CXorf51B

Summary

CXorf51B (chromosome X open reading frame 51B, HGNC:42787) is a protein-coding gene on chromosome Xq27.3, encoding Uncharacterized protein CXorf51B (P0DPH9).

At a glance

• MANE Select transcript: NM_001244892

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42787
Approved symbol	CXorf51B
Name	chromosome X open reading frame 51B
Location	Xq27.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000235699
Ensembl biotype	protein_coding
Entrez	100133053

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000438525

RefSeq mRNA: 1 — MANE Select: NM_001244892 NM_001244892

CCDS: CCDS83497

Canonical transcript exons

ENST00000438525 — 2 exons

Exon	Start	End
ENSE00001599806	146809771	146809923
ENSE00001729559	146810114	146810411

Expression profiles

Bgee: expression breadth broad, 31 present calls, max score 96.19.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0113 / max 9.9239, expressed in 3 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
209852	0.0113	3

Top tissues by expression

121 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	96.19	gold quality
testis	UBERON:0000473	95.85	gold quality
right testis	UBERON:0004534	95.73	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	95.38	gold quality
sural nerve	UBERON:0015488	37.71	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
monocyte	CL:0000576	29.18	silver quality
tonsil	UBERON:0002372	29.13	gold quality
leukocyte	CL:0000738	29.04	silver quality
duodenum	UBERON:0002114	28.14	gold quality
liver	UBERON:0002107	28.04	gold quality
lymph node	UBERON:0000029	27.57	gold quality
blood	UBERON:0000178	26.96	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
urinary bladder	UBERON:0001255	25.72	gold quality
muscle of leg	UBERON:0001383	25.23	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

8 targeting CXorf51B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-552-5P	99.93	68.56	1583
HSA-MIR-4420	99.82	70.08	1624
HSA-MIR-181B-2-3P	99.81	70.06	1646
HSA-MIR-181B-3P	99.81	70.06	1646
HSA-MIR-11399	98.71	65.69	869
HSA-MIR-653-3P	98.31	67.71	1542
HSA-MIR-649	97.96	67.21	704
HSA-MIR-490-3P	97.79	65.54	606

Cross-species orthologs

0 orthologs

Paralogs (1): CXorf51A (ENSG00000224440)

Protein

Protein identifiers

Uncharacterized protein CXorf51B — P0DPH9 (reviewed: P0DPH9)

All UniProt accessions (1): P0DPH9

RefSeq proteins (1): NP_001231821* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR040433	Spermatid_TP	Family

UniProt features (6 total): compositionally biased region 4, chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DPH9-F1	68.70	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 1 (showing top): chrXq27

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

4 interactions, top by confidence:

A	B	Type	Score
CXorf51B	AP2M1	psi-mi:“MI:0915”(physical association)	0.560
CXorf51B	AP2M1	psi-mi:“MI:0915”(physical association)	0.000

ESM2 similar proteins: A0A1B0GTR3, A0A7H0DN82, A7RR34, E9PVX6, O14598, O60356, O60829, O94243, P04605, P04614, P05909, P0C1K0, P0C765, P0C766, P0DPH9, P17285, P17759, P18098, P19416, P20290, P24109, P46012, P46583, Q06428, Q07555, Q08561, Q09821, Q1L9C7, Q32PF3, Q3KP22, Q5M948, Q5M951, Q5MJ08, Q5RCI9, Q6P8I4, Q758T8, Q76632, Q7M2N1, Q7TP40, Q80WR5

Diamond homologs: A0A1B0GTR3, P0DPH9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

688 scored. Top likely-pathogenic:

dbSNP variants (sampled 6 via entrez): RS1557052030 (X:146809744 T>C), RS1557052032 (X:146809918 G>A), RS1557052034 (X:146810110 G>A), RS879333579 (X:146808773 T>C), RS879685486 (X:146808500 C>T), RS879953135 (X:146809765 G>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.