CREG2

Summary

CREG2 (cellular repressor of E1A stimulated genes 2, HGNC:14272) is a protein-coding gene on chromosome 2q11.2, encoding Protein CREG2 (Q8IUH2).

Predicted to be located in Golgi apparatus; endoplasmic reticulum; and extracellular region. Predicted to be active in obsolete extracellular space.

Source: NCBI Gene 200407 — automated summary from GO annotations (Alliance of Genome Resources).

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 54 total
• GTEx eGene: eQTL in 11 tissues, sQTL in 2 (q < 0.05)
• Constraint (gnomAD): pLI 0.00 (LoF-tolerant), LOEUF 1.51 (unconstrained)
• MANE Select transcript: NM_153836
• Notable: 54 clinical variants but no curated precision-oncology (CIViC) evidence yet

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14272
Approved symbol	CREG2
Name	cellular repressor of E1A stimulated genes 2
Location	2q11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000175874
Ensembl biotype	protein_coding
OMIM	618540
Entrez	200407

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 4 protein_coding, 2 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

MANE Select: ENST00000324768

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 1: 1, TSL 3: 2

ENST00000324768, ENST00000486966, ENST00000495455, ENST00001049759, ENST00001115850, ENST00001115851, ENST00001138956

RefSeq mRNA: 1 — MANE Select: NM_153836 NM_153836

CCDS: CCDS2052

Canonical transcript exons

ENST00000324768 — 4 exons

Exon	Start	End
ENSE00001246894	101355253	101355366
ENSE00001246907	101345550	101351070
ENSE00001930395	101387017	101387503
ENSE00003692450	101383533	101383702

Expression profiles

Bgee: expression breadth ubiquitous, 154 present calls, max score 98.91.

FANTOM5 (CAGE): breadth broad, TPM avg 3.8468 / max 258.1187, expressed in 552 samples.

Highest expression (Bgee): Brodmann (1909) area 46, endothelial cell, Brodmann (1909) area 23, superior frontal gyrus, postcentral gyrus.

Genetic regulation across tissues (GTEx eQTL / sQTL)

CREG2 is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 11 tissues and its splicing (sQTL) in 2 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

13 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Esophagus Mucosa	eqtl	4.6e-54	-0.65	2:101386663:C:T
Brain Anterior cingulate cortex BA24	eqtl	5.5e-09	+0.17	2:101315616:C:T
Skin Sun Exposed Lower leg	eqtl	1.3e-07	-0.25	2:101381078:C:T
Brain Cortex	eqtl	2.1e-07	-0.12	2:101376012:A:G
Brain Nucleus accumbens basal ganglia	eqtl	4.5e-07	-0.18	2:101348558:A:G
Brain Frontal Cortex BA9	eqtl	1.2e-05	+0.12	2:101380691:C:T
Brain Cortex	sqtl	6.2e-05	-0.57	2:101381276:G:A
Whole Blood	eqtl	9.5e-04	-0.23	2:101355752:G:C
Pituitary	eqtl	1.9e-03	-0.25	2:101359450:C:T
Brain Frontal Cortex BA9	sqtl	4.0e-03	+0.48	2:101349576:C:A
Brain Hippocampus	eqtl	5.6e-03	+0.16	2:101314385:C:G
Brain Caudate basal ganglia	eqtl	1.2e-02	+0.19	2:101389211:C:T
Brain Amygdala	eqtl	2.9e-02	-0.16	2:101376643:T:A

FANTOM5 promoters

4 alternative TSS:

Promoter ID	TPM avg	Samples expressed
29945	3.3976	528
29944	0.2302	76
29943	0.1173	46
29946	0.1017	42

Top tissues by expression

showing 100 of 237 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
Brodmann (1909) area 46	UBERON:0006483	98.91	gold quality
endothelial cell	CL:0000115	98.29	gold quality
Brodmann (1909) area 23	UBERON:0013554	98.09	gold quality
superior frontal gyrus	UBERON:0002661	97.96	gold quality
postcentral gyrus	UBERON:0002581	97.62	gold quality
parietal lobe	UBERON:0001872	97.53	gold quality
middle temporal gyrus	UBERON:0002771	97.32	gold quality
entorhinal cortex	UBERON:0002728	96.50	gold quality
primary visual cortex	UBERON:0002436	95.77	gold quality
occipital lobe	UBERON:0002021	95.44	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	94.22	gold quality
prefrontal cortex	UBERON:0000451	93.78	gold quality
frontal cortex	UBERON:0001870	93.56	gold quality
Brodmann (1909) area 9	UBERON:0013540	93.15	gold quality
cerebral cortex	UBERON:0000956	91.96	gold quality
neocortex	UBERON:0001950	91.81	gold quality
Ammon’s horn	UBERON:0001954	91.47	gold quality
right frontal lobe	UBERON:0002810	91.07	gold quality
anterior cingulate cortex	UBERON:0009835	90.63	gold quality
temporal lobe	UBERON:0001871	90.10	gold quality
pons	UBERON:0000988	88.12	gold quality
buccal mucosa cell	CL:0002336	85.78	gold quality
amygdala	UBERON:0001876	85.78	gold quality
forebrain	UBERON:0001890	83.10	gold quality
nucleus accumbens	UBERON:0001882	78.72	gold quality
superior vestibular nucleus	UBERON:0007227	78.15	gold quality
hypothalamus	UBERON:0001898	77.98	gold quality
brain	UBERON:0000955	77.67	gold quality
corpus callosum	UBERON:0002336	73.36	gold quality
medulla oblongata	UBERON:0001896	72.85	gold quality
putamen	UBERON:0001874	72.73	gold quality
midbrain	UBERON:0001891	72.06	gold quality
substantia nigra	UBERON:0002038	71.84	gold quality
caudate nucleus	UBERON:0001873	71.30	gold quality
lateral nuclear group of thalamus	UBERON:0002736	69.56	gold quality
ventral tegmental area	UBERON:0002691	69.31	gold quality
substantia nigra pars compacta	UBERON:0001965	67.93	gold quality
adult organism	UBERON:0007023	66.93	gold quality
spinal cord	UBERON:0002240	64.63	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.62	gold quality
vagina	UBERON:0000996	64.16	gold quality
medial globus pallidus	UBERON:0002477	63.79	gold quality
globus pallidus	UBERON:0001875	63.55	gold quality
substantia nigra pars reticulata	UBERON:0001966	63.04	gold quality
cortical plate	UBERON:0005343	62.20	gold quality
dorsal plus ventral thalamus	UBERON:0001897	61.87	gold quality
oviduct epithelium	UBERON:0004804	61.27	silver quality
lateral globus pallidus	UBERON:0002476	60.73	gold quality
islet of Langerhans	UBERON:0000006	60.31	gold quality
pancreatic ductal cell	CL:0002079	60.27	silver quality
dorsal root ganglion	UBERON:0000044	60.15	silver quality
inferior vagus X ganglion	UBERON:0005363	59.14	gold quality
esophagus mucosa	UBERON:0002469	58.94	gold quality
lower esophagus mucosa	UBERON:0035834	58.16	gold quality
subthalamic nucleus	UBERON:0001906	56.51	gold quality
lower lobe of lung	UBERON:0008949	56.35	silver quality
ganglionic eminence	UBERON:0004023	55.09	gold quality
epithelial cell of pancreas	CL:0000083	54.68	gold quality
cardiac muscle of right atrium	UBERON:0003379	54.34	gold quality
left ventricle myocardium	UBERON:0006566	54.23	gold quality
kidney epithelium	UBERON:0004819	53.93	gold quality
upper arm skin	UBERON:0004263	53.52	gold quality
ileal mucosa	UBERON:0000331	53.03	silver quality
epithelium of nasopharynx	UBERON:0001951	52.83	gold quality
ectocervix	UBERON:0012249	51.81	gold quality
pituitary gland	UBERON:0000007	51.49	gold quality
colonic epithelium	UBERON:0000397	51.31	silver quality
adenohypophysis	UBERON:0002196	50.42	gold quality
myocardium	UBERON:0002349	50.25	gold quality
fallopian tube	UBERON:0003889	50.04	gold quality
granulocyte	CL:0000094	50.01	silver quality
cardiac atrium	UBERON:0002081	49.67	gold quality
right atrium auricular region	UBERON:0006631	49.50	gold quality
stromal cell of endometrium	CL:0002255	49.35	silver quality
urinary bladder	UBERON:0001255	49.25	gold quality
esophagus	UBERON:0001043	48.85	gold quality
cerebellar vermis	UBERON:0004720	48.63	gold quality
pancreas	UBERON:0001264	48.23	gold quality
mucosa of transverse colon	UBERON:0004991	48.22	gold quality
anatomical system	UBERON:0000467	48.12	gold quality
blood	UBERON:0000178	48.05	gold quality
material anatomical entity	UBERON:0000465	48.05	gold quality
multicellular organism	UBERON:0000468	48.05	gold quality
gall bladder	UBERON:0002110	47.99	gold quality
quadriceps femoris	UBERON:0001377	47.32	gold quality
nasal cavity epithelium	UBERON:0005384	47.03	gold quality
placenta	UBERON:0001987	46.46	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	45.81	gold quality
heart	UBERON:0000948	45.70	gold quality
vastus lateralis	UBERON:0001379	45.40	gold quality
vermiform appendix	UBERON:0001154	45.35	silver quality
hindlimb stylopod muscle	UBERON:0004252	44.95	gold quality
uterine cervix	UBERON:0000002	44.90	gold quality
female reproductive system	UBERON:0000474	44.85	gold quality
nasal cavity mucosa	UBERON:0001826	44.39	silver quality
tonsil	UBERON:0002372	44.39	silver quality
caecum	UBERON:0001153	44.06	silver quality
ventricular zone	UBERON:0003053	44.05	silver quality
heart left ventricle	UBERON:0002084	43.95	gold quality
cardiac ventricle	UBERON:0002082	43.81	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-HCAD-35	yes	38.72
E-ANND-3	yes	5.37
E-GEOD-36552	no	6.60

HPA expression

RNA tissue specificity: Tissue enriched

45 HPA tissues / cells by nTPM:

Tissue / cell	Axis	nTPM	Protein (IHC)
Postcentral gyrus	tissue	87.1
Hippocampus	tissue	70.3	high
Frontal cortex	tissue	43.9
Caudate putamen	tissue	19.4
Hippocampal formation	tissue	16.9
Prefrontal cortex	tissue	15.7
Cerebral cortex	tissue	15.7	high
Motor cortex	tissue	15.4
Temporal cortex	tissue	14.0
Entorhinal cortex	tissue	13.7
Retrosplenial and cingulate cortex	tissue	13.6
Nucleus accumbens	tissue	13.4
Amygdala	tissue	13.0
Somatosensory cortex	tissue	12.9
Periaqueductal gray	tissue	12.7
Insular cortex	tissue	12.6
Pons	tissue	12.4
Hypothalamus	tissue	12.3
Locus coeruleus	tissue	12.3
Retrosplenial cortex	tissue	11.7
Occipital cortex	tissue	10.5
Septum	tissue	10.0
Basal ganglia	tissue	9.5	not detected
Putamen	tissue	8.8
Ventral forebrain	tissue	8.6
Substantia nigra	tissue	8.5
Thalamus	tissue	7.8
Cerebellum	tissue	7.4	high
Medulla oblongata	tissue	6.5
Midbrain	tissue	6.0
Superior colliculi	tissue	4.7
Spinal cord	tissue	3.7
Choroid plexus	tissue	3.2
Olfactory bulb	tissue	1.6
Corpus callosum	tissue	1.3
Retina	tissue	0.7
Vagina	tissue	0.7	not detected
Fallopian tube	tissue	0.3	not detected
Parathyroid gland	tissue	0.2	not detected
Testis	tissue	0.1	not detected
Heart muscle	tissue	0.1	not detected
Urinary bladder	tissue	0.1	not detected
Small intestine	tissue	0.1	not detected
Duodenum	tissue	0.1	not detected
Adrenal gland	tissue	0.1	not detected

Brain sub-regions (HPA Brain Atlas): detected in 188; highest nTPM — Hippocampus, CA1 (88.5), Dentate gyrus (83.1), Hippocampus, CA3 (82.0), Precentral gyrus, middle (73.8), Perirhinal gyrus (72.7).

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

Targeting CREG2 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific).

showing 30 of 145 miRNAs:

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-8082	99.95	67.27	1170
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-10523-5P	99.91	69.22	2038
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-3681-3P	99.88	70.46	2254
HSA-MIR-579-3P	99.86	71.66	3628

Functional genomics

gnomAD constraint: pLI 3.38e-08, LOEUF 1.51, missense Z -1.03 — population loss-of-function intolerance (pLI ≥ 0.9 = LoF-intolerant; lower LOEUF = more constrained). gnomAD

Regional missense constraint (gnomAD)

ENST00000324768 splits into 3 regions with different missense tolerance; 0 are missense-constrained. Missense variants in a constrained region (low observed/expected) are more likely to be pathogenic. gnomAD

Region (GRCh38)	Missense obs / exp	o/e	Constrained
2:101,350,926–101,383,695	174 / 178.2	0.98	no
2:101,383,696–101,387,095	15 / 37.2	0.40	no
2:101,387,096–101,387,457	177 / 183.3	0.97	no

Literature-anchored findings (GeneRIF, showing 1)

• CREG2 are putative secreted glycoproteins and may be novel neuronal extracellular molecules. (PMID:12408961)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	creg2	ENSDARG00000000666
mus_musculus	Creg2	ENSMUSG00000050967
rattus_norvegicus	Creg2	ENSRNOG00000013991
drosophila_melanogaster	CREG	FBGN0025456

Paralogs (1): CREG1 (ENSG00000143162)

Mouse-model phenotypes

Observed phenotypes of the mouse ortholog (MGI:1928333) from MGI (Alliance of Genome Resources) — knockout/mutant phenotypes, ranked by annotation count. 2 distinct phenotype terms.

Mouse phenotype (MP)	Records
decreased grip strength	1
decreased fasting circulating glucose level	1

Additional cross-species homologs

Sequence homologs in species beyond Ensembl Compara’s model organisms, by Diamond local protein alignment (% sequence identity; best hit per species). Lower-identity rows are more distant homologs. The matched accessions’ gene symbols aren’t in biobtree yet, so each row shows the UniProt accession.

Organism	UniProt	Identity	Method
Gallus gallus	Q5ZJ73	63.7%	Diamond

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
RNF149	protein-coding	284996
SNORD89	snoRNA	692205
RFX8	protein-coding	731220
MIR5696	ncRNA	100847007
LINC01870	ncRNA	107985925
CNOT11	protein-coding	55571

Protein

Protein identifiers

Protein CREG2 — Q8IUH2 (reviewed: Q8IUH2)

Alternative names: Cellular repressor of E1A-stimulated genes 2

All UniProt accessions (1): Q8IUH2

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Secreted.

Tissue specificity. Brain specific mainly in the limbic system and faintly in the spinal cord but not in cerebellum.

Post-translational modifications. It is not sure whether N-glycosylation is on Asn-165 and/or Asn-166.

Similarity. Belongs to the CREG family.

RefSeq proteins (1): NP_722578* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR012349	Split_barrel_FMN-bd	Homologous_superfamily
IPR014631	CREG	Family
IPR055343	CREG_beta-barrel	Domain

Pfam: PF13883

UniProt features (6 total): glycosylation site 2, signal peptide 1, chain 1, sequence variant 1, mutagenesis site 1

Structure

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IUH2-F1	72.48	0.46

Human Protein Atlas

Protein class: Predicted secreted proteins

Protein evidence: Evidence at protein level

Antibody reliability (HPA): IH enhanced

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2)

Type	Positions
N-linked (glcnac…) asparagine	165, 166

Mutagenesis-validated functional residues (1)

Position	Phenotype
165–166	abolishes n-glycosylation.

Function

Pathways and Gene Ontology

Reactome pathways

0 curated (TAS) of 0; 0 disease pathways. Curated-first; evidence = TAS (manually curated) vs IEA (electronic inference).

MSigDB gene sets: 57 (showing top): GTCAACC_MIR3805P, chr2q11, MEISSNER_NPC_HCP_WITH_H3K4ME2, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP, GSE13547_WT_VS_ZFX_KO_BCELL_UP, MIR664B_3P, MIR4753_3P, MIR513A_3P_MIR513C_3P, MIR627_3P, MIR3606_3P, MIR6844, MIR543, MIR7152_5P, MIR4703_5P, MIR130B_5P

GO Cellular Component (5): endoplasmic reticulum (GO:0005783), Golgi apparatus (GO:0005794), extracellular region (GO:0005576), cytoplasm (GO:0005737), endomembrane system (GO:0012505)

GO top-level categories

7 GO namespaces:

Category	Terms
cellular anatomical structure	3
cytoplasm	2
endomembrane system	2
intracellular membrane-bounded organelle	2
intracellular anatomical structure	1
vacuole	1
plasma membrane	1

Protein interactions and networks

STRING

showing 15 of 392 interactions by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CREG2	ZNF572	Q7Z3I7	537
CREG2	SREK1IP1	Q8N9Q2	505
CREG2	A3GALT2	U3KPV4	500
CREG2	STK32A	Q8WU08	475
CREG2	PCP2	Q8IVA1	470
CREG2	SREK1	Q8WXA9	469
CREG2	SFXN3	Q9BWM7	464
CREG2	LRRN4	Q8WUT4	461
CREG2	PNMA6F	A0A0J9YX94	439
CREG2	PRDM12	Q9H4Q4	438
CREG2	IMPG1	Q17R60	437
CREG2	CLASP2	O75122	425
CREG2	SH3TC2	Q8TF17	401
CREG2	ZNF708	P17019	383
CREG2	KCNMB1	P78475	370

IntAct

Human interaction partners of CREG2 in IntAct, one row per partner (best MIscore; records = supporting IntAct interaction records).

1 partners by confidence:

Partner	Interaction type	MIscore	Records
GLDC	physical association	0.400	1

BioGRID (4 interactions; top human partners by supporting records): C16orf72 (Positive Genetic), GLDC (Affinity Capture-MS), TRIM25 (Affinity Capture-RNA), USP53 (Affinity Capture-MS)

Disease & clinical

Genetic variants

Variant evidence for CREG2: 54 ClinVar records (0 pathogenic / likely pathogenic); 2 GWAS associations.

ClinVar

54 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	51
Likely benign	1
Benign	0

SpliceAI

Top 10 splice-impact sites by Δscore (adjacent positions with the same effect merged into one range; 26 predictions of 378):

Position(s)	Effect	Δscore	Sites
2:101355367–101355368	acceptor_loss	1.0000	5
2:101355371–101355373	acceptor_gain	1.0000	2
2:101383544	donor_gain	1.0000
2:101387015–101387016	donor_loss	1.0000	4
2:101355251–101355252	donor_loss	0.9900	5
2:101355367	acceptor_loss	0.9900
2:101387015	donor_loss	0.9900
2:101383495	donor_gain	0.9800
2:101350910	donor_gain	0.9600
2:101383703–101383704	acceptor_loss	0.9600	5

AlphaMissense

326 missense substitutions predicted likely pathogenic (of 1,885 scored), across 101 residues. Top 20 hotspot residues, ranked by the number of likely-pathogenic substitutions (of those reachable by a single-nucleotide change), then by mean score:

Residue	Likely-pathogenic substitutions	Mean am_pathogenicity	Max am_pathogenicity
D161	8	0.838	0.917
F240	7	0.900	0.961
F104	7	0.849	0.958
W40	7	0.843	0.959
C203	7	0.839	0.899
C215	7	0.831	0.888
G169	6	0.876	0.963
R128	6	0.838	0.951
M260	6	0.832	0.947
G222	6	0.824	0.948
W255	6	0.804	0.917
W70	6	0.787	0.918
M224	6	0.727	0.893
Y282	5	0.959	0.975
S167	5	0.918	0.969
S160	5	0.908	0.980
F172	5	0.885	0.916
F257	5	0.864	0.880
G162	5	0.855	0.943
F234	5	0.855	0.918

HPA cancer prognostics

RNA cancer specificity: Cancer enhanced (Glioblastoma Multiforme)

Disease associations

OMIM: gene MIM:618540 | disease phenotypes:

GWAS associations

2 associations:

Study	Trait	p-value
GCST003095_4	Adiponectin levels (BMI-adjusted)	2e-6
GCST003096_3	Adiponectin levels	3e-6

EFO canonical traits (from GWAS)

2 canonical traits:

EFO ID	Trait name
EFO:0007737	BMI-adjusted adiponectin measurement
EFO:0004502	adiponectin measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (CPIC guideline: no)

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sotorasib	affects cotreatment, decreases expression	1
urushiol	increases expression	1
bisphenol A	affects cotreatment, increases methylation	1
sodium arsenite	decreases expression	1
2-tert-butylhydroquinone	affects response to substance	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, decreases expression	1
pentanal	increases expression	1
avobenzone	increases expression	1
dinophysistoxin 1	decreases expression	1
abrine	decreases expression	1
NSC 689534	affects binding, decreases expression	1
trametinib	affects cotreatment, decreases expression	1
NVP-BKM120	decreases expression, affects cotreatment	1
Fulvestrant	increases methylation, affects cotreatment	1
Atrazine	increases expression	1
Benzo(a)pyrene	increases methylation	1
Calcitriol	increases expression	1
Copper	decreases expression, affects binding	1
Diethylhexyl Phthalate	increases expression	1
Estradiol	increases expression	1
Lead	affects expression	1
Lipopolysaccharides	decreases expression, affects cotreatment	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	affects expression	1
Lactic Acid	decreases expression	1

Clinical trials (associated diseases)

Via MONDO — disease-level, not drug-specific.