardiac atrium	UBERON:0002081	87.24	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.10	gold quality
right lung	UBERON:0002167	87.03	gold quality
pigmented layer of retina	UBERON:0001782	86.60	gold quality
subcutaneous adipose tissue	UBERON:0002190	86.29	gold quality
right lobe of liver	UBERON:0001114	86.01	gold quality
omental fat pad	UBERON:0010414	86.01	gold quality
peritoneum	UBERON:0002358	85.99	gold quality
rectum	UBERON:0001052	85.59	gold quality
upper lobe of left lung	UBERON:0008952	85.42	gold quality
upper lobe of lung	UBERON:0008948	85.29	gold quality
colonic epithelium	UBERON:0000397	85.21	gold quality
adipose tissue of abdominal region	UBERON:0007808	85.14	gold quality
pericardium	UBERON:0002407	84.48	gold quality
endothelial cell	CL:0000115	83.96	gold quality
smooth muscle tissue	UBERON:0001135	83.88	gold quality
mucosa of stomach	UBERON:0001199	83.86	gold quality
lung	UBERON:0002048	83.80	gold quality
cardiac muscle of right atrium	UBERON:0003379	83.80	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.59	gold quality
descending thoracic aorta	UBERON:0002345	83.05	gold quality
tibial artery	UBERON:0007610	82.95	gold quality
popliteal artery	UBERON:0002250	82.93	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	82.85	gold quality

Single-cell (SCXA)

Detected in 7 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-GEOD-76312	yes	622.77
E-GEOD-81608	yes	604.99
E-CURD-119	yes	25.97
E-ANND-3	yes	25.21
E-GEOD-83139	no	547.98
E-MTAB-7249	no	252.68
E-MTAB-6678	no	3.39

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

184 targeting CPNE8, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882

Literature-anchored findings (GeneRIF, showing 1)

• CPNE8 Promotes Gastric Cancer Metastasis by Modulating Focal Adhesion Pathway and Tumor Microenvironment. (PMID:35982908)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	CPNE8	ENSDARG00000102191
mus_musculus	Cpne8	ENSMUSG00000052560
rattus_norvegicus	Cpne8	ENSRNOG00000026128
caenorhabditis_elegans		WBGENE00001577
caenorhabditis_elegans		WBGENE00012128

Paralogs (8): CPNE3 (ENSG00000085719), CPNE6 (ENSG00000100884), CPNE5 (ENSG00000124772), CPNE2 (ENSG00000140848), CPNE9 (ENSG00000144550), CPNE7 (ENSG00000178773), CPNE4 (ENSG00000196353), CPNE1 (ENSG00000214078)

Protein

Protein identifiers

Copine-8 — Q86YQ8 (reviewed: Q86YQ8)

Alternative names: Copine VIII

All UniProt accessions (3): Q86YQ8, E7ENV7, F8VZB5

UniProt curated annotations — full annotation on UniProt →

Function. Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.

Cofactor. Binds 3 Ca(2+) ions per C2 domain.

Similarity. Belongs to the copine family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q86YQ8-1	1	yes
Q86YQ8-2	2

RefSeq proteins (1): NP_705898* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000008	C2_dom	Domain
IPR002035	VWF_A	Domain
IPR010734	Copine_C	Domain
IPR035892	C2_domain_sf	Homologous_superfamily
IPR036465	vWFA_dom_sf	Homologous_superfamily
IPR037768	C2B_Copine	Domain
IPR045052	Copine	Family

Pfam: PF00168, PF07002

UniProt features (27 total): binding site 20, domain 3, chain 1, modified residue 1, splice variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86YQ8-F1	88.19	0.67

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (20): 101; 101; 104; 109; 111; 111; 173; 173; 179; 235; 235; 237 …

Post-translational modifications (1): 260

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-9013148	CDC42 GTPase cycle
R-HSA-9013405	RHOD GTPase cycle
R-HSA-9013406	RHOQ GTPase cycle
R-HSA-9013409	RHOJ GTPase cycle

MSigDB gene sets: 230 (showing top): GSE45365_NK_CELL_VS_BCELL_UP, TGGTGCT_MIR29A_MIR29B_MIR29C, RNGTGGGC_UNKNOWN, AP1_01, GOBP_REGULATION_OF_CELL_MORPHOGENESIS, GOBP_NEURON_PROJECTION_EXTENSION, GOBP_REGULATION_OF_DEVELOPMENTAL_GROWTH, GOBP_GROWTH, chr12q12, IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR, GOBP_NEUROGENESIS, GGGTGGRR_PAX4_03, GOBP_RESPONSE_TO_METAL_ION, WANG_RESPONSE_TO_BEXAROTENE_DN, GOBP_POSITIVE_REGULATION_OF_CELL_GROWTH

GO Biological Process (2): cellular response to calcium ion (GO:0071277), positive regulation of dendrite extension (GO:1903861)

GO Molecular Function (3): calcium-dependent phospholipid binding (GO:0005544), metal ion binding (GO:0046872), protein binding (GO:0005515)

GO Cellular Component (2): plasma membrane (GO:0005886), extracellular exosome (GO:0070062)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RHO GTPase cycle	4

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
response to calcium ion	1
cellular response to metal ion	1
positive regulation of cell growth	1
positive regulation of developmental growth	1
dendrite extension	1
regulation of dendrite extension	1
phospholipid binding	1
cation binding	1
binding	1
membrane	1
cell periphery	1
extracellular vesicle	1

Protein interactions and networks

STRING

1002 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CPNE8	VSTM2L	Q96N03	476
CPNE8	POPDC3	Q9HBV1	462
CPNE8	ZNF385B	Q569K4	458
CPNE8	RCAN2	Q14206	427
CPNE8	CBLN2	Q8IUK8	426
CPNE8	ANLN	Q9NQW6	425
CPNE8	SMIM12	Q96EX1	419
CPNE8	SYT10	Q6XYQ8	418
CPNE8	GNG4	P50150	416
CPNE8	SPON1	Q9HCB6	410
CPNE8	CNTNAP2	Q9UHC6	410
CPNE8	CNTN4	Q8IWV2	400
CPNE8	MSRB3	Q8IXL7	396
CPNE8	NR4A2	P43354	380
CPNE8	SERGEF	Q9UGK8	379

IntAct

60 interactions, top by confidence:

A	B	Type	Score
SORBS3	CPNE8	psi-mi:“MI:0915”(physical association)	0.560
CPNE8	NECAB1	psi-mi:“MI:0915”(physical association)	0.560
SLC25A41	NUDT19	psi-mi:“MI:0914”(association)	0.530
TMEM185A	TSPAN6	psi-mi:“MI:0914”(association)	0.530
NRAS	ESYT2	psi-mi:“MI:2364”(proximity)	0.480
SCRIB	CPNE8	psi-mi:“MI:0407”(direct interaction)	0.440
CPNE8	MPI	psi-mi:“MI:0915”(physical association)	0.400
CPNE5	CPNE8	psi-mi:“MI:0915”(physical association)	0.400
CTDSPL2	ELOC	psi-mi:“MI:0914”(association)	0.350
ARRB1		psi-mi:“MI:0914”(association)	0.350
RNF213	GNB1	psi-mi:“MI:0914”(association)	0.350
CSPP1	DCTN6	psi-mi:“MI:0914”(association)	0.350
CPNE8	Bgn	psi-mi:“MI:0914”(association)	0.350
CSAG2	CAMK2D	psi-mi:“MI:0914”(association)	0.350
ANLN	UBA6	psi-mi:“MI:0914”(association)	0.350
MCM7	VPS37C	psi-mi:“MI:0914”(association)	0.350
ZDHHC23	VPS37C	psi-mi:“MI:0914”(association)	0.350
SRSF7	IGF2BP3	psi-mi:“MI:0914”(association)	0.350
SNAPC1	RP2	psi-mi:“MI:0914”(association)	0.350
OGDHL	RP2	psi-mi:“MI:0914”(association)	0.350
CACYBP	VPS37C	psi-mi:“MI:0914”(association)	0.350
CACYBP	PSMD11	psi-mi:“MI:0914”(association)	0.350
CAPRIN1	VPS37C	psi-mi:“MI:0914”(association)	0.350
CFL2	VPS37C	psi-mi:“MI:0914”(association)	0.350
CSDE1	VPS37C	psi-mi:“MI:0914”(association)	0.350
EIF4A1	SNAP23	psi-mi:“MI:0914”(association)	0.350
TSC22D3	VPS37C	psi-mi:“MI:0914”(association)	0.350

BioGRID (126): CPNE8 (Affinity Capture-RNA), CPNE8 (Affinity Capture-RNA), CPNE8 (Affinity Capture-RNA), CPNE8 (Affinity Capture-MS), CPNE8 (Affinity Capture-MS), CPNE8 (Affinity Capture-MS), CPNE8 (Affinity Capture-MS), EIF3I (Co-fractionation), NDUFS1 (Co-fractionation), CPNE8 (Proximity Label-MS), CPNE8 (Affinity Capture-MS), CPNE8 (Affinity Capture-MS), CPNE8 (Affinity Capture-MS), CPNE8 (Affinity Capture-MS), CPNE8 (Affinity Capture-MS)

ESM2 similar proteins: A0JJX5, A2WWV5, A2X479, B6ETT4, B8XCH5, O49303, O49435, O64492, O65554, P59108, Q0JBH9, Q0JHU5, Q0VE82, Q1RLL3, Q25AG5, Q5BJS7, Q6YWF1, Q7XA06, Q84TJ7, Q86YQ8, Q8BLR2, Q8IYJ1, Q8L706, Q8LFN9, Q8RXU9, Q944C1, Q96A23, Q96FN4, Q9C6B7, Q9C8S6, Q9C8Y2, Q9DC53, Q9FHP6, Q9FI32, Q9FIK8, Q9FJG3, Q9FL59, Q9FVJ3, Q9LP65, Q9LVH4

Diamond homologs: A8WMY4, D4A1R8, H1UBN0, H2KYS8, O75131, O95741, P59108, Q08DB4, Q0VE82, Q1RLL3, Q1ZXB3, Q2KHY1, Q54FY7, Q54P51, Q55GG1, Q5BJS7, Q5R4W6, Q5RAE1, Q5S1W2, Q5XQC7, Q7YXU4, Q86K21, Q86YQ8, Q8BLR2, Q8BT60, Q8C166, Q8IYJ1, Q8JZW4, Q941L3, Q96A23, Q96FN4, Q99829, Q9DC53, Q9HCH3, Q9UBL6, Q9XUB9, Q9Z140, A0JJX5, Q09219, Q12466

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 62 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Signaling by RAF1 mutants	5	34.0×	1e-05
Signaling by moderate kinase activity BRAF mutants	5	30.9×	1e-05
Paradoxical activation of RAF signaling by kinase inactive BRAF	5	30.9×	1e-05
Signaling downstream of RAS mutants	5	30.9×	1e-05
Signaling by BRAF and RAF1 fusions	5	20.8×	6e-05
RAF/MAP kinase cascade	7	10.4×	6e-05

GO biological processes:

GO term	Partners	Fold	FDR
ubiquitin-dependent protein catabolic process	6	8.1×	7e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

57 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	39
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

4366 predictions. Top by Δscore:

Variant	Effect	Δscore
12:38654067:CAAA:C	acceptor_gain	1.0000
12:38670723:TCTTA:T	donor_loss	1.0000
12:38670724:CTTA:C	donor_loss	1.0000
12:38670725:TTA:T	donor_loss	1.0000
12:38670726:TA:T	donor_loss	1.0000
12:38670728:CCTG:C	donor_gain	1.0000
12:38670798:CATTG:C	acceptor_gain	1.0000
12:38670799:ATTG:A	acceptor_gain	1.0000
12:38670800:TTG:T	acceptor_gain	1.0000
12:38670801:TG:T	acceptor_gain	1.0000
12:38670801:TGC:T	acceptor_loss	1.0000
12:38670803:C:A	acceptor_loss	1.0000
12:38670803:C:CC	acceptor_gain	1.0000
12:38670804:T:C	acceptor_gain	1.0000
12:38670805:T:C	acceptor_gain	1.0000
12:38677450:A:AC	donor_gain	1.0000
12:38677451:C:CC	donor_gain	1.0000
12:38679583:A:AC	donor_gain	1.0000
12:38679584:C:CC	donor_gain	1.0000
12:38685628:T:C	acceptor_gain	1.0000
12:38702867:ACACT:A	donor_loss	1.0000
12:38702868:CACT:C	donor_loss	1.0000
12:38702869:ACTC:A	donor_loss	1.0000
12:38702870:CT:C	donor_loss	1.0000
12:38702872:C:CG	donor_loss	1.0000
12:38702873:A:AC	donor_gain	1.0000
12:38702873:A:AG	donor_loss	1.0000
12:38702874:C:CC	donor_gain	1.0000
12:38702874:C:T	donor_loss	1.0000
12:38705208:T:TA	donor_gain	1.0000

AlphaMissense

3716 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:38654068:A:C	F503L	1.000
12:38654068:A:T	F503L	1.000
12:38654070:A:G	F503L	1.000
12:38670790:A:G	L482S	1.000
12:38675721:A:C	F476L	1.000
12:38675721:A:T	F476L	1.000
12:38675723:A:G	F476L	1.000
12:38675734:C:T	G472E	1.000
12:38675735:C:G	G472R	1.000
12:38675735:C:T	G472R	1.000
12:38675740:C:T	G470D	1.000
12:38675741:C:G	G470R	1.000
12:38675746:A:T	I468K	1.000
12:38677498:T:A	D443V	1.000
12:38677510:A:G	L439P	1.000
12:38677513:A:G	L438P	1.000
12:38693705:A:C	F365L	1.000
12:38693705:A:T	F365L	1.000
12:38693707:A:G	F365L	1.000
12:38693709:C:T	G364E	1.000
12:38702876:G:C	N320K	1.000
12:38702876:G:T	N320K	1.000
12:38702886:G:A	T317I	1.000
12:38702891:A:C	D315E	1.000
12:38702891:A:T	D315E	1.000
12:38702892:T:A	D315V	1.000
12:38730344:C:T	G246E	1.000
12:38762164:A:G	W210R	1.000
12:38762164:A:T	W210R	1.000
12:38653992:C:G	A529P	0.999

dbSNP variants (sampled 300 via entrez): RS1000011004 (12:38853922 C>A,T), RS1000031331 (12:38808191 G>A), RS1000031880 (12:38902050 G>A), RS1000034419 (12:38664631 G>A), RS1000039302 (12:38713292 C>T), RS1000060097 (12:38769575 G>C), RS1000091690 (12:38752526 A>G), RS1000095394 (12:38671396 C>A), RS1000103417 (12:38682549 A>G), RS1000104751 (12:38766458 T>A), RS1000112533 (12:38866920 G>A,T), RS1000116432 (12:38707277 G>A), RS1000151593 (12:38791411 T>A), RS1000154216 (12:38682854 T>C), RS1000161529 (12:38661749 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

21 associations (top):

Study	Trait	p-value
GCST001969_21	Heart rate	4.000000e-09
GCST002783_441	Body mass index	1.000000e-07
GCST002783_517	Body mass index	7.000000e-08
GCST004139_14	Bipolar disorder	4.000000e-07
GCST005788_26	Heart rate response to recovery post exercise	2.000000e-07
GCST005789_22	Resting heart rate	8.000000e-07
GCST006304_11	Irritable bowel syndrome	3.000000e-06
GCST007565_158	Morning person	5.000000e-43
GCST007565_196	Morning person	6.000000e-29
GCST007565_207	Morning person	2.000000e-39
GCST007565_210	Morning person	1.000000e-40
GCST007565_63	Morning person	1.000000e-17
GCST007565_76	Morning person	2.000000e-43
GCST007565_78	Morning person	4.000000e-43
GCST007576_335	Chronotype	2.000000e-43
GCST007672_2	3-month functional outcome in ischaemic stroke (modified Rankin score)	5.000000e-07
GCST007672_9	3-month functional outcome in ischaemic stroke (modified Rankin score)	6.000000e-07
GCST008097_2	Bisphosphonate-associated atypical femoral fracture	2.000000e-06
GCST008403_9	Arterial stiffness index	3.000000e-06
GCST008522_57	Bitter alcoholic beverage consumption	8.000000e-07
GCST010989_38	Body size at age 10	3.000000e-12

EFO canonical traits (9, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index
EFO:0009185	heart rate response to recovery post exercise
EFO:0008328	chronotype measurement
EFO:0009603	stroke outcome severity measurement
EFO:0009958	response to bisphosphonate
EFO:0009960	atypical femoral fracture
EFO:0004517	arterial stiffness measurement
EFO:0010092	bitter alcoholic beverage consumption measurement
EFO:0009819	comparative body size at age 10, self-reported

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

44 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	6
sodium arsenite	decreases expression, increases abundance, increases expression	4
Cyclosporine	increases expression	3
bisphenol A	affects cotreatment, decreases methylation, decreases expression	2
potassium chromate(VI)	affects cotreatment, decreases expression	2
Arsenic	increases abundance, increases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Tobacco Smoke Pollution	affects expression, decreases expression	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	2
aristolochic acid I	decreases expression	1
sodium arsenate	increases abundance, increases expression	1
tris(2-butoxyethyl) phosphate	affects expression	1
epigallocatechin gallate	decreases expression, affects cotreatment	1
di-n-butylphosphoric acid	affects expression	1
chromium hexavalent ion	decreases expression	1
perfluorooctane sulfonic acid	decreases expression	1
K 7174	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	increases expression, affects cotreatment	1
bisphenol S	decreases methylation	1
jinfukang	decreases expression	1
incobotulinumtoxinA	increases expression	1
NSC 689534	affects binding, increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Temozolomide	decreases expression	1
Zoledronic Acid	decreases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Vorinostat	increases expression	1
Benzo(a)pyrene	increases expression	1
Cadmium	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.