CPS1-IT1

Summary

CPS1-IT1 (CPS1 intronic transcript 1, HGNC:30102) is a long non-coding RNA gene on chromosome 2q34.

This gene does not encode a protein, and it is located within an intron of the gene encoding carbamoyl-phosphate synthetase 1.

Source: NCBI Gene 29034 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30102
Approved symbol	CPS1-IT1
Name	CPS1 intronic transcript 1
Location	2q34
Locus type	RNA, long non-coding
Status	Approved
Aliases	PRO0132, CPS1-IT
Ensembl gene	ENSG00000280837
Ensembl biotype	lncRNA
Entrez	29034
RNAcentral	URS000075DB07 — lncRNA, 2306 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000628368

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000628368 — 1 exons

Exon	Start	End
ENSE00003764940	210617571	210619876

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 88.59.

Top tissues by expression

209 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.59	gold quality
islet of Langerhans	UBERON:0000006	72.93	gold quality
liver	UBERON:0002107	71.62	gold quality
cervix squamous epithelium	UBERON:0006922	71.46	gold quality
triceps brachii	UBERON:0001509	70.39	gold quality
gluteal muscle	UBERON:0002000	70.18	gold quality
jejunal mucosa	UBERON:0000399	69.99	gold quality
right lobe of liver	UBERON:0001114	67.44	gold quality
tongue squamous epithelium	UBERON:0006919	66.28	gold quality
mononuclear cell	CL:0000842	66.13	gold quality
cingulate cortex	UBERON:0003027	64.51	gold quality
mucosa of urinary bladder	UBERON:0001259	64.05	gold quality
quadriceps femoris	UBERON:0001377	62.89	gold quality
vastus lateralis	UBERON:0001379	62.71	gold quality
jejunum	UBERON:0002115	62.62	gold quality
smooth muscle tissue	UBERON:0001135	62.49	gold quality
olfactory bulb	UBERON:0002264	62.02	gold quality
type B pancreatic cell	CL:0000169	61.86	gold quality
duodenum	UBERON:0002114	61.84	silver quality
orbitofrontal cortex	UBERON:0004167	60.96	gold quality
nasal cavity epithelium	UBERON:0005384	60.87	gold quality
epithelial cell of pancreas	CL:0000083	60.73	gold quality
small intestine	UBERON:0002108	60.49	gold quality
diaphragm	UBERON:0001103	60.38	gold quality
muscle organ	UBERON:0001630	58.89	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	58.86	gold quality
Brodmann (1909) area 9	UBERON:0013540	58.62	gold quality
uterine cervix	UBERON:0000002	58.53	gold quality
putamen	UBERON:0001874	58.33	gold quality
thymus	UBERON:0002370	57.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.45

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• LncRNA CPS1-IT1 acts as a tumor suppressor in hepatocellular carcinoma by reducing HIF-1alpha activation and suppressing epithelial-mesenchymal transition. (PMID:27248828)
• CPS1-IT1 suppresses tumor growth by reducing cell proliferation, migration and invasion capacities as well as by promoting cell apoptosis, thereby suppressing epithelial-mesenchymal transition. (PMID:29145177)
• CPS1-IT1 controls melanoma metastasis through impairing Cyr61 expression via competitively binding with BRG1 (PMID:31111478)
• CPS1-IT1 plays an anti-oncogenic role in glioma. (PMID:31545272)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.