CTAGE8

Summary

CTAGE8 (CTAGE family member 8, HGNC:37294) is a protein-coding gene on chromosome 7q35, encoding cTAGE family member 8 (P0CG41).

Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; protein secretion; and vesicle cargo loading. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum exit site and endoplasmic reticulum membrane.

Source: NCBI Gene 100142659 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• MANE Select transcript: NM_001278507

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37294
Approved symbol	CTAGE8
Name	CTAGE family member 8
Location	7q35
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000289604
Ensembl biotype	protein_coding
Entrez	100142659

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000487179

RefSeq mRNA: 1 — MANE Select: NM_001278507 NM_001278507

CCDS: CCDS64791

Canonical transcript exons

ENST00000487179 — 1 exons

Exon	Start	End
ENSE00002489006	144266674	144269288

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

18 targeting CTAGE8, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-146A-5P	99.96	68.93	988
HSA-MIR-146B-5P	99.96	69.13	977
HSA-MIR-7153-5P	99.94	68.89	1006
HSA-MIR-1200	99.71	70.42	1838
HSA-MIR-519A-3P	99.67	71.67	1868
HSA-MIR-519B-3P	99.67	71.67	1868
HSA-MIR-519C-3P	99.67	71.67	1870
HSA-MIR-6126	99.62	68.09	996
HSA-MIR-1252-3P	99.55	67.71	2862
HSA-MIR-548G-3P	99.48	68.67	2159
HSA-MIR-548AV-3P	99.43	68.50	1721
HSA-MIR-302A-5P	99.39	68.21	1913
HSA-MIR-4324	99.04	70.14	1569
HSA-MIR-6715B-3P	98.80	68.07	1204
HSA-MIR-4782-5P	98.35	69.33	1474
HSA-MIR-5706	98.35	69.33	1463
HSA-MIR-152-5P	96.42	66.59	960
HSA-MIR-203A-5P	96.33	65.03	714

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mia2	ENSMUSG00000021000
rattus_norvegicus	Mia2	ENSRNOG00000005101
drosophila_melanogaster	Tango1	FBGN0286898

Paralogs (10): OTOR (ENSG00000125879), MIA2 (ENSG00000150527), MIA3 (ENSG00000154305), SPZ1 (ENSG00000164299), CTAGE1 (ENSG00000212710), CTAGE9 (ENSG00000236761), MIA (ENSG00000261857), CTAGE15 (ENSG00000271079), CTAGE6 (ENSG00000271321), CTAGE4 (ENSG00000288784)

Protein

Protein identifiers

cTAGE family member 8 — P0CG41 (reviewed: P0CG41)

All UniProt accessions (1): P0CG41

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Similarity. Belongs to the cTAGE family.

RefSeq proteins (1): NP_001265436* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR051500	cTAGE_MIA/OTOR	Family

UniProt features (9 total): compositionally biased region 3, region of interest 2, coiled-coil region 2, chain 1, transmembrane region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0CG41-F1	69.47	0.44

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 19 (showing top): GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_ENDOPLASMIC_RETICULUM_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT, GOBP_SECRETION, chr7q35, GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK, GOCC_ORGANELLE_SUBCOMPARTMENT, GOBP_GOLGI_VESICLE_TRANSPORT, GOBP_VESICLE_CARGO_LOADING, GOBP_INTRACELLULAR_TRANSPORT, GOCC_ENDOPLASMIC_RETICULUM_EXIT_SITE, MIR7153_5P, MIR146A_5P, MIR146B_5P, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION, GOBP_PROTEIN_LOCALIZATION_TO_EXTRACELLULAR_REGION

GO Biological Process (3): endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888), protein secretion (GO:0009306), vesicle cargo loading (GO:0035459)

GO Molecular Function (0):

GO Cellular Component (3): endoplasmic reticulum membrane (GO:0005789), endoplasmic reticulum exit site (GO:0070971), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
cytoplasm	1
intercellular transport	1
intracellular transport	1
Golgi vesicle transport	1
protein transport	1
secretion by cell	1
establishment of protein localization to extracellular region	1
protein localization to extracellular region	1
transport	1
vesicle-mediated transport	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
endoplasmic reticulum	1

Protein interactions and networks

STRING

503 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CTAGE8	PRR12	Q9ULL5	511
CTAGE8	ZNF891	A8MT65	474
CTAGE8	FAM86B2	P0C5J1	446
CTAGE8	SLC38A10	Q9HBR0	438
CTAGE8	OTOR	Q9NRC9	433
CTAGE8	FAM120A	Q9NZB2	397
CTAGE8	LSM8	O95777	391
CTAGE8	SNRNP35	Q16560	307
CTAGE8	WDR38	Q5JTN6	305
CTAGE8	WDFY3	Q8IZQ1	299
CTAGE8	NDST1	P52848	289
CTAGE8	TMEM131	Q92545	285
CTAGE8	PREB	Q9HCU5	274
CTAGE8	ZNF33A	P17013	249
CTAGE8	TMEM106A	Q96A25	249

IntAct

2 interactions, top by confidence:

A	B	Type	Score
MIA2	RGPD3	psi-mi:“MI:0914”(association)	0.530

BioGRID (11): CTAGE8 (Affinity Capture-MS), CTAGE8 (Affinity Capture-MS), MIA3 (Cross-Linking-MS (XL-MS)), CTAGE1 (Cross-Linking-MS (XL-MS)), MIA2 (Cross-Linking-MS (XL-MS)), CTAGE8 (Cross-Linking-MS (XL-MS)), CTAGE8 (Cross-Linking-MS (XL-MS)), ALB (Cross-Linking-MS (XL-MS)), EEA1 (Cross-Linking-MS (XL-MS)), CTAGE8 (Cross-Linking-MS (XL-MS)), CTAGE8 (Proximity Label-MS)

ESM2 similar proteins: A0JMQ7, A2BGP7, A4D2H0, A4FU28, B4F7A7, O75665, P0C219, P0CG41, Q05D60, Q15025, Q28BZ7, Q28C41, Q2T9X8, Q32LC2, Q499E4, Q4PJT6, Q4R7I4, Q5FWP9, Q5U3Z6, Q5U465, Q5XIA0, Q5XJA2, Q5ZJA3, Q6AXZ4, Q6NRH3, Q6P926, Q6PCG6, Q7M6Y5, Q80Z25, Q865V0, Q86UF2, Q86W54, Q86XR8, Q86YF9, Q86Z20, Q8BMD2, Q8CEE0, Q8IX94, Q8IYJ2, Q8IYX8

Diamond homologs: A4D2H0, A4FU28, P0CG41, Q86UF2, Q8IX94, Q8IX95, Q91ZV0, Q96PC5, Q96RT6, Q9I8P5, Q9I8P6, Q9JIE3, Q9NRC9, Q16674, Q61865, Q62946

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

21 predictions. Top by Δscore:

Variant	Effect	Δscore
7:144269118:C:CT	donor_gain	0.5800
7:144269153:T:C	donor_gain	0.4900
7:144269168:T:A	donor_gain	0.4500
7:144269115:A:T	donor_gain	0.4400
7:144267199:A:T	acceptor_gain	0.3400
7:144269119:C:CT	donor_gain	0.3400
7:144269120:A:T	donor_gain	0.3400
7:144267376:CCTT:C	acceptor_gain	0.3200
7:144269165:CT:C	donor_gain	0.3000
7:144267198:C:CT	acceptor_gain	0.2800
7:144267377:CTT:C	acceptor_gain	0.2600
7:144267378:TTT:T	acceptor_gain	0.2600
7:144269116:TACC:T	donor_gain	0.2600
7:144269117:ACCA:A	donor_gain	0.2600
7:144267201:C:CT	acceptor_gain	0.2300
7:144269072:C:CT	acceptor_gain	0.2300
7:144269118:CCA:C	donor_gain	0.2300
7:144267289:AT:A	donor_gain	0.2100
7:144269164:A:AC	donor_gain	0.2100
7:144269165:C:CC	donor_gain	0.2100
7:144267375:CCCTT:C	acceptor_gain	0.2000

AlphaMissense

5111 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:144268680:C:G	A191P	0.955
7:144268112:A:G	L380P	0.933
7:144268617:C:G	A212P	0.919
7:144268100:A:G	L384P	0.914
7:144268175:A:G	L359P	0.912
7:144269065:A:C	S62R	0.906
7:144269065:A:T	S62R	0.906
7:144269067:T:G	S62R	0.906
7:144267837:C:G	A472P	0.901
7:144269100:C:G	G51R	0.899
7:144269100:C:T	G51R	0.899
7:144267824:A:G	L476P	0.897
7:144267846:C:G	A469P	0.888
7:144269099:C:T	G51E	0.886
7:144268985:T:A	K89I	0.879
7:144268196:A:G	L352P	0.876
7:144268710:A:G	S181P	0.871
7:144267842:C:G	R470P	0.865
7:144267932:A:G	L440P	0.863
7:144268976:A:G	L92P	0.846
7:144268847:A:G	L135P	0.842
7:144267942:C:G	A437P	0.837
7:144268805:A:G	L149P	0.833
7:144268700:A:G	L184P	0.825
7:144266938:A:C	F771L	0.818
7:144266938:A:T	F771L	0.818
7:144266940:A:G	F771L	0.818
7:144268058:A:G	L398P	0.813
7:144267845:G:T	A469D	0.803
7:144268595:A:G	L219P	0.803

dbSNP variants (sampled 300 via entrez): RS1007037239 (7:144270471 T>C), RS1011375967 (7:144270623 T>C), RS1018140529 (7:144270515 A>T), RS1020220062 (7:144270700 A>G), RS1029716202 (7:144269794 G>T), RS1036457801 (7:144271110 T>G), RS1036572551 (7:144269394 T>C), RS1050809737 (7:144271286 A>C,G), RS1055992253 (7:144267286 C>T), RS1156569998 (7:144267503 C>G,T), RS1156955962 (7:144270975 G>T), RS1157140229 (7:144269420 C>T), RS1157457748 (7:144267468 C>T), RS1157702104 (7:144269621 T>TC), RS1157740566 (7:144269875 C>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST010136_23	Fruit consumption	5.000000e-08
GCST010136_24	Fruit consumption	1.000000e-48

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0008111	diet measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression	1
Smoke	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.