CREB3L4

Summary

CREB3L4 (cAMP responsive element binding protein 3 like 4, HGNC:18854) is a protein-coding gene on chromosome 1q21.3, encoding Cyclic AMP-responsive element-binding protein 3-like protein 4 (Q8TEY5). Transcriptional activator that may play a role in the unfolded protein response.

This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 148327 — RefSeq curated summary.

At a glance

• GWAS associations: 18
• Clinical variants (ClinVar): 74 total — 2 pathogenic
• MANE Select transcript: NM_001255978

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18854
Approved symbol	CREB3L4
Name	cAMP responsive element binding protein 3 like 4
Location	1q21.3
Locus type	gene with protein product
Status	Approved
Aliases	AIbZIP, CREB4, CREB3, hJAL, ATCE1
Ensembl gene	ENSG00000143578
Ensembl biotype	protein_coding
OMIM	607138
Entrez	148327

Gene structure

Transcript identifiers

Ensembl transcripts: 46 — 40 protein_coding, 6 protein_coding_CDS_not_defined

ENST00000271889, ENST00000368600, ENST00000368601, ENST00000368603, ENST00000368607, ENST00000431292, ENST00000449724, ENST00000461688, ENST00000468845, ENST00000473340, ENST00000477617, ENST00000479010, ENST00000492729, ENST00000885128, ENST00000885129, ENST00000885130, ENST00000885131, ENST00000885132, ENST00000885133, ENST00000885134, ENST00000885135, ENST00000885136, ENST00000885137, ENST00000885138, ENST00000885139, ENST00000885140, ENST00000885141, ENST00000885142, ENST00000930318, ENST00000930319, ENST00000930320, ENST00000930321, ENST00000930322, ENST00000930323, ENST00000930324, ENST00000930325, ENST00000930326, ENST00000930327, ENST00000946154, ENST00000946155, ENST00000946156, ENST00000946157, ENST00000946158, ENST00000946159, ENST00000946160, ENST00000946161

RefSeq mRNA: 5 — MANE Select: NM_001255978 NM_001255978, NM_001255979, NM_001255980, NM_001255981, NM_130898

CCDS: CCDS1056, CCDS58029

Canonical transcript exons

ENST00000368607 — 10 exons

Exon	Start	End
ENSE00000960970	153972972	153973078
ENSE00001421042	153967902	153968164
ENSE00001865408	153973872	153974359
ENSE00003465238	153972744	153972836
ENSE00003503193	153968930	153969176
ENSE00003510416	153973195	153973263
ENSE00003525228	153969334	153969455
ENSE00003542152	153968522	153968699
ENSE00003617392	153973620	153973716
ENSE00003623170	153973380	153973464

Expression profiles

Bgee: expression breadth ubiquitous, 217 present calls, max score 95.81.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.5866 / max 121.2029, expressed in 1670 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
5457	5.8602	1534
5456	2.2952	1054
5458	0.3595	156
5459	0.0718	39

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
parotid gland	UBERON:0001831	95.81	gold quality
right uterine tube	UBERON:0001302	95.00	gold quality
prostate gland	UBERON:0002367	94.41	gold quality
saliva-secreting gland	UBERON:0001044	92.40	gold quality
minor salivary gland	UBERON:0001830	91.76	gold quality
body of stomach	UBERON:0001161	89.35	gold quality
left ovary	UBERON:0002119	89.12	gold quality
right lobe of liver	UBERON:0001114	88.73	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	88.63	gold quality
mouth mucosa	UBERON:0003729	88.51	gold quality
pancreatic ductal cell	CL:0002079	88.23	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.22	gold quality
right ovary	UBERON:0002118	88.05	gold quality
stomach	UBERON:0000945	87.98	gold quality
mucosa of transverse colon	UBERON:0004991	87.57	gold quality
body of pancreas	UBERON:0001150	87.45	gold quality
rectum	UBERON:0001052	87.35	gold quality
oviduct epithelium	UBERON:0004804	87.02	gold quality
endocervix	UBERON:0000458	86.90	gold quality
ovary	UBERON:0000992	86.65	gold quality
fallopian tube	UBERON:0003889	86.34	gold quality
right lobe of thyroid gland	UBERON:0001119	86.10	gold quality
ileal mucosa	UBERON:0000331	86.01	gold quality
right adrenal gland	UBERON:0001233	85.60	gold quality
epithelium of mammary gland	UBERON:0003244	85.51	gold quality
mammary duct	UBERON:0001765	85.42	gold quality
fundus of stomach	UBERON:0001160	85.30	gold quality
ganglionic eminence	UBERON:0004023	85.14	gold quality
right adrenal gland cortex	UBERON:0035827	84.99	gold quality
left lobe of thyroid gland	UBERON:0001120	84.96	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-75688	yes	424.90
E-ANND-3	yes	3.72
E-CURD-10	no	109.16

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

3 targets.

Target	Regulation
CREB3L4
DNAJC12	Unknown
HSPA5	Activation

JASPAR motifs

Motif	Name	Family
MA1474.1	CREB3L4	CREB-related factors
MA1474.2	CREB3L4	CREB-related factors
MA1475.1	CREB3L4	CREB-related factors
MA1475.2	CREB3L4	CREB-related factors

JASPAR matrix evidence (PMIDs): PMID:21711675

Upstream regulators (CollecTRI, top): CREB3L4, CREM

miRNA regulators (miRDB)

11 targeting CREB3L4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-1323	99.83	69.89	2471
HSA-MIR-548O-3P	99.74	69.30	2228
HSA-MIR-6892-3P	99.68	66.40	1178
HSA-MIR-186-3P	99.51	66.24	1685
HSA-MIR-4640-5P	97.42	66.33	1543
HSA-MIR-4726-5P	97.24	65.67	1299
HSA-MIR-424-3P	97.20	65.86	385
HSA-MIR-6747-5P	96.17	64.99	743
HSA-MIR-4772-5P	95.60	68.04	617

Literature-anchored findings (GeneRIF, showing 10)

• AIbZIP, a novel bZIP gene located on chromosome 1q21.3 that is highly expressed in prostate tumors and of which the expression is up-regulated by androgens in LNCaP human prostate cancer cells. (PMID:11830526)
• identified a novel human CREB gene (CREB4) that was 1592 bp long and encoded a protein of 395 amino acid residues (PMID:12111373)
• S1P cleavage of CREB4 may be suppressed by a determinant in the C-terminal region (PMID:16236796)
• In LNCaP cell lines that conditionally express the processed form of AIbZIP, downstream targets of AIbZIP include genes for protein processing, transcriptional regulation, small molecule transport, signal transduction, metabolism & cell homeostasis. (PMID:17712038)
• AIbZIP induced by the androgen receptor axis plays a crucial role in the p21 dependent proliferation of androgen-sensitive prostate cancer cells. (PMID:27853318)
• CREB3L4 expression is mediated by an androgen-receptor -IRE1alpha axis, but is also directly regulated by androgen-receptor-to-androgen response elements binding. (PMID:28338058)
• Study demonstrated that MCU1 is frequently overexpressed in breast cancer and abnormally high expression of MUC1 indicates poor prognosis. Subsequent data mining across multiple large databases demonstrated a positive association between MUC1 mRNA expression CREB3L4 in breast cancer tissues. Results indicated that MUC1 transcript expression may regulate tumor invasion and metastasis associated with CREB3L4 transcription. (PMID:30483806)
• The Novel Transcription Factor CREB3L4 Contributes to the Progression of Human Breast Carcinoma. (PMID:32026099)
• MSC-AS1 knockdown inhibits cell growth and temozolomide resistance by regulating miR-373-3p/CPEB4 axis in glioma through PI3K/Akt pathway. (PMID:33106913)
• AIbZIP/CREB3L4 Promotes Cell Proliferation via the SKP2-p27 Axis in Luminal Androgen Receptor Subtype Triple-Negative Breast Cancer. (PMID:38236913)

Cross-species orthologs

8 orthologs

Organism	Symbol	Gene ID
mus_musculus	Creb3l4	ENSMUSG00000027938
rattus_norvegicus	Creb3l4	ENSRNOG00000023493
drosophila_melanogaster	CrebA	FBGN0004396
drosophila_melanogaster	Atf6	FBGN0033010
drosophila_melanogaster	CrebB	FBGN0265784
caenorhabditis_elegans		WBGENE00000222
caenorhabditis_elegans		WBGENE00000793
caenorhabditis_elegans		WBGENE00016162

Paralogs (9): CREB3L3 (ENSG00000060566), CREM (ENSG00000095794), CREB3 (ENSG00000107175), ATF6 (ENSG00000118217), CREB1 (ENSG00000118260), ATF1 (ENSG00000123268), CREB3L1 (ENSG00000157613), CREB3L2 (ENSG00000182158), ATF6B (ENSG00000213676)

Protein

Protein identifiers

Cyclic AMP-responsive element-binding protein 3-like protein 4 — Q8TEY5 (reviewed: Q8TEY5)

Alternative names: Androgen-induced basic leucine zipper protein, Attaching to CRE-like 1, Cyclic AMP-responsive element-binding protein 4, Transcript induced in spermiogenesis protein 40, hJAL

All UniProt accessions (4): Q8TEY5, Q5T4K9, Q5T4L1, Q5T4L2

UniProt curated annotations — full annotation on UniProt →

Function. Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5’-T[GT]ACGT[GA][GT]-3’ and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements.

Subunit / interactions. Binds DNA as a dimer.

Subcellular location. Endoplasmic reticulum membrane. Golgi apparatus membrane Nucleus.

Tissue specificity. According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to PubMed:12111373, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus.

Post-translational modifications. N-glycosylated in the C-terminal region. Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region.

Induction. By androgens.

Similarity. Belongs to the bZIP family. ATF subfamily.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8TEY5-1	1	yes
Q8TEY5-2	2

RefSeq proteins (5): NP_001242907, NP_001242908, NP_001242909, NP_001242910, NP_570968 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004827	bZIP	Domain
IPR046347	bZIP_sf	Homologous_superfamily
IPR051381	CREB_ATF_subfamily	Family

Pfam: PF00170

UniProt features (16 total): region of interest 4, chain 2, topological domain 2, site 1, glycosylation site 1, splice variant 1, sequence variant 1, mutagenesis site 1, sequence conflict 1, transmembrane region 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TEY5-F1	61.56	0.22

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 338–339 (cleavage; by ps1)

Glycosylation sites (1): 366

Mutagenesis-validated functional residues (1):

Position	Phenotype
335	abolishes cleavage by sp1.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-8874211	CREB3 factors activate genes

MSigDB gene sets: 353 (showing top): GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS, GOBP_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT, REACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR, GOBP_MYELOID_LEUKOCYTE_MIGRATION, GOBP_CELL_CHEMOTAXIS, GOBP_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, GOBP_GROWTH, GOBP_INDUCTION_OF_POSITIVE_CHEMOTAXIS, TGACCTY_ERR1_Q2, AP2_Q3, GOBP_MALE_GAMETE_GENERATION, GGGTGGRR_PAX4_03, GOBP_REGULATION_OF_POSITIVE_CHEMOTAXIS, GOBP_REGULATION_OF_LEUKOCYTE_MIGRATION

GO Biological Process (5): regulation of transcription by RNA polymerase II (GO:0006357), response to unfolded protein (GO:0006986), spermatogenesis (GO:0007283), positive regulation of transcription by RNA polymerase II (GO:0045944), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (8): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228), sequence-specific double-stranded DNA binding (GO:1990837), RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA binding (GO:0003677), DNA-binding transcription factor activity (GO:0003700), protein binding (GO:0005515)

GO Cellular Component (10): Golgi membrane (GO:0000139), chromatin (GO:0000785), nucleus (GO:0005634), nucleoplasm (GO:0005654), mitochondrion (GO:0005739), endoplasmic reticulum (GO:0005783), endoplasmic reticulum membrane (GO:0005789), Golgi apparatus (GO:0005794), nuclear membrane (GO:0031965), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Unfolded Protein Response (UPR)	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular membrane-bounded organelle	4
RNA polymerase II transcription regulatory region sequence-specific DNA binding	3
cellular anatomical structure	3
cytoplasm	3
regulation of DNA-templated transcription	2
transcription by RNA polymerase II	2
regulation of transcription by RNA polymerase II	2
transcription cis-regulatory region binding	2
endomembrane system	2
organelle membrane	2
response to topologically incorrect protein	1
developmental process involved in reproduction	1
male gamete generation	1
positive regulation of DNA-templated transcription	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription activator activity	1
positive regulation of transcription by RNA polymerase II	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
nucleic acid binding	1
transcription regulator activity	1
binding	1
Golgi apparatus	1
bounding membrane of organelle	1
chromosome	1
nuclear lumen	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
nucleus	1
nuclear envelope	1

Protein interactions and networks

STRING

806 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CREB3L4	HCFC1	P51610	882
CREB3L4	HCFC2	Q9Y5Z7	832
CREB3L4	CREBZF	Q9NS37	790
CREB3L4	HDAC3	O15379	788
CREB3L4	CREBRF	Q8IUR6	752
CREB3L4	MBTPS1	Q14703	571
CREB3L4	MBTPS2	O43462	566
CREB3L4	CREB1	P16220	548
CREB3L4	FBXL20	Q96IG2	543
CREB3L4	FBXL2	Q9UKC9	541
CREB3L4	PAQR4	Q8N4S7	530
CREB3L4	ARF4	P18085	510
CREB3L4	EIF2AK2	P19525	496
CREB3L4	EIF2S3	P41091	494
CREB3L4	XBP1	P17861	478

IntAct

12 interactions, top by confidence:

A	B	Type	Score
GET3	CREB3L4	psi-mi:“MI:0915”(physical association)	0.560
CREB3	MYO9A	psi-mi:“MI:0914”(association)	0.530
CREB3L4	CREB3	psi-mi:“MI:2364”(proximity)	0.480
GANAB	CREB3L4	psi-mi:“MI:0915”(physical association)	0.370
CREB3L4	LRRC4C	psi-mi:“MI:0915”(physical association)	0.370
SLC19A3	CREB3L4	psi-mi:“MI:0915”(physical association)	0.370
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
CREB3L3	AP3B1	psi-mi:“MI:0914”(association)	0.350
GET3	CREB3L4	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (14): CREB3L4 (Affinity Capture-RNA), CREB3L4 (Affinity Capture-RNA), CREB3L4 (Co-localization), CREB3L4 (Affinity Capture-MS), ASNA1 (Two-hybrid), CREB3L4 (Affinity Capture-MS), CREB3L4 (Affinity Capture-MS), CREB3L4 (Affinity Capture-MS), CREB3L4 (Affinity Capture-MS), CREM (Affinity Capture-Western), CREB3L4 (Reconstituted Complex), LRRC4C (Two-hybrid), GANAB (Two-hybrid), SLC19A3 (Two-hybrid)

ESM2 similar proteins: A1L224, A2VD01, D3ZLB7, F6VAN0, G3V909, O02761, O35451, O43889, O77628, O88479, O94983, O97930, P01100, P01101, P01102, P0C0N8, P0C0N9, P11939, P12841, P18850, P20389, P38532, Q00613, Q08CW8, Q08DJ8, Q1LYG4, Q3SYZ3, Q502F0, Q56TN0, Q56TT7, Q5FVM5, Q5RCM9, Q5UEM7, Q5UEM8, Q61817, Q64210, Q66HA2, Q68CJ9, Q6QDP7, Q6ZPJ0

Diamond homologs: A1L224, A2VD01, O43889, O44743, P29747, Q08CW8, Q1LYG4, Q3SYZ3, Q4JFH9, Q502F0, Q5FVM5, Q5RCM9, Q5UEM7, Q5UEM8, Q61817, Q66HA2, Q68CJ9, Q6QDP7, Q70SY1, Q8BH52, Q8SQ19, Q8TEY5, Q91XE9, Q96BA8, Q9D2A5, Q9Z125, F6VAN0, G3V909, O35451, P18850, Q99941, Q54Y73, P27699, Q03060, Q03061, Q1LZH5, Q54RZ9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

74 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	2
Likely pathogenic	0
Uncertain significance	49
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (2)

Variant ID	HGVS	Classification
2426580	NC_000001.10:g.(?153782653)(153964569_?)del	Pathogenic
60012	GRCh38/hg38 1q21.3(chr1:153939571-153978276)x1	Pathogenic

SpliceAI

3590 predictions. Top by Δscore:

Variant	Effect	Δscore
1:153972736:A:AG	acceptor_gain	1.0000
1:153972737:C:G	acceptor_gain	1.0000
1:153972742:A:AG	acceptor_gain	1.0000
1:153972743:G:GA	acceptor_gain	1.0000
1:153972743:GCT:G	acceptor_gain	1.0000
1:153973193:AG:A	acceptor_gain	1.0000
1:153973194:GG:G	acceptor_gain	1.0000
1:153973260:ACAT:A	donor_gain	1.0000
1:153973261:CAT:C	donor_gain	1.0000
1:153973262:AT:A	donor_gain	1.0000
1:153973263:TGTG:T	donor_loss	1.0000
1:153973264:G:GA	donor_loss	1.0000
1:153973264:G:GG	donor_gain	1.0000
1:153973265:T:A	donor_loss	1.0000
1:153973266:G:GT	donor_loss	1.0000
1:153973714:G:GT	donor_gain	1.0000
1:153973870:A:AG	acceptor_gain	1.0000
1:153973871:G:GA	acceptor_gain	1.0000
9:35732902:GTAG:G	donor_loss	1.0000
9:35733214:GAGA:G	acceptor_gain	1.0000
9:35735096:T:A	acceptor_gain	1.0000
9:35735107:A:AG	acceptor_gain	1.0000
9:35735108:G:GC	acceptor_gain	1.0000
9:35735108:GA:G	acceptor_gain	1.0000
9:35735108:GAC:G	acceptor_gain	1.0000
9:35735108:GACA:G	acceptor_gain	1.0000
9:35735180:G:GT	donor_gain	1.0000
9:35735181:A:T	donor_gain	1.0000
9:35735186:G:GT	donor_gain	1.0000
9:35735187:A:T	donor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000001382 (1:153972654 A>G), RS1000069787 (1:153967407 G>C), RS1000101967 (1:153967761 G>A), RS1001142587 (1:153966841 T>C), RS1001172019 (1:153967289 C>G), RS1001193282 (1:153967887 C>G,T), RS1002434171 (1:153974501 A>C,G), RS1002811548 (1:153974044 G>A), RS1002848754 (1:153965533 A>C), RS1003656024 (1:153970838 A>G), RS1003788759 (1:153971056 C>G), RS1004144381 (1:153970397 G>A,T), RS1004520784 (1:153970143 G>A), RS1005358731 (1:153967359 C>G,T), RS1005433438 (1:153968909 T>A,C)

Disease associations

OMIM: gene MIM:607138 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

18 associations (top):

Study	Trait	p-value
GCST003795_1	Age at first birth	6.000000e-10
GCST004865_47	Itch intensity from mosquito bite adjusted by bite size	9.000000e-06
GCST005751_3	Empathy quotient	3.000000e-07
GCST006044_1	Age at first birth	3.000000e-07
GCST006045_3	Age at first birth	5.000000e-06
GCST006585_2820	Blood protein levels	2.000000e-30
GCST010136_18	Fruit consumption	3.000000e-08
GCST010137_3	Cooked vegetable consumption	3.000000e-09
GCST010142_60	Fish- and plant-related diet	4.000000e-09
GCST010142_92	Fish- and plant-related diet	6.000000e-14
GCST010696_22	Cortical thickness (min-P)	4.000000e-10
GCST010697_50	Cortical surface area (min-P)	1.000000e-12
GCST010698_81	Subcortical volume (min-P)	1.000000e-23
GCST010699_7	Brain morphology (min-P)	1.000000e-10
GCST010700_11	Cortical thickness (MOSTest)	4.000000e-13
GCST010701_73	Cortical surface area (MOSTest)	4.000000e-09
GCST010702_45	Subcortical volume (MOSTest)	4.000000e-10
GCST010703_276	Brain morphology (MOSTest)	2.000000e-15

EFO canonical traits (7, from GWAS)

EFO ID	Trait name
EFO:0009101	age at first birth measurement
EFO:0008377	mosquito bite reaction itch intensity measurement
EFO:0008378	mosquito bite reaction size measurement
EFO:0009183	empathy measurement
EFO:0008111	diet measurement
EFO:0004346	neuroimaging measurement
EFO:0004840	cortical thickness

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

35 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression	6
Carbamazepine	affects expression	2
Estradiol	decreases expression	2
Nickel	decreases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
GSK-J4	decreases expression	1
methylmercuric chloride	decreases expression	1
methylselenic acid	affects expression	1
sodium arsenite	decreases expression	1
ferrous chloride	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Sunitinib	decreases expression	1
Atrazine	decreases expression	1
Chelating Agents	affects binding, affects expression	1
Copper	affects binding, affects expression	1
Coumestrol	affects cotreatment, decreases expression	1
Diclofenac	affects expression	1
Formaldehyde	increases expression	1
Hydrogen Peroxide	affects expression	1
Methyl Methanesulfonate	increases expression	1
Dihydrotestosterone	increases expression	1
Tetrachlorodibenzodioxin	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Tunicamycin	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D8J8	Ubigene HCT 116 CREB3L4 KO	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.