CYLD-AS1

Summary

CYLD-AS1 (CYLD antisense RNA 1, HGNC:55352) is a long non-coding RNA gene on chromosome 16q12.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55352
Approved symbol	CYLD-AS1
Name	CYLD antisense RNA 1
Location	16q12.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000261644
Ensembl biotype	lncRNA
Entrez	102724907
RNAcentral	URS00026A2177 — lncRNA, 2708 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000563315, ENST00000567728, ENST00000688175, ENST00000756782, ENST00000756783, ENST00000756784, ENST00000756785, ENST00000756786, ENST00000756787, ENST00000756788, ENST00000756789, ENST00000756790

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000563315 — 6 exons

Exon	Start	End
ENSE00002606565	50742671	50742815
ENSE00002623363	50740680	50741404
ENSE00003791971	50732218	50732360
ENSE00003792792	50729843	50729953
ENSE00003793289	50729013	50729150
ENSE00003799463	50727417	50728450

Expression profiles

Bgee: expression breadth ubiquitous, 126 present calls, max score 82.12.

Top tissues by expression

126 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	82.12	gold quality
monocyte	CL:0000576	80.83	gold quality
leukocyte	CL:0000738	80.55	gold quality
blood	UBERON:0000178	78.77	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.93	gold quality
bone marrow cell	CL:0002092	74.74	gold quality
lymph node	UBERON:0000029	74.72	gold quality
spleen	UBERON:0002106	74.49	gold quality
bone marrow	UBERON:0002371	74.08	gold quality
vermiform appendix	UBERON:0001154	73.98	gold quality
tonsil	UBERON:0002372	69.72	gold quality
right adrenal gland cortex	UBERON:0035827	66.11	gold quality
right coronary artery	UBERON:0001625	66.00	gold quality
right adrenal gland	UBERON:0001233	65.24	gold quality
ascending aorta	UBERON:0001496	64.53	gold quality
left adrenal gland	UBERON:0001234	64.51	gold quality
thoracic aorta	UBERON:0001515	64.45	gold quality
left adrenal gland cortex	UBERON:0035825	64.20	gold quality
adrenal gland	UBERON:0002369	64.13	gold quality
popliteal artery	UBERON:0002250	64.06	gold quality
tibial artery	UBERON:0007610	64.05	gold quality
rectum	UBERON:0001052	63.81	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.32	gold quality
small intestine	UBERON:0002108	62.22	gold quality
gastrocnemius	UBERON:0001388	61.96	gold quality
stromal cell of endometrium	CL:0002255	61.78	gold quality
muscle of leg	UBERON:0001383	61.41	gold quality
colonic epithelium	UBERON:0000397	61.20	silver quality
duodenum	UBERON:0002114	61.07	gold quality
upper lobe of left lung	UBERON:0008952	60.99	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Oxidative stress-induced lncRNA CYLD-AS1 promotes RPE inflammation via Nrf2/miR-134-5p/NF-kappaB signaling pathway. (PMID:36165267)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.