CYP2U1-AS1

Summary

CYP2U1-AS1 (CYP2U1 and SGMS2 antisense RNA 1, HGNC:54817) is a long non-coding RNA gene on chromosome 4q25.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54817
Approved symbol	CYP2U1-AS1
Name	CYP2U1 and SGMS2 antisense RNA 1
Location	4q25
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000245293
Ensembl biotype	lncRNA
Entrez	101929595
RNAcentral	URS0000580EA9 — lncRNA, 2810 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 21 — 21 lncRNA

ENST00000499098, ENST00000512428, ENST00000513071, ENST00000656249, ENST00000656358, ENST00000658105, ENST00000668082, ENST00000668384, ENST00000686573, ENST00000687236, ENST00000702404, ENST00000781789, ENST00000781790, ENST00000781791, ENST00000781792, ENST00000781793, ENST00000781794, ENST00000781795, ENST00000781796, ENST00000781797, ENST00000781946

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000499098 — 7 exons

Exon	Start	End
ENSE00001962569	107893067	107893637
ENSE00001965592	107886667	107886826
ENSE00001970380	107863479	107864446
ENSE00001971316	107873330	107873444
ENSE00001983897	107866908	107867645
ENSE00001986482	107931971	107932119
ENSE00001990580	107873980	107874088

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 94.03.

FANTOM5 (CAGE): breadth broad, TPM avg 2.0305 / max 143.5361, expressed in 531 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
53513	1.2465	458
53511	0.5233	86
53512	0.1740	92
53508	0.0318	9
53509	0.0313	15
53510	0.0236	14

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
C1 segment of cervical spinal cord	UBERON:0006469	94.03	gold quality
corpus callosum	UBERON:0002336	92.25	gold quality
substantia nigra	UBERON:0002038	90.26	gold quality
Ammon’s horn	UBERON:0001954	86.26	gold quality
putamen	UBERON:0001874	84.21	gold quality
amygdala	UBERON:0001876	84.16	gold quality
temporal lobe	UBERON:0001871	83.87	gold quality
hypothalamus	UBERON:0001898	82.16	gold quality
primary visual cortex	UBERON:0002436	82.10	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.57	gold quality
caudate nucleus	UBERON:0001873	78.52	gold quality
cerebral cortex	UBERON:0000956	76.38	gold quality
nucleus accumbens	UBERON:0001882	76.25	gold quality
prefrontal cortex	UBERON:0000451	75.66	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	74.88	gold quality
frontal cortex	UBERON:0001870	74.67	gold quality
brain	UBERON:0000955	74.66	gold quality
Brodmann (1909) area 9	UBERON:0013540	74.58	gold quality
skeletal muscle tissue	UBERON:0001134	74.38	gold quality
anterior cingulate cortex	UBERON:0009835	74.19	gold quality
superior frontal gyrus	UBERON:0002661	73.72	gold quality
right frontal lobe	UBERON:0002810	73.10	gold quality
colonic epithelium	UBERON:0000397	72.68	gold quality
hindlimb stylopod muscle	UBERON:0004252	72.44	gold quality
heart left ventricle	UBERON:0002084	71.91	gold quality
muscle of leg	UBERON:0001383	71.33	gold quality
liver	UBERON:0002107	71.22	gold quality
gastrocnemius	UBERON:0001388	71.12	gold quality
islet of Langerhans	UBERON:0000006	71.07	gold quality
muscle tissue	UBERON:0002385	70.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.26

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.