CRMA

Summary

CRMA (cardiomyocyte maturation associated lncRNA, HGNC:26393) is a long non-coding RNA gene on chromosome 20q13.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26393
Approved symbol	CRMA
Name	cardiomyocyte maturation associated lncRNA
Location	20q13.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ30313, CARMA
Ensembl gene	ENSG00000174403
Ensembl biotype	lncRNA
Entrez	253868
RNAcentral	URS000075A492 — lncRNA, 3610 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 28 — 28 lncRNA

ENST00000412495, ENST00000436101, ENST00000475015, ENST00000621644, ENST00000670040, ENST00000686642, ENST00000788149, ENST00000788150, ENST00000788151, ENST00000788152, ENST00000788153, ENST00000788154, ENST00000788155, ENST00000788156, ENST00000788157, ENST00000788158, ENST00000788159, ENST00000788160, ENST00000788161, ENST00000788162, ENST00000788163, ENST00000788164, ENST00000788165, ENST00000788166, ENST00000788167, ENST00000788168, ENST00000788169, ENST00000788170

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412495 — 7 exons

Exon	Start	End
ENSE00001210806	62547827	62548000
ENSE00001596639	62545706	62546858
ENSE00001597962	62545220	62545367
ENSE00001600508	62547548	62547702
ENSE00001649774	62548312	62548461
ENSE00001658025	62551426	62551526
ENSE00001659870	62544343	62544763

Expression profiles

Bgee: expression breadth ubiquitous, 150 present calls, max score 94.81.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5251 / max 57.1659, expressed in 182 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
188277	0.5140	180
188276	0.0112	3

Top tissues by expression

227 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	94.81	gold quality
muscle layer of sigmoid colon	UBERON:0035805	90.95	gold quality
right atrium auricular region	UBERON:0006631	90.66	gold quality
cardiac atrium	UBERON:0002081	89.96	gold quality
heart left ventricle	UBERON:0002084	86.75	gold quality
lower esophagus	UBERON:0013473	86.11	gold quality
lower esophagus muscularis layer	UBERON:0035833	86.11	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	86.10	gold quality
cardiac ventricle	UBERON:0002082	85.90	gold quality
heart	UBERON:0000948	85.11	gold quality
left uterine tube	UBERON:0001303	85.01	gold quality
hindlimb stylopod muscle	UBERON:0004252	83.46	gold quality
right coronary artery	UBERON:0001625	83.09	gold quality
muscle of leg	UBERON:0001383	82.10	gold quality
gastrocnemius	UBERON:0001388	81.46	gold quality
body of uterus	UBERON:0009853	81.36	gold quality
mucosa of stomach	UBERON:0001199	80.90	gold quality
buccal mucosa cell	CL:0002336	80.04	silver quality
lower esophagus mucosa	UBERON:0035834	79.98	gold quality
smooth muscle tissue	UBERON:0001135	79.44	gold quality
popliteal artery	UBERON:0002250	78.81	gold quality
tibial artery	UBERON:0007610	78.79	gold quality
left coronary artery	UBERON:0001626	77.90	gold quality
prostate gland	UBERON:0002367	77.86	gold quality
aorta	UBERON:0000947	77.68	gold quality
coronary artery	UBERON:0001621	77.35	gold quality
ascending aorta	UBERON:0001496	76.55	gold quality
thoracic aorta	UBERON:0001515	76.44	gold quality
colon	UBERON:0001155	75.52	gold quality
myometrium	UBERON:0001296	75.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.45

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The conserved long non-coding RNA CARMA regulates cardiomyocyte differentiation. (PMID:34459880)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.