CRIP3

Summary

CRIP3 (cysteine rich protein 3, HGNC:17751) is a protein-coding gene on chromosome 6p21.1, encoding Cysteine-rich protein 3 (Q6Q6R5).

Predicted to enable metal ion binding activity. Predicted to act upstream of or within T cell proliferation. Predicted to be located in cytoplasm.

Source: NCBI Gene 401262 — automated summary from GO annotations (Alliance of Genome Resources).

At a glance

• GWAS associations: 20
• Clinical variants (ClinVar): 37 total
• GTEx eGene: eQTL in 13 tissues, sQTL in 2 (q < 0.05)
• Constraint (gnomAD): pLI 0.00 (LoF-tolerant), LOEUF 1.04 (unconstrained)
• MANE Select transcript: NM_206922

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17751
Approved symbol	CRIP3
Name	cysteine rich protein 3
Location	6p21.1
Locus type	gene with protein product
Status	Approved
Aliases	TLP-A, bA480N24.2, TLP
Ensembl gene	ENSG00000146215
Ensembl biotype	protein_coding
Entrez	401262

Gene structure

Transcript identifiers

Ensembl transcripts: 34 — 24 protein_coding, 7 nonsense_mediated_decay, 3 retained_intron

MANE Select: ENST00000372569

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 1: 2, TSL 2: 2, TSL 3: 3

ENST00000372569, ENST00000274990, ENST00000416431, ENST00000451294, ENST00000477866, ENST00000485819, ENST00000487744, ENST00000875330, ENST00000875331, ENST00000875332, ENST00000875333, ENST00000917954, ENST00000917955, ENST00000917956, ENST00000917957, ENST00000917958, ENST00000917959, ENST00000917960, ENST00000917961, ENST00000917962, ENST00000917963, ENST00000996765, ENST00000996766, ENST00001027280, ENST00001027281, ENST00001077667, ENST00001077668, ENST00001077669, ENST00001077670, ENST00001077672, ENST00001077673, ENST00001077674, ENST00001077676, ENST00001140165

RefSeq mRNA: 2 — MANE Select: NM_206922 NM_001366068, NM_206922

CCDS: CCDS4894

Canonical transcript exons

ENST00000372569 — 8 exons

Exon	Start	End
ENSE00000974499	43308315	43308409
ENSE00000974501	43307612	43307743
ENSE00000974502	43306446	43306517
ENSE00000974503	43306219	43306313
ENSE00001458118	43305472	43305875
ENSE00003545360	43307839	43307896
ENSE00003570712	43306067	43306124
ENSE00003902020	43308750	43308826

Expression profiles

Bgee: expression breadth ubiquitous, 165 present calls, max score 95.03.

FANTOM5 (CAGE): breadth broad, TPM avg 1.1956 / max 53.0668, expressed in 275 samples.

Highest expression (Bgee): apex of heart, testis, cerebellar hemisphere, hemisphere of cerebellum, cerebellar cortex.

Genetic regulation across tissues (GTEx eQTL / sQTL)

CRIP3 is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 13 tissues and its splicing (sQTL) in 2 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

15 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Heart Left Ventricle	eqtl	5.9e-14	-0.32	6:43305866:A:G
Testis	sqtl	3.8e-10	-0.53	6:43305866:A:G
Liver	eqtl	3.1e-09	-0.39	6:43301291:A:C
Heart Atrial Appendage	eqtl	2.0e-07	+0.28	6:43292274:A:C
Testis	eqtl	1.8e-04	-0.11	6:43292274:A:C
Skin Sun Exposed Lower leg	eqtl	4.8e-03	-0.15	6:43336269:C:A
Cells EBV-transformed lymphocytes	sqtl	1.0e-02	-0.42	6:43396756:G:A
Brain Anterior cingulate cortex BA24	eqtl	1.0e-02	-1.77	6:43025564:A:G
Artery Tibial	eqtl	1.4e-02	-0.32	6:43168060:G:A
Skin Not Sun Exposed Suprapubic	eqtl	2.7e-02	-0.31	6:43465542:G:A
Brain Hippocampus	eqtl	2.7e-02	-2.64	6:43025564:A:G
Brain Spinal cord cervical c-1	eqtl	3.9e-02	-2.28	6:43239300:T:C
Muscle Skeletal	eqtl	4.4e-02	-0.35	6:43785985:G:A
Adipose Subcutaneous	eqtl	4.5e-02	-0.46	6:42623491:G:A
Ovary	eqtl	5.0e-02	-0.97	6:43884123:G:A

FANTOM5 promoters

2 alternative TSS:

Promoter ID	TPM avg	Samples expressed
73675	1.0381	246
73676	0.1574	90

Top tissues by expression

showing 100 of 241 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	95.03	gold quality
right testis	UBERON:0004534	92.37	gold quality
left testis	UBERON:0004533	92.14	gold quality
cerebellar hemisphere	UBERON:0002245	90.09	gold quality
right hemisphere of cerebellum	UBERON:0014890	90.00	gold quality
cerebellar cortex	UBERON:0002129	89.98	gold quality
testis	UBERON:0000473	88.30	gold quality
cerebellum	UBERON:0002037	88.29	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.70	gold quality
right lobe of liver	UBERON:0001114	85.23	gold quality
granulocyte	CL:0000094	85.16	gold quality
heart left ventricle	UBERON:0002084	84.88	gold quality
cardiac ventricle	UBERON:0002082	84.43	gold quality
nucleus accumbens	UBERON:0001882	83.88	gold quality
right frontal lobe	UBERON:0002810	81.96	gold quality
putamen	UBERON:0001874	81.85	gold quality
caudate nucleus	UBERON:0001873	81.47	gold quality
Brodmann (1909) area 9	UBERON:0013540	81.34	gold quality
amygdala	UBERON:0001876	81.14	gold quality
spleen	UBERON:0002106	80.55	gold quality
anterior cingulate cortex	UBERON:0009835	79.51	gold quality
hypothalamus	UBERON:0001898	79.40	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	77.06	gold quality
lymph node	UBERON:0000029	77.05	gold quality
heart	UBERON:0000948	76.87	gold quality
sperm	CL:0000019	76.36	silver quality
cortical plate	UBERON:0005343	76.34	gold quality
brain	UBERON:0000955	76.09	gold quality
liver	UBERON:0002107	75.49	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	75.18	gold quality
forebrain	UBERON:0001890	74.96	gold quality
vena cava	UBERON:0004087	74.54	gold quality
monocyte	CL:0000576	74.27	gold quality
spinal cord	UBERON:0002240	74.25	gold quality
leukocyte	CL:0000738	74.22	gold quality
neocortex	UBERON:0001950	74.22	gold quality
substantia nigra	UBERON:0002038	73.60	gold quality
cerebral cortex	UBERON:0000956	73.39	gold quality
Ammon’s horn	UBERON:0001954	73.26	gold quality
frontal cortex	UBERON:0001870	73.11	gold quality
adult mammalian kidney	UBERON:0000082	73.07	gold quality
kidney epithelium	UBERON:0004819	72.93	gold quality
upper arm skin	UBERON:0004263	72.83	gold quality
midbrain	UBERON:0001891	72.66	gold quality
cortex of kidney	UBERON:0001225	72.48	gold quality
prostate gland	UBERON:0002367	72.40	gold quality
right atrium auricular region	UBERON:0006631	72.23	gold quality
prefrontal cortex	UBERON:0000451	72.15	gold quality
temporal lobe	UBERON:0001871	71.98	gold quality
small intestine Peyer’s patch	UBERON:0003454	71.98	gold quality
lower esophagus mucosa	UBERON:0035834	71.82	gold quality
mucosa of transverse colon	UBERON:0004991	71.77	gold quality
cardiac atrium	UBERON:0002081	71.36	gold quality
ventricular zone	UBERON:0003053	71.34	gold quality
right ovary	UBERON:0002118	71.12	gold quality
blood	UBERON:0000178	70.68	gold quality
vermiform appendix	UBERON:0001154	70.62	gold quality
small intestine	UBERON:0002108	70.57	gold quality
pancreatic ductal cell	CL:0002079	70.41	silver quality
primary visual cortex	UBERON:0002436	70.35	gold quality
endocervix	UBERON:0000458	70.05	gold quality
tibial nerve	UBERON:0001323	69.94	gold quality
ganglionic eminence	UBERON:0004023	69.92	gold quality
right lobe of thyroid gland	UBERON:0001119	69.49	gold quality
caecum	UBERON:0001153	69.49	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	69.46	gold quality
metanephros cortex	UBERON:0010533	69.46	gold quality
pituitary gland	UBERON:0000007	69.25	gold quality
adenohypophysis	UBERON:0002196	69.20	gold quality
left ovary	UBERON:0002119	69.05	gold quality
occipital lobe	UBERON:0002021	68.91	gold quality
kidney	UBERON:0002113	68.77	gold quality
right uterine tube	UBERON:0001302	68.73	gold quality
bone marrow cell	CL:0002092	67.83	gold quality
left uterine tube	UBERON:0001303	67.76	gold quality
layer of synovial tissue	UBERON:0007616	67.76	gold quality
body of uterus	UBERON:0009853	67.76	gold quality
epithelial cell of pancreas	CL:0000083	67.74	gold quality
bone marrow	UBERON:0002371	67.31	gold quality
left lobe of thyroid gland	UBERON:0001120	66.96	gold quality
anatomical system	UBERON:0000467	66.79	gold quality
body of pancreas	UBERON:0001150	66.77	gold quality
material anatomical entity	UBERON:0000465	66.54	gold quality
multicellular organism	UBERON:0000468	66.54	gold quality
body of tongue	UBERON:0011876	66.47	gold quality
thyroid gland	UBERON:0002046	66.13	gold quality
tongue	UBERON:0001723	66.10	silver quality
superior surface of tongue	UBERON:0007371	65.99	gold quality
pharyngeal mucosa	UBERON:0000355	65.98	gold quality
ectocervix	UBERON:0012249	65.97	gold quality
saphenous vein	UBERON:0007318	65.95	gold quality
trachea	UBERON:0003126	65.65	gold quality
thymus	UBERON:0002370	65.64	silver quality
ventral tegmental area	UBERON:0002691	65.62	gold quality
lateral globus pallidus	UBERON:0002476	65.53	gold quality
pancreas	UBERON:0001264	65.51	gold quality
subthalamic nucleus	UBERON:0001906	65.50	gold quality
islet of Langerhans	UBERON:0000006	65.45	gold quality
pericardium	UBERON:0002407	65.39	gold quality
skin of abdomen	UBERON:0001416	65.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.54

HPA expression

RNA tissue specificity: Tissue enhanced

showing 60 of 75 HPA tissues / cells by nTPM:

Tissue / cell	Axis	nTPM
Heart muscle	tissue	22.8
Testis	tissue	7.9
Seminal vesicle	tissue	7.6
Nucleus accumbens	tissue	5.5
Tonsil	tissue	5.5
Lymph node	tissue	5.1
Hippocampus	tissue	4.5
Liver	tissue	3.8
Prostate	tissue	3.3
Postcentral gyrus	tissue	3.2
Spleen	tissue	2.6
Locus coeruleus	tissue	2.5
Bone marrow	tissue	2.4
Pituitary gland	tissue	2.3
Retina	tissue	2.3
Kidney	tissue	2.0
Parathyroid gland	tissue	1.9
Duodenum	tissue	1.9
Small intestine	tissue	1.8
Skin 1	tissue	1.7
Appendix	tissue	1.6
Epididymis	tissue	1.5
Thymus	tissue	1.5
Vagina	tissue	1.4
Choroid plexus	tissue	1.4
Cerebral cortex	tissue	1.2
Temporal cortex	tissue	1.2
Basal ganglia	tissue	1.1
Retrosplenial cortex	tissue	1.1
Occipital cortex	tissue	1.1
Amygdala	tissue	1.0
Prefrontal cortex	tissue	0.9
Insular cortex	tissue	0.9
Ovary	tissue	0.8
Motor cortex	tissue	0.8
Putamen	tissue	0.8
Hippocampal formation	tissue	0.8
Entorhinal cortex	tissue	0.8
Periaqueductal gray	tissue	0.8
Endometrium 1	tissue	0.7
Hypothalamus	tissue	0.7
Ventral forebrain	tissue	0.7
Retrosplenial and cingulate cortex	tissue	0.7
Olfactory bulb	tissue	0.7
Fallopian tube	tissue	0.7
Smooth muscle	tissue	0.6
Cerebellum	tissue	0.6
Gallbladder	tissue	0.6
Septum	tissue	0.6
Somatosensory cortex	tissue	0.6
Salivary gland	tissue	0.5
Colon	tissue	0.5
Medulla oblongata	tissue	0.5
Breast	tissue	0.4
Rectum	tissue	0.4
Skeletal muscle	tissue	0.4
Midbrain	tissue	0.4
Superior colliculi	tissue	0.4
Spinal cord	tissue	0.4
Adrenal gland	tissue	0.4

Brain sub-regions (HPA Brain Atlas): detected in 189; highest nTPM — Flocculonodular lobe (8.1), Vermis (7.9), Cerebellar cortex (7.2), Paraventricular nucleus (6.6), Supramarginal gyrus (6.3).

Regulation

Is transcription factor: no

Functional genomics

gnomAD constraint: pLI 1.71e-06, LOEUF 1.04, missense Z -0.0122 — population loss-of-function intolerance (pLI ≥ 0.9 = LoF-intolerant; lower LOEUF = more constrained). gnomAD

Regional missense constraint (gnomAD RMC): no regional variation along ENST00000372569 — one region, missense o/e 1.01.

Literature-anchored findings (GeneRIF, showing 1)

• TLP-mediated global transcriptional repression after double-strand DNA breaks slows down DNA repair and induces apoptosis. (PMID:30890736)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	crip3	ENSDARG00000043395
mus_musculus	Crip3	ENSMUSG00000023968
rattus_norvegicus	Crip3	ENSRNOG00000018613

Paralogs (20): FHL1 (ENSG00000022267), LMO3 (ENSG00000048540), LHX5 (ENSG00000089116), ZFHX4 (ENSG00000091656), LHX2 (ENSG00000106689), LHX6 (ENSG00000106852), LHX3 (ENSG00000107187), LHX4 (ENSG00000121454), LMO2 (ENSG00000135363), ZFHX2 (ENSG00000136367), LMX1B (ENSG00000136944), ZFHX3 (ENSG00000140836), LMO4 (ENSG00000143013), LHX9 (ENSG00000143355), LHX8 (ENSG00000162624), LMX1A (ENSG00000162761), LMO1 (ENSG00000166407), CRIP2 (ENSG00000182809), CRIP1 (ENSG00000213145), LHX1 (ENSG00000273706)

Mouse-model phenotypes

Observed phenotypes of the mouse ortholog (MGI:2152434) from MGI (Alliance of Genome Resources) — knockout/mutant phenotypes, ranked by annotation count. 4 distinct phenotype terms.

Mouse phenotype (MP)	Records
small thymus	1
decreased thymocyte number	1
decreased exploration in new environment	1
thymus hypoplasia	1

Additional cross-species homologs

Sequence homologs in species beyond Ensembl Compara’s model organisms, by Diamond local protein alignment (% sequence identity; best hit per species). Lower-identity rows are more distant homologs. The matched accessions’ gene symbols aren’t in biobtree yet, so each row shows the UniProt accession.

Organism	UniProt	Identity	Method
Gallus gallus	P67966	100.0%	Diamond
Coturnix japonica	P67967	100.0%	Diamond
Bos taurus	Q32LE9	100.0%	Diamond
Pongo abelii	Q5RCT4	99.5%	Diamond
Drosophila melanogaster	Q24400	76.7%	Diamond
Helianthus annuus	P29675	72.0%	Diamond
Dictyostelium discoideum	Q9BIW5	45.2%	Diamond

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
SLC22A7	protein-coding	10864
ZNF318	protein-coding	24149
DNPH1	protein-coding	10591
TTBK1	protein-coding	84630
CUL9	protein-coding	23113

Protein

Protein identifiers

Cysteine-rich protein 3 — Q6Q6R5 (reviewed: Q6Q6R5)

Alternative names: Chromosome 6 LIM domain only protein

All UniProt accessions (3): Q6Q6R5, H0Y7Q9, Q5T045

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Cytoplasm.

Tissue specificity. Expressed in most tissues, but not in skeletal muscle.

Isoforms (4)

UniProt ID	Names	Canonical?
Q6Q6R5-1	1, C	yes
Q6Q6R5-2	2, B
Q6Q6R5-3	3, A
Q6Q6R5-4	4, D

RefSeq proteins (2): NP_001352997, NP_996805* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001781	Znf_LIM	Domain

Pfam: PF00412

UniProt features (9 total): splice variant 3, domain 2, sequence conflict 2, chain 1, region of interest 1

Structure

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6Q6R5-F1	74.81	0.42

Human Protein Atlas

Protein class: Predicted intracellular proteins

Protein evidence: Evidence at protein level

Subcellular location (HPA, imaging): nuclear speckles

Antibody reliability (HPA): IH uncertain · IF approved

Function

Pathways and Gene Ontology

Reactome pathways

0 curated (TAS) of 0; 0 disease pathways. Curated-first; evidence = TAS (manually curated) vs IEA (electronic inference).

MSigDB gene sets: 44 (showing top): GSE13762_CTRL_VS_125_VITAMIND_DAY12_DC_DN, STK33_SKM_DN, ZNF322_TARGET_GENES, MIR4731_5P, GSE11057_EFF_MEM_VS_CENT_MEM_CD4_TCELL_DN, MIR423_5P, MIR3184_5P, MIR6759_3P, GSE12366_NAIVE_VS_MEMORY_BCELL_UP, MIR1911_5P, BLANCO_MELO_RESPIRATORY_SYNCYTIAL_VIRUS_INFECTION_A594_CELLS_DN, GSE15750_WT_VS_TRAF6KO_DAY10_EFF_CD8_TCELL_UP, HAY_BONE_MARROW_DENDRITIC_CELL, GSE17721_POLYIC_VS_CPG_16H_BMDC_UP, WRNIP1_TARGET_GENES

GO Molecular Function (2): metal ion binding (GO:0046872), protein binding (GO:0005515)

GO Cellular Component (1): cytoplasm (GO:0005737)

GO top-level categories

4 GO namespaces:

Category	Terms
cation binding	1
binding	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

showing 16 of 234 interactions by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CRIP3	HOXD8	P13378	390
CRIP3	CLRN2	A0PK11	380
CRIP3	SCO1	O75880	378
CRIP3	SMIM12	Q96EX1	366
CRIP3	BEND7	Q8N7W2	339
CRIP3	TCAIM	Q8N3R3	330
CRIP3	H0YIS7	H0YIS7	315
CRIP3	LRRC40	Q9H9A6	314
CRIP3	HOXD3	P31249	314
CRIP3	MNMIP1	A4FU49	307
CRIP3	COA6	Q5JTJ3	306
CRIP3	TMEM128	Q5BJH2	295
CRIP3	BTBD8	Q5XKL5	286
CRIP3	BAIAP2L2	Q6UXY1	286
CRIP3	TMEM179	Q6ZVK1	286
CRIP3	KLHDC7B	Q96G42	286

IntAct

BioGRID (2 interactions; top human partners by supporting records): FHL3 (Two-hybrid), PLOD3 (Two-hybrid)

Disease & clinical

Genetic variants

Variant evidence for CRIP3: 37 ClinVar records (0 pathogenic / likely pathogenic); 20 GWAS associations.

ClinVar

37 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	29
Likely benign	1
Benign	0

SpliceAI

Top 10 splice-impact sites by Δscore (adjacent positions with the same effect merged into one range; 31 predictions of 758):

Position(s)	Effect	Δscore	Sites
6:43306125–43306126	acceptor_loss	0.9900	6
6:43306134	acceptor_gain	0.9900
6:43306217–43306218	donor_loss	0.9900	4
6:43306314–43306315	acceptor_loss	0.9900	6
6:43306317	acceptor_gain	0.9900
6:43306320	acceptor_gain	0.9900
6:43306122	acceptor_gain	0.9800
6:43306218	donor_loss	0.9800
6:43306444–43306445	donor_loss	0.9800	5
6:43306518–43306519	acceptor_loss	0.9800	5

AlphaMissense

477 missense substitutions predicted likely pathogenic (of 1,340 scored), across 106 residues. Top 20 hotspot residues, ranked by the number of likely-pathogenic substitutions (of those reachable by a single-nucleotide change), then by mean score:

Residue	Likely-pathogenic substitutions	Mean am_pathogenicity	Max am_pathogenicity
H145	8	0.973	0.991
H26	8	0.971	0.990
H44	8	0.893	0.979
H163	8	0.875	0.978
W144	7	0.985	0.995
W25	7	0.983	0.993
C151	7	0.983	0.994
C172	7	0.983	0.991
C124	7	0.982	0.994
C29	7	0.981	0.990
C154	7	0.981	0.992
C176	7	0.981	0.991
C53	7	0.979	0.987
C32	7	0.978	0.991
C148	7	0.974	0.984
C57	7	0.973	0.987
C35	7	0.971	0.984
F62	7	0.968	0.993
C5	7	0.967	0.988
F181	7	0.966	0.992

HPA cancer prognostics

RNA cancer specificity: Cancer enhanced (Kidney Chromophobe, Liver Hepatocellular Carcinoma)

Human Protein Atlas survival analysis — favorable = higher expression predicts better survival.

1 prognostic cancer types:

Cancer	Prognostic	p-value
Kidney Renal Papillary Cell Carcinoma (TCGA)	favorable	0.000197

Disease associations

OMIM: gene `` | disease phenotypes:

GWAS associations

20 associations:

Study	Trait	p-value
GCST005962_28	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)	3e-31
GCST005956_15	Waist-to-hip ratio adjusted for BMI	7e-26
GCST008899_1	Adult hearing difficulty	6e-21
GCST006188_41	Systolic blood pressure (cigarette smoking interaction)	8e-21
GCST008058_65	Estimated glomerular filtration rate	1e-20
GCST008059_76	Estimated glomerular filtration rate	2e-20
GCST005958_10	Waist-to-hip ratio adjusted for BMI (age >50)	2e-19
GCST012442_45	Age-related hearing impairment	1e-17
GCST005957_3	Waist-to-hip ratio adjusted for BMI (age <50)	2e-14
GCST006187_17	Diastolic blood pressure (cigarette smoking interaction)	1e-10
GCST007703_114	Systolic blood pressure	4e-10
GCST007099_139	Systolic blood pressure	1e-9
GCST007706_67	Mean arterial pressure	4e-9
GCST012227_928	Hip circumference adjusted for BMI	2e-8
GCST004521_115	Autism spectrum disorder or schizophrenia	3e-8
GCST008839_556	Height	4e-8
GCST007704_30	Diastolic blood pressure	1e-6
GCST007707_27	Hypertension	1e-6
GCST007096_130	Pulse pressure	3e-6
GCST007705_94	Pulse pressure	4e-6

EFO canonical traits (from GWAS)

9 canonical traits:

EFO ID	Trait name
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0008007	age at assessment
EFO:0008343	sex interaction measurement
EFO:0006336	diastolic blood pressure
EFO:0006527	smoking status measurement
EFO:0006335	systolic blood pressure
EFO:0005763	pulse pressure measurement
EFO:0006340	mean arterial pressure
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (CPIC guideline: no)

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases expression, decreases methylation	2
Aflatoxin B1	decreases expression	2
propionaldehyde	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
pentanal	increases expression	1
di-n-butylphosphoric acid	affects expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	increases expression, affects cotreatment	1
Resveratrol	decreases expression, affects cotreatment	1
Sunitinib	increases expression	1
Leflunomide	decreases expression	1
Acetaminophen	decreases expression	1
Cisplatin	affects cotreatment, increases expression	1
Copper	affects cotreatment, decreases expression	1
Diethylhexyl Phthalate	decreases expression	1
N-Nitrosopyrrolidine	decreases expression	1
Phenylmercuric Acetate	affects cotreatment, decreases expression	1
Silicon Dioxide	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Urethane	decreases expression	1
Valproic Acid	affects expression	1
Cyclosporine	decreases methylation	1
Okadaic Acid	decreases expression	1
Copper Sulfate	decreases expression	1

Clinical trials (associated diseases)

Via MONDO — disease-level, not drug-specific.