CYP1B1-AS1

Summary

CYP1B1-AS1 (CYP1B1 antisense RNA 1, HGNC:28543) is a long non-coding RNA gene on chromosome 2p22.2.

Predicted to enable U4 snRNA binding activity. Predicted to be involved in formation of quadruple SL/U4/U5/U6 snRNP and spliceosomal tri-snRNP complex assembly. Predicted to be part of U4/U6 x U5 tri-snRNP complex and U6 snRNP.

Source: NCBI Gene 285154 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28543
Approved symbol	CYP1B1-AS1
Name	CYP1B1 antisense RNA 1
Location	2p22.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	MGC34824
Ensembl gene	ENSG00000232973
Ensembl biotype	lncRNA
Entrez	285154
RNAcentral	URS000075B013 — lncRNA, 1776 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 78 — 78 lncRNA

ENST00000413828, ENST00000427168, ENST00000585654, ENST00000589303, ENST00000593090, ENST00000603809, ENST00000606100, ENST00000606849, ENST00000609128, ENST00000609565, ENST00000610024, ENST00000610172, ENST00000612373, ENST00000620177, ENST00000625348, ENST00000626166, ENST00000626456, ENST00000626582, ENST00000626718, ENST00000626865, ENST00000627172, ENST00000627992, ENST00000628097, ENST00000628135, ENST00000628165, ENST00000628232, ENST00000628238, ENST00000628580, ENST00000629439, ENST00000629547, ENST00000629719, ENST00000629773, ENST00000630542, ENST00000630623, ENST00000630658, ENST00000653077, ENST00000653994, ENST00000657397, ENST00000660098, ENST00000660493, ENST00000767219, ENST00000767220, ENST00000767221, ENST00000767222, ENST00000767223, ENST00000767224, ENST00000767225, ENST00000767226, ENST00000767227, ENST00000767228, ENST00000767229, ENST00000767230, ENST00000767231, ENST00000767232, ENST00000767233, ENST00000767234, ENST00000767235, ENST00000767236, ENST00000767237, ENST00000767238, ENST00000767239, ENST00000767240, ENST00000767241, ENST00000767242, ENST00000767243, ENST00000767244, ENST00000767245, ENST00000767246, ENST00000767247, ENST00000767248, ENST00000767249, ENST00000767250, ENST00000767251, ENST00000767252, ENST00000767253, ENST00000767254, ENST00000767255, ENST00000767256

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000413828 — 4 exons

Exon	Start	End
ENSE00001671350	38131511	38131614
ENSE00001706852	38131089	38131190
ENSE00001768388	38180289	38181855
ENSE00003765177	38108073	38108080

Expression profiles

Bgee: expression breadth ubiquitous, 161 present calls, max score 91.65.

FANTOM5 (CAGE): breadth broad, TPM avg 1.2576 / max 39.9712, expressed in 442 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
19820	0.7256	274
19824	0.2790	134
19819	0.2531	116

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	91.65	gold quality
tibial nerve	UBERON:0001323	87.47	gold quality
colonic epithelium	UBERON:0000397	84.91	gold quality
monocyte	CL:0000576	84.61	gold quality
leukocyte	CL:0000738	84.05	gold quality
calcaneal tendon	UBERON:0003701	82.30	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.87	gold quality
left uterine tube	UBERON:0001303	81.34	gold quality
body of uterus	UBERON:0009853	80.68	gold quality
omental fat pad	UBERON:0010414	76.70	gold quality
peritoneum	UBERON:0002358	76.61	gold quality
endocervix	UBERON:0000458	76.35	gold quality
bone marrow cell	CL:0002092	76.14	gold quality
apex of heart	UBERON:0002098	75.46	gold quality
right uterine tube	UBERON:0001302	75.15	gold quality
adrenal tissue	UBERON:0018303	75.14	gold quality
ectocervix	UBERON:0012249	74.91	gold quality
lower esophagus mucosa	UBERON:0035834	74.86	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	74.76	gold quality
adipose tissue of abdominal region	UBERON:0007808	74.74	gold quality
uterine cervix	UBERON:0000002	73.96	gold quality
right atrium auricular region	UBERON:0006631	73.73	gold quality
granulocyte	CL:0000094	73.37	gold quality
smooth muscle tissue	UBERON:0001135	73.33	gold quality
skin of leg	UBERON:0001511	73.12	gold quality
mucosa of stomach	UBERON:0001199	73.09	gold quality
cardiac atrium	UBERON:0002081	72.88	gold quality
mucosa of transverse colon	UBERON:0004991	72.72	gold quality
small intestine Peyer’s patch	UBERON:0003454	72.38	gold quality
right adrenal gland cortex	UBERON:0035827	72.36	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	9.89
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Functional variant rs10175368 which affects the expression of CYP1B1 plays a protective role against breast cancer in a Chinese Han population. (PMID:37038992)
• FOXO1-regulated lncRNA CYP1B1-AS1 suppresses breast cancer cell proliferation by inhibiting neddylation. (PMID:37640964)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.