CT45A10

Summary

CT45A10 (cancer/testis antigen family 45 member A10, HGNC:51263) is a protein-coding gene on chromosome Xq26.3, encoding Cancer/testis antigen family 45 member A10 (P0DMU9).

Enables identical protein binding activity. Located in nucleus.

Source: NCBI Gene 102723631 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 1 total
• MANE Select transcript: NM_001291529

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51263
Approved symbol	CT45A10
Name	cancer/testis antigen family 45 member A10
Location	Xq26.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000269586
Ensembl biotype	protein_coding
Entrez	102723631

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 protein_coding

ENST00000611668, ENST00000617981, ENST00000682849, ENST00000865154, ENST00000922834

RefSeq mRNA: 6 — MANE Select: NM_001291529 NM_001291527, NM_001291528, NM_001291529, NM_001291530, NM_001385219, NM_001385220

CCDS: CCDS76035

Canonical transcript exons

ENST00000682849 — 5 exons

Exon	Start	End
ENSE00003087121	135881065	135881315
ENSE00003090066	135883008	135883256
ENSE00003188844	135882536	135882629
ENSE00003753141	135885176	135885350
ENSE00003916541	135893345	135893444

Expression profiles

Bgee: expression breadth broad, 56 present calls, max score 93.43.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.6507 / max 71.4845, expressed in 80 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
200622	0.3595	69
200621	0.2912	64

Top tissues by expression

104 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	93.43	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.25	gold quality
right testis	UBERON:0004534	73.62	gold quality
testis	UBERON:0000473	69.33	gold quality
left testis	UBERON:0004533	66.86	gold quality
Ammon’s horn	UBERON:0001954	53.57	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	52.69	gold quality
amygdala	UBERON:0001876	49.02	gold quality
temporal lobe	UBERON:0001871	48.74	gold quality
substantia nigra	UBERON:0002038	43.71	gold quality
anterior cingulate cortex	UBERON:0009835	43.38	gold quality
hypothalamus	UBERON:0001898	43.24	gold quality
bone marrow cell	CL:0002092	42.42	gold quality
nucleus accumbens	UBERON:0001882	41.08	gold quality
caudate nucleus	UBERON:0001873	41.02	gold quality
prefrontal cortex	UBERON:0000451	40.97	gold quality
cerebral cortex	UBERON:0000956	40.79	gold quality
granulocyte	CL:0000094	40.76	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	38.45	gold quality
Brodmann (1909) area 9	UBERON:0013540	38.00	gold quality
brain	UBERON:0000955	37.45	gold quality
frontal cortex	UBERON:0001870	37.24	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
superior frontal gyrus	UBERON:0002661	36.86	silver quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
putamen	UBERON:0001874	35.58	gold quality
skeletal muscle tissue	UBERON:0001134	35.55	silver quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
bone marrow	UBERON:0002371	34.94	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-GEOD-99795	no	16.86
E-ANND-3	no	0.81

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

28 targeting CT45A10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-221-3P	99.86	71.56	1329
HSA-MIR-222-3P	99.86	71.35	1337
HSA-MIR-3133	99.81	70.92	3506
HSA-MIR-4668-5P	99.79	70.58	3782
HSA-MIR-586	99.65	70.40	2051
HSA-MIR-4506	99.34	67.47	526
HSA-MIR-5006-5P	98.79	66.92	1246
HSA-MIR-501-5P	98.77	68.88	1328
HSA-MIR-4755-3P	98.77	65.59	1915
HSA-MIR-5572	98.55	65.84	970
HSA-MIR-4518	98.12	66.82	1030
HSA-MIR-6819-5P	97.96	66.59	1071
HSA-MIR-3151-3P	97.80	66.16	479
HSA-MIR-6737-5P	97.75	66.54	1044
HSA-MIR-1266-5P	97.71	66.92	1052
HSA-MIR-6812-5P	97.56	65.39	1059
HSA-MIR-3127-5P	97.52	65.24	786
HSA-MIR-937-5P	97.43	68.39	667
HSA-MIR-8081	96.42	67.75	738

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Ct45a	ENSMUSG00000064016
rattus_norvegicus	Ct45a9	ENSRNOG00000048059
drosophila_melanogaster	IntS6	FBGN0261383
caenorhabditis_elegans		WBGENE00000994

Paralogs (11): INTS6 (ENSG00000102786), INTS6L (ENSG00000165359), SAGE1 (ENSG00000181433), CT45A5 (ENSG00000228836), CT45A1 (ENSG00000268940), CT45A3 (ENSG00000269096), CT45A9 (ENSG00000270946), CT45A2 (ENSG00000271449), CT45A7 (ENSG00000273696), CT45A8 (ENSG00000278085), CT45A6 (ENSG00000278289)

Protein

Protein identifiers

Cancer/testis antigen family 45 member A10 — P0DMU9 (reviewed: P0DMU9)

Alternative names: Cancer/testis antigen 45A10

All UniProt accessions (1): P0DMU9

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Nucleus.

Similarity. Belongs to the CT45 family.

RefSeq proteins (6): NP_001278456, NP_001278457, NP_001278458, NP_001278459, NP_001372148, NP_001372149 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR029307	INT_SG_DDX_CT_C	Domain
IPR051113	Integrator_subunit6	Family

Pfam: PF15300

UniProt features (1 total): chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DMU9-F1	70.51	0.31

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 7 (showing top): chrXq26, CHAMP1_TARGET_GENES, MIR450A_1_3P, MIR501_5P, CC2D1A_TARGET_GENES, HE_LIM_SUN_FETAL_LUNG_C0_MYOFIBROBLAST_1_CELL, HE_LIM_SUN_FETAL_LUNG_C0_MYOFIBROBLAST_2_CELL

GO Biological Process (0):

GO Molecular Function (2): identical protein binding (GO:0042802), protein binding (GO:0005515)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein binding	1
binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

272 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CT45A10	DEFB123	Q8N688	506
CT45A10	CSAG1	Q6PB30	447
CT45A10	CLPSL1	A2RUU4	412
CT45A10	MAGEA10	P43363	404
CT45A10	GAGE12B	A1L429	398
CT45A10	NANOGNB	Q7Z5D8	392
CT45A10	RFPL4B	Q6ZWI9	392
CT45A10	ZNF525	Q8N782	371
CT45A10	CT45A3	P0DMU6	353
CT45A10	MAGEB2	O15479	350
CT45A10	GLB1L2	Q8IW92	348
CT45A10	PNLIPRP3	Q17RR3	325
CT45A10	VCX3B	Q9H321	325
CT45A10	FAM180B	Q6P0A1	324
CT45A10	PNMA5	Q96PV4	321

IntAct

19 interactions, top by confidence:

A	B	Type	Score
CT45A10	SDCBP2	psi-mi:“MI:0915”(physical association)	0.560
SDCBP	CT45A10	psi-mi:“MI:0915”(physical association)	0.560
CT45A10	CT45A1	psi-mi:“MI:0915”(physical association)	0.560
CT45A10	CT45A10	psi-mi:“MI:0915”(physical association)	0.560
CT45A10	DVL3	psi-mi:“MI:0915”(physical association)	0.560
CT45A10	SDCBP2	psi-mi:“MI:0915”(physical association)	0.000
CT45A10	DVL3	psi-mi:“MI:0915”(physical association)	0.000
CT45A10	CT45A1	psi-mi:“MI:0915”(physical association)	0.000
CT45A10	SDCBP	psi-mi:“MI:0915”(physical association)	0.000
CT45A10	CT45A10	psi-mi:“MI:0915”(physical association)	0.000
SDCBP	CT45A10	psi-mi:“MI:0915”(physical association)	0.000

ESM2 similar proteins: A0FKI7, A2YX04, A5WUN7, A5WV69, A7J1T2, C5DZR8, E9Q555, F4J6F6, O43310, O48767, P0DMS1, P0DMU7, P0DMU8, P0DMU9, P0DMV0, P0DMV1, P0DMV2, Q0V9S3, Q12912, Q14693, Q1LXZ9, Q2NKQ1, Q2PFD7, Q3TEL6, Q502L1, Q5DJT8, Q5R7V3, Q5T8D3, Q5XG73, Q621Z7, Q640U0, Q641E3, Q6IRN6, Q6Z8M8, Q700C2, Q758T8, Q80Y56, Q811D2, Q8AV28, Q8BLN6

Diamond homologs: A6NJ88, P0DMU7, P0DMU8, P0DMU9, P0DMV0, P0DMV1, P0DMV2, Q2TAF4, Q5DJT8, Q5HYN5, Q5JSJ4, Q5U4W6, Q6PCM2, Q7SYD9, Q8BND4, Q8NHU0, Q9NXZ1, Q9UL03, Q54Z23, Q9W485

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

270 predictions. Top by Δscore:

Variant	Effect	Δscore
X:135883006:A:AC	donor_gain	1.0000
X:135883007:C:CA	donor_gain	1.0000
X:135883007:CT:C	donor_gain	1.0000
X:135883007:CTT:C	donor_gain	1.0000
X:135882998:CA:C	donor_gain	0.9900
X:135882998:CACTA:C	donor_gain	0.9900
X:135883004:TTACT:T	donor_loss	0.9900
X:135883006:A:C	donor_loss	0.9900
X:135883006:ACTT:A	donor_gain	0.9900
X:135883007:C:CC	donor_gain	0.9900
X:135883007:CTTC:C	donor_gain	0.9900
X:135883007:CTTCG:C	donor_gain	0.9900
X:135883002:ACT:A	donor_loss	0.9800
X:135883040:TG:T	donor_gain	0.9800
X:135883093:T:TA	donor_gain	0.9800
X:135883001:TACTT:T	donor_loss	0.9700
X:135883002:A:AC	donor_gain	0.9700
X:135883003:C:CC	donor_gain	0.9700
X:135883003:CTTA:C	donor_gain	0.9700
X:135883005:TAC:T	donor_loss	0.9500
X:135889276:G:GG	donor_gain	0.9300
X:135890437:G:GT	donor_gain	0.9300
X:135882999:ACTAC:A	donor_loss	0.9200
X:135882993:T:TA	donor_gain	0.9000
X:135889374:G:T	donor_gain	0.9000
X:135883009:T:TA	donor_gain	0.8900
X:135883002:AC:A	donor_gain	0.8800
X:135883356:T:A	acceptor_gain	0.8800
X:135882999:A:C	donor_gain	0.8700
X:135883035:C:CT	donor_gain	0.8700

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000302091 (X:135892862 C>T), RS1001478751 (X:135892319 C>A), RS1001845807 (X:135892059 G>A), RS1002444008 (X:135893572 C>G), RS1007929067 (X:135890657 A>C), RS1008973105 (X:135893140 T>C), RS1009355060 (X:135892865 G>A,T), RS1010058538 (X:135892407 G>A,C,T), RS1010278238 (X:135892141 C>G), RS1013297055 (X:135889920 C>T), RS1015263915 (X:135890702 T>C), RS1015295202 (X:135891238 A>G), RS1018969993 (X:135893141 G>A), RS1020072444 (X:135892438 C>T), RS1020291415 (X:135892142 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Tretinoin	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.