CT45A7

Summary

CT45A7 (cancer/testis antigen family 45 member A7, HGNC:51260) is a protein-coding gene on chromosome Xq26.3, encoding Cancer/testis antigen family 45 member A7 (P0DMV0).

Located in nucleus.

Source: NCBI Gene 101060211 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001394668

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51260
Approved symbol	CT45A7
Name	cancer/testis antigen family 45 member A7
Location	Xq26.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000273696
Ensembl biotype	protein_coding
Entrez	101060211

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000610598, ENST00000620885

RefSeq mRNA: 2 — MANE Select: NM_001394668 NM_001291543, NM_001394668

CCDS: CCDS76032

Canonical transcript exons

ENST00000610598 — 5 exons

Exon	Start	End
ENSE00003091584	135837042	135837280
ENSE00003668015	135831197	135831445
ENSE00003727382	135830722	135830815
ENSE00003744623	135829229	135829497
ENSE00003752157	135833365	135833539

Expression profiles

Bgee: expression breadth broad, 48 present calls, max score 82.78.

Top tissues by expression

112 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.78	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.05	gold quality
apex of heart	UBERON:0002098	42.50	silver quality
sural nerve	UBERON:0015488	41.64	gold quality
skeletal muscle tissue	UBERON:0001134	37.52	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
prefrontal cortex	UBERON:0000451	34.26	gold quality
muscle tissue	UBERON:0002385	34.10	gold quality
fundus of stomach	UBERON:0001160	33.96	gold quality
urinary bladder	UBERON:0001255	33.09	gold quality
bone marrow	UBERON:0002371	32.79	gold quality
duodenum	UBERON:0002114	32.33	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
monocyte	CL:0000576	31.22	silver quality
leukocyte	CL:0000738	30.90	silver quality
liver	UBERON:0002107	30.63	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
vermiform appendix	UBERON:0001154	29.14	gold quality
right lobe of liver	UBERON:0001114	29.05	gold quality
frontal cortex	UBERON:0001870	28.26	gold quality
blood	UBERON:0000178	28.19	gold quality
muscle of leg	UBERON:0001383	27.88	silver quality
lymph node	UBERON:0000029	27.57	gold quality
gastrocnemius	UBERON:0001388	27.14	silver quality
tonsil	UBERON:0002372	27.05	gold quality
superior frontal gyrus	UBERON:0002661	26.81	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-6308	yes	211.76
E-HCAD-5	yes	151.27
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

15 targeting CT45A7, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-4493	99.90	66.48	977
HSA-MIR-3133	99.81	70.92	3506
HSA-MIR-586	99.65	70.40	2051
HSA-MIR-5006-5P	98.79	66.92	1246
HSA-MIR-5572	98.55	65.84	970
HSA-MIR-6819-5P	97.96	66.59	1071
HSA-MIR-3151-3P	97.80	66.16	479
HSA-MIR-6737-5P	97.75	66.54	1044
HSA-MIR-6812-5P	97.56	65.39	1059
HSA-MIR-3674	97.01	68.86	1171
HSA-MIR-6747-5P	96.17	64.99	743

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Ct45a	ENSMUSG00000064016
rattus_norvegicus	Ct45a9	ENSRNOG00000048059
drosophila_melanogaster	IntS6	FBGN0261383
caenorhabditis_elegans		WBGENE00000994

Paralogs (11): INTS6 (ENSG00000102786), INTS6L (ENSG00000165359), SAGE1 (ENSG00000181433), CT45A5 (ENSG00000228836), CT45A1 (ENSG00000268940), CT45A3 (ENSG00000269096), CT45A10 (ENSG00000269586), CT45A9 (ENSG00000270946), CT45A2 (ENSG00000271449), CT45A8 (ENSG00000278085), CT45A6 (ENSG00000278289)

Protein

Protein identifiers

Cancer/testis antigen family 45 member A7 — P0DMV0 (reviewed: P0DMV0)

Alternative names: Cancer/testis antigen 45A7

All UniProt accessions (1): P0DMV0

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the CT45 family.

RefSeq proteins (2): NP_001278472, NP_001381597* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR029307	INT_SG_DDX_CT_C	Domain
IPR051113	Integrator_subunit6	Family

Pfam: PF15300

UniProt features (4 total): region of interest 2, chain 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DMV0-F1	70.05	0.22

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 3 (showing top): chrXq26, HE_LIM_SUN_FETAL_LUNG_C0_MYOFIBROBLAST_1_CELL, HE_LIM_SUN_FETAL_LUNG_C0_MYOFIBROBLAST_2_CELL

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

2 interactions, top by confidence:

A	B	Type	Score
CT45A7	SDCBP2	psi-mi:“MI:0915”(physical association)	0.370

ESM2 similar proteins: A0FKI7, A2YX04, A5WUN7, A5WV69, A7J1T2, C5DZR8, E9Q555, F4J6F6, O43310, O48767, P0DMS1, P0DMU7, P0DMU8, P0DMU9, P0DMV0, P0DMV1, P0DMV2, Q0V9S3, Q12912, Q14693, Q1LXZ9, Q2NKQ1, Q2PFD7, Q3TEL6, Q502L1, Q5DJT8, Q5R7V3, Q5T8D3, Q5XG73, Q621Z7, Q640U0, Q641E3, Q6IRN6, Q6Z8M8, Q700C2, Q758T8, Q80Y56, Q811D2, Q8AV28, Q8BLN6

Diamond homologs: A6NJ88, P0DMU7, P0DMU8, P0DMU9, P0DMV0, P0DMV1, P0DMV2, Q2TAF4, Q5DJT8, Q5HYN5, Q5JSJ4, Q5U4W6, Q6PCM2, Q7SYD9, Q8BND4, Q8NHU0, Q9NXZ1, Q9UL03, Q54Z23, Q9W485

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

819 predictions. Top by Δscore:

Variant	Effect	Δscore
X:135830719:CACCT:C	donor_loss	1.0000
X:135830720:A:AC	donor_gain	1.0000
X:135830720:A:AT	donor_loss	1.0000
X:135830721:C:CC	donor_gain	1.0000
X:135830721:C:CG	donor_loss	1.0000
X:135830721:CCTTG:C	donor_gain	1.0000
X:135830731:T:TA	donor_gain	1.0000
X:135830811:ATATT:A	acceptor_gain	1.0000
X:135830812:TATT:T	acceptor_gain	1.0000
X:135830813:ATT:A	acceptor_gain	1.0000
X:135830814:TT:T	acceptor_gain	1.0000
X:135830815:TC:T	acceptor_loss	1.0000
X:135830816:C:CA	acceptor_loss	1.0000
X:135830816:C:CC	acceptor_gain	1.0000
X:135830822:A:AC	acceptor_gain	1.0000
X:135830822:A:C	acceptor_gain	1.0000
X:135830825:T:C	acceptor_gain	1.0000
X:135830825:T:TC	acceptor_gain	1.0000
X:135831444:CT:C	acceptor_gain	1.0000
X:135833364:CT:C	donor_gain	1.0000
X:135830824:G:C	acceptor_gain	0.9900
X:135830824:G:GC	acceptor_gain	0.9900
X:135830848:T:TC	acceptor_gain	0.9900
X:135831441:AAGCT:A	acceptor_gain	0.9900
X:135831442:AGCT:A	acceptor_gain	0.9900
X:135831443:GCT:G	acceptor_gain	0.9900
X:135831443:GCTC:G	acceptor_loss	0.9900
X:135831443:GCTCT:G	acceptor_gain	0.9900
X:135831444:CTC:C	acceptor_gain	0.9900
X:135831445:TCTG:T	acceptor_gain	0.9900

AlphaMissense

1259 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:135830729:C:G	A169P	0.881
X:135830799:G:C	F145L	0.852
X:135830799:G:T	F145L	0.852
X:135830801:A:G	F145L	0.852
X:135831234:T:A	K127N	0.840
X:135831234:T:G	K127N	0.840
X:135830777:C:G	G153R	0.836
X:135830777:C:T	G153R	0.836
X:135833486:A:C	F16L	0.835
X:135833486:A:T	F16L	0.835
X:135833488:A:G	F16L	0.835
X:135830748:A:C	F162L	0.823
X:135830748:A:T	F162L	0.823
X:135830750:A:G	F162L	0.823
X:135830791:A:T	L148H	0.766
X:135831246:A:C	N123K	0.763
X:135831246:A:T	N123K	0.763
X:135830751:A:C	F161L	0.762
X:135830751:A:T	F161L	0.762
X:135830753:A:G	F161L	0.762
X:135830752:A:G	F161S	0.730
X:135833444:C:A	R30S	0.719
X:135833444:C:G	R30S	0.719
X:135831226:A:G	L130S	0.713
X:135829479:A:C	F177L	0.703
X:135829479:A:T	F177L	0.703
X:135829481:A:G	F177L	0.703
X:135830744:A:G	S164P	0.702
X:135829468:A:G	L181P	0.699
X:135830776:C:T	G153E	0.698

dbSNP variants (sampled 264 via entrez): RS112696531 (X:135838954 A>G), RS1159476873 (X:135835081 G>C), RS1163535156 (X:135836052 A>T), RS1166663895 (X:135836151 A>C), RS1174654523 (X:135829393 C>T), RS1180746038 (X:135835289 G>C), RS1182372781 (X:135834487 A>C), RS1186522071 (X:135835760 A>T), RS1199750847 (X:135828857 G>A), RS1200592531 (X:135828760 A>ACACC), RS1203141885 (X:135834937 T>C), RS1205237826 (X:135828808 T>C), RS1209370400 (X:135834707 G>A), RS1209643029 (X:135835848 A>C,G), RS1227805553 (X:135835861 AT>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.