CRTAC1

Summary

CRTAC1 (cartilage acidic protein 1, HGNC:14882) is a protein-coding gene on chromosome 10q24.2, encoding Cartilage acidic protein 1 (Q9NQ79).

This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 55118 — RefSeq curated summary.

At a glance

• GWAS associations: 18
• Clinical variants (ClinVar): 127 total
• MANE Select transcript: NM_018058

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14882
Approved symbol	CRTAC1
Name	cartilage acidic protein 1
Location	10q24.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10320, CEP-68, ASPIC1
Ensembl gene	ENSG00000095713
Ensembl biotype	protein_coding
OMIM	606276
Entrez	55118

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 8 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000309155, ENST00000370591, ENST00000370597, ENST00000413387, ENST00000436034, ENST00000468549, ENST00000856695, ENST00000856696, ENST00000962752

RefSeq mRNA: 2 — MANE Select: NM_018058 NM_001206528, NM_018058

CCDS: CCDS31266, CCDS55723

Canonical transcript exons

ENST00000370597 — 15 exons

Exon	Start	End
ENSE00001133871	97936170	97936366
ENSE00001354558	98011138	98011337
ENSE00001602694	97901503	97901639
ENSE00001665569	97904669	97904814
ENSE00001688897	97917500	97917656
ENSE00001690903	97896909	97896991
ENSE00001711389	97884206	97884351
ENSE00001764978	97923264	97923400
ENSE00001771140	97908013	97908147
ENSE00001802342	97895245	97895413
ENSE00001806590	97895885	97895985
ENSE00003548016	97865000	97865714
ENSE00003655561	97880249	97880392
ENSE00003659451	97882786	97882828
ENSE00003844867	98030449	98030621

Expression profiles

Bgee: expression breadth ubiquitous, 225 present calls, max score 99.70.

FANTOM5 (CAGE): breadth broad, TPM avg 3.0622 / max 758.2570, expressed in 395 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
110959	2.0449	366
110958	1.0089	201
110957	0.0084	1

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tendon of biceps brachii	UBERON:0008188	99.70	gold quality
synovial joint	UBERON:0002217	99.47	gold quality
layer of synovial tissue	UBERON:0007616	97.90	gold quality
endothelial cell	CL:0000115	97.80	gold quality
Brodmann (1909) area 23	UBERON:0013554	95.41	gold quality
primary visual cortex	UBERON:0002436	92.75	gold quality
right uterine tube	UBERON:0001302	92.32	gold quality
middle temporal gyrus	UBERON:0002771	91.91	gold quality
popliteal artery	UBERON:0002250	91.13	gold quality
tibial artery	UBERON:0007610	91.09	gold quality
pons	UBERON:0000988	90.88	gold quality
prefrontal cortex	UBERON:0000451	90.29	gold quality
tendon	UBERON:0000043	87.84	gold quality
cartilage tissue	UBERON:0002418	87.57	gold quality
seminal vesicle	UBERON:0000998	87.07	gold quality
calcaneal tendon	UBERON:0003701	87.04	gold quality
occipital lobe	UBERON:0002021	86.37	gold quality
aorta	UBERON:0000947	86.33	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	86.12	gold quality
Brodmann (1909) area 9	UBERON:0013540	85.37	gold quality
frontal cortex	UBERON:0001870	85.33	gold quality
cingulate cortex	UBERON:0003027	85.03	gold quality
anterior cingulate cortex	UBERON:0009835	85.03	gold quality
neocortex	UBERON:0001950	84.85	gold quality
periodontal ligament	UBERON:0008266	84.69	gold quality
right frontal lobe	UBERON:0002810	84.39	gold quality
right coronary artery	UBERON:0001625	84.05	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.76	gold quality
left coronary artery	UBERON:0001626	83.60	gold quality
tibial nerve	UBERON:0001323	82.97	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-MTAB-8322	yes	8698.15
E-GEOD-135922	yes	26.61
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

20 targeting CRTAC1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-1193	100.00	65.93	529
HSA-MIR-432-3P	100.00	67.86	705
HSA-MIR-7978	99.86	66.90	856
HSA-MIR-370-5P	99.78	66.81	706
HSA-MIR-26A-1-3P	99.64	66.81	788
HSA-MIR-26A-2-3P	99.64	66.82	786
HSA-MIR-2113	99.58	71.22	1521
HSA-MIR-3140-5P	99.39	69.04	1136
HSA-MIR-4711-3P	98.97	66.87	1020
HSA-MIR-7113-3P	98.75	65.71	1120
HSA-MIR-455-5P	98.74	67.31	795
HSA-MIR-1-5P	98.70	68.66	1017
HSA-MIR-550A-3P	98.37	69.61	632
HSA-MIR-6867-3P	98.12	66.07	1305
HSA-MIR-676-3P	97.86	65.70	668
HSA-MIR-3664-3P	97.85	67.62	1452
HSA-MIR-1914-5P	97.83	66.21	807
HSA-MIR-200C-5P	97.71	67.73	596
HSA-MIR-510-5P	97.66	65.82	916
HSA-MIR-1227-3P	97.36	66.94	834

Literature-anchored findings (GeneRIF, showing 19)

• CRTAC1 acquired an alternate last exon from the tail-to-tail oriented neighbouring gene in humans resulting in the glycosylated isoform CRTAC1-A which represents a new extracellular matrix molecule of articular cartilage. (PMID:17074475)
• in bone fracture patients, 12 proteins were related to bone/cartilage metabolism, including: TGF-beta induced protein IG-H(3), cartilage acidic protein 1, procollagen C proteinase enhancer protein and TGF-beta receptor III. (PMID:17602227)
• Confirm the increase of CRTAC1 in cartilage biopsies from OA patients undergoing joint replacement by real-time PCR and immunohistochemistry. Furthermore, we report that proinflammatory cytokines interleukin-1beta and tumor necrosis factor alpha upregulate CRTAC1 expression in primary articular chondrocytes and synovial fibroblasts. (PMID:27415616)
• These results provided new insights into the mechanism of cataract development, and demonstrated that CRTAC1 could be a potentially novel target for cataract treatment. (PMID:27855397)
• It was shown for the first time the propensity of CRTAC1 to form amyloid-like structures, and it was hypothesized that the aggregating property of CRTAC1 may be related to its disease-association. (PMID:27862299)
• CSF levels of LOTUS correlated inversely with disease activity in both bacterial and viral meningitis; neuroinflammation down-regulated LOTUS expression. (PMID:29454354)
• CRTAC1 expression and nuclear factor-kappa B (NF-kappaB) p65 nuclear translocation were elevated in capsule tissues of cataract patients in comparison with normal controls. The regulatory network involving NF-kappaB, CRTAC1, and p38 may therefore play an important role in cataract formation. (PMID:31999475)
• Cartilage acidic protein 1 promotes increased cell viability, cell proliferation and energy metabolism in primary human dermal fibroblasts. (PMID:32084494)
• Down-regulation of CRTAC1 attenuates UVB-induced pyroptosis in HLECs through inhibiting ROS production. (PMID:32838966)
• The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in Iceland. (PMID:33982893)
• Deciphering the role of cartilage protein 1 in human dermal fibroblasts: a transcriptomic approach. (PMID:34269961)
• CRTAC1 (Cartilage acidic protein 1) inhibits cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) process in bladder cancer by downregulating Yin Yang 1 (YY1) to inactivate the TGF-beta pathway. (PMID:34818994)
• Mass spectrometry-based proteomics identify novel serum osteoarthritis biomarkers. (PMID:35606786)
• Plasma proteomics identifies CRTAC1 as a biomarker for osteoarthritis severity and progression. (PMID:35924962)
• Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements: Results From the UK Biobank Resource. (PMID:36239377)
• The oncogenic role of TFAP2A in bladder urothelial carcinoma via a novel long noncoding RNA TPRG1-AS1/DNMT3A/CRTAC1 axis. (PMID:36410635)
• Proteomic Analyses of Autologous Chondrocyte Implantation Plasma Highlight Cartilage Acidic Protein 1 as a Candidate for Preclinical Screening. (PMID:37039559)
• CRTAC1 identified as a promising diagnosis and prognostic biomarker in lung adenocarcinoma. (PMID:38755183)
• CRTAC1 has a Compact beta-propeller-TTR Core Stabilized by Potassium Ions. (PMID:39029889)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	crtac1a	ENSDARG00000059826
danio_rerio	crtac1b	ENSDARG00000102517
mus_musculus	Crtac1	ENSMUSG00000042401
rattus_norvegicus	Crtac1	ENSRNOG00000015220

Protein

Protein identifiers

Cartilage acidic protein 1 — Q9NQ79 (reviewed: Q9NQ79)

Alternative names: 68 kDa chondrocyte-expressed protein, ASPIC

All UniProt accessions (4): Q9NQ79, A0A0C4DFP6, H0Y6C6, Q5T4F6

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Secreted. Extracellular space. Extracellular matrix.

Tissue specificity. Expressed in the interterritorial matrix of articular deep zone cartilage (at protein level). Isoform 1 and isoform 2 are expressed in brain. Isoform 1 is detected in lung and chondrocytes. Detected in cartilage, bone, cultured chondrocytes and lung, and at low levels in heart. Not detected in osteoblasts.

Post-translational modifications. O-glycosylated.

Induction. Up-regulated by BMP4 (at protein level). Up-regulated in mesenchymal stem cells undergoing chondrogenic differentiation and by BMP4.

Miscellaneous. Shares an exon with the neighboring tail-to-tail oriented gene GOLGA7B.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9NQ79-1	1, CRTAC1-A	yes
Q9NQ79-2	2, CRTAC1-B
Q9NQ79-3	3

RefSeq proteins (2): NP_001193457, NP_060528* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001881	EGF-like_Ca-bd_dom	Domain
IPR011519	UnbV_ASPIC	Domain
IPR013517	FG-GAP	Repeat
IPR018097	EGF_Ca-bd_CS	Conserved_site
IPR027039	Crtac1	Family
IPR028994	Integrin_alpha_N	Homologous_superfamily
IPR049883	NOTCH1_EGF-like	Domain

Pfam: PF07593, PF07645, PF13517

UniProt features (22 total): glycosylation site 5, repeat 4, disulfide bond 3, splice variant 3, sequence variant 3, signal peptide 1, chain 1, sequence conflict 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NQ79-F1	86.55	0.74

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (3): 563–577, 570–586, 592–605

Glycosylation sites (5): 621, 626, 608, 618, 619

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 104 (showing top): RRAGTTGT_UNKNOWN, GOBP_NEURON_RECOGNITION, BENPORATH_ES_WITH_H3K27ME3, GOBP_SYNAPSE_ASSEMBLY, GOBP_NEUROGENESIS, GOBP_REGULATION_OF_CELL_JUNCTION_ASSEMBLY, TGACCTY_ERR1_Q2, AP2_Q3, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GGGTGGRR_PAX4_03, GOBP_FOREBRAIN_DEVELOPMENT, GOBP_CELL_JUNCTION_ORGANIZATION, GOBP_REGULATION_OF_SYNAPSE_ASSEMBLY, GOBP_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY, GOBP_HEAD_DEVELOPMENT

GO Biological Process (3): axonal fasciculation (GO:0007413), olfactory bulb development (GO:0021772), regulation of synapse assembly (GO:0051963)

GO Molecular Function (2): calcium ion binding (GO:0005509), protein binding (GO:0005515)

GO Cellular Component (5): postsynaptic density (GO:0014069), growth cone (GO:0030426), extracellular exosome (GO:0070062), glutamatergic synapse (GO:0098978), extracellular region (GO:0005576)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
neuron recognition	1
axon development	1
neuron projection fasciculation	1
olfactory lobe development	1
anatomical structure development	1
synapse assembly	1
regulation of synapse organization	1
regulation of cell junction assembly	1
metal ion binding	1
binding	1
asymmetric synapse	1
postsynaptic specialization	1
site of polarized growth	1
distal axon	1
extracellular vesicle	1
synapse	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1104 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CRTAC1	EGF	P01133	511
CRTAC1	GPLD1	P80108	467
CRTAC1	CILP	O75339	465
CRTAC1	LRFN1	Q9P244	423
CRTAC1	FNDC10	F2Z333	419
CRTAC1	NPIPB6	E9PJ23	392
CRTAC1	DNAI4	Q5VTH9	380
CRTAC1	CLDN19	Q8N6F1	347
CRTAC1	CCDC137	Q6PK04	343
CRTAC1	SCAPER	Q9BY12	335
CRTAC1	GOLGA7B	Q2TAP0	330
CRTAC1	VSTM2B	A6NLU5	328
CRTAC1	FAM204A	Q9H8W3	327
CRTAC1	IGFALS	P35858	324
CRTAC1	CLEC3B	P05452	322

IntAct

29 interactions, top by confidence:

A	B	Type	Score
MAPRE2	CRTAC1	psi-mi:“MI:0915”(physical association)	0.830
CRTAC1	MAPRE2	psi-mi:“MI:0915”(physical association)	0.830
TXNDC16	FOXRED2	psi-mi:“MI:0914”(association)	0.730
AQP1	CRTAC1	psi-mi:“MI:0915”(physical association)	0.560
CRTAC1	MORN4	psi-mi:“MI:0915”(physical association)	0.560
CRTAC1	AQP1	psi-mi:“MI:0915”(physical association)	0.560
MORN4	CRTAC1	psi-mi:“MI:0915”(physical association)	0.560
CRTAC1	MAPRE3	psi-mi:“MI:0915”(physical association)	0.560
CFP	B3GLCT	psi-mi:“MI:0914”(association)	0.530
	CD5L	psi-mi:“MI:0915”(physical association)	0.400
ITM2B	ILVBL	psi-mi:“MI:0914”(association)	0.350
WFDC2	WDR91	psi-mi:“MI:0914”(association)	0.350
C1orf54	AGRN	psi-mi:“MI:0914”(association)	0.350
CRTAC1	ZMYM6	psi-mi:“MI:0914”(association)	0.350
TXNDC16	SEMG1	psi-mi:“MI:0914”(association)	0.350
A2M	BMP7	psi-mi:“MI:0914”(association)	0.350
KRAS	IGKV2D-24	psi-mi:“MI:0914”(association)	0.350
MAPRE2	CRTAC1	psi-mi:“MI:0915”(physical association)	0.000
MAPRE3	CRTAC1	psi-mi:“MI:0915”(physical association)	0.000
DSCAM	CRTAC1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (43): CRTAC1 (Two-hybrid), CRTAC1 (Two-hybrid), MORN4 (Two-hybrid), ZMYM6 (Affinity Capture-MS), CRTAC1 (Affinity Capture-MS), CRTAC1 (Affinity Capture-MS), CRTAC1 (Affinity Capture-MS), MAPRE2 (Affinity Capture-MS), RUVBL1 (Affinity Capture-MS), MTO1 (Affinity Capture-MS), TRAPPC10 (Affinity Capture-MS), BRIP1 (Affinity Capture-MS), TRAPPC9 (Affinity Capture-MS), MOCOS (Affinity Capture-MS), ASPM (Affinity Capture-MS)

ESM2 similar proteins: A0A0N9E2K8, D3YXG0, F4IYM4, H2DF88, O15943, O18756, O93470, O94923, P04412, P0C2H4, P28825, P54834, P55024, P55033, P60755, P60756, Q08761, Q0E908, Q0V9M0, Q13219, Q14703, Q16819, Q5E9N5, Q5NDE5, Q5NDE6, Q60649, Q64230, Q6B3P0, Q6B457, Q75W54, Q7TN16, Q7Z553, Q8BLI4, Q8K3F2, Q8R4K8, Q8R555, Q8UVJ7, Q96RW7, Q98931, Q9EPS3

Diamond homologs: Q0V9M0, Q4V7M2, Q5XH36, Q8R555, Q9NQ79, A0A6I8RMG7, B5DFC9, O35568, O88322, P15306, P27590, P35555, P41413, P48960, Q04592, Q09165, Q12805, Q14112, Q19267, Q2KIT5, Q4G063, Q4V7F2, Q5EA46, Q5RBP1, Q5W7P8, Q60438, Q6UXH1, Q6UXI9, Q75N90, Q7SXF6, Q7YQD7, Q7ZXL5, Q80T14, Q862Z3, Q86XX4, Q8AVH7, Q8BPB5, Q8K4G1, Q8R4U0, Q8SQA4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

127 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	102
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2676 predictions. Top by Δscore:

Variant	Effect	Δscore
10:97880244:CT:C	donor_loss	1.0000
10:97880245:TCA:T	donor_loss	1.0000
10:97880248:C:CT	donor_loss	1.0000
10:97884201:CCCA:C	donor_loss	1.0000
10:97884202:CCACC:C	donor_loss	1.0000
10:97884203:CACCT:C	donor_loss	1.0000
10:97884205:C:CG	donor_loss	1.0000
10:97884207:T:TA	donor_gain	1.0000
10:97884222:T:TA	donor_gain	1.0000
10:97884347:CTTCC:C	acceptor_gain	1.0000
10:97884349:TCC:T	acceptor_gain	1.0000
10:97884350:CCC:C	acceptor_gain	1.0000
10:97884352:C:CC	acceptor_gain	1.0000
10:97895239:ACT:A	donor_loss	1.0000
10:97895241:TCA:T	donor_loss	1.0000
10:97895242:CA:C	donor_loss	1.0000
10:97895243:A:AC	donor_gain	1.0000
10:97895243:AC:A	donor_gain	1.0000
10:97895244:C:CC	donor_gain	1.0000
10:97895244:C:CT	donor_loss	1.0000
10:97895244:CC:C	donor_gain	1.0000
10:97895409:AAGCC:A	acceptor_gain	1.0000
10:97895410:AGCC:A	acceptor_gain	1.0000
10:97895411:GCC:G	acceptor_gain	1.0000
10:97895412:CC:C	acceptor_gain	1.0000
10:97895412:CCC:C	acceptor_gain	1.0000
10:97895413:CC:C	acceptor_gain	1.0000
10:97895413:CCT:C	acceptor_loss	1.0000
10:97895414:C:CA	acceptor_loss	1.0000
10:97895414:C:CC	acceptor_gain	1.0000

AlphaMissense

4340 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:97880311:C:G	C586S	0.999
10:97880312:A:T	C586S	0.999
10:97895943:A:G	L420P	0.999
10:97904712:C:G	R318P	0.999
10:97936189:G:C	N134K	0.999
10:97936189:G:T	N134K	0.999
10:97936245:C:A	G116W	0.999
10:97936346:A:T	V82D	0.999
10:97936351:G:C	N80K	0.999
10:97936351:G:T	N80K	0.999
10:97865591:T:A	I132N	0.998
10:97865595:G:C	E133D	0.998
10:97865595:G:T	E133D	0.998
10:97880312:A:G	C586R	0.998
10:97880338:C:G	C577S	0.998
10:97880339:A:G	C577R	0.998
10:97880339:A:T	C577S	0.998
10:97880359:C:G	C570S	0.998
10:97880360:A:G	C570R	0.998
10:97880360:A:T	C570S	0.998
10:97880380:C:G	C563S	0.998
10:97880381:A:T	C563S	0.998
10:97895928:C:A	G425V	0.998
10:97895928:C:T	G425E	0.998
10:97896909:C:A	G406W	0.998
10:97896915:C:G	G404R	0.998
10:97901514:G:C	N374K	0.998
10:97901514:G:T	N374K	0.998
10:97901599:C:G	R346P	0.998
10:97904729:G:C	N312K	0.998

dbSNP variants (sampled 300 via entrez): RS1000009290 (10:97877505 C>A), RS1000011797 (10:97955392 C>G), RS1000075711 (10:97904225 C>T), RS1000083887 (10:97984739 C>T), RS1000083894 (10:97877071 G>A), RS1000105693 (10:97942711 CTGTT>C), RS1000111140 (10:97977783 A>G,T), RS1000117718 (10:98030451 C>T), RS1000140194 (10:97864514 G>A), RS1000149214 (10:97931922 C>G,T), RS1000178042 (10:97868070 G>A), RS1000178911 (10:97996784 T>C,G), RS1000212191 (10:98021964 G>A), RS1000236117 (10:97948830 A>G), RS1000252480 (10:97996932 G>A)

Disease associations

OMIM: gene MIM:606276 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

18 associations (top):

Study	Trait	p-value
GCST000753_17	Metabolic syndrome	9.000000e-06
GCST004747_5	Lung cancer in never smokers	9.000000e-08
GCST005829_24	Hand grip strength	3.000000e-09
GCST005830_98	Hand grip strength	3.000000e-12
GCST006192_45	Systolic blood pressure x smoking status (ever vs never) interaction (2df test)	7.000000e-06
GCST006193_2	Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test)	3.000000e-07
GCST006195_88	Systolic blood pressure x smoking status (current vs non-current) interaction (2df test)	5.000000e-11
GCST006585_2276	Blood protein levels	9.000000e-47
GCST009602_20	Metabolic syndrome	2.000000e-10
GCST010241_286	Apolipoprotein A1 levels	6.000000e-09
GCST010242_331	HDL cholesterol levels	3.000000e-13
GCST010244_278	Triglyceride levels	6.000000e-16
GCST010397_23	Gut microbiota (bacterial taxa, rank normal transformation method)	1.000000e-06
GCST010574_4	Evening vs. morning chronotype (self-assessed)	9.000000e-06
GCST010988_447	Adult body size	2.000000e-18
GCST011122_68	Walking pace	1.000000e-08
GCST012332_28	Multisite chronic pain	1.000000e-08
GCST90026414_10	Severe insulin-resistant type 2 diabetes	8.000000e-06

EFO canonical traits (11, from GWAS)

EFO ID	Trait name
EFO:0000195	metabolic syndrome
EFO:0006941	grip strength measurement
EFO:0006335	systolic blood pressure
EFO:0006527	smoking status measurement
EFO:0006336	diastolic blood pressure
EFO:0004614	apolipoprotein A 1 measurement
EFO:0004612	high density lipoprotein cholesterol measurement
EFO:0004530	triglyceride measurement
EFO:0007874	gut microbiome measurement
EFO:0008328	chronotype measurement
EFO:0010100	multisite chronic pain

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases methylation, affects expression, increases expression	4
Smoke	decreases expression	2
Tobacco Smoke Pollution	decreases expression, increases methylation	2
Aflatoxin B1	decreases methylation	2
propionaldehyde	increases expression	1
sodium arsenite	decreases expression	1
butyraldehyde	increases expression	1
benzo(e)pyrene	increases methylation	1
aflatoxin B2	increases methylation	1
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
entinostat	increases expression	1
abrine	increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Sunitinib	decreases expression	1
Benzo(a)pyrene	increases methylation	1
Cisplatin	increases expression	1
Diethylhexyl Phthalate	decreases expression	1
Doxorubicin	increases expression	1
Methapyrilene	increases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1
Rotenone	decreases expression	1
Tretinoin	increases expression	1
Triclosan	increases expression	1
Tunicamycin	increases expression	1
Gold Compounds	increases expression	1
Antirheumatic Agents	decreases expression	1
Thapsigargin	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.