CTDNEP1

Summary

CTDNEP1 (CTD nuclear envelope phosphatase 1, HGNC:19085) is a protein-coding gene on chromosome 17p13.1, encoding CTD nuclear envelope phosphatase 1 (O95476). Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. It is a selective cancer dependency (DepMap: 40.1% of cell lines).

Enables protein serine/threonine phosphatase activity. Involved in several processes, including positive regulation of triglyceride biosynthetic process; protein dephosphorylation; and protein localization to nucleus. Located in endoplasmic reticulum membrane; lipid droplet; and nuclear membrane. Part of Nem1-Spo7 phosphatase complex.

Source: NCBI Gene 23399 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 36 total — 1 pathogenic
• Cancer dependency (DepMap): dependent in 40.1% of screened cell lines
• MANE Select transcript: NM_001143775

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19085
Approved symbol	CTDNEP1
Name	CTD nuclear envelope phosphatase 1
Location	17p13.1
Locus type	gene with protein product
Status	Approved
Aliases	HSA011916, NET56
Ensembl gene	ENSG00000175826
Ensembl biotype	protein_coding
OMIM	610684
Entrez	23399

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 11 protein_coding, 2 nonsense_mediated_decay, 2 retained_intron

ENST00000318988, ENST00000570380, ENST00000570385, ENST00000570484, ENST00000570828, ENST00000571409, ENST00000572043, ENST00000573600, ENST00000574205, ENST00000574322, ENST00000575783, ENST00000576613, ENST00000912384, ENST00000964617, ENST00000964618

RefSeq mRNA: 2 — MANE Select: NM_001143775 NM_001143775, NM_015343

CCDS: CCDS11093

Canonical transcript exons

ENST00000574322 — 8 exons

Exon	Start	End
ENSE00001278806	7246026	7246137
ENSE00001898059	7243591	7244245
ENSE00002653978	7251195	7251734
ENSE00003566528	7247064	7247182
ENSE00003589833	7246254	7246370
ENSE00003604175	7247277	7247343
ENSE00003610435	7246791	7246862
ENSE00003646929	7244551	7244635

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 99.15.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 124.1744 / max 731.4599, expressed in 1827 samples.

FANTOM5 promoters (12 alternative TSS)

Promoter ID	TPM avg	Samples expressed
164177	97.0433	1825
164176	21.1848	1807
164178	1.6808	1081
164172	0.8909	622
164174	0.6083	338
164173	0.5727	281
164175	0.5678	312
164171	0.4426	192
208047	0.4180	199
208046	0.3588	157

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
hindlimb stylopod muscle	UBERON:0004252	99.15	gold quality
gastrocnemius	UBERON:0001388	99.00	gold quality
skeletal muscle tissue	UBERON:0001134	98.87	gold quality
muscle tissue	UBERON:0002385	98.68	gold quality
muscle of leg	UBERON:0001383	98.60	gold quality
cortical plate	UBERON:0005343	98.54	gold quality
ganglionic eminence	UBERON:0004023	98.49	gold quality
granulocyte	CL:0000094	98.30	gold quality
ventricular zone	UBERON:0003053	98.21	gold quality
skin of leg	UBERON:0001511	98.13	gold quality
stromal cell of endometrium	CL:0002255	98.07	gold quality
zone of skin	UBERON:0000014	98.06	gold quality
right ovary	UBERON:0002118	98.06	gold quality
skin of abdomen	UBERON:0001416	98.02	gold quality
endocervix	UBERON:0000458	98.01	gold quality
body of uterus	UBERON:0009853	97.97	gold quality
left ovary	UBERON:0002119	97.93	gold quality
ovary	UBERON:0000992	97.89	gold quality
spleen	UBERON:0002106	97.89	gold quality
smooth muscle tissue	UBERON:0001135	97.88	gold quality
lower esophagus mucosa	UBERON:0035834	97.87	gold quality
ectocervix	UBERON:0012249	97.86	gold quality
lymph node	UBERON:0000029	97.83	gold quality
fallopian tube	UBERON:0003889	97.78	gold quality
body of stomach	UBERON:0001161	97.75	gold quality
left uterine tube	UBERON:0001303	97.75	gold quality
right lobe of thyroid gland	UBERON:0001119	97.73	gold quality
islet of Langerhans	UBERON:0000006	97.72	gold quality
upper lobe of left lung	UBERON:0008952	97.72	gold quality
body of pancreas	UBERON:0001150	97.71	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.14
E-MTAB-7249	no	348.96

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

50 targeting CTDNEP1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-29B-2-5P	99.67	68.98	1726
HSA-MIR-5700	99.64	69.88	2280
HSA-MIR-5003-5P	99.61	69.13	1624
HSA-MIR-1915-3P	99.58	66.79	1988
HSA-MIR-4328	99.57	71.06	4094
HSA-MIR-3136-3P	99.57	66.59	781
HSA-MIR-7155-3P	99.57	66.48	794
HSA-MIR-4762-5P	99.57	68.54	1424
HSA-MIR-5584-5P	99.49	68.22	2814
HSA-MIR-6081	99.48	66.07	1446
HSA-MIR-185-5P	99.35	68.60	2497
HSA-MIR-4644	99.35	69.12	2514
HSA-MIR-10522-5P	99.26	68.50	2087
HSA-MIR-6815-3P	99.13	68.98	1530
HSA-MIR-485-5P	99.10	64.78	1889
HSA-MIR-6884-5P	99.10	64.50	1987
HSA-MIR-7155-5P	98.65	66.14	1290
HSA-MIR-5011-3P	98.63	64.81	638

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 40.1% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 6)

• Dullard participates in a unique phosphatase cascade regulating nuclear membrane biogenesis, a cascade that is conserved from yeast to mammals. (PMID:17420445)
• dullard shows specificity for the peptide corresponding to the insulin-dependent phosphorylation site (Ser106) of lipin (PMID:21413788)
• CTDNEP1 is upregulated in non-alcoholic fatty liver disease. Up-regulation of miR-122 can trigger the compensatory response of LPIN1 and CTDNEP1 in hepatosteatosis. (PMID:28287811)
• Regulated lipid synthesis and LEM2/CHMP7 jointly control nuclear envelope closure. (PMID:32271860)
• Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability. (PMID:36765089)
• Structure and mechanism of the human CTDNEP1-NEP1R1 membrane protein phosphatase complex necessary to maintain ER membrane morphology. (PMID:38776370)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	ctdnep1a	ENSDARG00000016519
danio_rerio	ctdnep1b	ENSDARG00000035781
mus_musculus	Ctdnep1	ENSMUSG00000018559
rattus_norvegicus	Ctdnep1	ENSRNOG00000017352
drosophila_melanogaster	Dd	FBGN0029067
caenorhabditis_elegans		WBGENE00018474

Paralogs (5): TIMM50 (ENSG00000105197), CTDSPL2 (ENSG00000137770), CTDSP1 (ENSG00000144579), CTDSPL (ENSG00000144677), CTDSP2 (ENSG00000175215)

Protein

Protein identifiers

CTD nuclear envelope phosphatase 1 — O95476 (reviewed: O95476)

Alternative names: Serine/threonine-protein phosphatase dullard

All UniProt accessions (7): O95476, I3L0X6, I3L1D9, I3L2R5, I3L3K5, I3L4B2, I3L4W0

UniProt curated annotations — full annotation on UniProt →

Function. Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling.

Subunit / interactions. (Microbial infection) Interacts with Chandipura virus matrix protein. Interacts with CNEP1R1; the complex dephosphorylates LPIN1 and LPIN2.

Subcellular location. Endoplasmic reticulum membrane. Nucleus membrane.

Tissue specificity. Muscle specific with lower expression in other metabolic tissues.

Similarity. Belongs to the dullard family.

RefSeq proteins (2): NP_001137247, NP_056158 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004274	FCP1_dom	Domain
IPR011948	Dullard_phosphatase	Domain
IPR023214	HAD_sf	Homologous_superfamily
IPR036412	HAD-like_sf	Homologous_superfamily
IPR050365	TIM50	Family

Pfam: PF03031

Catalyzed reactions (Rhea), 2 shown:

• O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate (RHEA:20629)
• O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate (RHEA:47004)

UniProt features (30 total): strand 12, helix 11, turn 2, chain 1, transmembrane region 1, domain 1, sequence variant 1, mutagenesis site 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
8UJL	X-RAY DIFFRACTION	1.91
8UJM	X-RAY DIFFRACTION	2.16

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O95476-F1	90.19	0.69

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Mutagenesis-validated functional residues (1):

Position	Phenotype
67	abolishes phosphatase activity.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-4419969	Depolymerization of the Nuclear Lamina

MSigDB gene sets: 191 (showing top): MORF_MTA1, GOBP_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS, GOBP_MEMBRANE_DISASSEMBLY, MORF_UBE2I, MORF_HDAC1, MORF_CDK2, MORF_HDAC2, TAL1ALPHAE47_01, GOBP_REGULATION_OF_WNT_SIGNALING_PATHWAY, GOBP_GLYCEROLIPID_METABOLIC_PROCESS, MORF_TERF1, GOBP_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS, GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS, MORF_RAF1, GOBP_CANONICAL_WNT_SIGNALING_PATHWAY

GO Biological Process (10): protein dephosphorylation (GO:0006470), nuclear envelope organization (GO:0006998), mitotic nuclear membrane disassembly (GO:0007077), gamete generation (GO:0007276), mesoderm development (GO:0007498), positive regulation of triglyceride biosynthetic process (GO:0010867), protein localization to nucleus (GO:0034504), canonical Wnt signaling pathway (GO:0060070), positive regulation of canonical Wnt signaling pathway (GO:0090263), protein transport (GO:0015031)

GO Molecular Function (5): phosphoprotein phosphatase activity (GO:0004721), protein serine/threonine phosphatase activity (GO:0004722), protein binding (GO:0005515), hydrolase activity (GO:0016787), phosphatase activity (GO:0016791)

GO Cellular Component (12): nuclear envelope (GO:0005635), cytoplasm (GO:0005737), endoplasmic reticulum membrane (GO:0005789), lipid droplet (GO:0005811), nuclear membrane (GO:0031965), Nem1-Spo7 phosphatase complex (GO:0071595), nucleus (GO:0005634), mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), TIM23 mitochondrial import inner membrane translocase complex (GO:0005744), endoplasmic reticulum (GO:0005783), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Nuclear Envelope Breakdown	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular membrane-bounded organelle	3
nucleus	2
endomembrane system	2
cellular anatomical structure	2
organelle membrane	2
nuclear outer membrane-endoplasmic reticulum membrane network	2
cytoplasm	2
dephosphorylation	1
protein modification process	1
nucleus organization	1
endomembrane system organization	1
membrane organization	1
mitotic cell cycle	1
nuclear membrane disassembly	1
mitotic cell cycle process	1
sexual reproduction	1
multicellular organismal reproductive process	1
tissue development	1
regulation of triglyceride biosynthetic process	1
triglyceride biosynthetic process	1
positive regulation of lipid biosynthetic process	1
positive regulation of triglyceride metabolic process	1
protein localization to organelle	1
Wnt signaling pathway	1
positive regulation of Wnt signaling pathway	1
canonical Wnt signaling pathway	1
regulation of canonical Wnt signaling pathway	1
transport	1
intracellular protein localization	1
establishment of protein localization	1
phosphatase activity	1
catalytic activity, acting on a protein	1
phosphoprotein phosphatase activity	1
binding	1
catalytic activity	1
phosphoric ester hydrolase activity	1
organelle envelope	1
intracellular anatomical structure	1
endoplasmic reticulum subcompartment	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

899 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CTDNEP1	CNEP1R1	Q8N9A8	930
CTDNEP1	BMPR2	Q13873	847
CTDNEP1	LPIN1	Q14693	688
CTDNEP1	BMP1	P13497	649
CTDNEP1	LPIN3	Q9BQK8	649
CTDNEP1	LPIN2	Q92539	593
CTDNEP1	CTDP1	Q9Y5B0	550
CTDNEP1	SFT2D1	Q8WV19	497
CTDNEP1	GFM2	Q969S9	446
CTDNEP1	MAL2	Q969L2	409
CTDNEP1	MAN1B1	Q9UKM7	406
CTDNEP1	STMP1	E0CX11	394
CTDNEP1	RSL24D1	Q9UHA3	377
CTDNEP1	ARMC8	Q8IUR7	377
CTDNEP1	P4HA1	P13674	371

IntAct

52 interactions, top by confidence:

A	B	Type	Score
CDCA3	CTDSPL	psi-mi:“MI:0914”(association)	0.670
M	CTDNEP1	psi-mi:“MI:0915”(physical association)	0.580
CTDNEP1	UBQLN2	psi-mi:“MI:0915”(physical association)	0.560
EVA1C	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
PLXDC2	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
CCDC107	PLD2	psi-mi:“MI:0914”(association)	0.530
TLR5	MAN1A2	psi-mi:“MI:0914”(association)	0.530
SRPRB	CTDNEP1	psi-mi:“MI:0914”(association)	0.530
CNEP1R1	CTDNEP1	psi-mi:“MI:0915”(physical association)	0.460
CTDNEP1	CNEP1R1	psi-mi:“MI:0403”(colocalization)	0.460
	CTDNEP1	psi-mi:“MI:0915”(physical association)	0.400
FAM189B	KLRG2	psi-mi:“MI:0914”(association)	0.350
OLFM2	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
SRPRB	GOSR1	psi-mi:“MI:0914”(association)	0.350
SLC17A2	PSMD11	psi-mi:“MI:0914”(association)	0.350
PDGFRB	ABCD4	psi-mi:“MI:0914”(association)	0.350
HLA-DRB1	CTDNEP1	psi-mi:“MI:0914”(association)	0.350
ORF4	CTDNEP1	psi-mi:“MI:0914”(association)	0.350
	TMEM223	psi-mi:“MI:0914”(association)	0.350
CTDNEP1	HAX1	psi-mi:“MI:0914”(association)	0.350
ARL6IP1	ESYT2	psi-mi:“MI:0914”(association)	0.350
TTMP	TMEM223	psi-mi:“MI:0914”(association)	0.350

BioGRID (91): CTDNEP1 (Affinity Capture-RNA), CTDNEP1 (Affinity Capture-RNA), CTDNEP1 (Affinity Capture-MS), CTDNEP1 (Affinity Capture-MS), CTDNEP1 (Affinity Capture-MS), CTDNEP1 (Affinity Capture-MS), CTDNEP1 (Affinity Capture-MS), CTDNEP1 (Affinity Capture-MS), CTDNEP1 (Affinity Capture-MS), CTDNEP1 (Affinity Capture-MS), CTDNEP1 (Affinity Capture-MS), ATP2A2 (Affinity Capture-MS), HAX1 (Affinity Capture-MS), TUBB6 (Affinity Capture-MS), ACBD5 (Proximity Label-MS)

ESM2 similar proteins: A0A3L7I2I8, A6H7H7, D4ABP9, O60733, O95476, P37287, P97570, P97819, Q12980, Q1RMV9, Q20432, Q28EX9, Q28HW9, Q29I63, Q2KIX2, Q2KJD7, Q2TBU5, Q3B7T6, Q3TP92, Q3U1V6, Q3UHB1, Q4R678, Q5F480, Q5FWT7, Q5R4C4, Q5TFE4, Q5U395, Q5U3T3, Q5ZJJ8, Q61C05, Q66H63, Q6NWD4, Q6NYU2, Q80YV4, Q86UY8, Q8AYC9, Q8BGR9, Q8BM85, Q8JIL9, Q8VIJ8

Diamond homologs: A4QNX6, M9PFN0, O13636, O14595, O15194, O59718, O95476, P0CN66, P0CN67, P38757, P58465, P58466, Q02776, Q05D32, Q07800, Q07949, Q08BB5, Q09695, Q1RMV9, Q20432, Q28HW9, Q29I63, Q3B7T6, Q3KQB6, Q3TP92, Q3ZCQ8, Q4I099, Q4PEW9, Q4WI16, Q54GB2, Q59W44, Q5B4P0, Q5F3Z7, Q5RAJ8, Q5S7T7, Q5U395, Q5U3T3, Q5XIK8, Q61C05, Q66KM5

SIGNOR signaling

3 interactions.

A	Effect	B	Mechanism
CTDNEP1	up-regulates	BMPR1A	binding
CTDNEP1	down-regulates	BMPR2	binding
CTDNEP1	“up-regulates activity”	LPIN1	dephosphorylation

Disease & clinical

Clinical variants and AI predictions

ClinVar

36 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	16
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
3242525	Single allele	Pathogenic

SpliceAI

1620 predictions. Top by Δscore:

Variant	Effect	Δscore
17:7244545:CCTTA:C	donor_loss	1.0000
17:7244546:CTTA:C	donor_loss	1.0000
17:7244547:TTA:T	donor_loss	1.0000
17:7244547:TTAC:T	donor_loss	1.0000
17:7244548:TACCT:T	donor_loss	1.0000
17:7244549:ACC:A	donor_loss	1.0000
17:7244549:ACCTG:A	donor_loss	1.0000
17:7244550:C:A	donor_loss	1.0000
17:7244550:CC:C	donor_loss	1.0000
17:7244632:TTGT:T	acceptor_gain	1.0000
17:7244634:GT:G	acceptor_gain	1.0000
17:7244636:C:CC	acceptor_gain	1.0000
17:7244645:G:C	acceptor_gain	1.0000
17:7244645:G:GC	acceptor_gain	1.0000
17:7244651:A:AC	acceptor_gain	1.0000
17:7244651:A:C	acceptor_gain	1.0000
17:7244700:T:C	acceptor_gain	1.0000
17:7246249:CTTA:C	donor_loss	1.0000
17:7246250:TTACC:T	donor_loss	1.0000
17:7246251:TACCT:T	donor_loss	1.0000
17:7246252:A:AC	donor_gain	1.0000
17:7246252:ACCTG:A	donor_loss	1.0000
17:7246253:C:CC	donor_gain	1.0000
17:7246253:CCT:C	donor_gain	1.0000
17:7246253:CCTG:C	donor_gain	1.0000
17:7246253:CCTGT:C	donor_gain	1.0000
17:7246366:CTCAC:C	acceptor_gain	1.0000
17:7246367:TCAC:T	acceptor_gain	1.0000
17:7246368:CAC:C	acceptor_gain	1.0000
17:7246368:CACC:C	acceptor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000358411 (17:7245406 G>T), RS1000925641 (17:7250300 T>C), RS1001311160 (17:7243687 T>C,G), RS1001722108 (17:7247383 G>A,T), RS1001815552 (17:7253480 G>A), RS1001869509 (17:7248616 C>T), RS1002006530 (17:7248728 C>G), RS1002093312 (17:7253617 T>A), RS1002161901 (17:7253714 G>C,T), RS1002502621 (17:7243759 C>G), RS1002918626 (17:7247430 C>T), RS1003684242 (17:7250009 G>A), RS1004021333 (17:7251346 G>T), RS1004073932 (17:7251514 G>A,T), RS1004103045 (17:7251954 C>G,T)

Disease associations

OMIM: gene MIM:610684 | disease phenotypes: MIM:619376

GenCC curated gene-disease

Mondo (1): Faundes-Banka syndrome (MONDO:0859163)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, affects cotreatment, increases abundance	2
6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	decreases expression	1
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	increases expression	1
beta-lapachone	decreases expression, increases expression	1
manganese chloride	decreases expression, increases abundance, affects cotreatment	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Sunitinib	increases expression	1
Air Pollutants	affects expression, increases abundance	1
Arsenic	decreases expression, increases abundance, affects cotreatment	1
Atrazine	increases expression	1
Doxorubicin	increases expression	1
Ivermectin	decreases expression	1
Manganese	decreases expression, increases abundance, affects cotreatment	1
Ozone	affects expression, increases abundance	1
Selenium	affects cotreatment, decreases expression, increases expression	1
Smoke	decreases expression	1
Sodium Dodecyl Sulfate	increases expression	1
Vitamin E	affects cotreatment, decreases expression, increases expression	1
Cyclosporine	increases expression	1
Sodium Selenite	increases expression	1

Cellosaurus cell lines

3 cell lines: 2 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2VC	Abcam HEK293T CTDNEP1 KO	Transformed cell line	Female
CVCL_SJ98	HAP1 CTDNEP1 (-) 1	Cancer cell line	Male
CVCL_SJ99	HAP1 CTDNEP1 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.