CYTIP

Summary

CYTIP (cytohesin 1 interacting protein, HGNC:9506) is a protein-coding gene on chromosome 2q24.1, encoding Cytohesin-interacting protein (O60759). By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.

The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, but does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells. The encoded protein modulates the activation of ARF genes by CYTH1. This protein interacts with CYTH1 and SNX27 proteins and may act to sequester CYTH1 protein in the cytoplasm.

Source: NCBI Gene 9595 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 59 total — 1 pathogenic
• MANE Select transcript: NM_004288

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:9506
Approved symbol	CYTIP
Name	cytohesin 1 interacting protein
Location	2q24.1
Locus type	gene with protein product
Status	Approved
Aliases	B3-1, HE, CYBR, CASP, CYTHIP
Ensembl gene	ENSG00000115165
Ensembl biotype	protein_coding
OMIM	604448
Entrez	9595

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 5 protein_coding, 2 retained_intron, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000264192, ENST00000418920, ENST00000435117, ENST00000439355, ENST00000457793, ENST00000462109, ENST00000483929, ENST00000497432, ENST00000715893

RefSeq mRNA: 1 — MANE Select: NM_004288 NM_004288

CCDS: CCDS2204

Canonical transcript exons

ENST00000264192 — 8 exons

Exon	Start	End
ENSE00003470059	157427351	157427420
ENSE00003527985	157434370	157434424
ENSE00003591902	157430559	157430652
ENSE00003592117	157418523	157418589
ENSE00003631586	157430860	157430962
ENSE00003648172	157434698	157434747
ENSE00004028266	157443847	157444089
ENSE00004028268	157414619	157416143

Expression profiles

Bgee: expression breadth ubiquitous, 242 present calls, max score 98.33.

FANTOM5 (CAGE): breadth broad, TPM avg 68.6237 / max 6897.0224, expressed in 540 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
31399	59.2705	496
31398	7.7354	340
31397	0.8976	175
31389	0.3083	83
31405	0.2350	51
31390	0.1073	62
31391	0.0525	31
31404	0.0171	11

Top tissues by expression

285 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	98.33	gold quality
bone marrow cell	CL:0002092	96.38	gold quality
leukocyte	CL:0000738	96.33	gold quality
monocyte	CL:0000576	96.32	gold quality
mononuclear cell	CL:0000842	96.31	gold quality
vermiform appendix	UBERON:0001154	96.25	gold quality
bone marrow	UBERON:0002371	95.45	gold quality
lymph node	UBERON:0000029	95.40	gold quality
granulocyte	CL:0000094	94.39	gold quality
colonic epithelium	UBERON:0000397	93.84	gold quality
epithelium of nasopharynx	UBERON:0001951	92.95	gold quality
nasopharynx	UBERON:0001728	92.94	gold quality
spleen	UBERON:0002106	92.40	gold quality
caecum	UBERON:0001153	91.96	gold quality
tonsil	UBERON:0002372	91.84	gold quality
jejunal mucosa	UBERON:0000399	88.33	gold quality
periodontal ligament	UBERON:0008266	86.92	gold quality
right lung	UBERON:0002167	86.78	gold quality
pylorus	UBERON:0001166	86.65	gold quality
upper lobe of left lung	UBERON:0008952	86.01	gold quality
rectum	UBERON:0001052	85.93	gold quality
duodenum	UBERON:0002114	85.69	gold quality
upper lobe of lung	UBERON:0008948	85.48	gold quality
palpebral conjunctiva	UBERON:0001812	85.42	gold quality
amniotic fluid	UBERON:0000173	84.20	gold quality
parotid gland	UBERON:0001831	84.18	gold quality
gall bladder	UBERON:0002110	84.12	gold quality
small intestine Peyer’s patch	UBERON:0003454	84.10	gold quality
trabecular bone tissue	UBERON:0002483	83.57	gold quality
small intestine	UBERON:0002108	83.45	gold quality

Single-cell (SCXA)

Detected in 18 experiment(s), a significant marker in 18.

Experiment	Marker?	Max mean expression
E-MTAB-8142	yes	1410.42
E-HCAD-36	yes	863.82
E-CURD-79	yes	577.40
E-GEOD-135922	yes	384.61
E-HCAD-8	yes	88.93
E-HCAD-1	yes	86.64
E-CURD-122	yes	48.25
E-CURD-46	yes	40.53
E-MTAB-8410	yes	38.72
E-CURD-88	yes	36.79
E-MTAB-10287	yes	30.01
E-HCAD-10	yes	23.22
E-HCAD-11	yes	21.50
E-MTAB-10553	yes	13.82
E-MTAB-8498	yes	8.86

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

82 targeting CYTIP, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-223-3P	99.99	70.14	1140
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-6508-5P	99.92	70.67	2465
HSA-MIR-450B-5P	99.92	71.48	3175
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-8067	99.86	69.59	2260

Literature-anchored findings (GeneRIF, showing 7)

• observations suggest that CASP is a scaffolding protein that facilitates the function of at least one member of the cytohesin/ARNO family in response to specific cellular stimuli (PMID:12052827)
• Cybr not only regulates lymphocyte adhesion and cell-cell interaction but also contributes to the regulation of the signaling cascade and of the genetic program downstream of the T cell receptor. (PMID:16702224)
• These results suggest that endosomal SNX27 may recruit CASP to orchestrate intracellular trafficking and/or signaling complexes. (PMID:17577583)
• on infection of human monocyte-derived dendritic cells with herpes simplex virus type 1 (HSV-1), CYTIP is rapidly degraded and as a consequence beta-2 integrins, predominantly LFA-1, are activated (PMID:21562043)
• loss of DNA methylation enables HIF-driven cytohesin 1 interacting protein expression to protect cancer cells from death cytokine signals (PMID:23223005)
• a newly identified binding partner of CYTIP, SOCS-1, and confirm its function in regulating the degradation of CYTIP by the proteasome (PMID:23469018)
• CASP has a direct role in the secretion of IFN-gamma, and NK cell motility and ability to kill tumor cells. CASP polarizes to the leading edge of migrating NK cells, and to the immunological synapse when engaged with tumor cells. (PMID:25058460)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	cytip	ENSDARG00000061717
mus_musculus	Cytip	ENSMUSG00000026832
rattus_norvegicus	Cytip	ENSRNOG00000004772
drosophila_melanogaster	ssp6	FBGN0035676
caenorhabditis_elegans	gras-1	WBGENE00009272

Paralogs (1): TAMALIN (ENSG00000161835)

Protein

Protein identifiers

Cytohesin-interacting protein — O60759 (reviewed: O60759)

Alternative names: Cytohesin binder and regulator, Cytohesin-associated scaffolding protein, Cytohesin-binding protein HE, Pleckstrin homology Sec7 and coiled-coil domains-binding protein

All UniProt accessions (5): C9JNN8, C9JRF8, C9JSM2, O60759, F8WF61

UniProt curated annotations — full annotation on UniProt →

Function. By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.

Subunit / interactions. Interacts with CYTH1 and SNX27.

Subcellular location. Cytoplasm. Early endosome.

Tissue specificity. Expressed in lymph nodes, thymus, spleen, lung, peripheral blood leukocytes and bone marrow.

Induction. By TNF and bacterial lipopolysaccharides (LPS).

Isoforms (2)

UniProt ID	Names	Canonical?
O60759-1	1	yes
O60759-2	2

RefSeq proteins (1): NP_004279* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001478	PDZ	Domain
IPR036034	PDZ_sf	Homologous_superfamily
IPR052122	Intracell_Traff_Signaling_Reg	Family

Pfam: PF00595

UniProt features (21 total): strand 5, mutagenesis site 3, sequence variant 3, sequence conflict 2, helix 2, chain 1, domain 1, turn 1, region of interest 1, coiled-coil region 1, splice variant 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
2Z17	X-RAY DIFFRACTION	2.7

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O60759-F1	63.24	0.27

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Mutagenesis-validated functional residues (3):

Position	Phenotype
92	no membrane-association. no change in the binding to cyth1; when associated with e-82 and a-90.
82	no membrane-association. no change in the binding to cyth1; when associated with a-90 and a-92.
90	no membrane-association. no change in the binding to cyth1; when associated with e-82 and a-92.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 300 (showing top): GSE45365_NK_CELL_VS_CD11B_DC_DN, WALLACE_PROSTATE_CANCER_RACE_UP, MCLACHLAN_DENTAL_CARIES_UP, GNF2_CASP8, RACCACAR_AML_Q6, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP, LINDSTEDT_DENDRITIC_CELL_MATURATION_B, RHEIN_ALL_GLUCOCORTICOID_THERAPY_UP, AML_Q6, chr2q24, SU_THYMUS, LEE_EARLY_T_LYMPHOCYTE_DN, ONDER_CDH1_TARGETS_2_UP, GNF2_CD97, COATES_MACROPHAGE_M1_VS_M2_DN

GO Biological Process (1): regulation of cell adhesion (GO:0030155)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (6): nucleoplasm (GO:0005654), cytoplasm (GO:0005737), early endosome (GO:0005769), cytosol (GO:0005829), cell cortex (GO:0005938), endosome (GO:0005768)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
cytoplasm	2
cell adhesion	1
regulation of cellular process	1
binding	1
nuclear lumen	1
intracellular anatomical structure	1
endosome	1
cell periphery	1
endomembrane system	1
cytoplasmic vesicle	1

Protein interactions and networks

STRING

1542 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
CYTIP	SNX27	Q96L92	957
CYTIP	CYTH1	Q15438	936
CYTIP	CYTH3	O43739	747
CYTIP	SERPINB3	P29508	742
CYTIP	DGKZ	Q13574	713
CYTIP	RAB11A	P24410	497
CYTIP	TFRC	P02786	423
CYTIP	SERPINE2	P07093	365
CYTIP	TMEM86A	Q8N2M4	351
CYTIP	LHFPL2	Q6ZUX7	322
CYTIP	GPR157	Q5UAW9	318
CYTIP	SNX1	Q13596	317
CYTIP	SLCO6A1	Q86UG4	314
CYTIP	GPA33	Q99795	293
CYTIP	LZTS2	Q9BRK4	293
CYTIP	RPP21	Q9H633	293

IntAct

184 interactions, top by confidence:

A	B	Type	Score
CYTIP	CYTH1	psi-mi:“MI:0915”(physical association)	0.810
CYTIP	SCNM1	psi-mi:“MI:0915”(physical association)	0.560
CYTIP	MCRS1	psi-mi:“MI:0915”(physical association)	0.560
CYTIP	KIF9	psi-mi:“MI:0915”(physical association)	0.560
CYTIP	FGFR3	psi-mi:“MI:0915”(physical association)	0.560
CYTIP	SPRED1	psi-mi:“MI:0915”(physical association)	0.560
CYTIP	SNX27	psi-mi:“MI:0407”(direct interaction)	0.440
NHERF2	CYTIP	psi-mi:“MI:0407”(direct interaction)	0.440
CYTIP	SHANK1	psi-mi:“MI:0407”(direct interaction)	0.440
MAST2	CYTIP	psi-mi:“MI:0407”(direct interaction)	0.440
CYTIP	RHPN1	psi-mi:“MI:0407”(direct interaction)	0.440
CYTIP	PDZK1	psi-mi:“MI:0407”(direct interaction)	0.440
CYTIP	PARD3	psi-mi:“MI:0407”(direct interaction)	0.440
PARD3B	CYTIP	psi-mi:“MI:0407”(direct interaction)	0.440
CYTIP	MAST1	psi-mi:“MI:0407”(direct interaction)	0.440
CYTIP	PTPN3	psi-mi:“MI:0407”(direct interaction)	0.440
APBA3	CYTIP	psi-mi:“MI:0407”(direct interaction)	0.440
CYTIP	AHNAK	psi-mi:“MI:0407”(direct interaction)	0.440
CYTIP	APBA1	psi-mi:“MI:0407”(direct interaction)	0.440
CYTIP	APBA2	psi-mi:“MI:0407”(direct interaction)	0.440
CYTIP	ARHGAP21	psi-mi:“MI:0407”(direct interaction)	0.440
CYTIP	ARHGEF11	psi-mi:“MI:0407”(direct interaction)	0.440
CYTIP	CARD11	psi-mi:“MI:0407”(direct interaction)	0.440

BioGRID (34): CYTH3 (Affinity Capture-MS), CYTH1 (Affinity Capture-MS), CYTH2 (Affinity Capture-MS), BLK (Affinity Capture-MS), FAM175B (Affinity Capture-MS), EDEM2 (Affinity Capture-MS), HBB (Affinity Capture-MS), CYTH1 (Affinity Capture-MS), CYTH3 (Affinity Capture-MS), CYTH2 (Affinity Capture-MS), FAM175B (Affinity Capture-MS), EDEM2 (Affinity Capture-MS), HBB (Affinity Capture-MS), CYTIP (Affinity Capture-MS), CYTIP (Affinity Capture-MS)

ESM2 similar proteins: A1A5G4, D3YZU1, E9Q9R9, F1MAD2, O15018, O35346, O35867, O60759, P34152, P97306, P97879, Q00944, Q4L1J4, Q5F488, Q5I0L6, Q5JV73, Q5RD32, Q5SGD7, Q5TCQ9, Q68DX3, Q69Z98, Q6DD51, Q6P9H4, Q6RHR9, Q6ZWJ1, Q812E4, Q8BH60, Q8BMA3, Q8IWQ3, Q8TDM6, Q8TDW5, Q8TEW0, Q8TEW8, Q91VY6, Q925T6, Q96QZ7, Q99469, Q99NH2, Q9CSB4, Q9EQJ9

Diamond homologs: O15021, O60307, O60759, Q3T0X8, Q3U214, Q4ACU6, Q4L1J4, Q5I0L6, Q5RCF7, Q5T2W1, Q69ZH9, Q6AX33, Q6AYQ0, Q6RHR9, Q7Z6J2, Q811L6, Q865P3, Q8R4T5, Q91VY6, Q96QZ7, Q9BYB0, Q9JIL4, Q9JJ40, Q9JJA9, Q9JLU4, Q9P227, A1ZA47, A2RUV4, A4D2P6, A5PKA5, A8MUH7, B9EJ80, D3YZU1, D3ZFD0, G5EDM4, O14745, O14907, O14910, O15085, O88951

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 115 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Ras activation upon Ca2+ influx through NMDA receptor	5	38.6×	9e-06
Unblocking of NMDA receptors, glutamate binding and activation	5	36.7×	9e-06
Negative regulation of NMDA receptor-mediated neuronal transmission	5	36.7×	9e-06
Assembly and cell surface presentation of NMDA receptors	10	34.3×	3e-11
Dopamine Neurotransmitter Release Cycle	5	33.5×	1e-05
Long-term potentiation	5	32.1×	1e-05
Neurexins and neuroligins	11	29.3×	2e-11
Protein-protein interactions at synapses	7	25.1×	1e-06

GO biological processes:

GO term	Partners	Fold	FDR
establishment or maintenance of epithelial cell apical/basal polarity	11	59.7×	9e-15
protein localization to synapse	6	43.0×	7e-07
receptor clustering	7	40.8×	9e-08
regulation of postsynaptic membrane neurotransmitter receptor levels	7	32.4×	4e-07
protein-containing complex assembly	9	9.6×	3e-05
cell-cell adhesion	10	9.5×	1e-05
regulation of small GTPase mediated signal transduction	6	8.1×	3e-03
chemical synaptic transmission	7	5.1×	9e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

59 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	44
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
2684808	GRCh37/hg19 2q24.1(chr2:156828817-158377885)x1	Pathogenic

SpliceAI

978 predictions. Top by Δscore:

Variant	Effect	Δscore
2:157418598:T:TC	acceptor_gain	1.0000
2:157427426:T:C	acceptor_gain	1.0000
2:157430557:A:AC	donor_gain	1.0000
2:157430558:C:CC	donor_gain	1.0000
2:157434743:GCAAG:G	acceptor_gain	1.0000
2:157434744:CAAG:C	acceptor_gain	1.0000
2:157434744:CAAGC:C	acceptor_gain	1.0000
2:157434748:C:CC	acceptor_gain	1.0000
2:157443843:ATAC:A	donor_loss	1.0000
2:157443844:TACCT:T	donor_loss	1.0000
2:157443846:C:CT	donor_loss	1.0000
2:157443846:CCTG:C	donor_gain	1.0000
2:157418585:GTTTG:G	acceptor_gain	0.9900
2:157418586:TTTG:T	acceptor_gain	0.9900
2:157418590:C:CC	acceptor_gain	0.9900
2:157418598:T:C	acceptor_gain	0.9900
2:157427346:ATTAC:A	donor_loss	0.9900
2:157427347:TTAC:T	donor_loss	0.9900
2:157427348:TA:T	donor_loss	0.9900
2:157427349:A:C	donor_loss	0.9900
2:157427350:C:A	donor_loss	0.9900
2:157427353:TTAAA:T	donor_gain	0.9900
2:157427416:CTATC:C	acceptor_gain	0.9900
2:157427419:TC:T	acceptor_gain	0.9900
2:157427420:CC:C	acceptor_gain	0.9900
2:157427421:C:CA	acceptor_loss	0.9900
2:157427421:C:CC	acceptor_gain	0.9900
2:157427422:T:A	acceptor_loss	0.9900
2:157427426:T:TC	acceptor_gain	0.9900
2:157430563:G:C	donor_gain	0.9900

AlphaMissense

2376 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:157434380:A:G	F90S	0.997
2:157430586:A:G	L150P	0.994
2:157430883:G:T	A120D	0.992
2:157434379:A:C	F90L	0.992
2:157434379:A:T	F90L	0.992
2:157434381:A:G	F90L	0.992
2:157430562:A:G	L158P	0.991
2:157430868:A:G	L125P	0.991
2:157434383:C:T	G89E	0.991
2:157434385:A:C	F88L	0.990
2:157434385:A:T	F88L	0.990
2:157434387:A:G	F88L	0.990
2:157415723:A:G	I345T	0.989
2:157418552:A:G	L195P	0.987
2:157430631:T:A	N135I	0.986
2:157430643:A:T	L131H	0.986
2:157430888:G:C	S118R	0.986
2:157430888:G:T	S118R	0.986
2:157430890:T:G	S118R	0.986
2:157434380:A:C	F90C	0.984
2:157415723:A:T	I345N	0.983
2:157430583:A:T	I151N	0.983
2:157430634:A:T	I134N	0.982
2:157430643:A:C	L131R	0.982
2:157434384:C:G	G89R	0.982
2:157434384:C:T	G89R	0.982
2:157430634:A:C	I134S	0.981
2:157430630:A:C	N135K	0.980
2:157430630:A:T	N135K	0.980
2:157415725:A:C	F344L	0.979

dbSNP variants (sampled 300 via entrez): RS1000233226 (2:157414589 G>GAC), RS1000238425 (2:157443719 A>T), RS1000464971 (2:157420854 G>A,C), RS1000670294 (2:157414861 G>A), RS1000696968 (2:157426249 G>A), RS1000752363 (2:157432236 C>G), RS1000764716 (2:157427711 T>C), RS1000973584 (2:157438871 A>C,G), RS1001117582 (2:157431733 C>A), RS1001183565 (2:157422871 A>G), RS1001218448 (2:157440202 A>G), RS1001358530 (2:157425863 T>C), RS1001435889 (2:157429044 T>C), RS1001460042 (2:157439768 A>G), RS1001504299 (2:157415505 A>G)

Disease associations

OMIM: gene MIM:604448 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST008972_202	Urate levels	1.000000e-11
GCST009379_238	Type 2 diabetes	7.000000e-10

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004531	urate measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

46 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases methylation, decreases expression, affects cotreatment	2
Benzo(a)pyrene	decreases methylation, affects methylation, decreases expression	2
Dinitrochlorobenzene	increases expression	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
GSK-J4	increases expression	1
testosterone enanthate	affects expression	1
triphenyl phosphate	affects expression	1
propionaldehyde	decreases expression	1
kojic acid	increases expression	1
sodium arsenite	affects methylation	1
ammonium hexachloroplatinate	increases expression	1
butyraldehyde	decreases expression	1
4-phenylenediamine	increases expression	1
nickel sulfate	increases expression	1
pentanal	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
ON 01910	increases expression	1
(+)-JQ1 compound	decreases expression	1
Bortezomib	increases expression	1
Zoledronic Acid	increases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Air Pollutants	increases abundance, increases expression	1
Air Pollutants, Occupational	affects expression	1
Aldehydes	decreases expression	1
Cisplatin	increases expression	1
Dinitrofluorobenzene	increases expression	1
Diuron	decreases expression	1
Drugs, Chinese Herbal	increases expression	1
Dust	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.