CYB5R4

Summary

CYB5R4 (cytochrome b5 reductase 4, HGNC:20147) is a protein-coding gene on chromosome 6q14.2, encoding Cytochrome b5 reductase 4 (Q7L1T6). NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. It is a selective cancer dependency (DepMap: 18.5% of cell lines).

NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5 reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 [PubMed 10611283]).

Source: NCBI Gene 51167 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 104 total
• Cancer dependency (DepMap): dependent in 18.5% of screened cell lines
• MANE Select transcript: NM_016230

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20147
Approved symbol	CYB5R4
Name	cytochrome b5 reductase 4
Location	6q14.2
Locus type	gene with protein product
Status	Approved
Aliases	b5+b5R, dJ676J13.1
Ensembl gene	ENSG00000065615
Ensembl biotype	protein_coding
OMIM	608343
Entrez	51167

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 15 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000369679, ENST00000369681, ENST00000479164, ENST00000866276, ENST00000866277, ENST00000866278, ENST00000919968, ENST00000919969, ENST00000942763, ENST00000942764, ENST00000942765, ENST00000942766, ENST00000942767, ENST00000942768, ENST00000942769, ENST00000942770

RefSeq mRNA: 2 — MANE Select: NM_016230 NM_001400774, NM_016230

CCDS: CCDS5000

Canonical transcript exons

ENST00000369681 — 16 exons

Exon	Start	End
ENSE00000760138	83909009	83909090
ENSE00000760141	83919397	83919454
ENSE00000760143	83924470	83924592
ENSE00000798096	83893522	83893622
ENSE00000798097	83918005	83918065
ENSE00000798098	83921082	83921175
ENSE00000798099	83955298	83955462
ENSE00001012773	83922438	83922470
ENSE00001012778	83914416	83914448
ENSE00001450628	83959824	83967423
ENSE00001513536	83859689	83859857
ENSE00003466323	83864175	83864328
ENSE00003570228	83936224	83936376
ENSE00003600155	83940515	83940601
ENSE00003604818	83940056	83940206
ENSE00003684388	83934595	83934735

Expression profiles

Bgee: expression breadth ubiquitous, 257 present calls, max score 96.23.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 29.1148 / max 1502.6725, expressed in 1809 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
68781	28.9736	1809
68782	0.1412	41

Top tissues by expression

277 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	96.23	gold quality
mononuclear cell	CL:0000842	95.89	gold quality
leukocyte	CL:0000738	95.73	gold quality
sperm	CL:0000019	95.04	gold quality
blood	UBERON:0000178	93.04	gold quality
male germ cell	CL:0000015	92.56	gold quality
bone marrow	UBERON:0002371	90.34	gold quality
granulocyte	CL:0000094	90.20	gold quality
bone marrow cell	CL:0002092	89.21	gold quality
right testis	UBERON:0004534	89.05	gold quality
left testis	UBERON:0004533	88.70	gold quality
vermiform appendix	UBERON:0001154	88.05	gold quality
islet of Langerhans	UBERON:0000006	87.59	gold quality
testis	UBERON:0000473	86.84	gold quality
rectum	UBERON:0001052	85.71	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.12	gold quality
calcaneal tendon	UBERON:0003701	85.08	gold quality
lymph node	UBERON:0000029	83.60	gold quality
popliteal artery	UBERON:0002250	83.27	gold quality
tibial artery	UBERON:0007610	83.26	gold quality
ganglionic eminence	UBERON:0004023	83.22	gold quality
descending thoracic aorta	UBERON:0002345	82.75	gold quality
cortical plate	UBERON:0005343	82.75	gold quality
right lung	UBERON:0002167	82.66	gold quality
aorta	UBERON:0000947	82.29	gold quality
caecum	UBERON:0001153	82.19	gold quality
gastrocnemius	UBERON:0001388	82.12	gold quality
spleen	UBERON:0002106	82.08	gold quality
left coronary artery	UBERON:0001626	82.00	gold quality
muscle of leg	UBERON:0001383	81.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.43

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

70 targeting CYB5R4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-590-3P	99.96	74.34	6478
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-137-3P	99.87	74.74	2401
HSA-MIR-3941	99.86	70.54	2735
HSA-MIR-520F-3P	99.82	71.32	1216
HSA-MIR-4307	99.82	70.45	3374
HSA-MIR-8080	99.82	67.52	1342
HSA-MIR-4639-5P	99.81	67.37	1028
HSA-MIR-3133	99.81	70.92	3506
HSA-MIR-577	99.78	69.13	2479
HSA-MIR-199A-3P	99.75	70.48	929
HSA-MIR-199B-3P	99.75	70.48	929
HSA-MIR-3129-5P	99.75	70.46	914
HSA-MIR-4320	99.75	65.80	793
HSA-MIR-3617-5P	99.75	69.41	1968
HSA-MIR-641	99.75	69.35	1975
HSA-MIR-148A-3P	99.74	73.77	1700
HSA-MIR-148B-3P	99.74	73.75	1700

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 18.5% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 7)

• NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum (PMID:15131110)
• Variaation in the coding region is not a major contributor in the pathogenesis of nonautoimmune diabetes. (PMID:15504981)
• Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain. (PMID:20630863)
• Mutation in cytochrome b5 reductase is associated with developmental delay and severe neurological problems. (PMID:22627575)
• data provide first evidence for natural mutations in NCB5OR gene resulting in decreased protein levels and hence having potential implications in human pathology. (PMID:23523930)
• Cytosolic localization of NADH cytochrome b oxidoreductase (PMID:26878259)
• The N-terminal intrinsically disordered region of Ncb5or docks with the cytochrome b5 core to form a helical motif that is of ancient origin. (PMID:38041394)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	cyb5r4	ENSDARG00000020898
mus_musculus	Cyb5r4	ENSMUSG00000032872
rattus_norvegicus	Cyb5r4	ENSRNOG00000010024
drosophila_melanogaster	CG11257	FBGN0034442
caenorhabditis_elegans	Y52B11A.3	WBGENE00013123

Paralogs (5): CYB5R3 (ENSG00000100243), OXNAD1 (ENSG00000154814), CYB5R1 (ENSG00000159348), CYB5R2 (ENSG00000166394), CYB5RL (ENSG00000215883)

Protein

Protein identifiers

Cytochrome b5 reductase 4 — Q7L1T6 (reviewed: Q7L1T6)

Alternative names: Flavohemoprotein b5/b5R, N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein, cb5/cb5R

All UniProt accessions (2): Q7L1T6, A0A0A0MRM6

UniProt curated annotations — full annotation on UniProt →

Function. NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.

Subcellular location. Endoplasmic reticulum.

Tissue specificity. Widely expressed.

Polymorphism. Variants Arg-187 and Arg-223 do not influence the pathogenesis of non-autoimmune diabetes.

Similarity. Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

RefSeq proteins (2): NP_001387703, NP_057314* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001199	Cyt_B5-like_heme/steroid-bd	Domain
IPR001433	OxRdtase_FAD/NAD-bd	Domain
IPR007052	CS_dom	Domain
IPR008333	Cbr1-like_FAD-bd_dom	Domain
IPR008978	HSP20-like_chaperone	Homologous_superfamily
IPR017927	FAD-bd_FR_type	Domain
IPR017938	Riboflavin_synthase-like_b-brl	Homologous_superfamily
IPR018506	Cyt_B5_heme-BS	Binding_site
IPR036400	Cyt_B5-like_heme/steroid_sf	Homologous_superfamily
IPR037908	p23_NCB5OR	Domain
IPR039261	FNR_nucleotide-bd	Homologous_superfamily
IPR051872	Cytochrome_b5/Flavoprotein_Rdt	Family

Pfam: PF00173, PF00175, PF00970, PF04969

Enzyme classification (BRENDA):

• EC 1.6.2.2 — cytochrome-b5 reductase (BRENDA: 34 organisms, 101 substrates, 111 inhibitors, 300 Km, 221 kcat entries)

Substrate kinetics (BRENDA)

23 substrates with measured Km, best-characterized 15. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
NADH	0.0002–3.32	94
FERRICYANIDE	0.0006–4.35	72
FERRICYTOCHROME B5	—	66
CYTOCHROME B5	0.0011–0.042	19
NADPH	0.001–7.69	17
FERROCYTOCHROME B5	0.001–0.107	6
FERRICYTOCHOME B5	0.01–0.013	4
FERRICYTOCHROME C	0.0003–0.007	3
OXIDIZED 2,6-DICHLOROPHENOLINDOPHENOL	0.328–0.83	2
1,4-NAPHTHOQUINONE	0.0098	1
2-HYDROXYESTRADIOL	0.0026	1
2-METHYL-1,4-NAPHTHOQUINONE	0.077	1
9,10-PHENANTHRENEQUINONE	0.0057	1
AQUACOBALAMIN	0.0419	1
BENZAMIDOXIME	0.63	1

Catalyzed reactions (Rhea), 1 shown:

• 2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+) (RHEA:46680)

UniProt features (65 total): strand 24, helix 17, sequence variant 8, turn 5, binding site 4, domain 3, chain 1, modified residue 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
3LF5	X-RAY DIFFRACTION	1.25
6MV2	X-RAY DIFFRACTION	2.05
6MV1	X-RAY DIFFRACTION	2.15

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7L1T6-F1	87.02	0.71

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 89 (axial binding residue); 112 (axial binding residue); 365–380; 392–424

Post-translational modifications (1): 1

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-1237044	Erythrocytes take up carbon dioxide and release oxygen
R-HSA-1480926	O2/CO2 exchange in erythrocytes
R-HSA-382551	Transport of small molecules

MSigDB gene sets: 182 (showing top): GOBP_INSULIN_SECRETION, GOBP_REGULATION_OF_HORMONE_LEVELS, GOBP_SUPEROXIDE_METABOLIC_PROCESS, GOBP_HORMONE_TRANSPORT, GOBP_CELL_CELL_SIGNALING, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, GOBP_RESPONSE_TO_OXYGEN_LEVELS, TGCTGAY_UNKNOWN, TGIF_01, GOBP_ORGANIC_ANION_TRANSPORT, GOBP_BICARBONATE_TRANSPORT, GOBP_SECRETION, GOBP_SIGNAL_RELEASE, GOBP_RESPONSE_TO_ABIOTIC_STIMULUS, GOBP_CARBOHYDRATE_HOMEOSTASIS

GO Biological Process (8): detection of oxygen (GO:0003032), superoxide metabolic process (GO:0006801), bicarbonate transport (GO:0015701), insulin secretion (GO:0030073), glucose homeostasis (GO:0042593), response to antibiotic (GO:0046677), cell development (GO:0048468), reactive oxygen species metabolic process (GO:0072593)

GO Molecular Function (7): cytochrome-b5 reductase activity, acting on NAD(P)H (GO:0004128), NAD(P)H oxidase H2O2-forming activity (GO:0016174), oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor (GO:0016653), heme binding (GO:0020037), metal ion binding (GO:0046872), cytochrome-b5 reductase activity, acting on NADH (GO:0090524), oxidoreductase activity (GO:0016491)

GO Cellular Component (4): cytoplasm (GO:0005737), endoplasmic reticulum (GO:0005783), endoplasmic reticulum membrane (GO:0005789), perinuclear region of cytoplasm (GO:0048471)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
O2/CO2 exchange in erythrocytes	1
Transport of small molecules	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
cytoplasm	2
detection of chemical stimulus	1
response to oxygen levels	1
reactive oxygen species metabolic process	1
transport	1
protein secretion	1
peptide hormone secretion	1
carbohydrate homeostasis	1
response to chemical	1
cell differentiation	1
anatomical structure development	1
cellular developmental process	1
metabolic process	1
oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	1
oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	1
oxidoreductase activity, acting on NAD(P)H	1
tetrapyrrole binding	1
cation binding	1
cytochrome-b5 reductase activity, acting on NAD(P)H	1
catalytic activity	1
intracellular anatomical structure	1
endomembrane system	1
intracellular membrane-bounded organelle	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1

Protein interactions and networks

STRING

4264 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CYB5R4	CYB5B	O43169	965
CYB5R4	CYB5A	P00167	965
CYB5R4	SCD	O00767	868
CYB5R4	CYCS	P00001	717
CYB5R4	POR	P16435	685
CYB5R4	DHODH	Q02127	606
CYB5R4	PPY	P01298	582
CYB5R4	SCD5	Q86SK9	519
CYB5R4	FDXR	P22570	512
CYB5R4	SUOX	P51687	507
CYB5R4	CYP51A1	Q16850	504
CYB5R4	RIPPLY2	Q5TAB7	479
CYB5R4	HBA1	P01922	466
CYB5R4	MT-CYB	P00156	466
CYB5R4	FADS1	O60427	464

IntAct

3 interactions, top by confidence:

A	B	Type	Score
CYB5R4	PNLIPRP2	psi-mi:“MI:0915”(physical association)	0.400
N		psi-mi:“MI:0914”(association)	0.350

BioGRID (6): CYB5R4 (Negative Genetic), CYB5R4 (Affinity Capture-RNA), PNLIPRP2 (Affinity Capture-MS), CYB5R4 (Co-fractionation), CYB5R4 (Affinity Capture-RNA), CYB5R4 (Two-hybrid)

ESM2 similar proteins: A0AVT1, A0JMM9, A2RVS4, A3KMX8, A3KNL6, A6H630, A8MRP2, D2TN58, O74834, P0AE48, P0AE49, P0AE50, P0AE51, P35875, P38074, P41888, P54121, P87305, Q16P90, Q32LH7, Q4H4F0, Q4R526, Q58EM4, Q5SPB6, Q66I06, Q66KX0, Q6AXB1, Q6DJA3, Q6INN8, Q7L1T6, Q7TS68, Q84QC1, Q8GY54, Q8IU29, Q8IXY8, Q8RX87, Q8TEA1, Q9C5X8, Q9FIX1, Q9FIX2

Diamond homologs: A0A0C5PRW9, A0A286R227, A4FV48, A4IFP3, A4UVI1, A8MWK0, B2KKL4, B7GCG7, B8MKR3, B8R1K0, C8VJR5, D8X2C5, O04354, O22704, O43169, O48845, O60427, O74875, O94391, O95864, P00167, P00168, P00169, P00170, P00171, P00172, P00173, P00174, P00175, P04166, P08509, P08619, P09437, P11035, P11605, P11832, P17569, P17570, P17571, P23312

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

104 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	73
Likely benign	3
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

3105 predictions. Top by Δscore:

Variant	Effect	Δscore
6:83859854:CAAG:C	donor_loss	1.0000
6:83859855:AAGG:A	donor_loss	1.0000
6:83859858:GTAA:G	donor_loss	1.0000
6:83859859:T:G	donor_loss	1.0000
6:83864173:A:AC	acceptor_loss	1.0000
6:83864173:A:AG	acceptor_gain	1.0000
6:83864173:AG:A	acceptor_gain	1.0000
6:83864174:G:GC	acceptor_gain	1.0000
6:83864174:GG:G	acceptor_gain	1.0000
6:83864174:GGT:G	acceptor_gain	1.0000
6:83864174:GGTA:G	acceptor_gain	1.0000
6:83864174:GGTAC:G	acceptor_gain	1.0000
6:83864326:GAG:G	donor_gain	1.0000
6:83864329:G:GG	donor_gain	1.0000
6:83864330:T:A	donor_loss	1.0000
6:83893514:T:TA	acceptor_gain	1.0000
6:83893519:CAGGT:C	acceptor_loss	1.0000
6:83893520:A:AG	acceptor_gain	1.0000
6:83893520:AGGTT:A	acceptor_loss	1.0000
6:83893521:G:GG	acceptor_gain	1.0000
6:83893521:G:GT	acceptor_loss	1.0000
6:83893521:GGT:G	acceptor_gain	1.0000
6:83893620:CAG:C	donor_loss	1.0000
6:83893621:AG:A	donor_loss	1.0000
6:83893622:GG:G	donor_loss	1.0000
6:83893623:G:GC	donor_loss	1.0000
6:83893624:T:A	donor_loss	1.0000
6:83909001:C:G	acceptor_gain	1.0000
6:83909002:A:AG	acceptor_gain	1.0000
6:83909003:T:G	acceptor_gain	1.0000

AlphaMissense

3453 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:83864208:T:A	W37R	0.999
6:83864208:T:C	W37R	0.999
6:83893528:T:A	V79D	0.999
6:83909018:T:A	W114R	0.999
6:83909018:T:C	W114R	0.999
6:83909020:G:C	W114C	0.999
6:83909020:G:T	W114C	0.999
6:83864210:G:C	W37C	0.998
6:83864210:G:T	W37C	0.998
6:83864313:T:A	W72R	0.998
6:83864313:T:C	W72R	0.998
6:83893530:T:G	Y80D	0.998
6:83893557:C:G	H89D	0.998
6:83893614:T:C	F108L	0.998
6:83893616:T:A	F108L	0.998
6:83893616:T:G	F108L	0.998
6:83864284:T:C	L62P	0.997
6:83893537:T:A	V82D	0.997
6:83893559:T:A	H89Q	0.997
6:83893559:T:G	H89Q	0.997
6:83909012:C:G	H112D	0.997
6:83909040:T:C	L121P	0.997
6:83909055:T:A	V126D	0.996
6:83864209:G:C	W37S	0.995
6:83893594:G:A	G101E	0.995
6:83893615:T:G	F108C	0.995
6:83909048:T:C	C124R	0.995
6:83864315:G:C	W72C	0.994
6:83864315:G:T	W72C	0.994
6:83864326:G:T	R76I	0.994

dbSNP variants (sampled 300 via entrez): RS1000025040 (6:83921551 G>A), RS1000050890 (6:83935056 A>G), RS1000050902 (6:83902874 T>C), RS1000122358 (6:83933337 T>A), RS1000139262 (6:83914691 C>A,T), RS1000174311 (6:83959791 C>T), RS1000174910 (6:83898693 T>C), RS1000209883 (6:83947091 A>G), RS1000213251 (6:83914432 A>G), RS1000254577 (6:83870374 G>A,T), RS1000302010 (6:83881328 C>G,T), RS1000315576 (6:83914856 T>A), RS1000352673 (6:83921403 A>C,G), RS1000355619 (6:83877308 A>G), RS1000359193 (6:83953253 TATTTG>T)

Disease associations

OMIM: gene MIM:608343 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST012490_226	Femur bone mineral density x serum urate levels interaction	3.000000e-10

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004531	urate measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	5
aristolochic acid I	decreases expression	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
jinfukang	decreases expression	1
Vorinostat	increases expression	1
Benzo(a)pyrene	affects methylation	1
Calcitriol	increases expression	1
Carbamazepine	affects expression	1
Cisplatin	decreases expression	1
Succimer	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Estradiol	increases expression	1
Ivermectin	decreases expression	1
Nickel	increases expression	1
Silicon Dioxide	decreases expression, increases methylation	1
Sodium Dodecyl Sulfate	decreases expression	1
Thimerosal	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	increases expression	1
Cyclosporine	increases expression	1
Aflatoxin B1	increases expression	1
Asbestos, Crocidolite	affects expression	1
Antirheumatic Agents	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E1UX	HAP1 CYB5R4 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.