CT45A8

Summary

CT45A8 (cancer/testis antigen family 45 member A8, HGNC:51261) is a protein-coding gene on chromosome Xq26.3, encoding Cancer/testis antigen family 45 member A8 (P0DMV1).

At a glance

• MANE Select transcript: NM_001291535

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51261
Approved symbol	CT45A8
Name	cancer/testis antigen family 45 member A8
Location	Xq26.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000278085
Ensembl biotype	protein_coding
Entrez	102723737

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000611438, ENST00000611660

RefSeq mRNA: 1 — MANE Select: NM_001291535 NM_001291535

CCDS: CCDS76033

Canonical transcript exons

ENST00000611660 — 5 exons

Exon	Start	End
ENSE00003726803	135848446	135848694
ENSE00003737749	135846497	135846749
ENSE00003742592	135847972	135848065
ENSE00003746357	135854300	135854538
ENSE00003751832	135850615	135850789

Expression profiles

Bgee: expression breadth broad, 24 present calls, max score 84.78.

Top tissues by expression

112 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.78	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.90	gold quality
bone marrow cell	CL:0002092	38.58	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
prefrontal cortex	UBERON:0000451	34.69	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
bone marrow	UBERON:0002371	32.98	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
tonsil	UBERON:0002372	29.28	gold quality
liver	UBERON:0002107	28.85	gold quality
frontal cortex	UBERON:0001870	28.79	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	28.19	gold quality
duodenum	UBERON:0002114	28.14	gold quality
substantia nigra	UBERON:0002038	27.94	gold quality
primary visual cortex	UBERON:0002436	27.89	gold quality
lymph node	UBERON:0000029	27.57	gold quality
blood	UBERON:0000178	26.98	silver quality
islet of Langerhans	UBERON:0000006	26.93	gold quality
cerebral cortex	UBERON:0000956	26.48	gold quality
nucleus accumbens	UBERON:0001882	26.44	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
temporal lobe	UBERON:0001871	26.24	gold quality
amygdala	UBERON:0001876	26.15	gold quality
gall bladder	UBERON:0002110	25.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.14

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

18 targeting CT45A8, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-4493	99.90	66.48	977
HSA-MIR-3133	99.81	70.92	3506
HSA-MIR-4668-5P	99.79	70.58	3782
HSA-MIR-586	99.65	70.40	2051
HSA-MIR-4279	99.19	66.70	2437
HSA-MIR-5006-5P	98.79	66.92	1246
HSA-MIR-5572	98.55	65.84	970
HSA-MIR-6819-5P	97.96	66.59	1071
HSA-MIR-3151-3P	97.80	66.16	479
HSA-MIR-6737-5P	97.75	66.54	1044
HSA-MIR-6812-5P	97.56	65.39	1059
HSA-MIR-3674	97.01	68.86	1171
HSA-MIR-6747-5P	96.17	64.99	743

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Ct45a	ENSMUSG00000064016
rattus_norvegicus	Ct45a9	ENSRNOG00000048059
drosophila_melanogaster	IntS6	FBGN0261383
caenorhabditis_elegans		WBGENE00000994

Paralogs (11): INTS6 (ENSG00000102786), INTS6L (ENSG00000165359), SAGE1 (ENSG00000181433), CT45A5 (ENSG00000228836), CT45A1 (ENSG00000268940), CT45A3 (ENSG00000269096), CT45A10 (ENSG00000269586), CT45A9 (ENSG00000270946), CT45A2 (ENSG00000271449), CT45A7 (ENSG00000273696), CT45A6 (ENSG00000278289)

Protein

Protein identifiers

Cancer/testis antigen family 45 member A8 — P0DMV1 (reviewed: P0DMV1)

Alternative names: Cancer/testis antigen 45A8

All UniProt accessions (1): P0DMV1

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the CT45 family.

RefSeq proteins (1): NP_001278464* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR029307	INT_SG_DDX_CT_C	Domain
IPR051113	Integrator_subunit6	Family

Pfam: PF15300

UniProt features (1 total): chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DMV1-F1	68.94	0.15

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 3 (showing top): chrXq26, HE_LIM_SUN_FETAL_LUNG_C0_MYOFIBROBLAST_1_CELL, HE_LIM_SUN_FETAL_LUNG_C0_MYOFIBROBLAST_2_CELL

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

4 interactions, top by confidence:

A	B	Type	Score
CT45A6	AP3B1	psi-mi:“MI:0914”(association)	0.350
APOM	CT45A8	psi-mi:“MI:0914”(association)	0.350
FOXD4L1	CT45A8	psi-mi:“MI:0914”(association)	0.350

ESM2 similar proteins: A0A097I2D0, A0A1W2PP81, A0A1W2PPE2, A0A1W2PPH5, A0A1W2PPL8, A0A1W2PPW3, A0A1W2PQ09, A0A1W2PR64, A0A1W2PRV1, A6NLC8, F4HR03, O54825, O75461, P0C1H6, P0CV38, P0DMV1, P0DMV2, P0DW11, P0DW12, P0DW13, P0DW14, P40914, P49585, P49906, P81195, Q0MTC0, Q13895, Q15544, Q2N2K6, Q3SZB8, Q5DJT8, Q5RA91, Q5U1X0, Q6CER9, Q6RG77, Q6XL73, Q75DE4, Q7XHR2, Q7Z2G1, Q80WL2

Diamond homologs: A6NJ88, P0DMU7, P0DMU8, P0DMU9, P0DMV0, P0DMV1, P0DMV2, Q2TAF4, Q5DJT8, Q5HYN5, Q5JSJ4, Q5U4W6, Q6PCM2, Q7SYD9, Q8BND4, Q8NHU0, Q9NXZ1, Q9UL03, Q54Z23, Q9W485

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS113137972 (X:135854173 G>A), RS1158630939 (X:135855592 G>A), RS1160448692 (X:135854873 C>T), RS1162619517 (X:135855729 G>A,T), RS1164813436 (X:135854882 T>A,C,G), RS1168430111 (X:135854956 A>G), RS1171163870 (X:135855192 C>G,T), RS1172255322 (X:135855831 G>A), RS1178183183 (X:135855567 C>T), RS1180693223 (X:135855864 AAGAG>A,AAG), RS1182487382 (X:135855350 C>A), RS1182892742 (X:135853089 A>T), RS1186427012 (X:135855738 A>AG), RS1186676422 (X:135855641 C>G,T), RS1187369973 (X:135855775 AAAGG>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.