CTIF-AS1

Summary

CTIF-AS1 (CTIF antisense RNA 1, HGNC:58323) is a long non-coding RNA gene on chromosome 18q21.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product.
• Sense gene: antisense to CTIF — the sense gene carries 23 GWAS associations, 125 ClinVar variants (the sense gene’s biology, not this transcript’s)
• GTEx eGene: eQTL in 2 tissues, sQTL in 0 (q < 0.05)

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:58323
Approved symbol	CTIF-AS1
Name	CTIF antisense RNA 1
Location	18q21.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000267764
Ensembl biotype	lncRNA
Entrez	105372105

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 3: 1

ENST00000590649, ENST00000776736, ENST00000776737

RefSeq mRNA: 0

Canonical transcript exons

ENST00000590649 — 2 exons

Exon	Start	End
ENSE00002859370	48834692	48834770
ENSE00002949177	48826051	48826848

Expression profiles

Bgee: expression breadth ubiquitous, 119 present calls, max score 92.69.

Highest expression (Bgee): male germ line stem cell (sensu Vertebrata) in testis, colonic epithelium, bone marrow cell, skeletal muscle tissue, hindlimb stylopod muscle.

Genetic regulation across tissues (GTEx eQTL / sQTL)

CTIF-AS1 is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 2 tissues and its splicing (sQTL) in 0 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

2 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Cells Cultured fibroblasts	eqtl	4.4e-03	-0.66	18:48269030:G:A
Thyroid	eqtl	1.8e-02	-0.24	18:48758774:A:G

Top tissues by expression

showing 100 of 119 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	92.69	gold quality
colonic epithelium	UBERON:0000397	70.44	gold quality
bone marrow cell	CL:0002092	64.57	silver quality
skeletal muscle tissue	UBERON:0001134	63.12	silver quality
hindlimb stylopod muscle	UBERON:0004252	62.55	gold quality
urinary bladder	UBERON:0001255	61.28	gold quality
bone marrow	UBERON:0002371	59.37	gold quality
right uterine tube	UBERON:0001302	59.20	gold quality
fallopian tube	UBERON:0003889	59.19	gold quality
granulocyte	CL:0000094	58.28	gold quality
liver	UBERON:0002107	57.72	silver quality
adrenal tissue	UBERON:0018303	55.50	gold quality
right atrium auricular region	UBERON:0006631	53.83	gold quality
vermiform appendix	UBERON:0001154	53.82	gold quality
blood	UBERON:0000178	53.74	gold quality
right coronary artery	UBERON:0001625	53.52	gold quality
tonsil	UBERON:0002372	52.82	silver quality
monocyte	CL:0000576	52.61	gold quality
uterine cervix	UBERON:0000002	52.19	silver quality
heart	UBERON:0000948	52.05	gold quality
heart left ventricle	UBERON:0002084	51.88	gold quality
right lung	UBERON:0002167	51.77	gold quality
corpus callosum	UBERON:0002336	51.44	gold quality
right adrenal gland cortex	UBERON:0035827	51.43	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	51.16	gold quality
lung	UBERON:0002048	50.78	gold quality
kidney	UBERON:0002113	50.35	gold quality
smooth muscle tissue	UBERON:0001135	49.80	gold quality
adult mammalian kidney	UBERON:0000082	49.79	gold quality
placenta	UBERON:0001987	49.75	gold quality
lymph node	UBERON:0000029	49.40	gold quality
calcaneal tendon	UBERON:0003701	49.38	silver quality
cerebellum	UBERON:0002037	49.33	silver quality
cerebellar cortex	UBERON:0002129	49.32	silver quality
right lobe of liver	UBERON:0001114	49.31	silver quality
cerebellar hemisphere	UBERON:0002245	49.27	silver quality
popliteal artery	UBERON:0002250	49.27	gold quality
prefrontal cortex	UBERON:0000451	49.24	gold quality
tibial artery	UBERON:0007610	49.24	gold quality
muscle of leg	UBERON:0001383	48.78	gold quality
right hemisphere of cerebellum	UBERON:0014890	48.73	silver quality
islet of Langerhans	UBERON:0000006	48.71	gold quality
adrenal gland	UBERON:0002369	48.07	gold quality
primary visual cortex	UBERON:0002436	47.72	silver quality
thoracic mammary gland	UBERON:0005200	47.68	gold quality
upper lobe of left lung	UBERON:0008952	47.38	gold quality
ascending aorta	UBERON:0001496	47.23	gold quality
pancreas	UBERON:0001264	47.08	gold quality
gastrocnemius	UBERON:0001388	47.07	silver quality
thoracic aorta	UBERON:0001515	47.06	gold quality
right adrenal gland	UBERON:0001233	46.74	gold quality
myometrium	UBERON:0001296	46.63	gold quality
gall bladder	UBERON:0002110	46.54	gold quality
ovary	UBERON:0000992	46.39	silver quality
multicellular organism	UBERON:0000468	46.38	gold quality
cortex of kidney	UBERON:0001225	46.35	silver quality
left coronary artery	UBERON:0001626	46.30	gold quality
left adrenal gland	UBERON:0001234	45.81	gold quality
descending thoracic aorta	UBERON:0002345	45.78	gold quality
left uterine tube	UBERON:0001303	45.61	gold quality
stomach	UBERON:0000945	45.11	gold quality
subcutaneous adipose tissue	UBERON:0002190	45.10	gold quality
right lobe of thyroid gland	UBERON:0001119	45.04	gold quality
thyroid gland	UBERON:0002046	44.95	gold quality
superior frontal gyrus	UBERON:0002661	44.95	silver quality
adipose tissue	UBERON:0001013	44.81	gold quality
left ovary	UBERON:0002119	44.67	gold quality
body of pancreas	UBERON:0001150	44.58	silver quality
endocervix	UBERON:0000458	44.55	gold quality
apex of heart	UBERON:0002098	44.55	silver quality
lower esophagus	UBERON:0013473	44.54	gold quality
lower esophagus muscularis layer	UBERON:0035833	44.54	gold quality
esophagus	UBERON:0001043	44.51	silver quality
frontal cortex	UBERON:0001870	44.39	gold quality
brain	UBERON:0000955	44.37	silver quality
omental fat pad	UBERON:0010414	44.30	gold quality
left lobe of thyroid gland	UBERON:0001120	44.25	gold quality
endometrium	UBERON:0001295	44.13	silver quality
right ovary	UBERON:0002118	44.13	gold quality
body of uterus	UBERON:0009853	43.97	silver quality
small intestine	UBERON:0002108	43.85	silver quality
left adrenal gland cortex	UBERON:0035825	43.83	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	43.76	silver quality
intestine	UBERON:0000160	43.55	silver quality
body of stomach	UBERON:0001161	43.30	silver quality
colon	UBERON:0001155	43.02	silver quality
muscle layer of sigmoid colon	UBERON:0035805	43.02	silver quality
cerebral cortex	UBERON:0000956	42.85	silver quality
rectum	UBERON:0001052	42.49	silver quality
spleen	UBERON:0002106	42.32	silver quality
Ammon’s horn	UBERON:0001954	42.13	silver quality
esophagus mucosa	UBERON:0002469	42.06	silver quality
metanephros cortex	UBERON:0010533	42.06	silver quality
hypothalamus	UBERON:0001898	42.00	gold quality
prostate gland	UBERON:0002367	41.97	silver quality
zone of skin	UBERON:0000014	41.94	silver quality
ectocervix	UBERON:0012249	41.86	silver quality
anterior cingulate cortex	UBERON:0009835	41.78	gold quality
vagina	UBERON:0000996	41.71	silver quality
skin of leg	UBERON:0001511	41.52	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
CTIF	protein-coding	9811
MIR4743	ncRNA	100616366
SMAD7	protein-coding	4092
DYM-AS1	ncRNA	100129878
DYM	protein-coding	54808

Protein

Non-coding RNA — no protein product.

Function

Gene-set membership (MSigDB)

This non-coding RNA is a member of 6 curated MSigDB gene sets — regulatory-target and signature collections that include it (it has no protein-based pathway / GO / interaction data).

chr18q21, TFEB_TARGET_GENES, HBZ_TARGET_GENES, HMGB2_TARGET_GENES, EWSR1_TARGET_GENES, ADNP_TARGET_GENES

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No curated drug or pharmacology associations for this gene.