CTBP1-DT

Summary

CTBP1-DT (CTBP1 divergent transcript, HGNC:28307) is a long non-coding RNA gene on chromosome 4p16.3. Promotes DNA damage repair through both homologous recombination repair (HRR) and post-replication repair (PRR) mechanisms.

Involved in postreplication repair and recombinational repair. Located in nucleus.

Source: NCBI Gene 92070 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28307
Approved symbol	CTBP1-DT
Name	CTBP1 divergent transcript
Location	4p16.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	DDUP, MGC21675
Ensembl gene	ENSG00000196810
Ensembl biotype	lncRNA
Entrez	92070
RNAcentral	URS000075CDF7 — lncRNA, 2945 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 26 — 26 lncRNA

ENST00000357591, ENST00000505364, ENST00000507044, ENST00000514984, ENST00000578730, ENST00000581398, ENST00000670838, ENST00000707143, ENST00000707145, ENST00000707148, ENST00000707149, ENST00000707150, ENST00000707151, ENST00000707152, ENST00000707153, ENST00000707154, ENST00000707155, ENST00000707156, ENST00000707157, ENST00000707158, ENST00000707159, ENST00000707160, ENST00000707161, ENST00000707162, ENST00000707163, ENST00000711290

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000357591 — 2 exons

Exon	Start	End
ENSE00001417466	1250111	1252609
ENSE00004001371	1249252	1249472

Expression profiles

Bgee: expression breadth ubiquitous, 231 present calls, max score 99.70.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.8345 / max 110.0044, expressed in 1737 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
46548	2.8908	1403
46547	2.1419	1279
46546	1.8018	1108

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	99.70	gold quality
tendon of biceps brachii	UBERON:0008188	95.22	gold quality
oviduct epithelium	UBERON:0004804	91.72	gold quality
medial globus pallidus	UBERON:0002477	88.32	gold quality
tibialis anterior	UBERON:0001385	85.26	silver quality
stromal cell of endometrium	CL:0002255	84.57	gold quality
granulocyte	CL:0000094	84.33	gold quality
cortical plate	UBERON:0005343	83.17	gold quality
globus pallidus	UBERON:0001875	83.09	gold quality
ganglionic eminence	UBERON:0004023	82.22	gold quality
ventricular zone	UBERON:0003053	82.03	gold quality
hindlimb stylopod muscle	UBERON:0004252	81.19	gold quality
vermiform appendix	UBERON:0001154	80.98	gold quality
fallopian tube	UBERON:0003889	80.88	gold quality
gastrocnemius	UBERON:0001388	80.08	gold quality
muscle of leg	UBERON:0001383	79.97	gold quality
bone marrow cell	CL:0002092	79.95	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.59	gold quality
islet of Langerhans	UBERON:0000006	79.41	gold quality
ileal mucosa	UBERON:0000331	79.29	gold quality
adenohypophysis	UBERON:0002196	79.26	gold quality
smooth muscle tissue	UBERON:0001135	79.15	gold quality
left ventricle myocardium	UBERON:0006566	78.59	gold quality
cardiac muscle of right atrium	UBERON:0003379	78.55	gold quality
apex of heart	UBERON:0002098	78.46	gold quality
mucosa of stomach	UBERON:0001199	78.29	gold quality
gall bladder	UBERON:0002110	77.89	gold quality
left adrenal gland	UBERON:0001234	77.74	gold quality
prefrontal cortex	UBERON:0000451	77.69	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	77.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.43

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• lncRNA VIM-AS1 and lncRNA CTBP1-AS2 expression levels are associated with type 2 diabetes susceptibility. (PMID:30506719)
• LncRNA CTBP1-AS2 is upregulated in osteoarthritis and increases the methylation of miR-130a gene to inhibit chondrocyte proliferation. (PMID:32388751)
• Expression profiling revealed up-regulation of three lncRNAs in breast cancer samples. (PMID:32976818)
• SP1-induced upregulation of lncRNA CTBP1-AS2 accelerates the hepatocellular carcinoma tumorigenesis through targeting CEP55 via sponging miR-195-5p. (PMID:32988587)
• lncRNA CTBP1-AS2 promotes proliferation and migration of glioma by modulating miR-370-3p-Wnt7a-mediated epithelial-mesenchymal transition. (PMID:33150795)
• Long noncoding RNA CTBP1AS2 upregulates USP22 to promote pancreatic carcinoma progression by sponging miR1413p. (PMID:35039872)
• CTBP1-AS2 promoted non-small cell lung cancer progression via sponging the miR-623/MMP3 axis. (PMID:35076836)
• Regulatory Mechanism of lncRNA CTBP1-AS2 in Nasopharyngeal Carcinoma Cell Proliferation and Apoptosis via the miR-140-5p/BMP2 Axis. (PMID:35894463)
• The DDUP protein encoded by the DNA damage-induced CTBP1-DT lncRNA confers cisplatin resistance in ovarian cancer. (PMID:37633920)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.