CTBP1-AS

Summary

CTBP1-AS (CTBP1 antisense RNA, HGNC:48337) is a long non-coding RNA gene on chromosome 4p16.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48337
Approved symbol	CTBP1-AS
Name	CTBP1 antisense RNA
Location	4p16.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	PCAT10
Ensembl gene	ENSG00000280927
Ensembl biotype	lncRNA
Entrez	285463
RNAcentral	URS000075C726 — lncRNA, 3886 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000625256

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000625256 — 6 exons

Exon	Start	End
ENSE00003762291	1215546	1215690
ENSE00003762672	1212034	1212539
ENSE00003763331	1212675	1212770
ENSE00003764866	1215959	1218591
ENSE00003770166	1210890	1210956
ENSE00003770677	1210120	1210558

Expression profiles

Bgee: expression breadth ubiquitous, 157 present calls, max score 89.20.

Top tissues by expression

239 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	89.20	gold quality
tendon of biceps brachii	UBERON:0008188	75.67	gold quality
granulocyte	CL:0000094	75.37	gold quality
tendon	UBERON:0000043	71.15	gold quality
right hemisphere of cerebellum	UBERON:0014890	69.29	gold quality
cerebellar cortex	UBERON:0002129	68.66	gold quality
cerebellar hemisphere	UBERON:0002245	68.65	gold quality
body of pancreas	UBERON:0001150	68.21	gold quality
mucosa of transverse colon	UBERON:0004991	67.28	gold quality
small intestine Peyer’s patch	UBERON:0003454	67.08	gold quality
spleen	UBERON:0002106	67.05	gold quality
cerebellum	UBERON:0002037	66.82	gold quality
bone marrow cell	CL:0002092	66.74	silver quality
stromal cell of endometrium	CL:0002255	66.72	gold quality
apex of heart	UBERON:0002098	66.57	gold quality
transverse colon	UBERON:0001157	66.24	gold quality
mucosa of stomach	UBERON:0001199	66.23	gold quality
right lobe of liver	UBERON:0001114	66.09	gold quality
lower esophagus mucosa	UBERON:0035834	66.05	gold quality
body of stomach	UBERON:0001161	66.02	gold quality
left uterine tube	UBERON:0001303	65.89	gold quality
right ovary	UBERON:0002118	65.51	gold quality
right adrenal gland cortex	UBERON:0035827	65.34	gold quality
skin of abdomen	UBERON:0001416	65.20	gold quality
medial globus pallidus	UBERON:0002477	64.96	silver quality
monocyte	CL:0000576	64.95	gold quality
right adrenal gland	UBERON:0001233	64.79	gold quality
metanephros cortex	UBERON:0010533	64.75	gold quality
left ovary	UBERON:0002119	64.74	gold quality
right lobe of thyroid gland	UBERON:0001119	64.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.78

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• CTBP1-AS, a novel androgen receptor regulator, is associated with polycystic ovary syndrome in Chinese women. (PMID:25552498)
• Overexpressed LncRNA CTBP1-AS promoted breast cancer cell proliferation, invasion as well as migration, inhibited cell apoptosis and accelerated breast cancer development by sponging microRNA-940. (PMID:31165609)
• Androgen receptor coregulator long noncoding RNA CTBP1-AS is associated with polycystic ovary syndrome in Kashmiri women. (PMID:34611799)
• CTBP1AS upregulation is associated with polycystic ovary syndrome and can be effectively downregulated by cryptotanshinone. (PMID:35656892)
• LncRNA CTBP1-AS inhibits TP63-mediated activation of S100A14 during prostate cancer progression. (PMID:38476086)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.