CWC15

Summary

CWC15 (CWC15 spliceosome associated protein, HGNC:26939) is a protein-coding gene on chromosome 11q21, encoding Spliceosome-associated protein CWC15 homolog (Q9P013). Involved in pre-mRNA splicing as component of the spliceosome. It is a selective cancer dependency (DepMap: 51.4% of cell lines).

Predicted to enable RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in mitochondrion and nuclear speck. Part of Prp19 complex and U2-type catalytic step 2 spliceosome.

Source: NCBI Gene 51503 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 18 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 51.4% of screened cell lines
• MANE Select transcript: NM_016403

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26939
Approved symbol	CWC15
Name	CWC15 spliceosome associated protein
Location	11q21
Locus type	gene with protein product
Status	Approved
Aliases	C11orf5, HSPC148, Cwf15, AD002
Ensembl gene	ENSG00000150316
Ensembl biotype	protein_coding
Entrez	51503

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 13 protein_coding, 5 retained_intron

ENST00000279839, ENST00000539856, ENST00000542165, ENST00000542907, ENST00000616442, ENST00000621358, ENST00000884093, ENST00000884094, ENST00000884095, ENST00000884096, ENST00000884097, ENST00000884098, ENST00000884099, ENST00000884100, ENST00000928765, ENST00000928766, ENST00000928767, ENST00000928768

RefSeq mRNA: 3 — MANE Select: NM_016403 NM_001363371, NM_001363372, NM_016403

CCDS: CCDS73369

Canonical transcript exons

ENST00000279839 — 7 exons

Exon	Start	End
ENSE00001254719	94962620	94963514
ENSE00001377352	94966295	94966413
ENSE00001434060	94973498	94973556
ENSE00003581041	94971375	94971487
ENSE00003582644	94969989	94970096
ENSE00003602456	94970977	94971065
ENSE00003613033	94972055	94972193

Expression profiles

Bgee: expression breadth ubiquitous, 262 present calls, max score 99.12.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 66.2949 / max 2083.0208, expressed in 1818 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
121854	66.2949	1818

Top tissues by expression

263 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney epithelium	UBERON:0004819	99.12	gold quality
tibialis anterior	UBERON:0001385	98.95	gold quality
cardiac muscle of right atrium	UBERON:0003379	98.63	gold quality
left ventricle myocardium	UBERON:0006566	98.56	gold quality
myocardium	UBERON:0002349	98.24	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	98.12	gold quality
vastus lateralis	UBERON:0001379	98.11	gold quality
biceps brachii	UBERON:0001507	97.97	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	97.85	gold quality
body of tongue	UBERON:0011876	97.72	gold quality
hindlimb stylopod muscle	UBERON:0004252	97.69	gold quality
skeletal muscle tissue	UBERON:0001134	97.65	gold quality
left testis	UBERON:0004533	97.55	gold quality
calcaneal tendon	UBERON:0003701	97.54	gold quality
right testis	UBERON:0004534	97.54	gold quality
tongue	UBERON:0001723	97.53	gold quality
superior surface of tongue	UBERON:0007371	97.53	gold quality
deltoid	UBERON:0001476	97.52	gold quality
mammary duct	UBERON:0001765	97.47	gold quality
epithelium of mammary gland	UBERON:0003244	97.42	gold quality
lateral globus pallidus	UBERON:0002476	97.29	gold quality
testis	UBERON:0000473	97.28	gold quality
muscle tissue	UBERON:0002385	97.28	gold quality
upper arm skin	UBERON:0004263	97.04	gold quality
pons	UBERON:0000988	96.97	gold quality
ganglionic eminence	UBERON:0004023	96.94	gold quality
embryo	UBERON:0000922	96.93	gold quality
lateral nuclear group of thalamus	UBERON:0002736	96.83	gold quality
pharyngeal mucosa	UBERON:0000355	96.80	gold quality
quadriceps femoris	UBERON:0001377	96.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	11.13

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

60 targeting CWC15, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-6798-5P	100.00	65.77	699
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-1-3P	99.93	72.35	1914
HSA-MIR-206	99.93	72.50	1893
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-613	99.91	71.50	1710
HSA-MIR-498-3P	99.91	71.27	1114
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-424-5P	99.89	71.90	2641
HSA-MIR-6838-5P	99.89	71.94	2690
HSA-MIR-6124	99.87	69.78	3551
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-4503	99.85	71.45	1869
HSA-MIR-130B-5P	99.83	68.50	1888
HSA-MIR-548AZ-3P	99.82	70.56	3549
HSA-MIR-548BC	99.82	70.61	3524
HSA-MIR-548E-3P	99.82	70.59	3514
HSA-MIR-548F-3P	99.82	70.59	3540
HSA-MIR-4760-5P	99.80	69.88	1619
HSA-MIR-4668-5P	99.79	70.58	3782
HSA-MIR-548A-3P	99.76	70.58	3524
HSA-MIR-494-3P	99.70	71.45	2795
HSA-MIR-548AU-3P	99.70	68.22	1373
HSA-MIR-6892-3P	99.68	66.40	1178

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 51.4% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 1)

• The results show that CTNNBL1 enhances the association of CWC15 and CDC5L, both core Prp19 complex proteins and identify an overlap in the region of CDC5L that binds either CTNNBL1 or CWC15 suggesting the two proteins might exchange places in the complex. (PMID:26130721)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	cwc15	ENSDARG00000013382
mus_musculus	Cwc15	ENSMUSG00000004096
rattus_norvegicus	Cwc15	ENSRNOG00000008490
rattus_norvegicus	Cwc15-ps3	ENSRNOG00000025157
drosophila_melanogaster	c12.1	FBGN0040235
caenorhabditis_elegans		WBGENE00011687

Protein

Protein identifiers

Spliceosome-associated protein CWC15 homolog — Q9P013 (reviewed: Q9P013)

All UniProt accessions (1): Q9P013

UniProt curated annotations — full annotation on UniProt →

Function. Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.

Subunit / interactions. Identified in the spliceosome C complex. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CTNNBL1 in the complex. Component of the minor spliceosome, which splices U12-type introns.

Subcellular location. Nucleus.

Similarity. Belongs to the CWC15 family.

RefSeq proteins (3): NP_001350300, NP_001350301, NP_057487* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006973	Cwf_Cwc_15	Family

Pfam: PF04889

UniProt features (23 total): helix 6, modified residue 5, compositionally biased region 3, strand 2, turn 2, initiator methionine 1, chain 1, sequence conflict 1, region of interest 1, coiled-coil region 1

Structure

Experimental structures (PDB)

34 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
8C6J	ELECTRON MICROSCOPY	2.8
6ID1	ELECTRON MICROSCOPY	2.86
7DVQ	ELECTRON MICROSCOPY	2.89
6ID0	ELECTRON MICROSCOPY	2.9
6ICZ	ELECTRON MICROSCOPY	3
8I0R	ELECTRON MICROSCOPY	3
8I0T	ELECTRON MICROSCOPY	3
8I0V	ELECTRON MICROSCOPY	3
7QTT	ELECTRON MICROSCOPY	3.1
6QDV	ELECTRON MICROSCOPY	3.3
8I0U	ELECTRON MICROSCOPY	3.3
9FMD	ELECTRON MICROSCOPY	3.3
6FF4	ELECTRON MICROSCOPY	3.4
6ZYM	ELECTRON MICROSCOPY	3.4
8I0P	ELECTRON MICROSCOPY	3.4
8I0W	ELECTRON MICROSCOPY	3.4
8RO2	ELECTRON MICROSCOPY	3.5
5XJC	ELECTRON MICROSCOPY	3.6
7W59	ELECTRON MICROSCOPY	3.6
7W5A	ELECTRON MICROSCOPY	3.6
7ABF	ELECTRON MICROSCOPY	3.9
5YZG	ELECTRON MICROSCOPY	4.1
7AAV	ELECTRON MICROSCOPY	4.2
8I0S	ELECTRON MICROSCOPY	4.2
7W5B	ELECTRON MICROSCOPY	4.3
6FF7	ELECTRON MICROSCOPY	4.5
5Z58	ELECTRON MICROSCOPY	4.9
5Z56	ELECTRON MICROSCOPY	5.1
5MQF	ELECTRON MICROSCOPY	5.9
8CH6	ELECTRON MICROSCOPY	5.9

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9P013-F1	75.72	0.30

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (5): 110, 121, 2, 18, 47

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-72163	mRNA Splicing - Major Pathway
R-HSA-9918481	Dengue Virus-Host Interactions

MSigDB gene sets: 131 (showing top): SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4, REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA, GOBP_RNA_SPLICING, REACTOME_MRNA_SPLICING, NKX22_01, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN, GOBP_MRNA_CIS_SPLICING_VIA_SPLICEOSOME, HOXA4_Q2, NKX3A_01, REACTOME_METABOLISM_OF_RNA, GOCC_U2_TYPE_SPLICEOSOMAL_COMPLEX, GOCC_NUCLEAR_SPECK, GOCC_NUCLEAR_BODY, GOCC_RIBONUCLEOPROTEIN_GRANULE, GOCC_CATALYTIC_STEP_2_SPLICEOSOME

GO Biological Process (4): mRNA splicing, via spliceosome (GO:0000398), mRNA cis splicing, via spliceosome (GO:0045292), mRNA processing (GO:0006397), RNA splicing (GO:0008380)

GO Molecular Function (2): RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (8): Prp19 complex (GO:0000974), nucleus (GO:0005634), nucleoplasm (GO:0005654), spliceosomal complex (GO:0005681), mitochondrion (GO:0005739), nuclear speck (GO:0016607), U2-type catalytic step 2 spliceosome (GO:0071007), catalytic step 2 spliceosome (GO:0071013)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
mRNA Splicing	1
Dengue Virus Infection	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA processing	2
intracellular membrane-bounded organelle	2
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	1
mRNA processing	1
mRNA splicing, via spliceosome	1
mRNA metabolic process	1
nucleic acid binding	1
binding	1
protein-containing complex	1
nuclear lumen	1
cellular anatomical structure	1
nuclear protein-containing complex	1
ribonucleoprotein complex	1
cytoplasm	1
nuclear ribonucleoprotein granule	1
U2-type spliceosomal complex	1
U2 snRNP	1
U6 snRNP	1
catalytic step 2 spliceosome	1
Prp19 complex	1
spliceosomal complex	1
U5 snRNP	1
catalytic complex	1

Protein interactions and networks

STRING

2083 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CWC15	PLRG1	O43660	924
CWC15	CTNNBL1	Q8WYA6	918
CWC15	CTTNBP2	Q8WZ74	910
CWC15	ASZ1	Q8WWH4	909
CWC15	BCAS2	O75934	902
CWC15	CDC5L	Q99459	888
CWC15	FAM3B	P58499	862
CWC15	HSPA8	P11142	861
CWC15	SNW1	Q13573	805
CWC15	GP5	P40197	797
CWC15	RNF113A	O15541	755
CWC15	BUD31	P41223	745
CWC15	CWC22	Q9HCG8	727
CWC15	MYOM2	P54296	723
CWC15	CRNKL1	Q9BZJ0	709

IntAct

92 interactions, top by confidence:

A	B	Type	Score
CDC5L	PLRG1	psi-mi:“MI:0915”(physical association)	0.860
CTNNBL1	CWC15	psi-mi:“MI:0407”(direct interaction)	0.850
CWC15	CTNNBL1	psi-mi:“MI:0915”(physical association)	0.850
CWC15	CTNNBL1	psi-mi:“MI:0914”(association)	0.850
PPIE	AQR	psi-mi:“MI:0914”(association)	0.810
BCAS2	PLRG1	psi-mi:“MI:0914”(association)	0.790
PRPF19	AQR	psi-mi:“MI:0914”(association)	0.790
PRPF19	PLRG1	psi-mi:“MI:0914”(association)	0.770
SYF2	AQR	psi-mi:“MI:0914”(association)	0.730
SNW1	AQR	psi-mi:“MI:0914”(association)	0.650
SF3B1	SAP18	psi-mi:“MI:0914”(association)	0.640
SNRPA1	U2SURP	psi-mi:“MI:0914”(association)	0.640
SNRPE	PRMT5	psi-mi:“MI:0914”(association)	0.530
PPIL1	AQR	psi-mi:“MI:0914”(association)	0.530
ANGPTL4	NMT2	psi-mi:“MI:0914”(association)	0.530
CUL3	ACOT7	psi-mi:“MI:0914”(association)	0.500
FMR1	ACOT7	psi-mi:“MI:0914”(association)	0.500
CPSF6	DDX39A	psi-mi:“MI:0914”(association)	0.480
ESR2	FBLL1	psi-mi:“MI:0914”(association)	0.460
ENG	CWC15	psi-mi:“MI:0407”(direct interaction)	0.440
	CWC15	psi-mi:“MI:0407”(direct interaction)	0.440
LRRK1	CWC15	psi-mi:“MI:0407”(direct interaction)	0.440
LRRK2	CWC15	psi-mi:“MI:0407”(direct interaction)	0.440
Prpf8		psi-mi:“MI:0915”(physical association)	0.400
Snw1	DHX15	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (178): SIRT1 (Affinity Capture-MS), CTNNBL1 (Affinity Capture-MS), SIRT5 (Affinity Capture-MS), CWC15 (Proximity Label-MS), CWC15 (Affinity Capture-MS), CWC15 (Affinity Capture-MS), CWC15 (Affinity Capture-MS), CWC15 (Affinity Capture-MS), CWC15 (Affinity Capture-MS), CWC15 (Affinity Capture-MS), CWC15 (Affinity Capture-MS), CTNNBL1 (Affinity Capture-MS), SIRT5 (Affinity Capture-MS), SIRT1 (Affinity Capture-MS), CWC15 (Affinity Capture-MS)

ESM2 similar proteins: A4IGY3, A7SD85, A8WMM4, E1C760, F4ICK8, O08837, O15541, O48713, P19351, P92948, Q0JHZ2, Q0VFP5, Q12000, Q16543, Q1RMM1, Q28Y69, Q2KJC1, Q2KJD3, Q3TIV5, Q3TQI7, Q54DA5, Q568A0, Q5BH88, Q5BJP2, Q5EAC6, Q5H7N8, Q5PQS7, Q5RC87, Q5RE65, Q67ER4, Q6A068, Q6DD06, Q6DKE6, Q6NUB2, Q6U6G5, Q7JWR9, Q803J8, Q8GX84, Q8WU90, Q93618

Diamond homologs: O45766, P78794, Q0VFP5, Q2KJD3, Q5B020, Q5BJP2, Q5RE65, Q6BP48, Q6C0E6, Q6DKE6, Q6IQU4, Q6NUB2, Q9JHS9, Q9P013, Q9V3B6, Q59PD3

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
CWC15	“form complex”	PRP19-CDC5L	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 94 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
mRNA Splicing	22	33.5×	3e-26
mRNA Splicing - Major Pathway	37	28.1×	2e-43
Processing of Capped Intron-Containing Pre-mRNA	23	26.2×	4e-25
mRNA 3’-end processing	8	21.9×	1e-07
RNA Polymerase II Transcription Termination	7	21.4×	1e-06
mRNA Polyadenylation	16	19.5×	5e-15
mRNA Splicing - Minor Pathway	6	18.7×	2e-05
Dengue Virus-Host Interactions	27	17.1×	7e-25

GO biological processes:

GO term	Partners	Fold	FDR
U2-type prespliceosome assembly	6	44.6×	8e-07
mRNA splicing, via spliceosome	32	34.9×	7e-39
spliceosomal snRNP assembly	5	34.6×	4e-05
mRNA export from nucleus	5	17.6×	8e-04
regulation of alternative mRNA splicing, via spliceosome	5	14.5×	2e-03
RNA splicing	13	13.7×	4e-09
mRNA processing	11	10.3×	2e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

18 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	7
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1039 predictions. Top by Δscore:

Variant	Effect	Δscore
11:94963510:CCCAC:C	acceptor_gain	1.0000
11:94963511:CCAC:C	acceptor_gain	1.0000
11:94963511:CCACC:C	acceptor_gain	1.0000
11:94963512:CAC:C	acceptor_gain	1.0000
11:94963512:CACC:C	acceptor_gain	1.0000
11:94963513:ACCTG:A	acceptor_loss	1.0000
11:94963514:CCT:C	acceptor_loss	1.0000
11:94963515:C:CC	acceptor_gain	1.0000
11:94966283:A:AC	donor_gain	1.0000
11:94966284:C:CC	donor_gain	1.0000
11:94966291:GTA:G	donor_loss	1.0000
11:94966294:CCTT:C	donor_gain	1.0000
11:94966297:T:A	donor_gain	1.0000
11:94966412:TC:T	acceptor_gain	1.0000
11:94966412:TCCTG:T	acceptor_loss	1.0000
11:94966413:CC:C	acceptor_gain	1.0000
11:94966413:CCTG:C	acceptor_loss	1.0000
11:94966414:C:CC	acceptor_gain	1.0000
11:94966414:CTGT:C	acceptor_loss	1.0000
11:94966418:CAA:C	acceptor_gain	1.0000
11:94966419:A:T	acceptor_gain	1.0000
11:94966420:A:AC	acceptor_gain	1.0000
11:94966420:A:C	acceptor_gain	1.0000
11:94966423:A:AC	acceptor_gain	1.0000
11:94966423:A:C	acceptor_gain	1.0000
11:94969976:A:AC	donor_gain	1.0000
11:94969977:C:CC	donor_gain	1.0000
11:94969987:ACCTT:A	donor_gain	1.0000
11:94969988:CCTT:C	donor_gain	1.0000
11:94969988:CCTTC:C	donor_gain	1.0000

AlphaMissense

1523 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:94963406:G:C	F223L	1.000
11:94963406:G:T	F223L	1.000
11:94963407:A:C	F223C	1.000
11:94963407:A:G	F223S	1.000
11:94963408:A:G	F223L	1.000
11:94963408:A:T	F223I	1.000
11:94963416:T:C	H220R	1.000
11:94963417:G:C	H220D	1.000
11:94963417:G:T	H220N	1.000
11:94963418:A:C	F219L	1.000
11:94963418:A:T	F219L	1.000
11:94963419:A:C	F219C	1.000
11:94963419:A:G	F219S	1.000
11:94963420:A:G	F219L	1.000
11:94963420:A:T	F219I	1.000
11:94963425:G:A	S217F	1.000
11:94963426:A:G	S217P	1.000
11:94963428:C:G	R216P	1.000
11:94963431:A:G	L215P	1.000
11:94963436:G:C	D213E	1.000
11:94963436:G:T	D213E	1.000
11:94963437:T:A	D213V	1.000
11:94963437:T:C	D213G	1.000
11:94963437:T:G	D213A	1.000
11:94963438:C:G	D213H	1.000
11:94963439:A:C	N212K	1.000
11:94963439:A:T	N212K	1.000
11:94963445:A:C	F210L	1.000
11:94963445:A:T	F210L	1.000
11:94963446:A:G	F210S	1.000

dbSNP variants (sampled 300 via entrez): RS1000201931 (11:94972040 A>G), RS1000547672 (11:94965258 G>A), RS1001156033 (11:94966812 T>C), RS1001522139 (11:94967174 C>T), RS1001842168 (11:94970671 G>A), RS1001871770 (11:94970365 G>A), RS1002191139 (11:94964197 T>A,C), RS1002553600 (11:94967715 A>G), RS1002760799 (11:94973838 T>C), RS1002994880 (11:94967412 T>C), RS1003408489 (11:94962802 A>G), RS1003895208 (11:94962616 A>G), RS1003967016 (11:94969116 A>G), RS1004298421 (11:94965898 T>C), RS1004405749 (11:94972989 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST000253_20	Attention deficit hyperactivity disorder and conduct disorder	2.000000e-06
GCST011741_40	LDL cholesterol levels in HIV infection	1.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004611	low density lipoprotein cholesterol measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066384 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	affects expression, increases abundance, decreases expression	2
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases expression	1
sodium arsenite	increases abundance, increases expression, affects cotreatment	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
isobutyl alcohol	affects cotreatment, decreases expression, increases abundance	1
CGP 52608	affects binding, increases reaction	1
abrine	decreases expression	1
3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	decreases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Atrazine	increases expression	1
Doxorubicin	increases expression	1
Gasoline	decreases expression, increases abundance, affects cotreatment	1
Manganese	affects cotreatment, increases abundance, increases expression	1
Ozone	affects expression, increases abundance	1
Polycyclic Aromatic Hydrocarbons	decreases expression, increases abundance, affects cotreatment	1
Smoke	decreases expression, increases abundance	1
Thiram	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Valproic Acid	affects expression	1
Aflatoxin B1	decreases methylation	1
Copper Sulfate	decreases expression	1
1-Butanol	affects cotreatment, decreases expression, increases abundance	1
Particulate Matter	affects cotreatment, decreases expression, increases abundance	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651227	Binding	Binding affinity to human CWC15 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.