CSNK1A1L

Summary

CSNK1A1L (casein kinase 1 alpha 1 like, HGNC:20289) is a protein-coding gene on chromosome 13q13.3, encoding Casein kinase I isoform alpha-like (Q8N752). Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and signal transduction. Predicted to be active in cytoplasm and nucleus.

Source: NCBI Gene 122011 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 56 total — 1 pathogenic
• Druggable target: yes — 7 molecules with ChEMBL bioactivity
• MANE Select transcript: NM_145203

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20289
Approved symbol	CSNK1A1L
Name	casein kinase 1 alpha 1 like
Location	13q13.3
Locus type	gene with protein product
Status	Approved
Aliases	MGC33182
Ensembl gene	ENSG00000180138
Ensembl biotype	protein_coding
Entrez	122011

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000379800

RefSeq mRNA: 1 — MANE Select: NM_145203 NM_145203

CCDS: CCDS9363

Canonical transcript exons

ENST00000379800 — 1 exons

Exon	Start	End
ENSE00001482541	37103259	37105664

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 81.47.

Top tissues by expression

110 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.47	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.13	gold quality
blood	UBERON:0000178	66.11	gold quality
right testis	UBERON:0004534	59.50	gold quality
testis	UBERON:0000473	58.03	gold quality
bone marrow cell	CL:0002092	57.50	silver quality
left testis	UBERON:0004533	57.25	gold quality
bone marrow	UBERON:0002371	55.43	gold quality
cortical plate	UBERON:0005343	53.04	gold quality
ventricular zone	UBERON:0003053	47.92	silver quality
granulocyte	CL:0000094	44.41	silver quality
sural nerve	UBERON:0015488	42.44	gold quality
spleen	UBERON:0002106	42.01	silver quality
colonic epithelium	UBERON:0000397	41.30	gold quality
vermiform appendix	UBERON:0001154	40.07	silver quality
skeletal muscle tissue	UBERON:0001134	39.17	gold quality
stromal cell of endometrium	CL:0002255	38.94	gold quality
right lung	UBERON:0002167	38.80	silver quality
gall bladder	UBERON:0002110	38.63	gold quality
apex of heart	UBERON:0002098	37.58	silver quality
muscle tissue	UBERON:0002385	36.42	gold quality
liver	UBERON:0002107	36.31	gold quality
urinary bladder	UBERON:0001255	35.93	gold quality
monocyte	CL:0000576	35.65	gold quality
placenta	UBERON:0001987	34.32	gold quality
lung	UBERON:0002048	33.86	silver quality
upper lobe of left lung	UBERON:0008952	33.61	silver quality
fundus of stomach	UBERON:0001160	33.32	gold quality
corpus callosum	UBERON:0002336	32.93	gold quality
endometrium	UBERON:0001295	32.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.17

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

63 targeting CSNK1A1L, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-223-3P	99.99	70.14	1140
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-7-1-3P	99.91	71.53	4384
HSA-MIR-7-2-3P	99.91	71.40	4394
HSA-MIR-652-5P	99.91	67.49	505
HSA-MIR-6857-5P	99.87	65.32	985
HSA-MIR-659-3P	99.85	70.69	1620
HSA-MIR-609	99.82	64.26	505
HSA-MIR-3150A-3P	99.76	64.44	1640
HSA-MIR-6763-5P	99.76	64.68	1767
HSA-MIR-4679	99.76	69.19	1229
HSA-MIR-5580-3P	99.70	69.41	2052
HSA-MIR-3175	99.65	66.30	2031
HSA-MIR-6516-3P	99.65	68.57	1238
HSA-MIR-561-3P	99.64	70.90	3647
HSA-MIR-3685	99.62	68.83	1621
HSA-MIR-3942-3P	99.57	69.03	2854
HSA-MIR-4708-3P	99.51	67.99	870
HSA-MIR-4677-3P	99.49	67.91	1246

Literature-anchored findings (GeneRIF, showing 1)

• Casein kinase 1 controls the shuttling of epidermal growth factor receptor and estrogen receptor in endometrial carcinoma induced by breast cancer hormonal therapy: Relevance of GPER1/Src. (PMID:37257767)

Cross-species orthologs

69 orthologs

Organism	Symbol	Gene ID
danio_rerio	ttbk2a	ENSDARG00000005670
danio_rerio	ttbk2b	ENSDARG00000043026
danio_rerio	ttbk1a	ENSDARG00000056019
danio_rerio	ttbk1b	ENSDARG00000056659
drosophila_melanogaster	ball	FBGN0027889
drosophila_melanogaster	CG9962	FBGN0031441
caenorhabditis_elegans		WBGENE00007049
caenorhabditis_elegans		WBGENE00007269
caenorhabditis_elegans		WBGENE00007305
caenorhabditis_elegans		WBGENE00007335
caenorhabditis_elegans		WBGENE00007448
caenorhabditis_elegans		WBGENE00007777
caenorhabditis_elegans		WBGENE00007791
caenorhabditis_elegans		WBGENE00008088
caenorhabditis_elegans		WBGENE00008423
caenorhabditis_elegans		WBGENE00008464
caenorhabditis_elegans	F10G8.2	WBGENE00008662
caenorhabditis_elegans		WBGENE00008883
caenorhabditis_elegans		WBGENE00009324
caenorhabditis_elegans		WBGENE00009402
caenorhabditis_elegans		WBGENE00010555
caenorhabditis_elegans		WBGENE00010692
caenorhabditis_elegans		WBGENE00010874
caenorhabditis_elegans		WBGENE00011283
caenorhabditis_elegans		WBGENE00012169
caenorhabditis_elegans		WBGENE00012637
caenorhabditis_elegans		WBGENE00012731
caenorhabditis_elegans		WBGENE00013868
caenorhabditis_elegans		WBGENE00014007
caenorhabditis_elegans		WBGENE00015893
caenorhabditis_elegans		WBGENE00016111
caenorhabditis_elegans	C34B2.3	WBGENE00016388
caenorhabditis_elegans		WBGENE00016513
caenorhabditis_elegans		WBGENE00016541
caenorhabditis_elegans		WBGENE00016673
caenorhabditis_elegans		WBGENE00016765
caenorhabditis_elegans	C55B7.10	WBGENE00016946
caenorhabditis_elegans		WBGENE00016963
caenorhabditis_elegans		WBGENE00017050
caenorhabditis_elegans		WBGENE00017714
caenorhabditis_elegans		WBGENE00017725
caenorhabditis_elegans		WBGENE00017803
caenorhabditis_elegans		WBGENE00017895
caenorhabditis_elegans	F33D11.7	WBGENE00018004
caenorhabditis_elegans		WBGENE00018122
caenorhabditis_elegans		WBGENE00018123
caenorhabditis_elegans		WBGENE00018202
caenorhabditis_elegans		WBGENE00018203
caenorhabditis_elegans		WBGENE00018745
caenorhabditis_elegans		WBGENE00018839
caenorhabditis_elegans		WBGENE00019086
caenorhabditis_elegans		WBGENE00019119
caenorhabditis_elegans		WBGENE00019459
caenorhabditis_elegans		WBGENE00019556
caenorhabditis_elegans		WBGENE00019561
caenorhabditis_elegans		WBGENE00019562
caenorhabditis_elegans		WBGENE00019642
caenorhabditis_elegans	kin-35	WBGENE00019769
caenorhabditis_elegans		WBGENE00020071
caenorhabditis_elegans		WBGENE00020072
caenorhabditis_elegans		WBGENE00020223
caenorhabditis_elegans		WBGENE00020580
caenorhabditis_elegans	W09C3.1	WBGENE00021109
caenorhabditis_elegans	Y47G6A.13	WBGENE00021639
caenorhabditis_elegans	Y65B4A.9	WBGENE00022032
caenorhabditis_elegans		WBGENE00022102
caenorhabditis_elegans	Y71F9AL.2	WBGENE00022108
caenorhabditis_elegans		WBGENE00022705
caenorhabditis_elegans		WBGENE00022707

Paralogs (12): VRK2 (ENSG00000028116), CDC7 (ENSG00000097046), VRK1 (ENSG00000100749), VRK3 (ENSG00000105053), CSNK1A1 (ENSG00000113712), TTBK2 (ENSG00000128881), CSNK1G2 (ENSG00000133275), CSNK1D (ENSG00000141551), TTBK1 (ENSG00000146216), CSNK1G3 (ENSG00000151292), CSNK1G1 (ENSG00000169118), CSNK1E (ENSG00000213923)

Protein

Protein identifiers

Casein kinase I isoform alpha-like — Q8N752 (reviewed: Q8N752)

Alternative names: CK1

All UniProt accessions (1): Q8N752

UniProt curated annotations — full annotation on UniProt →

Function. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling.

Subunit / interactions. Interacts with FAM83A, FAM83B, FAM83C, FAM83D, FAM83E, FAM83F, FAM83G and FAM83H (via DUF1669).

Subcellular location. Cytoplasm.

Similarity. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

RefSeq proteins (1): NP_660204* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000719	Prot_kinase_dom	Domain
IPR008271	Ser/Thr_kinase_AS	Active_site
IPR011009	Kinase-like_dom_sf	Homologous_superfamily
IPR017441	Protein_kinase_ATP_BS	Binding_site
IPR050235	CK1_Ser-Thr_kinase-like	Family

Pfam: PF00069

Catalyzed reactions (Rhea), 2 shown:

• L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) (RHEA:17989)
• L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) (RHEA:46608)

UniProt features (19 total): sequence variant 9, compositionally biased region 2, binding site 2, chain 1, domain 1, sequence conflict 1, region of interest 1, active site 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N752-F1	92.06	0.88

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 136 (proton acceptor)

Ligand- & substrate-binding residues (2): 23–31; 46

Post-translational modifications (1): 8

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 61 (showing top): KEGG_HEDGEHOG_SIGNALING_PATHWAY, GOBP_REGULATION_OF_WNT_SIGNALING_PATHWAY, chr13q13, CATTTCA_MIR203, GOBP_CANONICAL_WNT_SIGNALING_PATHWAY, AACTTT_UNKNOWN, HNF1_01, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, GOBP_NEGATIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY, HOXA4_Q2, YNGTTNNNATT_UNKNOWN, CP2_01, GCCATNTTG_YY1_Q6, ATGTACA_MIR493, WGTTNNNNNAAA_UNKNOWN

GO Biological Process (4): signal transduction (GO:0007165), Wnt signaling pathway (GO:0016055), negative regulation of canonical Wnt signaling pathway (GO:0090090), protein phosphorylation (GO:0006468)

GO Molecular Function (7): protein serine/threonine kinase activity (GO:0004674), ATP binding (GO:0005524), protein serine kinase activity (GO:0106310), nucleotide binding (GO:0000166), protein kinase activity (GO:0004672), kinase activity (GO:0016301), transferase activity (GO:0016740)

GO Cellular Component (2): nucleus (GO:0005634), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein kinase activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
cell surface receptor signaling pathway	1
negative regulation of Wnt signaling pathway	1
canonical Wnt signaling pathway	1
regulation of canonical Wnt signaling pathway	1
phosphorylation	1
protein modification process	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
kinase activity	1
phosphotransferase activity, alcohol group as acceptor	1
catalytic activity, acting on a protein	1
transferase activity, transferring phosphorus-containing groups	1
catalytic activity	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

550 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CSNK1A1L	AXIN2	Q9Y2T1	476
CSNK1A1L	CSNK1A1	P48729	423
CSNK1A1L	ALPK3	Q96L96	380
CSNK1A1L	NPIPB9	F8W1W9	377
CSNK1A1L	GSK3B	P49841	375
CSNK1A1L	PSKH2	Q96QS6	371
CSNK1A1L	PROSER1	Q86XN7	365
CSNK1A1L	UEVLD	Q8IX04	353
CSNK1A1L	CCDC169	A6NNP5	348
CSNK1A1L	MTRNR2L10	P0CJ77	348
CSNK1A1L	AXIN1	O15169	341
CSNK1A1L	FAM25A	B3EWG3	325
CSNK1A1L	WNT8A	Q9H1J5	302
CSNK1A1L	NHLRC3	Q5JS37	301
CSNK1A1L	PSKH1	P11801	289

IntAct

34 interactions, top by confidence:

A	B	Type	Score
FAM83H	CSNK1A1	psi-mi:“MI:0914”(association)	0.920
FAM83G	CSNK1A1	psi-mi:“MI:0914”(association)	0.900
CSNK1A1	FAM83G	psi-mi:“MI:0914”(association)	0.900
FAM83B	CSNK1A1	psi-mi:“MI:0914”(association)	0.800
NCKIPSD	GEMIN2	psi-mi:“MI:0914”(association)	0.640
FAM83C	CSNK1A1	psi-mi:“MI:0914”(association)	0.610
FAM83D	HMMR	psi-mi:“MI:0914”(association)	0.560
FAM83E	CSNK1A1	psi-mi:“MI:0914”(association)	0.540
FAM83F	CSNK1A1	psi-mi:“MI:0914”(association)	0.540
VCAM1	PSMD11	psi-mi:“MI:0914”(association)	0.530
FAM83A	CSNK1A1	psi-mi:“MI:0914”(association)	0.430
Cbx1	FLOT1	psi-mi:“MI:0915”(physical association)	0.400
CEBPE	CSNK1A1L	psi-mi:“MI:0915”(physical association)	0.370
JAM2	CSNK1A1L	psi-mi:“MI:0915”(physical association)	0.370
JUN	TPM3	psi-mi:“MI:0914”(association)	0.350
	EGFR	psi-mi:“MI:0914”(association)	0.350
	SGK1	psi-mi:“MI:0914”(association)	0.350
HSCB	RBP5	psi-mi:“MI:0914”(association)	0.350
ARRB2		psi-mi:“MI:0914”(association)	0.350
FAM170A	NDC80	psi-mi:“MI:0914”(association)	0.350
PXN	PIK3C2A	psi-mi:“MI:0914”(association)	0.350
PRKD1		psi-mi:“MI:0914”(association)	0.350
CSNK1A1L	PLEKHG3	psi-mi:“MI:0914”(association)	0.350

BioGRID (71): CSNK1A1L (Reconstituted Complex), TNFRSF1B (Biochemical Activity), CSNK1A1L (Biochemical Activity), TNFRSF1A (Biochemical Activity), CSNK1A1L (Affinity Capture-MS), CSNK1A1L (Affinity Capture-MS), CSNK1A1L (Affinity Capture-MS), CSNK1A1L (Affinity Capture-MS), CSNK1A1L (Affinity Capture-MS), CSNK1A1L (Affinity Capture-MS), CSNK1A1L (Affinity Capture-MS), CSNK1A1L (Affinity Capture-MS), CSNK1A1L (Affinity Capture-MS), CSNK1A1L (Affinity Capture-MS), CSNK1A1L (Affinity Capture-MS)

ESM2 similar proteins: B9VVJ6, O15726, O76324, P35507, P35508, P40235, P40236, P42168, P48729, P48730, P49674, P54367, P67827, P67828, P67829, P67962, P67963, P78368, P97633, Q06486, Q39050, Q4R9A9, Q5BP74, Q5PRD4, Q5R4V3, Q5RC72, Q5ZLL1, Q62761, Q62762, Q62763, Q6P3K7, Q6P647, Q6QNL9, Q6QNM1, Q7RBX5, Q7T2E3, Q8BK63, Q8BVP5, Q8C4X2, Q8IHZ9

Diamond homologs: A7E3X2, B9VVJ6, O15726, O19175, O74135, O76324, O80888, P16912, P22517, P23291, P23292, P28327, P29295, P34516, P34633, P35507, P35508, P35509, P39962, P40230, P40233, P40234, P40235, P40236, P42158, P42168, P48729, P48730, P49615, P49674, P51166, P54367, P67827, P67828, P67829, P67962, P67963, P78368, P81123, P97633

SIGNOR signaling

17 interactions.

A	Effect	B	Mechanism
CSNK1A1L	up-regulates	GLI2	phosphorylation
CSNK1A1L	up-regulates	GLI3	phosphorylation
PRKACA	up-regulates	CSNK1A1L	phosphorylation
CSNK1A1L	up-regulates	GLIS2
CSNK1A1L	up-regulates	LRP6	phosphorylation
FAM83G	“up-regulates quantity”	CSNK1A1L	binding
FAM83B	“up-regulates quantity”	CSNK1A1L	binding
FAM83H	“up-regulates quantity”	CSNK1A1L	binding
FAM83A	“up-regulates quantity”	CSNK1A1L	binding
FAM83D	“up-regulates quantity”	CSNK1A1L	binding
FAM83E	“up-regulates quantity”	CSNK1A1L	binding
FAM83F	“up-regulates quantity”	CSNK1A1L	binding
FAM83C	“up-regulates quantity”	CSNK1A1L	binding
CSNK1A1L	“up-regulates activity”	NFAT5	phosphorylation
CSNK1A1L	down-regulates	CTNNB1	phosphorylation

Disease & clinical

Clinical variants and AI predictions

ClinVar

56 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	55
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
1527765	GRCh37/hg19 13q13.3(chr13:36064105-39230796)x1	Pathogenic

SpliceAI

79 predictions. Top by Δscore:

Variant	Effect	Δscore
13:37105484:C:CT	donor_gain	0.7900
13:37105485:C:CT	donor_gain	0.7800
13:37105368:C:CT	donor_gain	0.6800
13:37105369:C:CT	donor_gain	0.6500
13:37105483:A:AC	donor_gain	0.5900
13:37104782:C:CT	acceptor_gain	0.4500
13:37105388:G:GC	donor_gain	0.4500
13:37105414:C:A	donor_gain	0.4200
13:37105381:T:TA	donor_gain	0.4100
13:37105382:C:A	donor_gain	0.4100
13:37105406:AG:A	donor_gain	0.3900
13:37105423:A:T	donor_gain	0.3900
13:37105489:T:TA	donor_gain	0.3900
13:37105100:TG:T	donor_gain	0.3700
13:37105537:C:CC	acceptor_gain	0.3300
13:37104484:A:C	donor_gain	0.3200
13:37104502:AACCC:A	donor_gain	0.3200
13:37105367:G:C	donor_gain	0.3200
13:37105412:ATC:A	donor_gain	0.3200
13:37105592:CGG:C	donor_gain	0.3200
13:37104513:TAAA:T	donor_gain	0.3100
13:37104514:AAAA:A	donor_gain	0.3100
13:37105585:C:CT	donor_gain	0.3100
13:37105586:T:TT	donor_gain	0.3100
13:37105384:CGGTG:C	donor_gain	0.3000
13:37105392:CAGGG:C	donor_gain	0.3000
13:37105486:A:AA	donor_gain	0.3000
13:37104448:T:TA	donor_gain	0.2900
13:37104838:T:C	donor_gain	0.2900
13:37105582:CCG:C	donor_gain	0.2900

AlphaMissense

2257 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
13:37104365:A:G	W298R	0.998
13:37104365:A:T	W298R	0.998
13:37104596:A:G	W221R	0.998
13:37104596:A:T	W221R	0.998
13:37104690:G:C	S189R	0.998
13:37104690:G:T	S189R	0.998
13:37104692:T:G	S189R	0.998
13:37104363:C:A	W298C	0.996
13:37104363:C:G	W298C	0.996
13:37104853:C:G	R135P	0.996
13:37105119:C:A	K46N	0.996
13:37105119:C:G	K46N	0.996
13:37104453:A:C	F268L	0.995
13:37104453:A:T	F268L	0.995
13:37104455:A:G	F268L	0.995
13:37104660:G:C	S199R	0.995
13:37104660:G:T	S199R	0.995
13:37104662:T:G	S199R	0.995
13:37104369:A:C	F296L	0.994
13:37104369:A:T	F296L	0.994
13:37104371:A:G	F296L	0.994
13:37104650:C:G	D203H	0.994
13:37104991:A:T	V89D	0.994
13:37105126:G:T	A44E	0.994
13:37105173:A:C	F28L	0.994
13:37105173:A:T	F28L	0.994
13:37105175:A:G	F28L	0.994
13:37104594:C:A	W221C	0.993
13:37104594:C:G	W221C	0.993
13:37104787:T:A	D157V	0.993

dbSNP variants (sampled 300 via entrez): RS1000227474 (13:37105554 G>A), RS1000326070 (13:37102964 A>G), RS1000378569 (13:37102807 A>C), RS1001649216 (13:37105064 T>C), RS1001680246 (13:37105326 C>A,G,T), RS1001992740 (13:37106102 A>G), RS1002023869 (13:37106526 A>C,G), RS1003380964 (13:37106657 G>A,T), RS1003737819 (13:37107055 A>G), RS1005342465 (13:37106321 C>A), RS1007189241 (13:37103308 C>G,T), RS1007537938 (13:37103657 T>C), RS1008599522 (13:37104829 A>G), RS1008891491 (13:37105689 A>C,T), RS1010136781 (13:37104528 G>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST001841_12	Palmitoleic acid (16:1n-7) levels	3.000000e-06
GCST002337_99	Amyotrophic lateral sclerosis (sporadic)	4.000000e-07
GCST004289_2	Adiponectin levels in pregnancy	5.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004502	adiponectin measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5520 (SINGLE PROTEIN)

Molecules with ChEMBL bioactivity

7 molecules (phase ≥1), by development phase (incl. off-target/promiscuous compounds). Patent mentions across the top 20 by phase: 127,263 (via chembl_molecule»patent_compound — counts attach to the compound, not the gene–compound relationship, so off-target/promiscuous molecules can dominate).

Molecule	Name	Phase	Patents
CHEMBL288441	BOSUTINIB	4	12,255
CHEMBL535	SUNITINIB	4	79,020
CHEMBL428690	ALVOCIDIB	3	27,781
CHEMBL603469	LESTAURTINIB	3
CHEMBL1721885	SU-014813	2	363
CHEMBL230011	TG100-115	2	1,504
CHEMBL607707	PELITINIB	2	6,340

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: enzyme — Casein kinase 1 (CK1) family

Binding affinities (BindingDB)

4 measured of 4 human assays (4 total across all organisms); most potent 4 below. Values come from heterogeneous assays and are not directly comparable.

Ligand	Measure	Value
Staurosporine	KD	1.7 nM
5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[(2S)-3-morpholin-4-yl-2-oxidanyl-propyl]-1H-pyrrole-3-carboxamide	KD	2600 nM
(E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-ethoxy-6-quinolyl]-4-(dimethylamino)but-2-enamide	KD	3500 nM
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide	KD	3500 nM

ChEMBL bioactivities

27 potent at pChembl≥5 of 27 total, top 22 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
6.60	Kd	250	nM	STAUROSPORINE
6.28	IC50	520	nM	CHEMBL5303449
6.26	Kd	550	nM	SUNITINIB
6.00	IC50	1000	nM	TP-030-1
6.00	IC50	1000	nM	TP-030-2
6.00	IC50	1000	nM	TP-030n
6.00	Kd	1000	nM	PELITINIB
5.90	IC50	1270	nM	STAUROSPORINE
5.82	Kd	1500	nM	SU-014813
5.77	Kd	1700	nM	CHEMBL280317
5.77	IC50	1690	nM	STAUROSPORINE
5.77	Kd	1700	nM	SB-203580
5.72	Kd	1900	nM	SB-202190
5.72	Kd	1900	nM	TG100-115
5.70	Kd	2000	nM	CHEMBL1241674
5.62	IC50	2410	nM	STAUROSPORINE
5.62	Kd	2400	nM	ALVOCIDIB
5.58	Kd	2600	nM	BOSUTINIB
5.34	Kd	4600	nM	CHEMBL379218
5.28	Kd	5200	nM	TAE-684
5.23	Kd	5900	nM	SB-431542
5.15	Kd	7100	nM	LESTAURTINIB

PubChem BioAssay actives

22 with measured affinity, of 191 total; 15 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one	435281: Binding constant for full-length CSNK1A1L	kd	0.2500	uM
Sunitinib	435281: Binding constant for full-length CSNK1A1L	kd	0.5500	uM
(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide	435281: Binding constant for full-length CSNK1A1L	kd	1.0000	uM
5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide	435281: Binding constant for full-length CSNK1A1L	kd	1.5000	uM
4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine	435281: Binding constant for full-length CSNK1A1L	kd	1.7000	uM
4-[4-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-1H-imidazol-5-yl]pyridine	1899314: Binding affinity to CK1a1L (unknown origin)	kd	1.7000	uM
3-[2,4-diamino-7-(3-hydroxyphenyl)pteridin-6-yl]phenol	624723: Binding constant for CSNK1A1L kinase domain	kd	1.9000	uM
4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1H-imidazol-2-yl]phenol	435281: Binding constant for full-length CSNK1A1L	kd	1.9000	uM
2-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol	624723: Binding constant for CSNK1A1L kinase domain	kd	2.0000	uM
2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one	624723: Binding constant for CSNK1A1L kinase domain	kd	2.4000	uM
Bosutinib	624723: Binding constant for CSNK1A1L kinase domain	kd	2.6000	uM
(2S)-1-[[5-(3-methyl-2H-indazol-5-yl)-3-pyridinyl]oxy]-3-phenylpropan-2-amine	624723: Binding constant for CSNK1A1L kinase domain	kd	4.6000	uM
5-chloro-2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine	624723: Binding constant for CSNK1A1L kinase domain	kd	5.2000	uM
4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide	435281: Binding constant for full-length CSNK1A1L	kd	5.9000	uM
(15S,16S,18R)-16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaen-3-one	624723: Binding constant for CSNK1A1L kinase domain	kd	7.1000	uM

CTD chemical–gene interactions

14 total (human), top 14 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Aflatoxin B1	decreases methylation, increases methylation	2
bisphenol A	decreases methylation	1
pyrogallol 1,3-dimethyl ether	affects cotreatment, affects localization, increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
sodium arsenite	affects expression	1
CGP 52608	affects binding, increases reaction	1
Air Pollutants	increases abundance, increases expression	1
Benzo(a)pyrene	increases methylation	1
Coal	increases abundance, increases expression	1
Furaldehyde	affects cotreatment, affects localization, decreases expression	1
Smoke	increases abundance, increases expression	1
Sodium Chloride	affects cotreatment, affects localization, decreases expression, increases expression	1
Urethane	increases expression	1
Copper Sulfate	increases expression	1

ChEMBL screening assays

93 unique, capped per target: 93 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL1033256	Binding	Inhibition of CSNK1A1L at 3 uM	Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. — J Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.